# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mitochondrial transport	13	3.971956e-26	4.020536077230769e-23	2.310138	201	0.03551237	161	0.001043575720993789	1.504288	88	239	0.01914708	
GO Biological Process	liver regeneration	18	8.918722e-24	6.520081266555555e-21	4.374654	71	0.01254417	258	0.007421400579069766	2.217848	19	35	0.00413403	
GO Biological Process	regulation of mitochondrial membrane permeability	26	2.046462e-19	1.0357459022307692e-16	2.987302	93	0.0164311	342	0.021019297790350878	1.734942	31	73	0.006744996	
GO Biological Process	mitochondrial membrane organization	28	2.680092e-19	1.2595475224285714e-16	2.465188	128	0.02261484	410	0.036811853168292684	1.515592	46	124	0.0100087	
GO Biological Process	regulation of PERK-mediated unfolded protein response	31	1.309077e-18	5.556820723548387e-16	7.378381	34	0.006007067	313	0.014877910140575079	3.268407	8	10	0.001740644	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	36	7.415162e-18	2.7104476877222222e-15	4.095383	56	0.009893993	285	0.010186441923508772	2.486832	14	23	0.003046127	
GO Biological Process	regulation of membrane permeability	37	8.779656e-18	3.1224727919999998e-15	2.740115	97	0.01713781	319	0.01614702939278997	1.714905	34	81	0.007397737	
GO Biological Process	cellular response to epidermal growth factor stimulus	39	2.362605e-17	7.97167158846154e-15	3.12214	77	0.01360424	346	0.022142173902601155	2.042755	19	38	0.00413403	
GO Biological Process	acute inflammatory response	40	4.676636e-17	1.5384963281e-14	2.867991	86	0.01519435	397	0.03290899506599496	1.717098	29	69	0.006309835	
GO Biological Process	response to epidermal growth factor	47	4.19744e-16	1.1751938927659575e-13	2.930693	78	0.01378092	390	0.03144172657820513	1.945481	20	42	0.00435161	
GO Biological Process	negative regulation of PERK-mediated unfolded protein response	49	8.950989e-16	2.4037972296122453e-13	8.307737	26	0.00459364	384	0.030057081874479166	4.085509	5	5	0.001087903	
GO Biological Process	regulation of collagen biosynthetic process	52	1.504535e-15	3.807341550961538e-13	3.421533	60	0.01060071	401	0.03312960375810473	2.10865	16	31	0.003481288	
GO Biological Process	regulation of collagen metabolic process	65	1.192359e-14	2.4138849355384614e-12	3.149388	63	0.01113074	371	0.028668048430188678	2.042755	18	36	0.003916449	
GO Biological Process	negative regulation of protein ubiquitination	67	2.275341e-14	4.468837644626865e-12	2.25106	111	0.01961131	315	0.015467180504126985	1.539467	52	138	0.01131419	
GO Biological Process	maintenance of protein location in cell	95	7.184617e-13	9.951828958210526e-11	2.508749	79	0.0139576	409	0.036806076909535454	1.644168	33	82	0.007180157	
GO Biological Process	regulation of multicellular organismal metabolic process	100	1.362005e-12	1.7922623794999998e-10	2.763919	65	0.0114841	317	0.0156530663659306	2.097964	19	37	0.00413403	
GO Biological Process	maintenance of protein location	175	1.48879e-10	1.1194850062857143e-8	2.199499	82	0.01448763	450	0.04916471428444444	1.588809	35	90	0.007615318	
GO Biological Process	animal organ regeneration	188	2.669587e-10	1.8685689006914892e-8	2.022694	97	0.01713781	319	0.01614702939278997	1.714905	34	81	0.007397737	
GO Biological Process	translational termination	207	5.296806e-10	3.367182133043478e-8	2.443455	62	0.01095406	416	0.038608727425480764	1.591198	37	95	0.008050479	
GO Biological Process	DNA biosynthetic process	223	8.281439e-10	4.886791739955157e-8	2.010178	93	0.0164311	420	0.04030272725	1.52341	44	118	0.009573542	
GO Cellular Component	mitochondrial outer membrane	37	2.679152e-16	1.2512363935135136e-14	2.05494	157	0.02773852	42	0.000249309792	1.615738	70	177	0.01523064	
GO Cellular Component	catalytic step 2 spliceosome	40	7.082993e-13	3.059852976e-11	2.509488	79	0.0139576	59	0.02156989472542373	1.617181	38	96	0.008268059	
GO Cellular Component	Bcl-2 family protein complex	43	7.72975e-12	3.106280930232558e-10	7.15359	21	0.003710247	67	0.030610410985074627	3.501865	6	7	0.001305483	
GO Cellular Component	spliceosomal snRNP complex	53	4.610383e-9	1.5031588347169812e-7	2.772763	44	0.007773852	57	0.008991402442105263	1.845069	28	62	0.006092254	
GO Cellular Component	small nuclear ribonucleoprotein complex	63	2.806001e-7	0.000007696459885714287	2.361875	45	0.00795053	64	0.026806863599999998	1.717098	29	69	0.006309835	
GO Cellular Component	tRNA methyltransferase complex	73	0.000001396165	0.000033048946849315065	10.53356	8	0.001413428	62	0.024445965832258065	4.085509	5	5	0.001087903	
GO Cellular Component	U2 snRNP	111	0.00002177424	0.0003389719524324324	3.531019	16	0.002826855	73	0.04482346783561644	2.365295	11	19	0.002393386	
GO Cellular Component	fibrinogen complex	137	0.000240332	0.0030313408467153285	2.85834	16	0.002826855	66	0.03058525963636364	3.177618	7	9	0.001523064	
GO Cellular Component	U1 snRNP	162	0.0006303203	0.006723416533333333	2.610664	16	0.002826855	58	0.011606362262068966	2.580322	12	19	0.002610966	
Human Phenotype	Abnormal CNS myelination	9	1.001499e-12	7.425558696666666e-10	2.237908	98	0.01731449	3	0.0004440652393666667	1.862992	57	125	0.01240209	
Human Phenotype	Hypoglycemia	17	6.778108e-10	2.6606067461176473e-7	2.027327	92	0.01625442	71	0.04216644263661972	1.590818	44	113	0.009573542	
Human Phenotype	Nevus	190	0.00006250178	0.0021951283049473683	2.239553	30	0.005300353	75	0.04667483234	2.269727	15	27	0.003263708	
Human Phenotype	Elevated circulating follicle stimulating hormone level	357	0.001809394	0.03382096964145658	2.523763	14	0.002473498	69	0.03190091478695652	3.57482	7	8	0.001523064	
Mouse Phenotype Single KO	abnormal branching of the mammary ductal tree	11	1.98174e-19	1.649708470909091e-16	3.03206	91	0.01607774	109	0.014446419236697247	2.150268	20	38	0.00435161	
Mouse Phenotype Single KO	abnormal mammary gland duct morphology	16	2.68866e-17	1.53875372625e-14	2.545708	107	0.01890459	122	0.02025110330409836	1.927127	25	53	0.005439513	
Mouse Phenotype Single KO	abnormal rostral-caudal body axis extension	218	4.177135e-7	0.000017545883116972476	2.920954	30	0.005300353	164	0.046558498490243905	2.828429	9	13	0.001958225	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	262	0.000002003185	0.00007001208032442747	3.025523	25	0.004416961	93	0.008376667044838708	2.553443	15	24	0.003263708	
Mouse Phenotype Single KO	abnormal B cell apoptosis	263	0.000002022852	0.00007043063028136882	2.041161	53	0.009363958	165	0.048656307767878784	1.990376	19	39	0.00413403	
Mouse Phenotype	thick epidermis	34	6.480842e-16	1.8224508930000002e-13	2.160923	136	0.02402827	195	0.012780620170769228	1.606269	46	117	0.0100087	
Mouse Phenotype	abnormal branching of the mammary ductal tree	41	5.253726e-15	1.2251432752682927e-12	2.367509	105	0.01855124	181	0.011181198608287292	1.875316	28	61	0.006092254	
Mouse Phenotype	abnormal mammary gland duct morphology	56	2.042962e-13	3.4879928003571434e-11	2.078553	123	0.02173145	208	0.018330974342307692	1.728485	33	78	0.007180157	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	125	3.646657e-10	2.78925500616e-8	3.562867	35	0.006183746	170	0.009077342754705882	2.315122	17	30	0.003698869	
Mouse Phenotype	increased liver adenoma incidence	205	2.613866e-8	0.0000012190816012682928	3.18558	32	0.00565371	249	0.033613480987951805	2.188666	15	28	0.003263708	
Mouse Phenotype	lymph node hyperplasia	247	1.382886e-7	0.000005352944553036438	2.238136	53	0.009363958	138	0.004528683351956522	2.135607	23	44	0.005004352	
Mouse Phenotype	decreased circulating noradrenaline level	314	7.729851e-7	0.00002353665777420382	2.832829	30	0.005300353	200	0.016917520229999997	3.268407	8	10	0.001740644	
Mouse Phenotype	abnormal subarachnoid space morphology	366	0.000002369875	0.00006190812807377049	4.014201	17	0.003003534	270	0.04202810215555555	3.501865	6	7	0.001305483	
Mouse Phenotype	lymphoid hyperplasia	551	0.00006413297	0.0011128408823411979	2.114497	34	0.006007067	214	0.020342828006074766	2.170427	17	32	0.003698869	
Mouse Phenotype	abnormal intestinal lipid absorption	629	0.0001572697	0.002390549446263911	2.064136	32	0.00565371	262	0.0409984438167939	2.042755	17	34	0.003698869	
Mouse Phenotype	absent thymus corticomedullary boundary	833	0.001108846	0.012727102768307323	2.784659	13	0.00229682	270	0.04202810215555555	3.501865	6	7	0.001305483