# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	12	7.480398e-46	8.2028797735e-43	2.609413	291	0.01801858	273	0.00006959337186080586	1.42582	83	113	0.008580585	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	16	1.866854e-42	1.535370736625e-39	2.214686	371	0.02297214	318	0.00027168621760691826	1.340038	107	155	0.01106172	
GO Biological Process	endoplasmic reticulum unfolded protein response	17	3.483571e-42	2.6964888699411767e-39	2.576802	273	0.01690402	345	0.0006118587907536231	1.379257	81	114	0.008373824	
GO Biological Process	regulation of DNA-templated transcription in response to stress	22	3.799641e-39	2.272703450863636e-36	2.362319	298	0.01845201	293	0.0001303439819249147	1.402867	86	119	0.008890727	
GO Biological Process	cellular response to topologically incorrect protein	26	4.730845e-37	2.3943534367307693e-34	2.28605	301	0.01863777	389	0.0013388913777377894	1.326703	95	139	0.009821152	
GO Biological Process	cellular response to unfolded protein	33	1.724111e-35	6.875023226969697e-33	2.328543	277	0.0171517	355	0.0007496656352676056	1.363636	85	121	0.008787346	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	35	9.116077e-35	3.427384492657143e-32	2.40544	254	0.01572755	602	0.01762490229435216	1.321652	64	94	0.006616355	
GO Biological Process	nuclear-transcribed mRNA catabolic process	39	7.250547e-33	2.4464089223846154e-30	2.014184	355	0.02198142	252	0.00003209588191785714	1.333333	136	198	0.01405975	
GO Biological Process	response to topologically incorrect protein	40	7.860566e-33	2.58592969985e-30	2.015552	354	0.0219195	430	0.0027650045786976746	1.272549	118	180	0.0121989	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	41	1.22393e-32	3.9282182609756096e-30	2.504575	220	0.01362229	253	0.00003202480344189723	1.431206	87	118	0.008994107	
GO Biological Process	protein targeting to ER	50	5.74058e-31	1.5108058443999998e-28	2.573488	198	0.01226006	218	0.000005169219185183486	1.499126	78	101	0.008063682	
GO Biological Process	negative regulation of endoplasmic reticulum unfolded protein response	52	7.348915e-31	1.8596994708653846e-28	6.134419	68	0.004210526	746	0.044989880144772114	1.941176	9	9	0.0009304249	
GO Biological Process	cotranslational protein targeting to membrane	65	7.376606e-28	1.4933655131384615e-25	2.519657	184	0.01139319	219	0.000005493872285251141	1.505402	76	98	0.007856921	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	69	5.79858e-27	1.1058480321739129e-24	3.152503	123	0.007616099	717	0.037498983900976286	1.603581	19	23	0.00196423	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	71	6.99956e-27	1.2972846484507042e-24	2.544132	174	0.01077399	240	0.000018674633230416668	1.498082	71	92	0.007340019	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	76	5.452236e-25	9.440259674210526e-23	2.27847	200	0.0123839	225	0.000009706522881777779	1.478992	80	105	0.008270444	
GO Biological Process	protein localization to endoplasmic reticulum	83	2.733118e-24	4.333144549638554e-22	2.130882	225	0.01393189	193	0.0000014871981347668394	1.471537	94	124	0.009717771	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	93	8.553733e-24	1.2103072316881719e-21	2.337076	180	0.01114551	372	0.0010493078571505376	1.443439	58	78	0.005996072	
GO Biological Process	negative regulation of response to endoplasmic reticulum stress	113	1.830843e-21	2.1320409767256636e-19	2.59258	132	0.008173375	579	0.014922646906735752	1.504412	31	40	0.003204797	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	117	2.607316e-21	2.9324505336752135e-19	2.281472	168	0.01040248	652	0.023566114033742327	1.529412	26	33	0.002687894	
GO Cellular Component	catalytic step 2 spliceosome	42	3.926367e-19	1.6154195657142856e-17	2.070689	186	0.01151703	66	0.00014216363345454546	1.435662	71	96	0.007340019	
GO Cellular Component	mitochondrial ribosome	54	2.39787e-14	7.673184e-13	2.229466	114	0.007058824	92	0.0020591768347826087	1.39308	61	85	0.006306213	
GO Cellular Component	endopeptidase complex	62	2.352109e-13	6.555555406451612e-12	2.088741	122	0.00755418	84	0.0008421749485714285	1.462916	52	69	0.005375788	
GO Cellular Component	ESCRT complex	63	3.027398e-13	8.30372022857143e-12	2.927219	63	0.003900929	78	0.0005821824738461538	1.733193	25	28	0.002584514	
GO Cellular Component	proteasome complex	71	1.004483e-12	2.4447135549295778e-11	2.05566	120	0.007430341	88	0.0011885547272727272	1.455882	51	68	0.005272408	
GO Cellular Component	mitochondrial large ribosomal subunit	74	2.531076e-12	5.910404497297297e-11	2.500639	76	0.004705882	110	0.010301424872727272	1.446367	38	51	0.003928461	
GO Cellular Component	signal recognition particle	76	1.145293e-11	2.604034610526316e-10	4.854593	29	0.001795666	127	0.01786939766929134	1.941176	10	10	0.001033805	
GO Cellular Component	ESCRT III complex	148	1.521094e-7	0.0000017759800216216217	3.072106	30	0.001857585	152	0.04871174021052632	1.779412	11	12	0.001137186	
GO Cellular Component	U2-type prespliceosome	269	0.0001535163	0.0009861567524163568	2.228878	27	0.001671827	148	0.03502898854054054	1.698529	14	16	0.001447328	
GO Molecular Function	ribonucleoprotein complex binding	11	5.117654e-20	1.9642486534545453e-17	2.015146	209	0.01294118	51	0.0001521959805490196	1.417903	84	115	0.008683966	
GO Molecular Function	rRNA binding	25	5.740191e-15	9.6940345608e-13	2.655616	85	0.005263158	88	0.007842561706818182	1.455882	45	60	0.004652124	
Human Phenotype	Increased serum lactate	5	2.028135e-20	2.7067489710000002e-17	2.138631	185	0.01145511	79	0.01069856749493671	1.358824	70	100	0.007236638	
Human Phenotype	Abnormality of the mitochondrion	25	1.329167e-15	3.5478125564000004e-13	2.091119	145	0.008978328	67	0.005408995360149254	1.449047	53	71	0.005479169	
Human Phenotype	Abnormality of mitochondrial metabolism	26	2.180265e-15	5.595733978846154e-13	2.095851	142	0.00879257	76	0.010187818364473683	1.434783	51	69	0.005272408	
Human Phenotype	CNS hypomyelination	225	0.000001079704	0.000032021621297777776	2.124533	51	0.003157895	68	0.005598069981764706	1.682353	26	30	0.002687894	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	224	2.904879e-10	1.2398905410267858e-8	2.390289	67	0.004148607	249	0.011324213509638555	1.617647	25	30	0.002584514