# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mitochondrial transport	67	3.872466e-135	7.605638819999999e-133	2.082331	1401	0.03201042	180	1.3479852972777777e-9	1.242018	215	239	0.01580882	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	96	8.513184e-112	1.166926961e-109	2.21596	1006	0.02298535	900	0.03101614314888889	1.140159	128	155	0.009411765	
GO Biological Process	cellular response to insulin stimulus	99	7.495495e-110	9.962951384343432e-108	2.039246	1198	0.02737222	443	0.0003709213175395034	1.203415	129	148	0.009485294	
GO Biological Process	nuclear-transcribed mRNA catabolic process	109	4.825154e-103	5.825156099633028e-101	2.127112	1016	0.02321384	226	6.784640658407079e-8	1.241201	178	198	0.01308824	
GO Biological Process	mRNA catabolic process	111	6.083355e-102	7.21178995e-100	2.057901	1087	0.02483606	189	2.7721995675661376e-9	1.251022	193	213	0.01419118	
GO Biological Process	endoplasmic reticulum unfolded protein response	134	5.249487e-94	5.155074584552239e-92	2.431082	698	0.01594809	368	0.00007746671117663044	1.24744	103	114	0.007573529	
GO Biological Process	response to topologically incorrect protein	141	8.200958e-91	7.653645838439715e-89	2.050531	976	0.02229991	315	0.000007101394294920635	1.219585	159	180	0.01169118	
GO Biological Process	response to unfolded protein	153	4.833196e-87	4.1568644551633987e-85	2.072692	911	0.02081477	308	0.0000054348293512987006	1.233966	143	160	0.01051471	
GO Biological Process	regulation of mRNA stability	156	4.809017e-86	4.056529147628205e-84	2.000455	983	0.02245984	462	0.0005213698337662338	1.197793	131	151	0.009632353	
GO Biological Process	mitochondrial membrane organization	159	9.40181e-85	7.781032565408805e-83	2.112057	848	0.01937533	287	0.000002417453186550523	1.269318	114	124	0.008382353	
GO Biological Process	macroautophagy	161	2.744203e-84	2.2429172221739132e-82	2.09764	857	0.01958096	258	3.775272216589147e-7	1.261004	137	150	0.01007353	
GO Biological Process	cellular response to unfolded protein	165	5.168529e-82	4.121980188545454e-80	2.236482	721	0.0164736	327	0.000017502347266666665	1.255147	110	121	0.008088235	
GO Biological Process	cellular response to topologically incorrect protein	166	1.330111e-81	1.0543934125903615e-79	2.163527	772	0.01763886	353	0.000041920137963172806	1.231669	124	139	0.009117647	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	172	3.902588e-79	2.9857067146511625e-77	2.256628	682	0.01558252	380	0.00009404207477105262	1.246261	102	113	0.0075	
GO Biological Process	regulation of mitochondrial membrane permeability	173	6.015073e-79	4.575280092890173e-77	2.430087	585	0.01336623	603	0.0032309011189054727	1.24827	66	73	0.004852941	
GO Biological Process	regulation of membrane permeability	175	1.820533e-78	1.3689367855428571e-76	2.323399	636	0.0145315	560	0.001998314225875	1.2443	73	81	0.005367647	
GO Biological Process	IRE1-mediated unfolded protein response	188	5.948343e-75	4.1635236987765957e-73	3.024892	381	0.008705189	1016	0.04983743298818897	1.21403	51	58	0.00375	
GO Biological Process	positive regulation of mRNA catabolic process	197	1.15271e-71	7.699751720812183e-70	3.166483	340	0.00776841	991	0.04374112681130172	1.325435	24	25	0.001764706	
GO Biological Process	regulation of DNA-templated transcription in response to stress	201	2.150929e-69	1.4081629209452735e-67	2.085632	713	0.01629081	336	0.000027059591893750002	1.253038	108	119	0.007941176	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	203	2.697384e-69	1.7485160618719214e-67	2.522424	477	0.01089862	504	0.0010091313346825396	1.277627	62	67	0.004558824	
GO Cellular Component	cleavage furrow	72	2.215401e-56	5.3169624e-55	2.368329	436	0.009961843	87	0.000020954860137931034	1.354111	51	52	0.00375	
GO Cellular Component	PcG protein complex	80	4.331763e-50	9.35660808e-49	2.288742	414	0.009459182	146	0.004229607846575343	1.290619	43	46	0.003161765	
GO Cellular Component	P-body	82	1.677175e-49	3.5343395121951217e-48	2.005971	555	0.01268079	123	0.0007599725736585366	1.247586	75	83	0.005514706	
GO Cellular Component	methyltransferase complex	90	4.72486e-46	9.0717312e-45	2.013714	510	0.01165261	65	2.840733636923077e-7	1.319973	87	91	0.006397059	
GO Cellular Component	cell division site part	94	5.926552e-45	1.0894767931914896e-43	2.080188	459	0.01048735	101	0.00010809909481188117	1.31276	58	61	0.004264706	
GO Cellular Component	cytoplasmic stress granule	104	3.913014e-41	6.501623261538461e-40	2.330008	325	0.007425686	131	0.0018275433526717556	1.316445	41	43	0.003014706	
GO Cellular Component	spliceosomal snRNP complex	136	1.918095e-32	2.437108941176471e-31	2.241106	275	0.006283273	152	0.0058342907368421045	1.247049	56	62	0.004117647	
GO Cellular Component	U1 snRNP	176	6.489315e-25	6.371327454545454e-24	2.827518	134	0.003061667	185	0.020286477145945944	1.380662	19	19	0.001397059	
GO Cellular Component	protein phosphatase type 2A complex	181	4.720719e-24	4.50685217237569e-23	2.087617	235	0.005369342	168	0.011709833142857142	1.380662	21	21	0.001544118	
GO Cellular Component	MLL1 complex	184	1.396879e-23	1.3118515826086957e-22	2.481345	159	0.003632874	167	0.010718525317365269	1.333053	28	29	0.002058824	
GO Cellular Component	mitochondrial nucleoid	218	6.740319e-20	5.34278496880734e-19	2.066628	196	0.00447826	109	0.00034691898715596335	1.347789	41	42	0.003014706	
GO Cellular Component	U5 snRNP	341	7.865584e-11	3.9858443260997075e-10	2.136529	91	0.002079192	160	0.008901588960000002	1.380662	22	22	0.001617647	
GO Cellular Component	Ino80 complex	441	1.347281e-7	5.279141877551021e-7	2.244984	53	0.001210958	202	0.048948388752475244	1.380662	16	16	0.001176471	
GO Molecular Function	unfolded protein binding	28	4.799608e-81	7.237123205714287e-79	2.561829	544	0.01242946	118	0.004199168998305085	1.211335	93	106	0.006838235	
GO Molecular Function	protein transporter activity	35	1.823807e-69	2.200032329714286e-67	2.209773	625	0.01428017	66	0.00003723286485151515	1.279989	89	96	0.006544118	
GO Molecular Function	ribonucleoprotein complex binding	37	5.792631e-68	6.609861643783784e-66	2.198743	618	0.01412023	92	0.00027262091889130436	1.236593	103	115	0.007573529	
GO Molecular Function	rRNA binding	49	6.310924e-54	5.437698189387755e-52	3.066576	266	0.006077638	148	0.023034941024324324	1.242596	54	60	0.003970588	
GO Molecular Function	thyroid hormone receptor binding	65	1.835655e-39	1.1923285246153845e-37	2.8295	218	0.004980922	119	0.004209156605042017	1.380662	28	28	0.002058824	
GO Molecular Function	mitogen-activated protein kinase binding	111	8.267584e-27	3.1446612295495497e-25	2.317857	209	0.004775287	169	0.04625568239053254	1.329526	26	27	0.001911765	
Human Phenotype	Increased serum lactate	11	1.062731e-52	6.446912693636364e-50	2.145645	503	0.01149268	80	0.00001766167099625	1.284015	93	100	0.006838235	
Human Phenotype	Abnormal CSF metabolite level	22	5.149572e-40	1.5619588161818183e-37	2.369995	305	0.006968721	316	0.028575475367088606	1.227255	56	63	0.004117647	
Mouse Phenotype Single KO	increased liver adenoma incidence	67	9.195259e-55	1.2567311442238804e-52	3.565848	219	0.00500377	370	0.038916284802702705	1.380662	20	20	0.001470588	
Mouse Phenotype Single KO	abnormal cell adhesion	69	6.655595e-53	8.832649770289855e-51	2.033954	574	0.0131149	342	0.02705497232163743	1.240255	53	59	0.003897059	
Mouse Phenotype Single KO	increased integument system tumor incidence	129	9.415196e-42	6.683329439689922e-40	2.047148	442	0.01009893	401	0.04894633436408977	1.198996	66	76	0.004852941	
Mouse Phenotype Single KO	prenatal lethality prior to heart atrial septation	135	4.362409e-41	2.959005867629629e-39	2.099105	409	0.00934494	354	0.03265443107909605	1.237835	52	58	0.003823529	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	153	1.335115e-37	7.990619643790851e-36	2.148533	353	0.008065437	153	0.000498099144627451	1.311629	57	60	0.004191176	
Mouse Phenotype Single KO	absent somites	210	4.461794e-31	1.9455546503809521e-29	2.101912	304	0.006945872	335	0.02601718821164179	1.303958	34	36	0.0025	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	399	3.272311e-20	7.509912738596491e-19	2.347585	150	0.00342724	287	0.013782998348083624	1.380662	24	24	0.001764706	
Mouse Phenotype	increased liver adenoma incidence	57	4.833598e-79	8.107724645263157e-77	3.797784	295	0.006740238	341	0.003326386856304985	1.380662	28	28	0.002058824	
Mouse Phenotype	abnormal cellular replicative senescence	131	2.317474e-53	1.6914022071755728e-51	2.114759	527	0.01204104	202	0.0001189567787079208	1.282043	78	84	0.005735294	
Mouse Phenotype	early cellular replicative senescence	156	5.560198e-47	3.407759812692307e-45	2.108951	465	0.01062444	147	0.00001426582501020408	1.323922	70	73	0.005147059	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	178	1.142626e-42	6.137442239325843e-41	2.935663	223	0.005095163	311	0.0019111258477813506	1.380662	30	30	0.002205882	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	191	4.362409e-41	2.183716882146597e-39	2.099105	409	0.00934494	524	0.02303372623282443	1.237835	52	58	0.003823529	
Mouse Phenotype	absent somites	196	1.067286e-40	5.206286452040816e-39	2.067581	420	0.009596271	359	0.004327577586350975	1.296131	46	49	0.003382353	
Mouse Phenotype	increased fibroblast apoptosis	337	2.322215e-27	6.588337571216617e-26	2.01643	294	0.00671739	684	0.049425114245614035	1.236843	43	48	0.003161765	
Mouse Phenotype	decreased classified tumor incidence	440	6.51456e-22	1.4155842763636363e-20	2.097793	210	0.004798136	534	0.024809541685393257	1.331352	27	28	0.001985294	
Mouse Phenotype	impaired muscle regeneration	601	1.088723e-17	1.7319934447587352e-16	2.053077	175	0.003998446	488	0.01614831740409836	1.380662	22	22	0.001617647