# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	6	2.654341e-25	5.821412203166667e-22	2.867682	132	0.01980198	140	1.390485212e-8	1.917004	69	113	0.01153653	
GO Biological Process	regulation of mRNA stability	8	8.89182e-24	1.46259324225e-20	2.351632	176	0.02640264	123	1.8641970158536585e-9	1.829608	88	151	0.01471326	
GO Biological Process	RNA catabolic process	11	5.484151e-23	6.560540273545454e-20	2.161443	203	0.03045305	172	1.5584785144186048e-7	1.576234	121	241	0.02023073	
GO Biological Process	regulation of DNA-templated transcription in response to stress	12	6.685903e-23	7.331649798083333e-20	2.631177	137	0.02055206	125	3.36624800424e-9	1.925876	73	119	0.01220532	
GO Biological Process	regulation of RNA stability	13	1.568094e-22	1.5872729958461538e-19	2.261976	180	0.0270027	122	1.8611830734426231e-9	1.805179	92	160	0.01538204	
GO Biological Process	mRNA catabolic process	15	4.771114e-22	4.1855392750666665e-19	2.237427	180	0.0270027	196	0.000002422366458469388	1.562351	106	213	0.01772279	
GO Biological Process	nuclear-transcribed mRNA catabolic process	18	2.977587e-21	2.1767815185e-18	2.281845	166	0.02490249	207	0.000010333324066666667	1.553865	98	198	0.01638522	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	24	5.780255e-20	3.1692656477083336e-17	2.838549	104	0.01560156	269	0.0002667776901672862	1.639177	59	113	0.009864571	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	25	2.367884e-19	1.24635942224e-16	2.813318	102	0.01530153	189	0.0000013028823374074074	1.782564	67	118	0.01120214	
GO Biological Process	regulation of hematopoietic stem cell differentiation	28	7.333107e-18	3.4462983933214285e-15	2.840372	92	0.01380138	289	0.0005223503752941176	1.645921	54	103	0.009028591	
GO Biological Process	regulation of cellular amino acid metabolic process	30	1.328334e-17	5.826515702e-15	3.66557	63	0.009450945	275	0.0003088891024	1.883665	36	60	0.00601906	
GO Biological Process	protein targeting to ER	32	1.888721e-17	7.7667748871875e-15	2.834045	90	0.01350135	101	1.4284016327722774e-10	2.0826	67	101	0.01120214	
GO Biological Process	antigen processing and presentation of peptide antigen via MHC class I	37	1.047155e-16	3.724192606756757e-14	2.89298	83	0.01245125	249	0.00009368156336947791	1.763731	50	89	0.008359806	
GO Biological Process	cotranslational protein targeting to membrane	42	1.893561e-16	5.932706952142858e-14	2.820005	85	0.01275128	109	2.9035381789908257e-10	2.082283	65	98	0.01086775	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	45	1.094253e-15	3.1998389393333334e-13	2.83392	80	0.0120012	117	1.3024845682051282e-9	2.081586	61	92	0.01019896	
GO Biological Process	viral gene expression	46	2.452622e-15	7.016098456086956e-13	2.472988	99	0.01485149	145	2.0499498582758622e-8	1.854001	75	127	0.01253971	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	47	3.510594e-15	9.828916265106384e-13	2.673785	85	0.01275128	188	0.0000012479218659042553	1.972213	49	78	0.00819261	
GO Biological Process	protein localization to endoplasmic reticulum	50	4.568302e-15	1.20228572036e-12	2.386258	104	0.01560156	120	1.47769977425e-9	1.924174	76	124	0.01270691	
GO Biological Process	RNA phosphodiester bond hydrolysis	52	1.550263e-14	3.9230597725e-12	2.276392	110	0.01650165	408	0.008198134405882353	1.463499	62	133	0.01036616	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	56	3.424057e-14	8.04592251125e-12	2.484066	90	0.01350135	121	1.74380240446281e-9	2.003263	67	105	0.01120214	
GO Cellular Component	ribosomal subunit	23	2.391361e-17	1.796639916521739e-15	2.283116	133	0.019952	38	3.4649751410526316e-8	1.680025	99	185	0.01655242	
GO Cellular Component	ribosome	27	3.834123e-16	2.45383872e-14	2.00273	166	0.02490249	36	3.3736416e-9	1.636234	123	236	0.02056512	
GO Cellular Component	peptidase complex	28	1.085781e-15	6.700819885714286e-14	2.677069	88	0.01320132	43	0.000001530762463255814	1.8908	53	88	0.008861394	
GO Cellular Component	mitochondrial ribosome	30	1.279647e-14	7.37076672e-13	3.079758	65	0.009750975	99	0.004315622400000001	1.588188	43	85	0.007189433	
GO Cellular Component	proteasome complex	32	5.907561e-14	3.1900829399999997e-12	2.863693	69	0.01035104	59	0.0000365605846779661	1.892899	41	68	0.006855041	
GO Cellular Component	endopeptidase complex	33	6.061616e-14	3.1740825599999997e-12	2.862076	69	0.01035104	63	0.000058465344000000005	1.865465	41	69	0.006855041	
GO Cellular Component	mitochondrial large ribosomal subunit	37	2.742535e-13	1.2808379675675676e-11	3.666929	46	0.00690069	111	0.008469016735135136	1.723615	28	51	0.004681491	
GO Cellular Component	large ribosomal subunit	38	6.678653e-13	3.037029574736842e-11	2.419152	85	0.01275128	62	0.00005364929961290322	1.665269	61	115	0.01019896	
GO Cellular Component	chromosome, telomeric region	39	7.310772e-13	3.239234363076923e-11	2.089795	116	0.01740174	92	0.002720405426086956	1.428728	76	167	0.01270691	
GO Cellular Component	nuclear chromosome, telomeric region	46	2.490369e-10	9.355125286956522e-9	2.090138	90	0.01350135	124	0.01813779870967742	1.403235	59	132	0.009864571	
GO Cellular Component	cytoplasmic exosome (RNase complex)	47	5.333616e-10	1.96095498893617e-8	7.305396	17	0.002550255	88	0.0026187663272727274	2.656451	11	13	0.001839157	
GO Cellular Component	proteasome accessory complex	59	2.226531e-8	6.521094183050848e-7	3.644534	27	0.004050405	51	0.000009654369882352943	2.616201	20	24	0.003343922	
GO Cellular Component	mitochondrial nucleoid	60	2.335437e-8	6.72605856e-7	2.769158	40	0.0060006	69	0.00038976692869565217	2.018212	27	42	0.004514295	
GO Cellular Component	proteasome regulatory particle, base subcomplex	64	4.746749e-8	0.0000012816222300000001	6.174857	15	0.002250225	105	0.005877352594285714	2.616201	10	12	0.001671961	
GO Cellular Component	small ribosomal subunit	80	6.915666e-7	0.000014937838560000002	2.156058	51	0.007650765	80	0.0015468829199999999	1.700531	39	72	0.006520649	
GO Cellular Component	spliceosomal snRNP complex	85	9.927339e-7	0.00002018169622588235	2.300804	43	0.006450645	118	0.013927407620338984	1.620357	32	62	0.005350276	
GO Cellular Component	small nuclear ribonucleoprotein complex	87	0.000001771143	0.0000351785644137931	2.139128	48	0.00720072	106	0.005842204981132076	1.63797	36	69	0.00601906	
GO Cellular Component	proteasome regulatory particle	91	0.000002926258	0.00005556674531868132	3.130023	23	0.003450345	65	0.00013480606523076923	2.541453	17	21	0.002842334	
GO Cellular Component	exosome (RNase complex)	96	0.000006040282	0.00010872507600000001	2.990845	23	0.003450345	98	0.004028459951020408	2.183959	16	23	0.002675138	
GO Cellular Component	cytosolic small ribosomal subunit	109	0.00002870582	0.00045507942165137614	2.177381	35	0.005250525	77	0.0011798826638961038	1.926476	27	44	0.004514295	
GO Molecular Function	ribonucleoprotein complex binding	5	9.088165e-15	7.674046526e-12	2.38269	102	0.01530153	47	0.0009968402506382978	1.61067	59	115	0.009864571	
GO Molecular Function	structural constituent of ribosome	6	3.077527e-14	2.165553165666667e-11	2.188715	117	0.01755176	16	2.4732122407499996e-7	1.724755	89	162	0.01488045	
GO Molecular Function	unfolded protein binding	11	4.174333e-13	1.6021849023636364e-10	2.504481	81	0.01215122	96	0.030307059668749997	1.480869	50	106	0.008359806	
GO Molecular Function	mRNA 5'-UTR binding	16	3.77941e-11	9.9729181375e-9	3.889015	35	0.005250525	67	0.0062272231462686565	2.28323	16	22	0.002675138	
GO Molecular Function	NF-kappaB binding	20	3.343315e-10	7.057737964999999e-8	3.297211	39	0.005850585	86	0.020548076346511627	2.018212	18	28	0.00300953	
GO Molecular Function	rRNA binding	22	6.824252e-10	1.3096359974545454e-7	3.103397	41	0.006150615	106	0.044221228	1.622045	31	60	0.00518308	
GO Molecular Function	thiolester hydrolase activity	43	4.755803e-7	0.00004669534945581395	2.689587	34	0.00510051	105	0.042501667714285714	1.84673	20	34	0.003343922	
GO Molecular Function	thyroid hormone receptor binding	63	0.000005694086	0.00038159414431746035	2.55656	30	0.00450045	86	0.020548076346511627	2.018212	18	28	0.00300953	
Human Phenotype	Increased serum lactate	1	5.924758e-15	3.9535910134e-11	2.548664	91	0.01365137	38	0.001605417032	1.663904	53	100	0.008861394	
Human Phenotype	Progressive external ophthalmoplegia	2	9.172236e-12	3.0603165414e-8	5.075228	28	0.00420042	43	0.0027889586239534885	2.720849	13	15	0.00217355	
Human Phenotype	Increased CSF lactate	7	2.101638e-9	0.000002003461482	2.704136	48	0.00720072	87	0.04015423292183908	1.677977	31	58	0.00518308	
Human Phenotype	Abnormal CSF metabolite level	8	2.363362e-9	0.0000019713393282499997	2.601952	51	0.007650765	89	0.042470900822471916	1.644469	33	63	0.005517472	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	12	4.908789e-9	0.0000027296957497500003	4.737588	22	0.00330033	53	0.010367553035094339	2.441788	14	18	0.002340746	
Human Phenotype	External ophthalmoplegia	21	1.383474e-7	0.00004396153334285715	2.583602	40	0.0060006	55	0.010803737445818182	2.060259	21	32	0.003511119	
Human Phenotype	Tethered cord	139	0.0003940069	0.01891516578201439	2.840902	15	0.002250225	54	0.010334517115185184	2.854038	10	11	0.001671961	
Mouse Phenotype	spleen atrophy	80	0.00001173475	0.001402449309375	2.218361	37	0.005550555	172	0.02514663068372093	2.052712	17	26	0.002842334	
Mouse Phenotype	ovary hypoplasia	99	0.0000338576	0.0032698233696969695	3.124181	18	0.00270027	188	0.03467174086117021	2.790615	8	9	0.001337569