# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA metabolic process	21	1.733225e-46	1.0860717988095239e-43	2.052417	486	0.02742818	129	1.1585081592248062e-18	1.411697	228	259	0.0194722	
GO Biological Process	rRNA processing	22	1.998288e-46	1.195248717818182e-43	2.070803	475	0.02680738	126	6.739779753095239e-19	1.419093	223	252	0.01904518	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	31	2.397185e-38	1.0175663682258064e-35	2.573335	248	0.01399628	255	3.5504865543137257e-9	1.426966	105	118	0.008967461	
GO Biological Process	viral gene expression	32	3.689008e-38	1.5169892585000002e-35	2.480944	264	0.01489926	159	1.6394318086163524e-14	1.502622	119	127	0.01016312	
GO Biological Process	viral transcription	36	1.211589e-33	4.4286943475e-31	2.433978	240	0.01354478	179	5.350615541564246e-13	1.504298	106	113	0.009052865	
GO Biological Process	multi-organism metabolic process	41	9.978383e-32	3.2025741926097564e-29	2.13399	298	0.0168181	170	1.0411687201764704e-13	1.46182	134	147	0.01144419	
GO Biological Process	translational elongation	42	1.609723e-31	5.043415465952381e-29	2.401727	230	0.01298042	189	6.2266772715343914e-12	1.489093	104	112	0.008882057	
GO Biological Process	cotranslational protein targeting to membrane	45	7.604321e-31	2.223672445311111e-28	2.533687	203	0.01145663	291	3.635020002233678e-8	1.440002	88	98	0.007515586	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	49	3.505597e-30	9.41431651489796e-28	2.57206	193	0.01089226	327	2.9153587437003057e-7	1.42933	82	92	0.00700316	
GO Biological Process	mitochondrial translational elongation	52	1.114788e-28	2.821056786923077e-26	2.653074	173	0.009763531	211	6.13463537085308e-11	1.528173	81	85	0.006917756	
GO Biological Process	mitochondrial translational termination	53	6.610319e-28	1.641229957e-25	2.609806	173	0.009763531	198	2.7755534352525255e-11	1.529908	83	87	0.007088564	
GO Biological Process	protein targeting to ER	55	1.07498e-27	2.5719385127272726e-25	2.392994	202	0.01140019	351	0.0000010136055285754986	1.397229	88	101	0.007515586	
GO Biological Process	protein localization to endoplasmic reticulum	63	7.443562e-27	1.5547592437777777e-24	2.14073	248	0.01399628	247	2.0302307210931173e-9	1.422582	110	124	0.009394483	
GO Biological Process	translational initiation	66	2.952862e-26	5.887380463333334e-24	2.041961	271	0.01529432	257	3.980596475953308e-9	1.390567	124	143	0.01059014	
GO Biological Process	mitochondrial translation	67	7.767877e-26	1.5256342304925374e-23	2.307259	202	0.01140019	166	7.208102259156626e-14	1.528702	102	107	0.008711248	
GO Biological Process	translational termination	72	1.313395e-24	2.4004117784722223e-22	2.341547	186	0.01049721	217	8.465403005990784e-11	1.502356	89	95	0.007600991	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	73	1.346194e-24	2.4266529926027393e-22	2.201317	212	0.01196456	325	2.7714530254153847e-7	1.405093	92	105	0.007857204	
GO Biological Process	regulation of viral transcription	109	2.051412e-17	2.4765624319266055e-15	2.141427	155	0.008747672	1109	0.04894580822182146	1.258239	51	65	0.004355624	
GO Biological Process	snRNA metabolic process	110	2.562723e-17	3.065715632454545e-15	2.135742	155	0.008747672	336	5.080196437500001e-7	1.435816	77	86	0.006576138	
GO Biological Process	cytoplasmic translation	162	8.257884e-14	6.7077466392592585e-12	2.592873	81	0.004571364	698	0.0027207834957020055	1.417169	38	43	0.003245367	
GO Cellular Component	ribosomal subunit	21	3.487154e-42	2.869429577142857e-40	2.266781	351	0.01980924	44	5.404673454545455e-15	1.430272	165	185	0.01409172	
GO Cellular Component	large ribosomal subunit	25	3.227694e-32	2.2309820928e-30	2.44121	228	0.01286754	57	2.3162330273684213e-10	1.450247	104	115	0.008882057	
GO Cellular Component	mitochondrial ribosome	30	4.6827e-28	2.6972351999999996e-26	2.780699	156	0.008804109	62	2.2890010529032255e-9	1.49044	79	85	0.006746947	
GO Cellular Component	mitochondrial large ribosomal subunit	41	7.358937e-19	3.101522716097561e-17	2.879002	96	0.005417913	97	0.0000030423346144329898	1.509307	48	51	0.004099411	
GO Cellular Component	cytosolic large ribosomal subunit	46	1.126646e-15	4.2322701913043474e-14	2.197815	130	0.007336757	129	0.0002730892353488372	1.393325	53	61	0.004526433	
GO Cellular Component	small ribosomal subunit	51	8.155448e-14	2.7632576752941176e-12	2.067568	130	0.007336757	110	0.00003020166981818182	1.403183	63	72	0.005380477	
GO Cellular Component	spliceosomal snRNP complex	53	2.304766e-13	7.514406883018868e-12	2.194137	109	0.006151589	94	0.00000204557514893617	1.474313	57	62	0.00486805	
GO Cellular Component	nuclear ubiquitin ligase complex	58	4.600618e-12	1.37066688e-10	2.40437	80	0.004514927	204	0.01326915105882353	1.363092	34	40	0.002903749	
GO Cellular Component	mitochondrial nucleoid	71	2.897199e-10	7.051211087323943e-9	2.161683	83	0.004684237	115	0.0001027029888	1.489093	39	42	0.003330771	
GO Cellular Component	mitochondrial small ribosomal subunit	74	9.671611e-10	2.258451865945946e-8	2.62055	53	0.002991139	205	0.013264195434146342	1.43182	25	28	0.00213511	
GO Cellular Component	INO80-type complex	85	7.828596e-9	1.5915075162352942e-7	2.845323	41	0.0023139	212	0.01664663909433962	1.464191	21	23	0.001793492	
GO Cellular Component	spliceosomal tri-snRNP complex	93	2.156119e-8	4.006208206451613e-7	2.359307	54	0.003047576	166	0.0019355796433734938	1.493042	27	29	0.002305919	
GO Cellular Component	precatalytic spliceosome	96	3.209588e-8	5.7772584e-7	2.446607	49	0.002765393	205	0.013264195434146342	1.43182	25	28	0.00213511	
GO Cellular Component	sex chromosome	107	8.391276e-8	0.0000013551518624299063	2.123753	62	0.003499069	191	0.005643678760209425	1.480281	24	26	0.002049705	
GO Cellular Component	cytoplasmic exosome (RNase complex)	110	1.686597e-7	0.00000264949056	3.718337	23	0.001298042	215	0.01728352833488372	1.603638	13	13	0.001110257	
GO Cellular Component	Ino80 complex	123	9.578328e-7	0.00001345638275121951	2.929564	28	0.001580225	258	0.03721635795348837	1.503411	15	16	0.001281066	
GO Cellular Component	U4/U6 x U5 tri-snRNP complex	130	0.000001957749	0.000026023002092307696	2.173618	46	0.002596083	202	0.011801837940594058	1.470002	22	24	0.001878897	
GO Cellular Component	SAGA-type complex	145	0.000003695595	0.000044041297655172415	2.047447	50	0.00282183	251	0.032245464478087654	1.411202	22	25	0.001878897	
GO Cellular Component	U5 snRNP	151	0.000004610421	0.00005276031449006622	2.261724	39	0.002201027	234	0.022250281846153845	1.457853	20	22	0.001708088	
GO Cellular Component	Sin3-type complex	153	0.000004996564	0.000056431781647058814	2.040634	49	0.002765393	188	0.004786377089361703	1.603638	16	16	0.00136647	
GO Molecular Function	structural constituent of ribosome	7	5.227528e-37	3.152946173714286e-34	2.230945	317	0.0178904	38	9.884233083157894e-14	1.445254	146	162	0.01246904	
GO Molecular Function	rRNA binding	8	5.09039e-32	2.6864533225e-29	3.559505	125	0.007054574	107	0.00026945683912149533	1.416547	53	60	0.004526433	
GO Molecular Function	snRNA binding	11	5.646008e-16	2.167040525090909e-13	2.997723	75	0.004232745	103	0.0001814054852815534	1.519236	36	38	0.003074558	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	43	5.312613e-8	0.0000052162446711627905	2.000805	74	0.004176308	142	0.005528474114084507	1.493042	27	29	0.002305919	
GO Molecular Function	mRNA 5'-UTR binding	108	0.000009462626	0.00036991858307407405	2.006499	48	0.002708956	158	0.011661286918987343	1.530746	21	22	0.001793492	
GO Molecular Function	pseudouridine synthase activity	192	0.0001920369	0.0042228114156250005	2.62919	19	0.001072295	195	0.046559761323076924	1.603638	13	13	0.001110257	
Human Phenotype	Exercise intolerance	1	1.064976e-13	7.106584848e-10	2.114711	122	0.006885264	215	0.0015707615048372093	1.351638	59	70	0.005038859	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	3	2.073455e-18	6.328875811666667e-15	2.240068	149	0.008409052	321	0.009698064594080997	1.336365	50	60	0.004270219	
Mouse Phenotype Single KO	early cellular replicative senescence	4	9.760983e-18	2.2345330332749998e-14	2.301603	135	0.00761894	260	0.0038422595903846155	1.387764	45	52	0.003843198	
Mouse Phenotype Single KO	abnormal sternebra number	17	1.564569e-9	8.427504901764706e-7	3.299994	36	0.002031717	454	0.04337350203303965	1.603638	13	13	0.001110257	
Mouse Phenotype Single KO	lumbar vertebral transformation	27	1.252393e-8	0.000004247467667037037	2.022615	79	0.004458491	292	0.00594352646369863	1.434834	34	38	0.002903749	
Mouse Phenotype	early cellular replicative senescence	1	8.495369e-24	8.1224223009e-20	2.229329	199	0.01123088	158	0.0000035139022891139235	1.449865	66	73	0.00563669	
Mouse Phenotype	abnormal cellular replicative senescence	2	1.317407e-22	6.2978641635e-19	2.111239	213	0.01202099	210	0.00009236677221428571	1.374547	72	84	0.006149116	
Mouse Phenotype	increased adrenal gland tumor incidence	13	1.886942e-11	1.3877732663076922e-8	2.903023	54	0.003047576	430	0.0072164871558139535	1.603638	17	17	0.001451875	
Mouse Phenotype	sacral vertebral transformation	19	7.705979e-11	3.877729748368421e-8	3.138402	45	0.002539647	498	0.012875524157228917	1.527275	20	21	0.001708088	
Mouse Phenotype	abnormal sternebra number	27	1.564569e-9	5.54031267e-7	3.299994	36	0.002031717	617	0.033323091213938415	1.603638	13	13	0.001110257	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	43	5.592803e-8	0.000012435532437906976	2.042656	70	0.003950562	368	0.0030918611217391305	1.539493	24	25	0.002049705	
Mouse Phenotype	increased pheochromocytoma incidence	61	2.476615e-7	0.00003881789510655738	2.878364	32	0.001805971	701	0.0470529134636234	1.603638	12	12	0.001024853