# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	18	3.531905e-49	2.5820187719444442e-46	2.715285	292	0.01781248	284	0.000006757498642253521	1.450533	87	114	0.008806559	
GO Biological Process	cellular response to topologically incorrect protein	20	3.791806e-48	2.4948187577e-45	2.491596	333	0.02031355	300	0.000016960907052666667	1.394757	102	139	0.01032493	
GO Biological Process	response to topologically incorrect protein	28	3.790697e-45	1.7814922079642858e-42	2.215654	395	0.02409565	244	4.5672996045491805e-7	1.393846	132	180	0.01336168	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	30	2.820304e-44	1.2370793445333334e-41	2.234786	380	0.02318063	375	0.0003667097484	1.324358	108	155	0.01093228	
GO Biological Process	cellular response to unfolded protein	33	6.788316e-43	2.7068924316363635e-40	2.476223	299	0.01823949	291	0.000011282494946048112	1.429451	91	121	0.009211459	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	35	1.302012e-42	4.8951931165714285e-40	2.526562	286	0.01744647	346	0.00016402412064739886	1.396088	83	113	0.00840166	
GO Biological Process	mRNA catabolic process	43	4.433297e-39	1.3566919819302324e-36	2.052151	406	0.02476667	166	7.39126919746988e-10	1.427755	160	213	0.01619597	
GO Biological Process	response to unfolded protein	47	9.342736e-39	2.615767298382979e-36	2.162493	356	0.02171659	233	2.3951689884549356e-7	1.425524	120	160	0.01214698	
GO Biological Process	regulation of DNA-templated transcription in response to stress	49	2.156063e-38	5.7901291871428576e-36	2.335111	299	0.01823949	321	0.00005653143294392523	1.405559	88	119	0.008907784	
GO Biological Process	nuclear-transcribed mRNA catabolic process	50	1.09023e-37	2.8692673139999996e-35	2.090531	374	0.02281462	169	1.046452734260355e-9	1.439923	150	198	0.01518372	
GO Biological Process	IRE1-mediated unfolded protein response	54	1.625844e-36	3.961940962222222e-34	3.32792	157	0.009577259	566	0.005318312146113074	1.441909	44	58	0.004453892	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	56	2.488791e-35	5.8482144230357135e-33	2.407103	258	0.01573842	539	0.004045567315955473	1.354753	67	94	0.006782063	
GO Biological Process	translational elongation	57	5.43298e-35	1.254255856491228e-32	2.562137	227	0.01384737	180	3.954729830222222e-9	1.561288	92	112	0.009312683	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	66	3.581431e-32	7.140613716515152e-30	2.478665	221	0.01348136	211	5.3339364141232224e-8	1.514116	94	118	0.009515133	
GO Biological Process	mitochondrial translational termination	75	7.746493e-30	1.3591480184933334e-27	2.755685	169	0.01030928	231	2.027742656017316e-7	1.572992	72	87	0.007288187	
GO Biological Process	multi-organism metabolic process	78	2.935384e-29	4.95214334051282e-27	2.128578	275	0.01677545	163	6.716559461656442e-10	1.512801	117	147	0.0118433	
GO Biological Process	translational termination	86	2.318421e-28	3.5474537138372097e-26	2.53095	186	0.01134631	240	3.6475168919999996e-7	1.540566	77	95	0.007794311	
GO Biological Process	protein targeting to ER	93	9.321654e-28	1.318963924580645e-25	2.458512	192	0.01171232	201	2.9792859813432837e-8	1.56196	83	101	0.00840166	
GO Biological Process	mitochondrial transmembrane transport	96	3.820864e-27	5.237369726666667e-25	2.461897	187	0.01140731	374	0.0003642974151871658	1.442699	63	83	0.006377164	
GO Biological Process	mitochondrial translation	100	1.01288e-26	1.3328487919999997e-24	2.395121	194	0.01183432	221	1.1604761333936651e-7	1.527664	86	107	0.008705335	
GO Cellular Component	ribosomal subunit	35	9.155659e-37	4.5202796434285713e-35	2.219782	318	0.01939852	45	2.8232298239999998e-9	1.438366	140	185	0.01417147	
GO Cellular Component	mitochondrial ribosome	39	1.531953e-31	6.787730215384615e-30	3.005625	156	0.009516257	66	0.000012521368145454547	1.498198	67	85	0.006782063	
GO Cellular Component	large ribosomal subunit	42	1.202108e-27	4.9458157714285715e-26	2.372493	205	0.01250534	54	9.6435296e-8	1.504031	91	115	0.009211459	
GO Cellular Component	mitochondrial large ribosomal subunit	47	1.465461e-22	5.387907676595745e-21	3.209126	99	0.006039163	79	0.00004347680810126582	1.60255	43	51	0.004352667	
GO Cellular Component	catalytic step 2 spliceosome	49	9.030121e-22	3.184499813877551e-20	2.149671	196	0.01195632	77	0.00004152888935064935	1.445323	73	96	0.007389412	
GO Cellular Component	spliceosomal snRNP complex	57	2.016356e-17	6.1127424e-16	2.480407	114	0.006954188	140	0.004959295817142858	1.410196	46	62	0.004656342	
GO Cellular Component	nuclear ubiquitin ligase complex	65	2.451545e-16	6.517338092307692e-15	2.793769	86	0.005246142	191	0.02810781989528796	1.425524	30	40	0.003036745	
GO Cellular Component	PcG protein complex	70	1.022401e-15	2.523869897142857e-14	2.110673	143	0.008723236	183	0.023944112262295085	1.404864	34	46	0.003441644	
GO Cellular Component	endopeptidase complex	75	2.916086e-15	6.718662144e-14	2.175848	129	0.007869212	93	0.00017070525522580644	1.487503	54	69	0.00546614	
GO Cellular Component	proteasome complex	83	6.267154e-14	1.304776158072289e-12	2.109571	125	0.007625206	98	0.00024316486530612244	1.481427	53	68	0.005364915	
GO Cellular Component	small nuclear ribonucleoprotein complex	85	1.293721e-13	2.630058691764706e-12	2.138378	118	0.007198194	150	0.006740845056	1.377318	50	69	0.005061241	
GO Cellular Component	intrinsic component of mitochondrial membrane	90	3.05067e-13	5.8572864e-12	2.033611	129	0.007869212	162	0.0097901792	1.374351	47	65	0.004757567	
GO Cellular Component	integral component of mitochondrial membrane	92	3.966677e-13	7.450454191304347e-12	2.031916	128	0.007808211	169	0.013083413964497042	1.366127	46	64	0.004656342	
GO Cellular Component	small ribosomal subunit	101	3.482105e-12	5.957502415841584e-11	2.02852	118	0.007198194	168	0.012570325714285714	1.346328	51	72	0.005162466	
GO Cellular Component	mitochondrial nucleoid	103	7.497446e-12	1.2578239502912622e-10	2.336537	83	0.005063137	123	0.001803076682926829	1.538661	34	42	0.003441644	
GO Cellular Component	DNA-directed RNA polymerase III complex	129	4.588168e-10	6.146011088372093e-9	3.703382	33	0.002013054	201	0.037184453731343284	1.600588	16	19	0.001619597	
GO Cellular Component	methylosome	135	7.192318e-10	9.20616704e-9	4.173024	28	0.001708046	210	0.043613740799999995	1.742307	11	12	0.001113473	
GO Cellular Component	zonula adherens	160	9.570369e-9	1.0335998520000001e-7	3.334392	32	0.001952053	213	0.047563613746478876	1.900698	8	8	0.0008097986	
GO Cellular Component	precatalytic spliceosome	196	1.378079e-7	0.0000012149594448979592	2.42863	45	0.002745074	199	0.036898965226130655	1.493406	22	28	0.002226946	
GO Cellular Component	Lewy body	209	5.430115e-7	0.0000044895879043062205	3.09253	27	0.001647044	213	0.047563613746478876	1.900698	8	8	0.0008097986	
GO Molecular Function	unfolded protein binding	9	5.067154e-39	2.377058243111111e-36	2.778637	221	0.01348136	55	0.00002720715908	1.452421	81	106	0.00819921	
GO Molecular Function	structural constituent of ribosome	10	3.202805e-26	1.3522242710000002e-23	2.046268	269	0.01640944	18	6.007160113333334e-9	1.478321	126	162	0.01275433	
GO Molecular Function	rRNA binding	42	1.462697e-12	1.470358746190476e-10	2.462353	80	0.004880132	106	0.012202046013207546	1.425524	45	60	0.004555117	
GO Molecular Function	mRNA 5'-UTR binding	65	4.332918e-10	2.8143968916923075e-8	2.575451	57	0.003477094	140	0.029230558611428568	1.641512	19	22	0.001923272	
GO Molecular Function	cAMP response element binding	279	0.00003042555	0.00046041817956989247	2.031937	41	0.002501068	100	0.009954521828000001	1.900698	13	13	0.001315923	
Human Phenotype	Increased serum lactate	5	1.747342e-29	2.3320026332e-26	2.414427	212	0.01293235	53	0.000004765891853584906	1.501552	79	100	0.007996761	
Human Phenotype	Abnormality of lipid metabolism	10	1.270913e-23	8.480802449e-21	2.021525	248	0.01512841	192	0.022206113980729168	1.282971	81	120	0.00819921	
Human Phenotype	Abnormal CSF metabolite level	27	1.216238e-15	3.005909694074074e-13	2.344307	113	0.006893186	160	0.01167301217	1.417981	47	63	0.004757567	
Human Phenotype	Increased CSF lactate	38	1.879776e-13	3.300985591578947e-11	2.290837	100	0.006100165	232	0.04660811499568965	1.376368	42	58	0.004251442	
Human Phenotype	Abnormality of reticulocytes	197	2.913575e-7	0.000009869180697969544	2.045358	62	0.003782102	237	0.04919800175949367	1.49752	26	33	0.002631845	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	344	0.00002330565	0.0004520889606104651	2.262931	33	0.002013054	210	0.030093288474761903	1.773985	14	15	0.001417147	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	429	0.00008040532	0.0012506869472261072	2.091069	34	0.002074056	184	0.019179743317934782	1.781905	15	16	0.001518372	
Human Phenotype	Language impairment	510	0.0002370153	0.0031011825429411765	2.204277	26	0.001586043	204	0.027893251216666668	1.900698	11	11	0.001113473	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	2	3.546399e-35	1.6237187821499999e-31	2.286665	285	0.01738547	181	0.004940162544806629	1.36932	67	93	0.006782063	
Mouse Phenotype Single KO	decreased sensitivity to induced cell death	29	5.491376e-23	1.7339493114482757e-20	2.074444	226	0.01378637	163	0.0036741125465644176	1.41334	58	78	0.00587104	
Mouse Phenotype Single KO	absent hypoglossal nerve	95	2.225244e-14	2.1449009797894735e-12	3.577327	52	0.003172086	282	0.03075189789822695	1.773985	14	15	0.001417147	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	203	6.557443e-10	2.957955938472906e-8	2.622933	54	0.003294089	198	0.007551098062121213	1.795104	17	18	0.001720822	
Mouse Phenotype Single KO	thin hypoglossal nerve	282	2.864722e-8	9.302219629078014e-7	2.539906	46	0.002806076	282	0.03075189789822695	1.773985	14	15	0.001417147	
Mouse Phenotype Single KO	spontaneous chromosome breakage	309	7.196964e-8	0.000002132770205436893	2.180138	59	0.003599097	287	0.03467168831010453	1.596587	21	25	0.002125721	
Mouse Phenotype Single KO	abnormal DNA replication	448	0.000003241296	0.00006625122203571429	2.057476	50	0.003050082	255	0.020872128247843135	1.652781	20	23	0.002024496	
Mouse Phenotype Single KO	abnormal hepatic vein morphology	889	0.0006180572	0.006366197728233972	2.063953	26	0.001586043	272	0.0287073094625	1.900698	11	11	0.001113473	
Mouse Phenotype	decreased circulating free fatty acid level	7	4.539405e-38	6.200178743571428e-35	2.139654	358	0.02183859	206	0.0009456367386407767	1.357642	85	119	0.00860411	
Mouse Phenotype	pancytopenia	42	5.723503e-24	1.3029145757857142e-21	2.93166	121	0.007381199	384	0.017942767672656252	1.572992	24	29	0.002429396	
Mouse Phenotype	absent hypoglossal nerve	150	2.225244e-14	1.4183705256e-12	3.577327	52	0.003172086	411	0.022030751637226273	1.773985	14	15	0.001417147	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	249	8.830958e-11	3.3908750778313254e-9	2.425151	69	0.004209114	469	0.03673605294243071	1.520559	24	30	0.002429396	
Mouse Phenotype	abnormal hypoglossal nerve topology	285	6.557443e-10	2.1998495622105262e-8	2.622933	54	0.003294089	289	0.005401663944290657	1.795104	17	18	0.001720822	
Mouse Phenotype	heterochrony	363	1.215172e-8	3.2006224495867767e-7	2.263201	61	0.0037211	496	0.04410350511290323	1.677087	15	17	0.001518372	
Mouse Phenotype	thin hypoglossal nerve	384	2.864722e-8	7.1327101671875e-7	2.539906	46	0.002806076	411	0.022030751637226273	1.773985	14	15	0.001417147	
Mouse Phenotype	abnormal lipoprotein lipase activity	766	0.00003252535	0.00040597241690600526	2.255641	32	0.001952053	455	0.03407389105054945	1.900698	10	10	0.001012248	
Mouse Phenotype	abnormal hepatic vein morphology	1072	0.0006180572	0.0055123553070895535	2.063953	26	0.001586043	403	0.020230492375682384	1.900698	11	11	0.001113473