# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	negative regulation of translation	155	2.357182e-112	2.001171479870968e-110	2.026735	1247	0.0248263	236	7.1313193194915255e-9	1.257807	137	143	0.00957908	
GO Biological Process	nuclear-transcribed mRNA catabolic process	173	9.872836e-102	7.509632885780346e-100	2.035884	1116	0.02221824	496	0.00010783161121169355	1.167016	176	198	0.01230597	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	176	9.517451e-100	7.11591691528409e-98	2.329588	808	0.01608632	549	0.00023230301771038248	1.208327	104	113	0.00727171	
GO Biological Process	mitochondrial membrane organization	195	1.0489e-90	7.07819235897436e-89	2.070381	954	0.01899301	498	0.00010933601710441767	1.207015	114	124	0.007970913	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	198	3.934996e-90	2.615182442626263e-88	2.437831	666	0.01325927	446	0.000026870515725336323	1.223884	110	118	0.007691232	
GO Biological Process	regulation of DNA-templated transcription in response to stress	200	7.146489e-90	4.70203243755e-88	2.166503	850	0.01692249	556	0.0002547409628956835	1.202566	109	119	0.007621312	
GO Biological Process	gene silencing by miRNA	234	7.108305e-78	3.9973583544871794e-76	2.811555	445	0.008859424	692	0.0017405395988872832	1.283055	43	44	0.003006573	
GO Biological Process	posttranscriptional gene silencing	236	2.158834e-77	1.2037329070338982e-75	2.628481	496	0.009874774	560	0.0002833043406785714	1.287645	51	52	0.003565935	
GO Biological Process	posttranscriptional gene silencing by RNA	250	1.001605e-75	5.2720480779999996e-74	2.619635	488	0.009715503	583	0.00035107647720411663	1.28715	50	51	0.003496015	
GO Biological Process	translational initiation	270	1.895425e-71	9.237739842592592e-70	2.046697	770	0.01532979	697	0.0018641970158536586	1.165996	127	143	0.008879877	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	278	5.986997e-69	2.833917033201439e-67	2.325271	557	0.01108921	755	0.003275212355099337	1.211902	72	78	0.005034261	
GO Biological Process	regulation of mitochondrial membrane permeability	289	2.963996e-66	1.3495925039446366e-64	2.193465	606	0.01206474	615	0.000615437871300813	1.240954	69	73	0.0048245	
GO Biological Process	organelle transport along microtubule	294	3.023806e-65	1.3534103113605442e-63	2.197687	594	0.01182584	856	0.008404796265771028	1.213432	61	66	0.004265138	
GO Biological Process	maintenance of protein location in cell	299	1.353043e-63	5.954746768227425e-62	2.157791	603	0.01200502	934	0.013443955749892935	1.184806	74	82	0.005174102	
GO Biological Process	gene silencing by RNA	306	1.728988e-62	7.43521342875817e-61	2.134842	607	0.01208465	559	0.00027926411152057244	1.244691	73	77	0.005104181	
GO Biological Process	regulation of membrane permeability	341	2.39804e-58	9.253902744868035e-57	2.030859	638	0.01270183	608	0.0005330576712828947	1.231851	76	81	0.005313942	
GO Biological Process	regulation of ubiquitin protein ligase activity	359	1.351313e-56	4.953183222005571e-55	2.157629	535	0.01065122	1142	0.0380012792206655	1.155917	81	92	0.005663544	
GO Biological Process	viral gene expression	363	6.73707e-56	2.4422342735537192e-54	2.028846	612	0.0121842	677	0.001438748303308715	1.178503	114	127	0.007970913	
GO Biological Process	RNA 3'-end processing	408	8.960343e-50	2.8899302337500005e-48	2.042412	534	0.01063131	896	0.011224248091294643	1.165653	95	107	0.006642428	
GO Biological Process	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	415	1.86643e-49	5.918157197590362e-48	2.280491	412	0.008202433	824	0.006711573880703883	1.255811	44	46	0.003076493	
GO Cellular Component	ribonucleoprotein granule	43	8.631115e-137	3.4685038883720926e-135	2.053043	1471	0.02928587	68	0.000008359784470588236	1.18497	176	195	0.01230597	
GO Cellular Component	cytoplasmic ribonucleoprotein granule	48	1.040004e-124	3.7440144000000004e-123	2.031704	1376	0.02739453	74	0.000017860680389189188	1.184458	166	184	0.01160677	
GO Cellular Component	cytoplasmic stress granule	54	1.674629e-104	5.3588128e-103	3.148451	504	0.01003404	163	0.008901114581595093	1.251828	41	43	0.002866732	
GO Cellular Component	P-body	60	8.613122e-91	2.4805791360000003e-89	2.324237	738	0.01469271	160	0.00863041824	1.186349	75	83	0.005244022	
GO Cellular Component	ficolin-1-rich granule lumen	61	2.610139e-89	7.393967527868854e-88	2.223806	797	0.01586733	201	0.03186904835820895	1.1329	107	124	0.007481471	
GO Cellular Component	cleavage furrow	72	8.597525e-77	2.063406e-75	2.518021	532	0.01059149	124	0.001435332541935484	1.262397	50	52	0.003496015	
GO Cellular Component	cell division site part	94	2.47443e-59	4.548739404255319e-58	2.175874	551	0.01096976	176	0.014355242181818183	1.205279	56	61	0.003915536	
GO Cellular Component	methyltransferase complex	105	3.687198e-52	6.068074422857143e-51	2.009244	584	0.01162675	135	0.00238115968	1.197474	83	91	0.005803384	
GO Cellular Component	histone methyltransferase complex	113	2.704445e-47	4.135646867256637e-46	2.043182	506	0.01007386	147	0.0035152022204081638	1.217756	64	69	0.004474899	
GO Cellular Component	PcG protein complex	119	4.914535e-44	7.136400403361345e-43	2.105088	437	0.008700153	153	0.004746582211764706	1.255811	44	46	0.003076493	
GO Cellular Component	cytoplasmic microtubule	126	2.016025e-41	2.764834285714286e-40	2.094427	415	0.008262159	199	0.031058646512562814	1.207862	46	50	0.003216333	
GO Cellular Component	precatalytic spliceosome	299	1.835363e-14	1.0607047705685619e-13	2.166496	123	0.002448785	212	0.03875044075471698	1.266004	27	28	0.001887848	
GO Molecular Function	ligand-dependent nuclear receptor transcription coactivator activity	83	3.18615e-42	1.6207138915662648e-40	2.046344	448	0.00891915	122	0.0045141104901639355	1.261407	49	51	0.003426094	
GO Molecular Function	kinesin binding	123	5.543469e-29	1.9028070014634143e-27	2.075975	291	0.005793466	128	0.0082302843390625	1.280071	39	40	0.002726891	
GO Molecular Function	ATPase activator activity	216	3.198834e-19	6.252535716666667e-18	2.061169	190	0.003782675	165	0.04863229683636364	1.312893	23	23	0.001608167	
Human Phenotype	Low posterior hairline	67	1.209698e-41	1.2048230976119403e-39	2.158269	389	0.00774453	331	0.022255442845921448	1.274279	33	34	0.00230737	
Human Phenotype	Cafe-au-lait spot	77	5.163081e-39	4.47444669e-37	2.023938	424	0.008441339	308	0.015583918376948051	1.235664	48	51	0.003356174	
Human Phenotype	Microretrognathia	339	1.049528e-20	2.0659293050147493e-19	2.31188	159	0.003165502	385	0.04326528812207793	1.312893	22	22	0.001538246	
Mouse Phenotype Single KO	enlarged liver sinusoidal spaces	53	1.388598e-77	2.399130544528302e-75	2.721865	468	0.009317327	519	0.009286590075722542	1.27741	36	37	0.00251713	
Mouse Phenotype Single KO	abnormal liver sinusoid morphology	67	5.399263e-68	7.379261386716418e-66	2.21165	611	0.01216429	524	0.009554324676526718	1.213432	61	66	0.004265138	
Mouse Phenotype Single KO	increased integument system tumor incidence	87	1.066043e-57	1.1220408909195404e-55	2.171208	538	0.01071094	590	0.014452021281694916	1.191969	69	76	0.0048245	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	125	3.962188e-47	2.9025404412799995e-45	3.010136	238	0.004738299	724	0.03157140088812155	1.312893	22	22	0.001538246	
Mouse Phenotype Single KO	small superior cervical ganglion	135	7.571213e-44	5.135525736370371e-42	2.552796	291	0.005793466	423	0.003535712529787234	1.312893	32	32	0.002237449	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	152	3.645785e-41	2.1963456082236842e-39	2.121386	400	0.007963527	291	0.0004788840380756013	1.26913	58	60	0.004055377	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	187	1.488309e-35	7.287938777005347e-34	2.493944	244	0.004857751	650	0.020386102310769233	1.312893	24	24	0.001678087	
Mouse Phenotype Single KO	subcutaneous edema	250	3.844994e-30	1.4083444023200002e-28	2.219254	260	0.005176293	466	0.005537738980472103	1.312893	30	30	0.002097609	
Mouse Phenotype Single KO	increased fibroblast apoptosis	252	1.182918e-29	4.298404811904762e-28	2.121868	283	0.005634195	581	0.013601788887091223	1.275382	34	35	0.00237729	
Mouse Phenotype	enlarged liver sinusoidal spaces	79	1.919365e-85	2.3229175651898734e-83	2.64683	542	0.01079058	614	0.0030261577157980456	1.280872	40	41	0.002796812	
Mouse Phenotype	abnormal cell adhesion	96	3.320235e-77	3.3067465453125e-75	2.028375	852	0.01696231	266	0.00001087279795488722	1.278343	74	76	0.005174102	
Mouse Phenotype	abnormal liver sinusoid morphology	107	2.867947e-69	2.562658062336449e-67	2.039025	753	0.01499134	500	0.00088906916754	1.228733	73	78	0.005104181	
Mouse Phenotype	abnormal cellular replicative senescence	141	7.826303e-56	5.306899502340426e-54	2.059481	589	0.01172629	342	0.00006869989455263157	1.250375	80	84	0.005593623	
Mouse Phenotype	early cellular replicative senescence	168	1.51785e-49	8.638192767857143e-48	2.058939	521	0.01037249	368	0.00012896656229347824	1.258939	70	73	0.00489442	
Mouse Phenotype	absent segment of posterior cerebral artery	182	3.962188e-47	2.081454915824176e-45	3.010136	238	0.004738299	981	0.024328398204892968	1.312893	22	22	0.001538246	
Mouse Phenotype	decreased classified tumor incidence	212	1.956745e-42	8.824735351415093e-41	2.515553	289	0.005753648	1124	0.04043949991548043	1.266004	27	28	0.001887848	
Mouse Phenotype	increased fibroblast apoptosis	214	3.592337e-42	1.6049688811682245e-40	2.217185	371	0.007386171	647	0.0038984349459041732	1.258189	46	48	0.003216333	
Mouse Phenotype	decreased spongiotrophoblast size	219	2.341492e-41	1.0222376717808218e-39	2.997794	209	0.004160943	1176	0.04597252378061225	1.312893	19	19	0.001328486	
Mouse Phenotype	abnormal cerebral artery morphology	267	1.488309e-35	5.329484025842696e-34	2.493944	244	0.004857751	882	0.01568660912244898	1.312893	24	24	0.001678087	
Mouse Phenotype	abnormal spongiotrophoblast size	306	2.748821e-32	8.588718163725489e-31	2.304145	258	0.005136475	1124	0.04043949991548043	1.266004	27	28	0.001887848	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	327	4.252481e-31	1.2433630226605504e-29	2.13937	292	0.005813375	1057	0.03379073585335857	1.267621	28	29	0.001957768	
Mouse Phenotype	subcutaneous edema	337	3.844994e-30	1.090860167181009e-28	2.219254	260	0.005176293	654	0.004119938696788991	1.312893	30	30	0.002097609	
Mouse Phenotype	abnormal transitional stage T1 B cell morphology	408	4.748411e-27	1.1127342541911766e-25	2.106589	261	0.005196201	759	0.008044960475889328	1.312893	27	27	0.001887848	
Mouse Phenotype	increased mouth tumor incidence	524	1.668211e-22	3.0438483532442748e-21	2.052593	228	0.00453921	882	0.01568660912244898	1.312893	24	24	0.001678087