# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of intrinsic apoptotic signaling pathway 24 8.539819e-44 4.682311592541667e-41 2.288091 357 0.02373355 272 0.000011626402232352942 1.415086 107 155 0.01168122 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 34 6.676935e-40 2.5841702254411764e-37 2.541679 264 0.01755086 536 0.002841077200746269 1.360547 75 113 0.008187773 GO Biological Process endoplasmic reticulum unfolded protein response 37 2.618593e-39 9.312990618108107e-37 2.574063 254 0.01688605 380 0.0002411044616 1.420538 79 114 0.008624454 GO Biological Process liver regeneration 40 1.144195e-38 3.76411550125e-36 3.547216 153 0.01017152 656 0.011430436969512195 1.581344 27 35 0.002947598 GO Biological Process cellular response to topologically incorrect protein 41 1.273613e-38 4.087676455365853e-36 2.372899 291 0.01934583 365 0.0001846747399260274 1.386257 94 139 0.01026201 GO Biological Process nuclear-transcribed mRNA catabolic process 43 2.344898e-38 7.17593320511628e-36 2.156458 354 0.0235341 253 0.000005972318774308301 1.376947 133 198 0.01451965 GO Biological Process mRNA catabolic process 45 8.862231e-38 2.5915132828666665e-35 2.082226 378 0.02512964 242 0.000004832619368305785 1.366594 142 213 0.01550218 GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to stress 49 6.849392e-37 1.83941121077551e-34 4.505998 110 0.007312857 884 0.03409787172058824 1.62283 19 24 0.002074236 GO Biological Process response to topologically incorrect protein 57 1.282907e-35 2.9617145987719297e-33 2.109001 345 0.02293578 306 0.000037062843839542484 1.366594 120 180 0.01310044 GO Biological Process regulation of DNA-templated transcription in response to stress 60 2.98962e-35 6.55673493e-33 2.332061 274 0.01821566 421 0.00048521952736342046 1.395304 81 119 0.008842795 GO Biological Process cellular response to unfolded protein 63 4.491625e-35 9.38179259920635e-33 2.373707 263 0.01748438 390 0.0002601381453153846 1.406123 83 121 0.009061135 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 64 4.888342e-35 1.00508894340625e-32 2.47078 243 0.01615477 586 0.005891751377133105 1.373863 63 94 0.006877729 GO Biological Process response to unfolded protein 85 3.548839e-31 5.494020282470588e-29 2.072058 313 0.0208084 345 0.00010108759056811595 1.370864 107 160 0.01168122 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 87 5.700447e-31 8.622089893448276e-29 2.517941 206 0.01369499 435 0.0006627032728045977 1.389756 80 118 0.008733624 GO Biological Process cellular response to epidermal growth factor stimulus 111 6.846448e-29 8.116433264144145e-27 2.654738 174 0.01156761 642 0.010029722160280372 1.56439 29 38 0.003165939 GO Biological Process regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 116 5.654929e-28 6.414931957844828e-26 3.258021 122 0.008110624 491 0.0014974170148268839 1.719263 26 31 0.002838428 GO Biological Process response to epidermal growth factor 118 8.919939e-28 9.947243839067795e-26 2.544832 180 0.01196649 587 0.005903645241396934 1.561822 32 42 0.00349345 GO Biological Process platelet-derived growth factor receptor signaling pathway 134 3.84081e-25 3.771732745522388e-23 2.478688 170 0.01130169 794 0.024053276437027708 1.552948 25 33 0.002729258 GO Biological Process negative regulation of response to endoplasmic reticulum stress 137 4.704969e-24 4.519174238759124e-22 2.78355 132 0.008775429 671 0.01282456725081967 1.537418 30 40 0.003275109 GO Biological Process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 155 2.69309e-22 2.2863465361290323e-20 2.415687 157 0.01043744 598 0.006942114069063545 1.437983 47 67 0.005131004 GO Cellular Component PcG protein complex 45 3.534568e-20 1.357274112e-18 2.364586 147 0.009772637 110 0.007184904610909091 1.515137 34 46 0.00371179 GO Cellular Component mitochondrial ribosome 58 5.43258e-16 1.618534179310345e-14 2.372693 113 0.007512299 100 0.0037754208 1.398749 58 85 0.006331878 GO Cellular Component mitochondrial large ribosomal subunit 78 4.358244e-12 9.655186707692308e-11 2.54353 72 0.004786598 127 0.017759472377952754 1.446982 36 51 0.003930131 GO Cellular Component endopeptidase complex 89 4.418104e-11 8.578071586516855e-10 2.003633 109 0.007246377 153 0.048433773176470594 1.336885 45 69 0.004912664 GO Cellular Component very-low-density lipoprotein particle 96 1.147796e-10 2.0660328000000002e-9 2.929207 49 0.003257546 154 0.04842911875324675 1.639913 16 20 0.001746725 GO Cellular Component cytoplasmic stress granule 104 2.998664e-10 4.982395569230769e-9 2.023425 97 0.006448611 95 0.003009481162105263 1.573172 33 43 0.00360262 GO Cellular Component zonula adherens 217 0.00001731778 0.00013790379649769585 2.725403 24 0.001595533 146 0.03790223605479452 2.049891 8 8 0.0008733624 GO Molecular Function unfolded protein binding 14 4.625955e-22 1.3950558578571427e-19 2.315683 169 0.01123521 82 0.005814075009756097 1.37304 71 106 0.007751092 GO Molecular Function ribonucleoprotein complex binding 18 3.494258e-19 8.195976264444445e-17 2.029005 196 0.01303018 111 0.03919373886486486 1.301235 73 115 0.007969432 Human Phenotype Abnormality of the odontoid process 58 1.586581e-11 1.8253887953448276e-9 2.951606 53 0.003523468 201 0.009420705687064677 1.77036 19 22 0.002074236 Human Phenotype CNS hypomyelination 95 6.1913e-10 4.3488994631578945e-8 2.549384 57 0.00378939 174 0.003715524865977012 1.708242 25 30 0.002729258 Human Phenotype Dysphonia 174 3.779078e-8 0.0000014492981318390803 2.258626 57 0.00378939 236 0.02492265405 1.693388 19 23 0.002074236 Human Phenotype Abnormality of monocarboxylic acid metabolism 412 0.00002478466 0.0004014272722815534 2.141805 37 0.002459779 266 0.032461661439849625 1.892207 12 13 0.001310044 Mouse Phenotype Single KO absent segment of posterior cerebral artery 108 1.061514e-16 9.000262683333334e-15 3.125286 74 0.004919559 380 0.03638403824210526 1.677183 18 22 0.001965066 Mouse Phenotype Single KO increased incidence of corneal inflammation 281 4.733885e-10 1.5426400336298934e-8 2.676442 53 0.003523468 382 0.03686639362565445 1.793654 14 16 0.001528384 Mouse Phenotype Single KO abnormal adrenal medulla morphology 515 7.402955e-7 0.000013162885230097088 2.084851 55 0.003656429 297 0.014157354048821548 1.822125 16 18 0.001746725 Mouse Phenotype Single KO abnormal nucleotide metabolism 724 0.00002106659 0.00026644580749999995 2.470007 28 0.001861455 250 0.006628887823600001 2.049891 12 12 0.001310044 Mouse Phenotype extramedullary hematopoiesis 5 9.224296e-50 1.76386988112e-46 2.108891 487 0.03237601 532 0.011562606133082708 1.253362 107 175 0.01168122 Mouse Phenotype abnormal mesangial matrix morphology 51 3.895371e-27 7.302674927647058e-25 2.371585 201 0.01336258 610 0.02045801652295082 1.446982 36 51 0.003930131 Mouse Phenotype expanded mesangial matrix 56 1.468518e-26 2.5072322496428573e-24 2.380443 195 0.0129637 591 0.01748739255329949 1.464208 35 49 0.003820961 Mouse Phenotype abnormal hair follicle outer root sheath morphology 62 1.70327e-25 2.626607172580645e-23 2.826641 137 0.009107831 599 0.019516171777963272 1.610629 22 28 0.002401747 Mouse Phenotype abnormal sebaceous gland physiology 84 1.033006e-22 1.1757821864285713e-20 3.578196 86 0.005717325 500 0.008780487765 1.822125 16 18 0.001746725 Mouse Phenotype pancytopenia 113 8.253438e-20 6.983285019292036e-18 2.798897 106 0.007046935 704 0.03709814674431818 1.55509 22 29 0.002401747 Mouse Phenotype renal glomerulus hypertrophy 141 4.738308e-17 3.2129760842553188e-15 2.195299 143 0.009506715 717 0.039295603322175736 1.507273 25 34 0.002729258 Mouse Phenotype absent segment of posterior cerebral artery 149 1.061514e-16 6.811500237583893e-15 3.125286 74 0.004919559 626 0.023060582166134186 1.677183 18 22 0.001965066 Mouse Phenotype dry eyes 155 2.166495e-16 1.3363779803225806e-14 2.861264 83 0.005517883 628 0.02341447793789809 1.793654 14 16 0.001528384 Mouse Phenotype increased incidence of corneal inflammation 228 1.46042e-13 6.12415597368421e-12 2.787762 70 0.004653636 698 0.035129511098853865 1.659435 17 21 0.001855895 Mouse Phenotype increased skin papilloma incidence 251 1.490954e-12 5.679287328286852e-11 2.10937 111 0.007379338 450 0.005595337287333333 1.561822 32 42 0.00349345 Mouse Phenotype spleen atrophy 268 4.107231e-12 1.4652699847388063e-10 2.311583 87 0.005783805 739 0.04180722556562923 1.576839 20 26 0.002183406 Mouse Phenotype abnormal sublingual gland morphology 308 4.055359e-11 1.2588729675e-9 2.874256 53 0.003523468 687 0.03428898866812227 1.879067 11 12 0.001200873 Mouse Phenotype increased liver adenoma incidence 448 8.668215e-9 1.8499286521205357e-7 2.284963 61 0.004055312 176 0.00004467724922727273 1.90347 26 28 0.002838428 Mouse Phenotype decreased abdominal adipose tissue amount 457 1.467926e-8 3.0710810691466087e-7 2.387489 54 0.003589948 323 0.001424655009380805 1.803904 22 25 0.002401747 Mouse Phenotype increased incidence of tumors by UV-induction 524 7.260157e-8 0.0000013247015472709925 3.535681 26 0.001728494 609 0.020315021266009852 1.892207 12 13 0.001310044 Mouse Phenotype decreased embryonic epiblast cell proliferation 642 9.066262e-7 0.000013501951866355139 2.494729 37 0.002459779 733 0.041770848114597546 2.049891 8 8 0.0008733624 Mouse Phenotype abnormal nucleotide metabolism 786 0.000008056235 0.00009799702650763358 2.511526 30 0.001994416 320 0.0012850252903125 2.049891 14 14 0.001528384 Mouse Phenotype decreased mortality induced by ionizing radiation 1457 0.00200387 0.013149623246396708 2.260958 17 0.001130169 733 0.041770848114597546 2.049891 8 8 0.0008733624