# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ribonucleoprotein complex biogenesis	14	5.442113e-17	5.115197497642857e-14	2.128983	148	0.0603097	68	0.00004909756425147059	1.636217	101	454	0.0395613	
GO Biological Process	ncRNA metabolic process	22	1.033293e-15	6.180501175909091e-13	2.029512	152	0.06193969	198	0.015462921583333334	1.391463	105	555	0.04112808	
GO Biological Process	ncRNA processing	25	9.713599e-15	5.11284996964e-12	2.218038	116	0.04726976	162	0.007353523751975309	1.504407	81	396	0.03172738	
GO Biological Process	rRNA processing	26	1.244995e-13	6.301111232692307e-11	2.549734	81	0.03300733	172	0.008863825894186047	1.634417	56	252	0.02193498	
GO Biological Process	rRNA metabolic process	28	6.107323e-13	2.8702236913214285e-10	2.469897	81	0.03300733	203	0.01595176762955665	1.590244	56	259	0.02193498	
GO Biological Process	mRNA splicing, via spliceosome	32	5.791571e-12	2.38160258715625e-9	2.116246	102	0.04156479	136	0.0027145846236029413	1.651621	64	285	0.02506855	
GO Biological Process	RNA splicing, via transesterification reactions	33	6.758898e-12	2.6951617812727275e-9	2.11038	102	0.04156479	140	0.003696068902357143	1.634417	64	288	0.02506855	
GO Biological Process	RNA catabolic process	34	7.990265e-12	3.0924675627941177e-9	2.342737	81	0.03300733	197	0.01529851980609137	1.617462	53	241	0.02075989	
GO Biological Process	ribosome biogenesis	35	1.173022e-11	4.410227570857143e-9	2.145613	96	0.0391198	178	0.009837690578089888	1.548395	68	323	0.02663533	
GO Biological Process	DNA conformation change	36	1.205325e-11	4.4057976875e-9	2.115604	99	0.0403423	215	0.023492652531627908	1.544262	59	281	0.02311007	
GO Biological Process	nuclear-transcribed mRNA catabolic process	37	1.338786e-11	4.761374317297298e-9	2.539088	68	0.02770986	238	0.032676815829411766	1.634417	44	198	0.01723463	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	44	7.803492e-11	2.333776164272727e-8	3.221646	43	0.01752241	270	0.04565406853777778	1.807554	29	118	0.01135919	
GO Biological Process	DNA replication	48	1.606663e-10	4.404599670208334e-8	2.1969	81	0.03300733	170	0.00853805459764706	1.699948	49	212	0.01919311	
GO Biological Process	telomere organization	49	1.71074e-10	4.594209726530612e-8	3.042771	45	0.01833741	133	0.002430876910977444	2.074452	33	117	0.01292597	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	54	3.488802e-10	8.501693614444444e-8	3.113888	42	0.01711491	221	0.02620619613438914	1.887535	29	113	0.01135919	
GO Biological Process	regulation of hematopoietic stem cell differentiation	55	3.804351e-10	9.102082692545455e-8	3.270715	39	0.01589242	224	0.027984505106249998	1.927977	27	103	0.01057579	
GO Biological Process	DNA strand elongation	60	6.253457e-10	1.3714873443833335e-7	6.270213	19	0.007742461	115	0.0013993005977391304	3.837327	12	23	0.004700353	
GO Biological Process	chromatin remodeling	61	6.587208e-10	1.4210011487213114e-7	2.152791	79	0.03219234	145	0.004896157159172414	1.85	41	163	0.01605954	
GO Biological Process	regulation of cellular amino acid metabolic process	63	8.339476e-10	1.7418915029206349e-7	4.267322	27	0.01100244	248	0.03941336456169355	2.206463	18	60	0.007050529	
GO Biological Process	DNA-dependent DNA replication	70	1.483078e-9	2.7879747717142855e-7	2.572703	53	0.02159739	240	0.03292235954416666	1.854708	29	115	0.01135919	
GO Cellular Component	intracellular ribonucleoprotein complex	10	3.539086e-33	6.115540608e-31	2.213598	271	0.1104319	18	3.14161056e-8	1.572173	174	814	0.06815511	
GO Cellular Component	ribonucleoprotein complex	11	4.323096e-33	6.791190807272727e-31	2.21078	271	0.1104319	20	3.8135854079999997e-8	1.5664	174	817	0.06815511	
GO Cellular Component	spliceosomal complex	25	3.472908e-11	2.4004740096000002e-9	2.425992	71	0.02893236	34	0.001573283011764706	1.818948	46	186	0.01801802	
GO Cellular Component	endopeptidase complex	34	1.875336e-8	9.531119435294118e-7	3.380213	30	0.01222494	39	0.009911400369230768	2.238441	21	69	0.008225617	
GO Cellular Component	nuclear chromosome, telomeric region	40	3.219383e-8	0.0000013907734560000002	2.649553	42	0.01711491	49	0.02390052166530612	1.783	32	132	0.01253427	
GO Cellular Component	cytoplasmic stress granule	43	6.206101e-8	0.0000024939866344186047	3.452313	27	0.01100244	37	0.004220795052972973	2.736698	16	43	0.006267137	
GO Cellular Component	proteasome complex	44	6.399524e-8	0.0000025132676072727273	3.269385	29	0.01181744	46	0.01932180104347826	2.163199	20	68	0.007833921	
GO Cellular Component	signal recognition particle, endoplasmic reticulum targeting	48	2.472302e-7	0.0000089002872	13.29855	8	0.003259984	50	0.026447364864	5.253483	5	7	0.00195848	
GO Cellular Component	protein-DNA complex	54	7.168283e-7	0.000022938505600000004	2.004446	60	0.02444988	45	0.018717980159999998	1.638463	45	202	0.01762632	
GO Molecular Function	proteasome binding	7	6.884731e-13	4.1524763259999997e-10	8.735392	20	0.008149959	22	0.006583637110909091	4.903251	8	12	0.003133568	
GO Molecular Function	protein kinase A regulatory subunit binding	108	0.0004373915	0.017098767712962964	2.700334	16	0.006519967	33	0.050928693812121215	3.483889	9	19	0.003525264	
GO Molecular Function	ATP-dependent protein binding	145	0.00103329	0.030086554344827588	4.573686	7	0.002852486	27	0.021498768014814814	5.516157	6	8	0.002350176	
Mouse Phenotype Single KO	abnormal chromosome morphology	33	0.000005362606	0.0014880419133939393	2.608148	29	0.01181744	23	0.017804014819565218	2.536164	20	58	0.007833921	
Mouse Phenotype	early cellular replicative senescence	21	7.71719e-7	0.0003513526361428571	2.669314	33	0.01344743	53	0.03383628880188679	2.216538	22	73	0.008617313	
Mouse Phenotype	abnormal telomere morphology	42	0.000008201395	0.0018669889903571428	3.014565	22	0.008964955	39	0.024371317506153848	2.941951	14	35	0.005483745	
Mouse Phenotype	abnormal telomere length	57	0.00002513647	0.004216312099473684	3.075654	19	0.007742461	44	0.02819808346363636	3.370985	11	24	0.004308656	
Mouse Phenotype	abnormal chromosome morphology	70	0.00004953217	0.006765386819571428	2.087273	36	0.01466993	32	0.01604045384625	2.292429	24	77	0.009400705	
Mouse Phenotype	increased midbrain apoptosis	90	0.0001197093	0.012717117969999999	4.935403	9	0.003667482	31	0.014282160116129032	7.354877	5	5	0.00195848