# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process mitochondrial transport 25 1.791311e-32 9.428744579600002e-30 2.467361 222 0.03792927 329 0.016813770260790274 1.368886 89 239 0.01742365 GO Biological Process mitochondrial membrane organization 33 2.547461e-29 1.0158193726969698e-26 2.868129 154 0.02631129 297 0.011976989502020202 1.541548 52 124 0.01018011 GO Biological Process negative regulation of gene expression, epigenetic 50 1.931914e-24 5.0844112651999995e-22 3.281311 104 0.01776867 367 0.02910912071008174 1.515543 47 114 0.009201253 GO Biological Process regulation of gene expression, epigenetic 67 1.893589e-21 3.719065321044776e-19 2.141703 192 0.03280369 352 0.023878773740625 1.348854 91 248 0.01781519 GO Biological Process macromolecular complex disassembly 109 1.72386e-15 2.0811260311926605e-13 2.08155 144 0.02460277 315 0.013602800851746031 1.424209 74 191 0.01448708 GO Biological Process platelet aggregation 167 3.105533e-13 2.4470484279640722e-11 3.15665 56 0.009567743 190 0.0016659238593684214 2.151804 24 41 0.004698512 GO Biological Process erythrocyte differentiation 170 5.739331e-13 4.442579801705883e-11 2.425123 85 0.01452247 236 0.004251540194830508 1.811362 34 69 0.006656226 GO Biological Process erythrocyte homeostasis 185 2.239233e-12 1.592760380918919e-10 2.307848 89 0.01520588 275 0.008900407858545454 1.718649 36 77 0.007047768 GO Biological Process multi-organism metabolic process 227 3.668264e-11 2.1264619372687225e-9 2.102852 97 0.0165727 251 0.0063066525912350594 1.525414 61 147 0.01194205 GO Biological Process cotranslational protein targeting to membrane 242 6.685439e-11 3.635276520702479e-9 2.4938 66 0.01127627 298 0.01218094628557047 1.612938 43 98 0.008418168 GO Biological Process myeloid cell homeostasis 243 7.257932e-11 3.93033445218107e-9 2.009515 105 0.01793952 212 0.0031213048686792454 1.702568 44 95 0.008613939 GO Biological Process regulation of CD4-positive, alpha-beta T cell differentiation 251 1.010927e-10 5.299915694422311e-9 2.4489 67 0.01144712 349 0.022766367047564472 1.929899 21 40 0.004111198 GO Biological Process translational initiation 266 2.714308e-10 1.3427661267669173e-8 2.075775 91 0.01554758 407 0.039245117081081075 1.439552 56 143 0.01096319 GO Biological Process viral gene expression 267 2.79778e-10 1.37887591835206e-8 2.219056 78 0.0133265 260 0.006872333300384616 1.563023 54 127 0.01057165 GO Biological Process neurotrophin TRK receptor signaling pathway 268 2.839873e-10 1.3943988360820895e-8 4.088748 30 0.005125577 449 0.04743502980623608 2.450666 10 15 0.001957713 GO Biological Process regulation of CD4-positive, alpha-beta T cell activation 304 1.201773e-9 5.2020167457236844e-8 2.183186 75 0.01281394 282 0.010298056080141843 1.914583 25 48 0.004894283 GO Biological Process viral transcription 328 3.458351e-9 1.3874524636890244e-7 2.179839 71 0.01213053 233 0.003995982799484979 1.626548 50 113 0.009788567 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 438 1.036357e-7 0.0000031135666125570776 2.346872 49 0.008371775 366 0.029095915234972677 1.769925 26 54 0.005090055 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 441 1.069421e-7 0.000003191045564399093 2.218948 55 0.00939689 294 0.011337709358843538 1.638217 41 92 0.008026625 GO Biological Process TORC1 signaling 445 1.10784e-7 0.000003275970013483146 4.754608 18 0.003075346 356 0.02477468216994382 3.216499 7 8 0.001370399 GO Cellular Component ribosomal subunit 55 2.261077e-11 7.103892829090908e-10 2.052827 105 0.01793952 57 0.017650401347368422 1.410789 71 185 0.01389977 GO Cellular Component PcG protein complex 58 2.252923e-10 6.7121567999999995e-9 2.521707 61 0.01042201 49 0.010001568783673469 1.917912 24 46 0.004698512 GO Cellular Component platelet dense tubular network 115 0.000001075507 0.000016160661704347827 3.866403 19 0.003246199 79 0.04722057478481013 2.673453 8 11 0.001566171 GO Cellular Component platelet dense tubular network membrane 117 0.000001108498 0.00001637166276923077 4.041129 18 0.003075346 83 0.04793476163855422 2.85911 7 9 0.001370399 GO Cellular Component cytosolic large ribosomal subunit 124 0.000002956689 0.00004120289187096774 2.200782 43 0.00734666 55 0.016958117585454544 1.747606 29 61 0.005677369 GO Cellular Component cytoplasmic dynein complex 135 0.000008090656 0.00010356039680000001 2.386738 33 0.005638134 74 0.03840935351351351 2.172181 13 22 0.002545027 GO Cellular Component cytoplasmic stress granule 161 0.00005369007 0.0005762511860869565 2.037164 38 0.006492397 76 0.04564396042105263 1.795255 21 43 0.004111198 GO Cellular Component podosome 169 0.00006914781 0.0007070261282840236 2.106117 34 0.005808987 70 0.03314400274285715 2.028137 16 29 0.003132341 GO Molecular Function nerve growth factor binding 100 0.000005001004 0.00021114238888 5.806534 11 0.001879378 65 0.026267829033846155 3.675998 6 6 0.001174628 GO Molecular Function transcription factor activity, transcription factor recruiting 174 0.0001699258 0.004123142112643678 2.44717 22 0.003758756 71 0.042442981064788735 2.625713 10 14 0.001957713 Mouse Phenotype Single KO decreased erythroid progenitor cell number 16 3.584137e-32 2.0512464068125e-29 3.390995 133 0.02272339 52 0.00008844365932307692 2.23443 31 51 0.006068912 Mouse Phenotype Single KO decreased erythrocyte cell number 22 6.755066e-28 2.8116426982727273e-25 2.211871 236 0.0403212 208 0.02221515494903846 1.428388 68 175 0.01331245 Mouse Phenotype Single KO abnormal erythropoiesis 27 2.064034e-26 7.000133088148147e-24 2.481031 177 0.0302409 40 0.000024223469949999998 1.871417 56 110 0.01096319 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 58 1.158443e-19 1.828941819137931e-17 2.306496 149 0.02545703 64 0.000189249292859375 1.90287 44 85 0.008613939 Mouse Phenotype Single KO extramedullary hematopoiesis 105 9.673636e-14 8.436331890666667e-12 2.190949 112 0.01913549 113 0.003422433612123894 1.644526 51 114 0.009984338 Mouse Phenotype Single KO abnormal liver sinusoid morphology 106 1.24916e-13 1.0791092566037736e-11 2.547212 82 0.01400991 87 0.0008182282608735631 1.949393 35 66 0.006851997 Mouse Phenotype Single KO decreased circulating alanine transaminase level 143 6.073404e-11 3.889102127832168e-9 2.091618 96 0.01640185 139 0.006267515237769784 1.764479 36 75 0.007047768 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 148 8.693911e-11 5.3790637180405405e-9 2.745108 55 0.00939689 91 0.0008881185122417581 2.28508 23 37 0.004502741 Mouse Phenotype Single KO persistent right dorsal aorta 153 1.123872e-10 6.726337192156863e-9 3.143171 44 0.007517512 135 0.0062797708904444435 2.888284 11 14 0.002153485 Mouse Phenotype Single KO absent hypoglossal nerve 562 0.0001042203 0.0016981232866548042 3.08287 16 0.002733641 181 0.013222303270718232 2.695732 11 15 0.002153485 Mouse Phenotype Single KO abnormal tail position or orientation 728 0.0007795296 0.009805154597802198 2.557657 16 0.002733641 149 0.0067552172302013415 3.675998 7 7 0.001370399 Mouse Phenotype abnormal embryonic erythropoiesis 10 1.436868e-34 1.3737894948e-31 4.842397 95 0.01623099 405 0.024676350814814816 2.01587 17 31 0.003328113 Mouse Phenotype decreased erythroid progenitor cell number 21 8.42939e-31 3.8377808471428567e-28 2.952511 155 0.02648215 89 0.00002381754675505618 2.031473 42 76 0.008222396 Mouse Phenotype decreased erythrocyte cell number 27 1.274877e-28 4.5144811099999996e-26 2.071318 281 0.04800957 161 0.0006252507996894409 1.479947 93 231 0.01820673 Mouse Phenotype abnormal erythropoiesis 29 1.053074e-27 3.4718760393103444e-25 2.342401 208 0.03553733 47 3.100095256595745e-7 1.850335 75 149 0.01468285 Mouse Phenotype extramedullary hematopoiesis 49 1.987316e-23 3.877699648163265e-21 2.203522 198 0.03382881 81 0.000012813180051851852 1.680456 80 175 0.01566171 Mouse Phenotype abnormal platelet physiology 53 9.077976e-23 1.6376326138867924e-20 2.40839 160 0.02733641 388 0.020393240909536082 1.475969 53 132 0.01037588 Mouse Phenotype abnormal erythroid progenitor cell morphology 64 7.663804e-21 1.1449004694375e-18 2.207971 174 0.02972834 97 0.00004253385313608247 1.791663 58 119 0.01135474 Mouse Phenotype pancytopenia 76 6.723011e-19 8.457724759342105e-17 4.071546 60 0.01025115 437 0.02937522077574371 2.028137 16 29 0.003132341 Mouse Phenotype increased circulating tumor necrosis factor level 92 2.515071e-16 2.6137601990217392e-14 2.595279 97 0.0165727 416 0.027746182882211538 1.537918 41 98 0.008026625 Mouse Phenotype abnormal third pharyngeal arch artery morphology 96 3.612546e-16 3.5978700318750005e-14 3.49215 61 0.01042201 395 0.021665555188860756 2.275618 13 21 0.002545027 Mouse Phenotype abnormal circulating tumor necrosis factor level 130 1.00157e-13 7.36616213076923e-12 2.124007 120 0.02050231 415 0.02769446171566265 1.43515 57 146 0.01115897 Mouse Phenotype abnormal liver sinusoid morphology 135 1.630177e-13 1.1545275775555556e-11 2.300588 99 0.0169144 101 0.000054456587699999995 1.979384 42 78 0.008222396 Mouse Phenotype abnormal circulating interleukin-10 level 166 5.201603e-12 2.995935318253012e-10 3.303736 47 0.00803007 272 0.006380065845220588 2.100571 20 35 0.003915427 Mouse Phenotype decreased mean corpuscular hemoglobin 176 1.003416e-11 5.450943395454546e-10 2.252738 88 0.01503502 401 0.023969117042394014 1.623168 34 77 0.006656226 Mouse Phenotype enlarged liver sinusoidal spaces 217 8.930312e-10 3.934687236497696e-8 2.472605 59 0.0100803 116 0.00010866233102586207 2.331121 26 41 0.005090055 Mouse Phenotype heart hemorrhage 227 1.825673e-9 7.689541653303965e-8 2.020822 88 0.01503502 457 0.03249028643763676 1.627942 31 70 0.006068912 Mouse Phenotype persistent right dorsal aorta 262 1.482115e-8 5.408588364503818e-7 2.661353 44 0.007517512 439 0.029322280257403188 2.378587 11 17 0.002153485 Mouse Phenotype increased respiratory quotient 294 5.237627e-8 0.0000017032976784693877 2.25088 56 0.009567743 461 0.032875156295010845 1.706714 26 56 0.005090055 Mouse Phenotype abnormal sixth pharyngeal arch artery morphology 335 2.06159e-7 0.0000058838394 2.077485 61 0.01042201 531 0.050191936960451974 1.969285 15 28 0.00293657 Mouse Phenotype decreased B cell apoptosis 347 2.976099e-7 0.000008200139060230547 2.656053 36 0.006150692 273 0.006388964891208791 2.450666 14 21 0.002740799