# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of ARF protein signal transduction 95 5.078274e-11 7.034211322736842e-9 6.429891 21 0.00999524 367 0.025136235746594005 3.586134 8 17 0.003246753 GO Biological Process pericyte cell differentiation 104 6.376502e-11 8.068114405576923e-9 9.18767 16 0.007615421 462 0.043778739761904766 4.762835 5 8 0.002029221 GO Biological Process mammary gland epithelium development 189 8.577848e-9 5.972269938201058e-7 2.540863 49 0.02332223 319 0.01515869774106583 2.399058 17 54 0.006899351 GO Biological Process regulation of pri-miRNA transcription from RNA polymerase II promoter 220 2.756088e-8 0.000001648516454181818 3.494346 28 0.01332699 366 0.02487834068360656 2.890548 11 29 0.004464286 GO Biological Process regulation of transforming growth factor beta2 production 246 6.484572e-8 0.0000034687188190243904 6.013957 15 0.007139457 462 0.043778739761904766 4.762835 5 8 0.002029221 GO Biological Process fat cell differentiation 273 1.569754e-7 0.0000075664442805860805 2.084853 61 0.02903379 477 0.04745408511320755 1.83186 25 104 0.0101461 GO Biological Process mesoderm morphogenesis 297 3.726705e-7 0.000016511687237373734 2.213708 50 0.02379819 197 0.0028749255504060913 2.429736 22 69 0.008928571 GO Biological Process mesoderm formation 308 4.811691e-7 0.0000205574811262987 2.235671 48 0.02284626 228 0.004867325949385965 2.388526 21 67 0.008522727 GO Biological Process notochord morphogenesis 328 7.959834e-7 0.00003193398036768293 4.130567 18 0.008567349 208 0.003508117278557692 5.334375 7 10 0.002840909 GO Biological Process notochord development 379 0.000002191418 0.0000760867268126649 3.178868 23 0.01094717 109 0.0003072026497889908 4.656994 11 18 0.004464286 GO Biological Process regulation of cell junction assembly 390 0.000002619441 0.00008838262594615383 2.11827 47 0.0223703 288 0.011789979675694444 2.137467 23 82 0.009334416 GO Biological Process platelet-derived growth factor receptor signaling pathway 394 0.000002796031 0.00009338317748477156 2.818488 27 0.01285102 260 0.007412803797307693 3.002029 13 33 0.005275974 GO Biological Process regulation of focal adhesion assembly 399 0.000003002405 0.00009901916640350879 2.387985 36 0.0171347 319 0.01515869774106583 2.399058 17 54 0.006899351 GO Biological Process bone cell development 401 0.000003286611 0.0001078516562319202 3.429018 20 0.009519277 422 0.035190065969194315 3.117492 9 22 0.003652597 GO Biological Process transforming growth factor beta receptor signaling pathway 405 0.000003501108 0.0001137557535111111 2.134347 45 0.02141837 297 0.013014091496969696 2.048531 25 93 0.0101461 GO Biological Process Rho protein signal transduction 410 0.000003870386 0.00012422051066829267 2.554189 31 0.01475488 271 0.009626532002214023 2.373609 19 61 0.007711039 GO Biological Process regulation of adherens junction organization 427 0.000005668804 0.00017469740476814988 2.318465 36 0.0171347 374 0.02602700314064171 2.272791 17 57 0.006899351 GO Biological Process regulation of mitochondrial membrane potential 436 0.000007391102 0.00022307227343577982 2.728509 26 0.01237506 440 0.040850500531818185 2.110302 18 65 0.007305195 GO Biological Process embryonic placenta development 472 0.00001231054 0.00034320846580508473 2.009385 46 0.02189434 318 0.015133181044025158 2.054976 24 89 0.00974026 GO Biological Process cartilage development involved in endochondral bone morphogenesis 492 0.00001507954 0.00040331639605691055 2.982543 21 0.00999524 470 0.04591404682553192 2.981949 9 23 0.003652597 GO Cellular Component ruffle 24 1.361228e-12 9.800841599999998e-11 2.426027 81 0.03855307 27 0.0297406848 1.740493 37 162 0.01501623 GO Cellular Component calcium channel complex 90 0.00009303538 0.0017862792960000001 2.067464 34 0.01618277 38 0.041760348631578945 2.177296 18 63 0.007305195 GO Cellular Component actomyosin 102 0.0002453113 0.004155862023529412 2.060403 30 0.01427891 21 0.010635839999999999 2.381417 20 64 0.008116883 GO Cellular Component voltage-gated calcium channel complex 107 0.0002928413 0.004729250153271028 2.248681 24 0.01142313 33 0.03274346356363636 2.540179 14 42 0.005681818 GO Molecular Function Rho guanyl-nucleotide exchange factor activity 64 0.00001762769 0.0011628766746875 2.119102 39 0.01856259 28 0.007203561321428571 2.315099 24 79 0.00974026 Mouse Phenotype Single KO abnormal capillary density 6 1.992972e-21 3.041607434e-18 20.13364 22 0.0104712 269 0.02200609218773234 5.44324 5 7 0.002029221 Mouse Phenotype Single KO abnormal adipose tissue development 20 1.190833e-17 5.4522288905e-15 9.968527 26 0.01237506 353 0.0336775523427762 4.156656 6 11 0.002435065 Mouse Phenotype Single KO abnormal white adipose tissue morphology 63 1.229783e-11 1.7874798303174603e-9 2.041968 107 0.05092813 108 0.001002174299074074 1.758585 57 247 0.02313312 Mouse Phenotype Single KO abnormal mean corpuscular volume 74 5.376711e-11 6.653316571216216e-9 2.246324 81 0.03855307 368 0.034085837641304344 1.574195 44 213 0.01785714 Mouse Phenotype Single KO abnormal capillary morphology 76 6.552435e-11 7.8948220125e-9 2.752393 55 0.02617801 282 0.022938492818439717 2.078328 21 77 0.008522727 Mouse Phenotype Single KO abnormal body temperature 80 9.992782e-11 1.1437988096750002e-8 2.691128 56 0.02665397 200 0.010348637038 2.017201 27 102 0.01095779 Mouse Phenotype Single KO abnormal white adipose tissue amount 83 1.463605e-10 1.6147266246987953e-8 2.117622 88 0.04188482 314 0.02667198759267516 1.614202 43 203 0.0174513 Mouse Phenotype Single KO arthritis 91 3.318964e-10 3.339753115164835e-8 2.817215 49 0.02332223 325 0.028592493009230766 1.823718 28 117 0.01136364 Mouse Phenotype Single KO abnormal macrophage cell number 94 4.083668e-10 3.9781008378723406e-8 2.025345 93 0.04426464 403 0.04642653533002482 1.56128 42 205 0.01704545 Mouse Phenotype Single KO decreased body temperature 115 1.362553e-9 1.0849476366086955e-7 3.014903 41 0.01951452 290 0.02340467311310345 2.161047 19 67 0.007711039 Mouse Phenotype Single KO joint inflammation 117 1.410816e-9 1.1041745394871796e-7 2.660934 50 0.02379819 369 0.034787864867208675 1.767964 29 125 0.01176948 Mouse Phenotype Single KO abnormal heart ventricle wall thickness 132 5.423452e-9 3.762314391212121e-7 2.214853 66 0.03141361 238 0.01608687139579832 1.833512 32 133 0.01298701 Mouse Phenotype Single KO abnormal basicranium morphology 134 5.714749e-9 3.9052206412686563e-7 2.334086 59 0.02808187 73 0.00016353962965753426 2.72162 25 70 0.0101461 Mouse Phenotype Single KO thin ventricular wall 154 2.193808e-8 0.0000013044610296103895 2.343044 54 0.02570205 343 0.03166186256559767 1.905134 24 96 0.00974026 Mouse Phenotype Single KO pale yolk sac 163 3.883351e-8 0.000002181585589386503 2.322521 53 0.02522608 137 0.003280560084233577 2.268017 25 84 0.0101461 Mouse Phenotype Single KO abnormal white fat cell morphology 167 5.778714e-8 0.0000031686038382035926 2.52384 44 0.02094241 372 0.035311484325268816 1.975694 21 81 0.008522727 Mouse Phenotype Single KO abnormal myelopoiesis 170 6.776648e-8 0.0000036502215138823528 2.28119 53 0.02522608 143 0.003676379254685315 2.078328 30 110 0.01217532 Mouse Phenotype Single KO abnormal follicular B cell morphology 179 9.162267e-8 0.000004687088207765363 2.885035 34 0.01618277 231 0.015255573892207792 2.324909 18 59 0.007305195 Mouse Phenotype Single KO abnormal placenta vasculature 210 3.026668e-7 0.000013197713750476188 2.171116 53 0.02522608 219 0.013884073370319636 1.9217 29 115 0.01176948 Mouse Phenotype Single KO decreased follicular B cell number 225 4.12548e-7 0.00001678978682666667 3.210592 26 0.01237506 365 0.03382989676438356 2.370833 14 45 0.005681818 Mouse Phenotype decreased capillary density 36 1.422648e-15 3.77831598e-13 16.66524 17 0.008091385 747 0.04554788724497992 5.080357 4 6 0.001623377 Mouse Phenotype abnormal body temperature 40 2.227778e-15 5.3249463645e-13 2.839168 77 0.03664921 237 0.0011223141525316456 2.020597 35 132 0.01420455 Mouse Phenotype extramedullary hematopoiesis 41 4.819646e-15 1.1239179367317073e-12 2.635261 85 0.04045693 275 0.002142703193781818 1.828929 42 175 0.01704545 Mouse Phenotype arthritis 45 2.683083e-14 5.700657014e-12 2.947865 67 0.03188958 279 0.0022699530867741936 1.905134 37 148 0.01501623 Mouse Phenotype joint inflammation 49 7.031512e-14 1.372005841469388e-11 2.832156 69 0.0328415 281 0.0022791127318505335 1.869188 39 159 0.01582792 Mouse Phenotype abnormal capillary density 59 7.22555e-13 1.1709065008474577e-10 7.609515 22 0.0104712 709 0.041599304166431594 4.233631 5 9 0.002029221 Mouse Phenotype abnormal energy expenditure 62 1.710024e-12 2.637022494193548e-10 2.104344 108 0.05140409 224 0.0009398659341964286 1.723693 57 252 0.02313312 Mouse Phenotype abnormal fat cell morphology 81 2.116862e-11 2.498681182962963e-9 2.022483 107 0.05092813 106 0.000021229100083018868 1.974412 57 220 0.02313312 Mouse Phenotype osteosclerosis 87 5.751018e-11 6.320170471034482e-9 6.039212 22 0.0104712 763 0.04780290735648755 3.51717 6 13 0.002435065 Mouse Phenotype abnormal brown adipose tissue morphology 91 8.565571e-11 8.999497179230768e-9 2.236883 80 0.03807711 101 0.000018695465803960395 2.229136 43 147 0.0174513 Mouse Phenotype abnormal white adipose tissue physiology 94 1.005877e-10 1.0231053188297872e-8 4.545974 28 0.01332699 549 0.022971390956284154 2.704061 11 31 0.004464286 Mouse Phenotype increased energy expenditure 100 1.715321e-10 1.6400184080999998e-8 2.301158 73 0.03474536 197 0.0006053515603553299 1.965044 41 159 0.01663961 Mouse Phenotype increased incidence of corneal inflammation 101 1.808037e-10 1.7115486888118814e-8 5.987651 21 0.00999524 756 0.045701074126984126 2.903061 8 21 0.003246753 Mouse Phenotype abnormal follicular B cell morphology 112 6.005689e-10 5.1268207615178565e-8 2.700184 51 0.02427416 204 0.0006788975520588236 2.219574 30 103 0.01217532 Mouse Phenotype abnormal liver sinusoid morphology 113 6.271349e-10 5.306227237964601e-8 2.913188 45 0.02141837 314 0.003450634932802547 2.247081 23 78 0.009334416 Mouse Phenotype cortical renal glomerulopathies 123 1.298789e-9 1.0095708641463414e-7 2.128251 78 0.03712518 695 0.03833973381151079 1.564215 39 190 0.01582792 Mouse Phenotype abnormal mean corpuscular volume 128 2.067876e-9 1.5446064403125e-7 2.030206 85 0.04045693 687 0.03755802956331878 1.493003 48 245 0.01948052 Mouse Phenotype enlarged liver sinusoidal spaces 129 2.306396e-9 1.7094148958139536e-7 3.619237 31 0.01475488 239 0.0011788360963179917 2.973868 16 41 0.006493506 Mouse Phenotype abnormal coronary vessel morphology 132 2.802799e-9 2.0301182756818184e-7 2.323349 62 0.02950976 209 0.000703441196985646 2.411562 25 79 0.0101461 Mouse Phenotype increased circulating interleukin-6 level 137 4.191042e-9 2.9248578512408763e-7 2.697602 46 0.02189434 516 0.018777248127906973 1.925188 24 95 0.00974026