# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	16	1.109767e-62	9.127139970625e-60	2.618769	400	0.01808318	330	0.00004599357605454545	1.341112	93	113	0.008070815	
GO Biological Process	regulation of DNA-templated transcription in response to stress	21	3.912171e-55	2.451440866142857e-52	2.396128	414	0.01871609	317	0.000023314481081072552	1.341961	98	119	0.00850473	
GO Biological Process	mRNA catabolic process	25	1.048584e-53	5.5193267424e-51	2.071484	553	0.025	162	2.8399997485185184e-10	1.354111	177	213	0.01536058	
GO Biological Process	nuclear-transcribed mRNA catabolic process	29	5.832597e-50	2.6465911697586207e-47	2.0878	504	0.02278481	170	9.131254577058824e-10	1.357936	165	198	0.01431919	
GO Biological Process	endoplasmic reticulum unfolded protein response	34	8.090628e-48	3.1313109956470586e-45	2.418873	351	0.01586799	291	0.0000037950546956013743	1.37223	96	114	0.008331164	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	36	1.534667e-47	5.609634181388888e-45	2.087666	479	0.02165461	538	0.0032916749317843863	1.230027	117	155	0.01015361	
GO Biological Process	liver regeneration	42	2.816124e-45	8.823184694285715e-43	3.231994	205	0.009267631	616	0.008093568985876624	1.443292	31	35	0.002690272	
GO Biological Process	IRE1-mediated unfolded protein response	45	1.530044e-44	4.4741886657777773e-42	3.204621	204	0.009222423	520	0.002830371840576923	1.376666	49	58	0.004252365	
GO Biological Process	cellular response to topologically incorrect protein	46	6.838501e-44	1.956257275195652e-41	2.190301	395	0.01785714	263	5.648803457034222e-7	1.35989	116	139	0.01006682	
GO Biological Process	positive regulation of nuclease activity	49	1.815939e-43	4.876722714489795e-41	5.256052	112	0.005063291	672	0.01286512741577381	1.629524	15	15	0.001301744	
GO Biological Process	response to topologically incorrect protein	51	2.258751e-43	5.828020472352941e-41	2.003665	482	0.02179024	240	1.5202000545e-7	1.330778	147	180	0.01275709	
GO Biological Process	cellular response to unfolded protein	58	1.36459e-41	3.0959723810344825e-39	2.221777	362	0.01636528	277	0.0000014039698141155234	1.373648	102	121	0.008851861	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	62	1.46383e-40	3.106861124193548e-38	2.288633	331	0.01496383	746	0.022119079520107235	1.248146	72	94	0.006248373	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	72	2.685014e-38	4.9072360036111114e-36	2.493122	263	0.01188969	375	0.00022582619587733333	1.378828	66	78	0.005727675	
GO Biological Process	response to epidermal growth factor	79	1.845962e-36	3.074811893417722e-34	2.461201	256	0.01157324	811	0.029665221242909986	1.357936	35	42	0.003037403	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	82	2.349414e-35	3.770236442195122e-33	2.319012	279	0.01261302	214	2.3647633061682243e-8	1.422381	103	118	0.008938644	
GO Biological Process	translational elongation	87	1.099655e-34	1.6632597867816093e-32	2.308654	276	0.0124774	167	4.829613816107784e-10	1.469481	101	112	0.008765079	
GO Biological Process	mitochondrial translational termination	95	1.490279e-33	2.0642717222105263e-31	2.586009	214	0.009674503	244	1.7319778725409835e-7	1.460952	78	87	0.006769071	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	96	1.509787e-33	2.069509076354167e-31	2.458834	235	0.01062387	493	0.0018055968372819471	1.36199	56	67	0.004859846	
GO Biological Process	mitochondrial translational elongation	102	2.093272e-32	2.700526102745098e-30	2.56746	209	0.009448463	256	3.55260719328125e-7	1.456986	76	85	0.006595505	
GO Cellular Component	mitochondrial ribosome	39	2.033758e-37	9.01111236923077e-36	2.869984	201	0.009086799	72	1.65872928e-7	1.456986	76	85	0.006595505	
GO Cellular Component	ribosomal subunit	40	5.747306e-36	2.482836192e-34	2.017535	390	0.0176311	44	5.048768290909091e-12	1.400509	159	185	0.01379849	
GO Cellular Component	large ribosomal subunit	51	1.891484e-25	6.408792847058824e-24	2.101312	245	0.01107595	65	2.9788992e-8	1.416977	100	115	0.008678296	
GO Cellular Component	catalytic step 2 spliceosome	53	2.678977e-25	8.734475954716981e-24	2.064539	254	0.01148282	106	0.0003479419290566038	1.323988	78	96	0.006769071	
GO Cellular Component	mitochondrial large ribosomal subunit	62	8.356523e-22	2.3290438296774194e-20	2.810675	117	0.005289331	105	0.00034493611885714283	1.437815	45	51	0.003905233	
GO Cellular Component	PcG protein complex	66	1.304104e-20	3.414381381818182e-19	2.111133	193	0.008725136	123	0.001820825912195122	1.416977	40	46	0.003471318	
GO Cellular Component	nuclear ubiquitin ligase complex	68	4.374348e-20	1.1115990211764707e-18	2.720469	113	0.005108499	137	0.0033733158306569347	1.425833	35	40	0.003037403	
GO Cellular Component	endopeptidase complex	82	1.154731e-16	2.433384351219512e-15	2.05001	164	0.007414105	90	0.0000491816832	1.416977	60	69	0.005206977	
GO Cellular Component	proteasome complex	93	1.949831e-15	3.622911793548387e-14	2.00114	160	0.007233273	92	0.00006859573982608695	1.413851	59	68	0.005120194	
GO Cellular Component	spliceosomal tri-snRNP complex	95	2.367242e-15	4.305888606315789e-14	2.79985	80	0.003616637	192	0.030564504000000003	1.404762	25	29	0.002169574	
GO Cellular Component	mitochondrial small ribosomal subunit	118	5.360202e-13	7.849516149152543e-12	2.732875	69	0.003119349	128	0.0026023842	1.513129	26	28	0.002256357	
GO Cellular Component	ESCRT complex	224	1.168565e-7	9.014644285714285e-7	2.103264	62	0.002802893	202	0.04127234756435643	1.396734	24	28	0.002082791	
GO Cellular Component	palmitoyltransferase complex	270	0.00000151426	0.000009691264	2.099208	51	0.002305606	199	0.04029233173869347	1.629524	11	11	0.0009546125	
GO Cellular Component	Ino80 complex	329	0.00002031579	0.00010670421009118542	2.430508	29	0.001311031	143	0.004869551127272727	1.629524	16	16	0.001388527	
GO Molecular Function	unfolded protein binding	9	8.521816e-43	3.997678572444445e-40	2.581028	277	0.0125226	82	0.00046804391765853663	1.322066	86	106	0.007463334	
GO Molecular Function	rRNA binding	35	5.254528e-18	6.338462061714286e-16	2.554769	112	0.005063291	99	0.0024544426414141417	1.385095	51	60	0.004425931	
GO Molecular Function	NF-kappaB binding	50	1.438161e-14	1.2143831484000002e-12	2.445871	96	0.004339964	142	0.0336032547887324	1.454932	25	28	0.002169574	
GO Molecular Function	aminoacyl-tRNA editing activity	234	3.956995e-7	0.000007139501235042735	2.626838	36	0.001627486	152	0.04850091940789474	1.629524	13	13	0.001128178	
Human Phenotype	Abnormal CSF metabolite level	33	2.195778e-16	4.440129270909091e-14	2.167846	141	0.006374322	145	0.0009586178686206896	1.396734	54	63	0.00468628	
Human Phenotype	Exercise intolerance	35	6.347759e-16	1.2102455944857142e-13	2.082747	150	0.006781193	201	0.008153585984577114	1.326898	57	70	0.004946628	
Human Phenotype	Abnormality of transition element cation homeostasis	36	1.041545e-15	1.9306193847222221e-13	3.014855	73	0.003300181	250	0.0204901431612	1.460952	26	29	0.002256357	
Human Phenotype	Increased CSF lactate	45	9.262792e-15	1.373569133688889e-12	2.156111	127	0.00574141	180	0.004146413131666666	1.376666	49	58	0.004252365	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	23	2.121564e-31	8.446591977391305e-29	2.015722	339	0.0153255	292	0.04967540789726028	1.244045	71	93	0.00616159	
Mouse Phenotype Single KO	pale liver	51	5.163026e-25	9.27016256509804e-23	2.025699	263	0.01188969	205	0.01238034440292683	1.303619	64	80	0.005554109	
Mouse Phenotype Single KO	absent hypoglossal nerve	65	3.449829e-22	4.860012946615385e-20	3.874737	76	0.003435805	240	0.025067005159166666	1.629524	15	15	0.001301744	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	80	5.824148e-20	6.6664654045e-18	2.900681	101	0.004566004	118	0.0016640651372033899	1.629524	22	22	0.001909225	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	87	3.418376e-19	3.597938969195402e-17	2.234341	157	0.007097649	243	0.025363800957613168	1.499162	23	25	0.001996008	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	151	1.608602e-14	9.75494603576159e-13	2.367371	102	0.004611212	177	0.006732433337853108	1.561627	23	24	0.001996008	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	174	2.692797e-13	1.417123110862069e-11	2.663781	74	0.003345389	182	0.007627121897252747	1.629524	18	18	0.001562093	
Mouse Phenotype Single KO	thin hypoglossal nerve	202	2.763489e-12	1.2527360778712873e-10	2.700704	66	0.002983725	240	0.025067005159166666	1.629524	15	15	0.001301744	
Mouse Phenotype	extramedullary hematopoiesis	2	3.410241e-70	1.63026571005e-66	2.090759	710	0.03209765	263	0.003889622015589354	1.219815	131	175	0.01136857	
Mouse Phenotype	increased keratinocyte apoptosis	7	2.741172e-53	3.7440493559999995e-50	6.48266	115	0.005198915	471	0.03544522531847134	1.629524	13	13	0.001128178	
Mouse Phenotype	absent hypoglossal nerve	97	3.449829e-22	3.400393306082474e-20	3.874737	76	0.003435805	375	0.016750683329600002	1.629524	15	15	0.001301744	
Mouse Phenotype	absent segment of posterior cerebral artery	122	5.824148e-20	4.564317953114754e-18	2.900681	101	0.004566004	191	0.0010734184757591623	1.629524	22	22	0.001909225	
Mouse Phenotype	abnormal vitelline vein morphology	133	3.418376e-19	2.4573754087218044e-17	2.234341	157	0.007097649	378	0.01702467829920635	1.499162	23	25	0.001996008	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	188	6.084798e-16	3.094508174361702e-14	2.552637	98	0.00443038	357	0.013917125507563025	1.466571	27	30	0.00234314	
Mouse Phenotype	abnormal cerebral artery morphology	213	1.608602e-14	7.220583907042254e-13	2.367371	102	0.004611212	276	0.00450802535652174	1.561627	23	24	0.001996008	
Mouse Phenotype	abnormal hypoglossal nerve topology	240	2.692797e-13	1.072743004875e-11	2.663781	74	0.003345389	281	0.005157934935587189	1.629524	18	18	0.001562093	
Mouse Phenotype	thin hypoglossal nerve	274	2.763489e-12	9.64296289379562e-11	2.700704	66	0.002983725	375	0.016750683329600002	1.629524	15	15	0.001301744	
Mouse Phenotype	increased liver adenoma incidence	413	3.607853e-9	8.352223373607748e-8	2.063264	81	0.003661844	294	0.0062689330653061225	1.513129	26	28	0.002256357	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	670	0.000002163118	0.00003086801671343284	2.107072	49	0.00221519	428	0.026957440549065417	1.543759	18	19	0.001562093