# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	25	4.317431e-35	2.27252298116e-32	2.12509	333	0.02564695	191	6.076367357382199e-8	1.432851	145	213	0.01625378	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	27	2.439564e-34	1.1889712102222224e-31	2.53186	227	0.01748306	370	0.0006018286432432433	1.415624	76	113	0.008519224	
GO Biological Process	RNA catabolic process	30	1.016594e-33	4.459120148666667e-31	2.006183	367	0.02826556	154	6.337558967792207e-9	1.432318	164	241	0.01838359	
GO Biological Process	nuclear-transcribed mRNA catabolic process	36	7.91192e-31	2.8920265355555556e-28	2.103058	298	0.02295132	201	1.8591153041791046e-7	1.435097	135	198	0.01513283	
GO Biological Process	cotranslational protein targeting to membrane	38	1.408277e-30	4.876715011315789e-28	2.827456	166	0.01278497	172	1.9855079559302327e-8	1.653778	77	98	0.008631319	
GO Biological Process	regulation of DNA-templated transcription in response to stress	39	1.714135e-30	5.783667298717949e-28	2.327011	236	0.01817622	358	0.00038650666259776534	1.414998	80	119	0.008967605	
GO Biological Process	endoplasmic reticulum unfolded protein response	42	5.119682e-30	1.6040451294761904e-27	2.453741	209	0.01609673	748	0.03393818690374332	1.292427	70	114	0.007846654	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	46	1.501006e-29	4.293856076956522e-27	2.605513	184	0.01417129	228	0.0000010078760903070175	1.534013	86	118	0.009640175	
GO Biological Process	multi-organism metabolic process	49	7.28048e-29	1.9551803330612243e-26	2.276999	233	0.01794516	137	3.2886012289051095e-10	1.589345	111	147	0.01244255	
GO Biological Process	viral gene expression	51	1.111888e-28	2.8688890572549024e-26	2.487971	194	0.01494147	145	2.272122784206897e-9	1.60761	97	127	0.01087322	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	59	5.698519e-27	1.2709629071355934e-24	2.508262	179	0.0137862	470	0.0023822972406170213	1.37837	74	113	0.008295034	
GO Biological Process	cellular response to topologically incorrect protein	61	1.366509e-26	2.9478511362295086e-24	2.19165	232	0.01786815	780	0.042038703019230766	1.256828	83	139	0.00930389	
GO Biological Process	regulation of cellular amino acid metabolic process	64	3.271478e-26	6.7264654690625e-24	3.315742	111	0.008548983	422	0.0013155538746445496	1.543527	44	60	0.004932182	
GO Biological Process	cellular response to unfolded protein	66	4.431916e-26	8.83630040060606e-24	2.248055	215	0.01655884	804	0.04963334206343284	1.269843	73	121	0.008182939	
GO Biological Process	protein targeting to ER	67	5.142195e-26	1.0099424478358209e-23	2.602836	161	0.01239988	192	6.068323566979167e-8	1.625496	78	101	0.008743414	
GO Biological Process	mitochondrial membrane organization	69	5.462126e-26	1.041682841072464e-23	2.098882	250	0.01925447	267	0.000012493746015730336	1.476761	87	124	0.00975227	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	76	5.725596e-25	9.913568126842104e-23	2.673448	147	0.01132163	195	9.225302525641025e-8	1.647242	72	92	0.008070844	
GO Biological Process	viral transcription	80	2.045642e-24	3.3648253847500002e-22	2.40816	174	0.01340111	162	1.0284830714814814e-8	1.620517	87	113	0.00975227	
GO Biological Process	regulation of hematopoietic stem cell differentiation	89	3.958005e-23	5.8520660443820215e-21	2.472685	156	0.01201479	433	0.0015079621389145496	1.410018	69	103	0.007734559	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	94	9.40879e-23	1.3171305064893619e-20	2.366431	167	0.01286198	161	9.777807209937888e-9	1.643756	82	105	0.009191795	
GO Cellular Component	large ribosomal subunit	37	9.409873e-22	4.394665011891892e-20	2.352485	161	0.01239988	63	0.000013780086857142857	1.482518	81	115	0.0090797	
GO Cellular Component	proteasome core complex	40	1.855076e-20	8.01392832e-19	5.284329	50	0.003850893	137	0.019497692496350364	1.666307	19	24	0.002129806	
GO Cellular Component	endopeptidase complex	46	2.136116e-18	8.024366191304348e-17	2.512875	118	0.009088108	80	0.0001549526328	1.555728	51	69	0.005716848	
GO Cellular Component	peptidase complex	48	5.122659e-18	1.8441572399999998e-16	2.249035	144	0.01109057	68	0.0000332342174117647	1.53077	64	88	0.007174084	
GO Cellular Component	proteasome complex	49	5.213124e-18	1.8384241371428573e-16	2.492987	117	0.009011091	88	0.00022139018181818181	1.547654	50	68	0.005604753	
GO Cellular Component	catalytic step 2 spliceosome	59	2.739637e-14	8.023885993220339e-13	2.007862	145	0.01116759	130	0.014757758030769232	1.337431	61	96	0.006837798	
GO Cellular Component	outer mitochondrial membrane protein complex	61	1.211684e-13	3.4324425442622945e-12	4.554842	37	0.002849661	143	0.024893918433566434	1.824168	13	15	0.001457236	
GO Cellular Component	mitochondrial outer membrane translocase complex	67	7.375914e-13	1.9023252823880597e-11	4.917045	32	0.002464572	156	0.040471111384615385	1.913463	10	11	0.001120951	
GO Cellular Component	cytosolic large ribosomal subunit	76	7.638068e-12	1.7366554610526316e-10	2.191806	95	0.007316697	82	0.0001716553264390244	1.587233	46	61	0.005156373	
GO Cellular Component	mitochondrial ribosome	82	2.799769e-11	5.900001014634147e-10	2.189287	90	0.006931608	163	0.043644488245398766	1.31241	53	85	0.005941038	
GO Cellular Component	intrinsic component of mitochondrial membrane	86	8.878819e-11	1.784023166511628e-9	2.03015	102	0.007855823	160	0.04346573399999999	1.36003	42	65	0.004707992	
GO Cellular Component	axon cytoplasm	105	4.744451e-9	7.808010788571428e-8	2.091947	77	0.005930376	132	0.015429521454545455	1.525986	29	40	0.003250757	
GO Cellular Component	ESCRT complex	151	8.724204e-7	0.000009983724842384106	2.369532	41	0.003157733	105	0.0028645714285714286	1.72895	23	28	0.002578186	
GO Cellular Component	nuclear pore outer ring	183	0.00001185809	0.00011197147278688526	3.259193	19	0.001463339	119	0.008486324168067227	2.104809	10	10	0.001120951	
GO Molecular Function	rRNA binding	18	5.547889e-14	1.3012881865555555e-11	2.797968	72	0.005545287	88	0.016646866227272728	1.473366	42	60	0.004707992	
GO Molecular Function	mRNA 5'-UTR binding	40	1.802343e-10	1.9023730365000002e-8	2.852321	50	0.003850893	107	0.0403835878317757	1.722116	18	22	0.002017711	
GO Molecular Function	ubiquitin-specific protease binding	242	0.0001050458	0.0018326585438016528	2.420833	24	0.001848429	110	0.04254248403636363	1.841708	14	16	0.001569331	
Human Phenotype	Increased serum lactate	7	2.782426e-19	2.652446956857143e-16	2.243121	156	0.01201479	21	0.0000057861392342857146	1.578607	75	100	0.008407129	
Human Phenotype	Abnormality of mitochondrial metabolism	23	5.590545e-13	1.621987251521739e-10	2.111222	115	0.008857055	59	0.0008113613611694915	1.555728	51	69	0.005716848	
Human Phenotype	Abnormality of the mitochondrion	25	1.091245e-12	2.912751154e-10	2.080811	116	0.008934073	63	0.0009679703392698412	1.54155	52	71	0.005828943	
Human Phenotype	Increased CSF lactate	30	1.147377e-11	2.552148907e-9	2.342767	81	0.006238447	128	0.04013196939453125	1.451592	40	58	0.004483802	
Human Phenotype	Abnormality of monocarboxylic acid metabolism	87	1.483915e-7	0.000011381798614942528	2.615411	39	0.003003697	90	0.004637878840222222	2.104809	13	13	0.001457236	
Mouse Phenotype Single KO	spontaneous chromosome breakage	73	1.784233e-11	2.238112545342466e-9	2.752541	59	0.004544054	147	0.011469765425170069	1.768039	21	25	0.002353996	
Mouse Phenotype	spontaneous chromosome breakage	256	1.877097e-7	0.000007010517350390625	2.101009	60	0.004621072	341	0.04994360784457477	1.596752	22	29	0.002466091