# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	12	1.685308e-26	1.8480806643333335e-23	2.078559	254	0.06343656	58	4.851525915e-13	1.608969	219	555	0.047557	
GO Biological Process	ncRNA processing	20	1.958263e-21	1.2884391408499997e-18	2.168019	185	0.0462038	84	2.233994030714286e-10	1.647485	160	396	0.03474484	
GO Biological Process	viral gene expression	25	4.990992e-19	2.62705854912e-16	3.285377	79	0.01973027	69	2.605216912898551e-11	2.247454	70	127	0.01520087	
GO Biological Process	translation	30	3.467926e-17	1.5211479411333335e-14	2.001947	176	0.04395604	60	1.2773757116000001e-12	1.742813	159	372	0.03452769	
GO Biological Process	rRNA processing	31	4.383113e-17	1.8605607731290323e-14	2.353695	122	0.03046953	114	2.9062436422807016e-8	1.73133	107	252	0.02323561	
GO Biological Process	rRNA metabolic process	35	4.191989e-16	1.576068092885714e-13	2.279997	122	0.03046953	130	1.6667280500769234e-7	1.684537	107	259	0.02323561	
GO Biological Process	ribosome biogenesis	36	4.653834e-16	1.7011056001666667e-13	2.068414	151	0.03771229	112	2.8266448430357142e-8	1.641109	130	323	0.02823018	
GO Biological Process	termination of RNA polymerase II transcription	37	1.509781e-15	5.369515724054054e-13	4.02095	49	0.01223776	170	0.000015104372375882353	2.186499	37	69	0.008034745	
GO Biological Process	multi-organism metabolic process	38	2.036086e-15	7.050751493157893e-13	2.693644	85	0.02122877	78	1.762912917051282e-10	2.108108	76	147	0.0165038	
GO Biological Process	viral transcription	39	1.369768e-14	4.621737721025641e-12	3.006944	67	0.01673327	96	2.250339780208333e-9	2.201142	61	113	0.01324647	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	40	1.508243e-14	4.96174240925e-12	3.030636	66	0.01648352	159	0.000004170121032012578	1.935096	56	118	0.01216069	
GO Biological Process	mitochondrial translation	41	2.225718e-14	7.14346906390244e-12	3.133875	62	0.01548452	149	0.0000016354031694630873	2.019708	53	107	0.01150923	
GO Biological Process	DNA-templated transcription, termination	42	3.271772e-14	1.0250773273333333e-11	3.00871	65	0.01623377	193	0.0000637639322134715	1.870424	50	109	0.01085776	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	45	4.973614e-14	1.4543952583555555e-11	3.302607	56	0.01398601	133	2.867513308345865e-7	2.171725	49	92	0.01064061	
GO Biological Process	cotranslational protein targeting to membrane	46	6.170131e-14	1.765059865847826e-11	3.20354	58	0.01448551	126	1.194736940952381e-7	2.163584	52	98	0.01129207	
GO Biological Process	protein targeting to ER	50	1.584741e-13	4.1707213638000003e-11	3.093054	59	0.01473526	138	4.37486783942029e-7	2.09932	52	101	0.01129207	
GO Biological Process	translational initiation	51	1.605884e-13	4.143495599215687e-11	2.600866	78	0.01948052	140	4.642862712071428e-7	1.910449	67	143	0.0145494	
GO Biological Process	RNA catabolic process	52	1.679655e-13	4.250496181730769e-11	2.109434	119	0.02972028	150	0.0000017997239711333335	1.65808	98	241	0.02128122	
GO Biological Process	protein localization to endoplasmic reticulum	53	2.888541e-13	7.171756796037737e-11	2.71215	71	0.01773227	124	7.75285088766129e-8	2.038762	62	124	0.01346363	
GO Biological Process	translational termination	54	4.623379e-13	1.1266489677962964e-10	3.119773	56	0.01398601	181	0.00002682459968950276	1.97438	46	95	0.009989142	
GO Cellular Component	ribosomal subunit	18	1.519874e-19	1.45907904e-17	2.857903	100	0.02497502	28	1.821675497142857e-12	2.049783	93	185	0.02019544	
GO Cellular Component	ribosome	22	3.596658e-17	2.8250113745454543e-15	2.390191	119	0.02972028	29	6.083149903448277e-12	1.900541	110	236	0.02388708	
GO Cellular Component	large ribosomal subunit	32	8.702047e-12	4.69910538e-10	2.795551	59	0.01473526	41	7.068219629268294e-8	2.056491	58	115	0.01259501	
GO Cellular Component	mitochondrial ribosome	33	1.738746e-11	9.104706327272729e-10	3.3919	43	0.01073926	59	0.0004133551728813559	1.870864	39	85	0.008469055	
GO Cellular Component	mitochondrial membrane part	35	4.292053e-11	2.1190478811428572e-9	2.065714	100	0.02497502	51	0.00005220121976470588	1.596389	83	212	0.01802389	
GO Cellular Component	mitochondrial protein complex	36	7.273294e-11	3.49118112e-9	2.243088	81	0.02022977	48	0.0000085259952	1.74751	69	161	0.01498371	
GO Cellular Component	spliceosomal complex	38	4.079904e-10	1.8552826610526315e-8	2.010401	96	0.02397602	39	6.59399483076923e-8	1.81954	83	186	0.01802389	
GO Cellular Component	small ribosomal subunit	40	5.375112e-10	2.322048384e-8	3.026426	43	0.01073926	55	0.00008120717149090908	2.038762	36	72	0.00781759	
GO Cellular Component	inner mitochondrial membrane protein complex	42	5.545481e-9	2.2815693257142853e-7	2.207267	67	0.01673327	49	0.00002053590817959184	1.785777	60	137	0.01302932	
GO Cellular Component	cytosolic ribosome	43	5.814052e-9	2.3364376409302326e-7	2.285888	62	0.01548452	40	6.44271408e-8	2.075169	57	112	0.01237785	
GO Cellular Component	mitochondrial large ribosomal subunit	44	8.104607e-9	3.182900203636363e-7	3.715985	28	0.006993007	75	0.002981541888	1.998786	25	51	0.005428882	
GO Cellular Component	spliceosomal snRNP complex	47	3.160825e-8	0.000001162107574468085	3.028736	34	0.008491508	81	0.0065511104	1.841463	28	62	0.006080347	
GO Cellular Component	small nuclear ribonucleoprotein complex	49	9.156438e-8	0.000003229045890612245	2.745165	37	0.009240759	79	0.0036737083139240503	1.831931	31	69	0.006731813	
GO Cellular Component	cytosolic small ribosomal subunit	50	1.157658e-7	0.000004000866048	3.107126	30	0.007492507	56	0.00014411671200000002	2.316775	25	44	0.005428882	
GO Cellular Component	methyltransferase complex	51	1.610083e-7	0.000005455340047058824	2.244314	52	0.01298701	86	0.009825892241860465	1.657895	37	91	0.008034745	
GO Cellular Component	catalytic step 2 spliceosome	54	2.717618e-7	0.0000086963776	2.245176	50	0.01248751	69	0.0017102128695652174	1.741443	41	96	0.008903366	
GO Cellular Component	respiratory chain	57	0.000001523012	0.00004617131115789474	2.148678	48	0.01198801	68	0.001689045797647059	1.718956	43	102	0.009337676	
GO Cellular Component	respiratory chain complex	59	0.000003384745	0.00009913287050847457	2.186598	43	0.01073926	63	0.0010324898742857143	1.807085	39	88	0.008469055	
GO Cellular Component	preribosome	60	0.000004274206	0.00012309713280000002	2.322899	37	0.009240759	88	0.010934699563636364	1.716852	32	76	0.006948969	
GO Cellular Component	mitochondrial respiratory chain	64	0.000008802232	0.00023766026399999997	2.060983	45	0.01123876	64	0.00102594762	1.778495	41	94	0.008903366	
GO Molecular Function	structural constituent of ribosome	5	3.052579e-17	2.5775977076e-14	2.802962	90	0.02247752	8	9.71108553e-11	2.089102	83	162	0.01802389	
GO Molecular Function	snRNA binding	7	1.55867e-11	9.401006771428571e-9	4.952601	28	0.006993007	24	0.00008761005351666668	2.575279	24	38	0.005211726	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	37	0.00006115782	0.006978603136216216	2.632333	22	0.005494505	41	0.04013487777073171	2.249669	16	29	0.003474484	
GO Molecular Function	Ran GTPase binding	63	0.0004835731	0.032407073463492066	2.171946	24	0.005994006	42	0.0469135974	2.166185	17	32	0.00369164	
Human Phenotype	Exercise intolerance	1	3.400442e-12	2.2691149466e-8	3.451825	45	0.01123876	34	0.00006209740713529412	2.155263	37	70	0.008034745	
Human Phenotype	Increased CSF lactate	2	8.184528e-10	0.0000027307677672	3.376456	36	0.008991009	37	0.00009946454578108108	2.249669	32	58	0.006948969	
Human Phenotype	Abnormal CSF metabolite level	5	1.003486e-8	0.000013392524156	3.057756	36	0.008991009	49	0.0008168879600816327	2.071124	32	63	0.006948969	
Human Phenotype	Increased serum lactate	7	3.753812e-8	0.000035784553537142855	2.378005	51	0.01273726	50	0.00080647155416	1.834886	45	100	0.009771987	
Human Phenotype	Mitochondrial inheritance	10	4.35357e-7	0.0002905137261	3.124028	27	0.006743257	85	0.015913629089411765	1.927557	26	55	0.005646037	
Human Phenotype	Abnormality of the mitochondrion	12	7.094423e-7	0.00039450903899166664	2.384916	41	0.01023976	42	0.0002684390607857143	2.067477	36	71	0.00781759	
Human Phenotype	Abnormality of mitochondrial metabolism	13	9.968514e-7	0.0005116914917076923	2.381281	40	0.00999001	43	0.0003597513619069767	2.068309	35	69	0.007600434	
Human Phenotype	Abnormal mitochondria in muscle tissue	19	0.00001548295	0.005437775018421053	3.632416	16	0.003996004	69	0.004089490991014493	2.659255	15	23	0.003257329	
Human Phenotype	Lipid accumulation in hepatocytes	27	0.00004703985	0.011625811816666666	2.027428	39	0.00974026	72	0.005994542187916666	1.868865	33	72	0.007166124	
Human Phenotype	Leukodystrophy	29	0.00005757391	0.013247955221724138	2.324681	28	0.006993007	53	0.0009121435756037735	2.201863	27	50	0.005863192	
Human Phenotype	Acute necrotizing encephalopathy	37	0.0001035966	0.018683786805405406	3.393868	14	0.003496503	81	0.012161254160493828	2.650391	13	20	0.002823018	
Human Phenotype	Increased muscle lipid content	39	0.0001177044	0.020139524646153848	3.784949	12	0.002997003	102	0.025989372352941173	2.575279	12	19	0.002605863	
Human Phenotype	Postnatal microcephaly	42	0.000127175	0.020205685119047617	2.147197	30	0.007492507	114	0.030888866279824564	1.91394	23	49	0.004994571	
Human Phenotype	Increased intramyocellular lipid droplets	69	0.0003372491	0.03261540933768116	3.600879	11	0.002747253	113	0.03070908104159292	2.638398	11	17	0.002388708	
Human Phenotype	Glomerulosclerosis	83	0.0005594644	0.04497958965301205	2.110916	25	0.006243756	124	0.04003132161854839	2.100543	17	33	0.00369164	
Mouse Phenotype Single KO	inner cell mass degeneration	24	0.0001235173	0.047126996504166664	2.218987	28	0.006993007	27	0.001939125322037037	2.548453	20	32	0.004343105	
Mouse Phenotype	inner cell mass degeneration	32	0.0001235173	0.036904653290625006	2.218987	28	0.006993007	30	0.0018222102745	2.548453	20	32	0.004343105