# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	16	3.322941e-33	2.7329112886875e-30	2.158019	303	0.02604435	115	1.8207776464347824e-11	1.569205	146	213	0.01780054	
GO Biological Process	endoplasmic reticulum unfolded protein response	17	3.542236e-33	2.741899030823529e-30	2.646752	202	0.0173629	310	0.00016094598861612902	1.48605	74	114	0.00902219	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	19	7.121347e-33	4.932095009105263e-30	2.589146	208	0.01787863	378	0.0010733952954761904	1.438422	71	113	0.008656425	
GO Biological Process	nuclear-transcribed mRNA catabolic process	20	1.353999e-32	8.9086364205e-30	2.2132	281	0.02415334	128	8.64532935390625e-11	1.572462	136	198	0.01658132	
GO Biological Process	cellular response to topologically incorrect protein	23	4.873823e-31	2.7884624720434783e-28	2.393253	227	0.01951178	302	0.00010106229646688742	1.449353	88	139	0.01072909	
GO Biological Process	RNA catabolic process	24	9.047095e-31	4.960446796041666e-28	2.013251	330	0.02836514	120	3.124214166333333e-11	1.52938	161	241	0.01962936	
GO Biological Process	response to topologically incorrect protein	28	4.763468e-30	2.238659836142857e-27	2.157729	273	0.0234657	284	0.00003814036067464789	1.411747	111	180	0.01353328	
GO Biological Process	rRNA processing	29	1.41463e-29	6.419005575862069e-27	2.03842	307	0.02638817	156	2.351935062820513e-9	1.471706	162	252	0.01975128	
GO Biological Process	protein targeting to ER	30	1.427399e-29	6.2610478136666665e-27	2.85074	158	0.01358088	119	3.0044750437815127e-11	1.813323	80	101	0.009753719	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	32	2.625008e-29	1.0794525085e-26	2.702408	171	0.0146983	185	2.6819101832972974e-8	1.649086	85	118	0.01036333	
GO Biological Process	regulation of DNA-templated transcription in response to stress	35	7.537162e-29	2.833757564514286e-26	2.365943	215	0.01848032	332	0.00027486130771686745	1.462087	76	119	0.009266033	
GO Biological Process	rRNA metabolic process	37	1.243666e-28	4.423081322702702e-26	2.000321	311	0.02673199	164	4.267534309268293e-9	1.458447	165	259	0.02011704	
GO Biological Process	cellular response to unfolded protein	38	1.520718e-28	5.266086358421053e-26	2.403893	206	0.01770672	308	0.0001334934408051948	1.47576	78	121	0.009509876	
GO Biological Process	response to unfolded protein	44	1.732953e-27	5.182711028863636e-25	2.148364	251	0.02157469	293	0.00005267201883276451	1.430825	100	160	0.01219215	
GO Biological Process	IRE1-mediated unfolded protein response	45	2.790011e-27	8.158612166444445e-25	3.375057	113	0.00971291	512	0.006331116164648438	1.53937	39	58	0.004754938	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	47	9.391442e-27	2.6294039420851065e-24	2.609401	165	0.01418257	108	2.8993444016666665e-12	1.831456	84	105	0.0102414	
GO Biological Process	protein localization to endoplasmic reticulum	50	2.361388e-26	6.2147009384e-24	2.432159	185	0.01590167	123	3.16114698601626e-11	1.735452	94	124	0.01146062	
GO Biological Process	cotranslational protein targeting to membrane	51	2.413744e-26	6.227932803137254e-24	2.775364	146	0.01254942	157	2.7739096566242037e-9	1.75203	75	98	0.009144111	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	54	1.908641e-24	4.65107535537037e-22	2.760405	136	0.01168987	165	4.445063146606061e-9	1.766758	71	92	0.008656425	
GO Biological Process	viral gene expression	56	5.668705e-24	1.332044448125e-21	2.418855	169	0.01452639	175	1.0926880186857141e-8	1.640379	91	127	0.01109485	
GO Cellular Component	ribosomal subunit	34	5.638322e-24	2.8655942399999997e-22	2.144218	218	0.01873818	74	0.000030386903351351347	1.398341	113	185	0.01377713	
GO Cellular Component	large ribosomal subunit	38	5.901942e-20	2.683830467368421e-18	2.36455	145	0.01246347	84	0.0002943170742857143	1.45322	73	115	0.008900268	
GO Cellular Component	nuclear ubiquitin ligase complex	44	6.161615e-17	2.4198342545454545e-15	3.249974	71	0.006102802	151	0.02305134834437086	1.545291	27	40	0.00329188	
GO Cellular Component	methyltransferase complex	46	2.698173e-16	1.0135745530434781e-14	2.138985	144	0.01237751	63	0.000006483560228571428	1.610071	64	91	0.007802975	
GO Cellular Component	catalytic step 2 spliceosome	48	1.376106e-15	4.9539816e-14	2.132674	138	0.01186178	108	0.0024521904	1.430825	60	96	0.007315289	
GO Cellular Component	peptidase complex	59	1.421075e-12	4.162063728813559e-11	2.056814	118	0.01014269	154	0.028587403636363633	1.35278	52	88	0.006339917	
GO Cellular Component	spliceosomal snRNP complex	60	1.720073e-12	4.95381024e-11	2.452661	80	0.006876397	168	0.040072114285714285	1.403131	38	62	0.004633016	
GO Cellular Component	MLL1 complex	64	2.340749e-12	6.320022299999999e-11	3.111598	53	0.004555613	120	0.006299616960000001	1.736725	22	29	0.002682273	
GO Cellular Component	mitochondrial intermembrane space	70	6.16063e-11	1.52079552e-9	2.104718	95	0.008165721	136	0.014096134588235294	1.408812	48	78	0.005852231	
GO Cellular Component	Bcl-2 family protein complex	71	6.981933e-11	1.6992648202816899e-9	4.640344	28	0.002406739	160	0.0327229308	2.28932	7	7	0.0008534504	
GO Cellular Component	cytosolic large ribosomal subunit	103	9.680368e-9	1.6240462042718447e-7	2.03416	79	0.006790442	98	0.0010896884375510205	1.576253	42	61	0.005120702	
GO Cellular Component	anaphase-promoting complex	126	1.263682e-7	0.0000017330496	3.031414	31	0.002664604	155	0.02859833310967742	1.744244	16	21	0.001950744	
GO Cellular Component	outer mitochondrial membrane protein complex	133	2.158816e-7	0.000002804837630075188	3.434718	25	0.002148874	171	0.0474104387368421	1.831456	12	15	0.001463058	
GO Cellular Component	cytosolic small ribosomal subunit	146	4.863958e-7	0.000005756794126027397	2.067429	58	0.004985388	131	0.011747296195419846	1.5609	30	44	0.003657644	
GO Cellular Component	prespliceosome	177	0.000005170421	0.000050477330440677965	2.620449	29	0.002492694	155	0.02859833310967742	1.744244	16	21	0.001950744	
GO Cellular Component	pronucleus	254	0.0002682238	0.0018247666393700788	2.268234	24	0.002062919	128	0.0105366474	1.984077	13	15	0.001584979	
GO Molecular Function	unfolded protein binding	7	1.872818e-21	1.1295767994285715e-18	2.497975	141	0.01211965	96	0.016996215137500003	1.382231	64	106	0.007802975	
GO Molecular Function	structural constituent of ribosome	10	8.855088e-21	3.7386181536000004e-18	2.100853	196	0.01684717	57	0.00041345179378947367	1.399029	99	162	0.01207023	
GO Molecular Function	ribonucleoprotein complex binding	11	2.120569e-20	8.13912938e-18	2.235219	167	0.01435448	44	0.00009549073956363636	1.512942	76	115	0.009266033	
GO Molecular Function	NF-kappaB binding	46	4.894866e-9	4.492635706956521e-7	2.518963	52	0.004469658	111	0.029289330046846848	1.71699	21	28	0.002560351	
GO Molecular Function	ribosome binding	51	1.512541e-8	0.0000012521466866666666	2.012137	79	0.006790442	81	0.006387442950617284	1.581712	38	55	0.004633016	
GO Molecular Function	nucleoside-triphosphate diphosphatase activity	103	0.000001116856	0.00004578025273786407	3.322334	23	0.001976964	90	0.01182683528	2.28932	10	10	0.001219215	
GO Molecular Function	ubiquitin-protein transferase regulator activity	122	0.000003144725	0.00010882810614754099	2.132784	46	0.003953928	125	0.044033636096	1.885322	14	17	0.001706901	
GO Molecular Function	mRNA 5'-UTR binding	216	0.00009258229	0.0018096408721296295	2.100979	33	0.002836514	74	0.002562362609189189	1.97714	19	22	0.002316508	
GO Molecular Function	cullin family protein binding	236	0.000142941	0.002557190262711864	2.13493	30	0.002578649	108	0.02642893814814815	1.907766	15	18	0.001828822	
Human Phenotype	Increased serum lactate	5	6.748193e-18	9.0061383778e-15	2.262698	141	0.01211965	64	0.0005626013598593751	1.510951	66	100	0.008046818	
Human Phenotype	Atherosclerosis	10	3.085418e-14	2.0588994314e-11	2.699821	78	0.006704487	93	0.007414965847311827	1.750656	26	34	0.003169959	
Human Phenotype	Coronary artery disease	11	3.37861e-14	2.049587684545455e-11	2.903041	69	0.005930892	124	0.012465416928225807	1.831456	20	25	0.00243843	
Human Phenotype	Increased CSF lactate	13	1.37983e-13	7.082773530769231e-11	2.582341	80	0.006876397	125	0.013150385008800001	1.53937	39	58	0.004754938	
Human Phenotype	Abnormal CSF metabolite level	16	4.63054e-13	1.93122458875e-10	2.455527	84	0.007220217	87	0.005370115925287356	1.562552	43	63	0.005242624	
Human Phenotype	Abnormality of the mitochondrion	17	6.726341e-13	2.6402866760588235e-10	2.162111	108	0.009283136	130	0.013742514793076923	1.483221	46	71	0.005608388	
Human Phenotype	Abnormal coronary artery morphology	20	3.494116e-12	1.1658118034e-9	2.574857	71	0.006102802	160	0.03211554748	1.71699	21	28	0.002560351	
Human Phenotype	Abnormality of mitochondrial metabolism	23	1.85553e-11	5.3834572565217396e-9	2.089853	102	0.008767406	152	0.0264677872	1.459856	44	69	0.005364545	
Human Phenotype	Arteriosclerosis	27	4.82192e-11	1.1917285985185186e-8	2.312689	78	0.006704487	169	0.038373840667455625	1.608711	26	37	0.003169959	
Human Phenotype	Ependymoma	240	0.0001506039	0.004187415936249999	3.273671	14	0.001203369	181	0.04877033941436465	2.28932	8	8	0.0009753719	
Mouse Phenotype Single KO	decreased liver regeneration	1	2.899134e-25	2.6547370038e-21	4.866236	68	0.005844937	211	0.04465026976777251	1.831456	16	20	0.001950744	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	46	5.459355e-10	1.0867676898913043e-7	2.82611	48	0.004125838	119	0.00606885638420168	1.907766	20	24	0.00243843	
Mouse Phenotype Single KO	abnormal rostral-caudal body axis extension	47	5.722142e-10	1.1148437083829788e-7	2.605275	55	0.004727523	171	0.019967191928070175	2.113218	12	13	0.001463058	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	20	6.076657e-15	2.9049458788500004e-12	3.16956	64	0.005501117	180	0.0028173908620000004	1.831456	24	30	0.002926116