# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	46	2.956177e-48	8.45659416152174e-46	2.555401	315	0.03914016	306	0.00012070428175490196	1.423053	117	248	0.01879518	
GO Biological Process	response to topologically incorrect protein	71	1.410344e-24	2.61390376e-22	2.262249	198	0.02460239	158	9.78778912721519e-8	1.659012	99	180	0.01590361	
GO Biological Process	cellular response to topologically incorrect protein	75	8.470133e-23	1.4861130686266666e-20	2.423265	159	0.01975646	172	5.776988439244185e-7	1.714349	79	139	0.01269076	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	78	3.960539e-22	6.681632397564103e-20	2.216126	185	0.02298708	207	0.000003227651598309179	1.634686	84	155	0.01349398	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	79	2.581443e-21	4.2998998021518986e-19	4.593748	60	0.007455268	576	0.004047598741666667	2.136606	17	24	0.002730924	
GO Biological Process	regulation of viral transcription	81	9.4908e-21	1.541844903703704e-18	3.011328	99	0.01230119	581	0.004112049341824441	1.670614	36	65	0.005783133	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	89	1.399133e-19	2.06867316258427e-17	2.470522	130	0.01615308	308	0.00012638873435389612	1.700728	53	94	0.008514056	
GO Biological Process	response to unfolded protein	92	2.353077e-19	3.3656674177173914e-17	2.14053	173	0.02149602	174	7.280329433390805e-7	1.659012	88	160	0.01413655	
GO Biological Process	endoplasmic reticulum unfolded protein response	95	4.536723e-19	6.284077679684211e-17	2.44339	129	0.01602883	203	0.0000030915696259605913	1.746328	66	114	0.01060241	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	109	2.340157e-17	2.8251491709174313e-15	7.887069	30	0.003727634	762	0.02259039377296588	2.467952	9	11	0.001445783	
GO Biological Process	cellular response to unfolded protein	114	4.197019e-17	4.8446116685087714e-15	2.260444	134	0.0166501	228	0.000008533576871052632	1.695159	68	121	0.01092369	
GO Biological Process	histone ubiquitination	116	6.99474e-17	7.934808936206896e-15	3.062694	77	0.009567594	603	0.005598728960199004	1.856237	24	39	0.003855422	
GO Biological Process	negative regulation of chromatin organization	128	3.527228e-16	3.6261557228125e-14	2.630399	94	0.01167992	779	0.024038587546854943	1.668639	26	47	0.004176707	
GO Biological Process	positive regulation of viral process	139	1.940316e-15	1.8368790103597122e-13	2.176037	130	0.01615308	250	0.0000330129096936	1.711219	59	104	0.009477912	
GO Biological Process	negative regulation of histone modification	143	4.199358e-15	3.864290344195804e-13	2.763577	80	0.009940358	785	0.02472507371464968	1.746328	22	38	0.003534137	
GO Biological Process	negative regulation of histone methylation	146	1.086103e-14	9.789061217123288e-13	3.351036	58	0.007206759	816	0.028529969845588237	2.129213	12	17	0.001927711	
GO Biological Process	regulation of DNA-templated transcription in response to stress	149	1.52663e-14	1.3482499442953023e-12	2.099814	132	0.01640159	668	0.011375636374550897	1.444823	57	119	0.009156627	
GO Biological Process	positive regulation of viral life cycle	151	3.912569e-14	3.409635461655629e-12	2.150151	121	0.01503479	301	0.00010299955873754153	1.692869	55	98	0.008835341	
GO Biological Process	erythrocyte homeostasis	152	4.300773e-14	3.723281046513158e-12	2.187589	116	0.01441352	372	0.00044648380879032265	1.723649	44	77	0.007068273	
GO Biological Process	histone monoubiquitination	162	1.520565e-13	1.2351305453703703e-11	3.217861	56	0.00695825	690	0.013781767792463769	1.939105	18	28	0.002891566	
GO Cellular Component	PcG protein complex	29	2.120801e-24	1.2637048717241379e-22	3.216912	107	0.01329523	44	0.000018500321454545456	2.098355	32	46	0.005140562	
GO Cellular Component	cytoplasmic stress granule	34	6.552898e-18	3.3304140423529414e-16	3.119054	80	0.009940358	65	0.001714473216	1.89401	27	43	0.004337349	
GO Cellular Component	histone methyltransferase complex	39	3.338224e-17	1.4790900184615387e-15	2.595734	103	0.01279821	64	0.00146180619	1.704914	39	69	0.00626506	
GO Cellular Component	methyltransferase complex	42	1.07077e-16	4.405453714285715e-15	2.426414	113	0.01404076	86	0.008745213097674419	1.524766	46	91	0.007389558	
GO Cellular Component	PML body	46	1.562436e-15	5.8693248e-14	2.16782	132	0.01640159	81	0.0062657664	1.523741	49	97	0.007871486	
GO Cellular Component	ficolin-1-rich granule lumen	47	2.904997e-15	1.0680499608510637e-13	2.194197	126	0.01565606	67	0.0018946761743283578	1.508193	62	124	0.009959839	
GO Cellular Component	histone acetyltransferase complex	55	4.267466e-12	1.340760226909091e-10	2.11764	105	0.01304672	45	0.0000521133696	1.794558	47	79	0.007550201	
GO Cellular Component	podosome	56	8.491511e-12	2.62023768e-10	2.748046	61	0.007579523	72	0.002046432	2.080266	20	29	0.003212851	
GO Cellular Component	protein acetyltransferase complex	57	1.670516e-11	5.064301136842105e-10	2.027915	110	0.01366799	55	0.0005247932858181818	1.660707	49	89	0.007871486	
GO Cellular Component	nuclear ubiquitin ligase complex	64	1.221352e-10	3.2976504e-9	3.04383	46	0.005715706	129	0.04788952409302326	1.659012	22	40	0.003534137	
GO Cellular Component	vesicle coat	65	3.296608e-10	8.763905575384617e-9	2.253333	75	0.009319085	85	0.00846741345882353	1.7152	29	51	0.004658635	
GO Cellular Component	MLL1 complex	80	3.293512e-8	7.113985920000001e-7	2.970413	35	0.004348907	100	0.02275483968	1.872239	18	29	0.002891566	
GO Cellular Component	SAGA-type complex	110	0.000001942727	0.00003051847505454545	2.704675	30	0.003727634	71	0.001960317674366197	2.171798	18	25	0.002891566	
GO Cellular Component	protein phosphatase type 2A complex	117	0.0000024481	0.000036156553846153846	2.173974	45	0.005591451	84	0.007724569371428572	2.154561	15	21	0.002409639	
GO Cellular Component	sex chromosome	122	0.000003516265	0.00004980414688524591	2.488728	33	0.004100398	58	0.0010760056386206896	2.204282	19	26	0.003052209	
GO Cellular Component	clathrin vesicle coat	138	0.00002129045	0.0002665934608695652	2.085398	40	0.004970179	107	0.024786625794392524	1.930487	16	25	0.002570281	
GO Cellular Component	platelet dense tubular network membrane	143	0.00002292802	0.00027706026965034966	3.102233	19	0.002360835	61	0.0013650616445901641	3.016386	9	9	0.001445783	
GO Cellular Component	platelet dense tubular network	146	0.000027196	0.0003218814246575342	2.95988	20	0.002485089	76	0.0027899333052631577	2.742169	10	11	0.001606426	
GO Cellular Component	sex chromatin	148	0.00003008268	0.00035123561513513514	4.382752	12	0.001491054	101	0.022677827168316834	3.016386	6	6	0.0009638554	
GO Cellular Component	STAGA complex	168	0.0001192221	0.001226284457142857	3.349379	14	0.001739563	87	0.010236260855172413	2.513655	10	12	0.001606426	
GO Molecular Function	chromatin DNA binding	27	4.757688e-15	7.439614346666666e-13	2.107341	136	0.01689861	69	0.00010206366820289855	1.682215	58	104	0.009317269	
GO Molecular Function	SUMO transferase activity	30	9.788577e-14	1.3775790698000001e-11	4.170794	41	0.005094433	90	0.0026252161444444448	2.381357	15	19	0.002409639	
GO Molecular Function	ankyrin binding	32	2.860153e-13	3.7736143643749997e-11	3.337336	52	0.006461233	150	0.04962153190666667	2.063843	13	19	0.002088353	
GO Molecular Function	histone methyltransferase activity	33	6.708669e-13	8.583030459999999e-11	2.206103	103	0.01279821	98	0.004089002691836734	1.738256	34	59	0.005461847	
GO Molecular Function	nucleosome binding	37	1.48339e-11	1.692668264864865e-9	2.300222	83	0.01031312	122	0.023035668042622956	1.599598	35	66	0.00562249	
GO Molecular Function	histone-lysine N-methyltransferase activity	45	6.324925e-10	5.9341851888888893e-8	2.155715	80	0.009940358	89	0.0026337737325842696	1.861174	29	47	0.004658635	
GO Molecular Function	ubiquitin-protein transferase regulator activity	54	6.822411e-9	5.334114674444445e-7	2.815006	42	0.005218688	111	0.012144039084684685	2.306648	13	17	0.002088353	
GO Molecular Function	MAP kinase activity	75	9.310873e-8	0.000005241400774133333	3.218903	29	0.00360338	121	0.02276879588595041	2.370017	11	14	0.001767068	
GO Molecular Function	protein serine/threonine kinase inhibitor activity	91	4.593349e-7	0.000021311120305494506	2.08514	57	0.007082505	135	0.03438490622222222	1.828112	20	33	0.003212851	
GO Molecular Function	cAMP response element binding	96	6.220217e-7	0.000027355996014583332	2.927487	29	0.00360338	144	0.04590879658333333	2.320297	10	13	0.001606426	
GO Molecular Function	disordered domain specific binding	143	0.00001682992	0.0004968945611188811	2.008481	45	0.005591451	136	0.037455317779411766	1.848752	19	31	0.003052209	
GO Molecular Function	S100 protein binding	195	0.00008589841	0.0018598107026666668	2.802785	19	0.002360835	144	0.04590879658333333	2.320297	10	13	0.001606426	
GO Molecular Function	calcium-dependent protein serine/threonine kinase activity	220	0.0002422864	0.004649696276363636	2.751697	17	0.002112326	137	0.04031378240875912	2.467952	9	11	0.001445783	
GO Molecular Function	lysine-acetylated histone binding	245	0.0003935145	0.006781298853061225	2.062939	28	0.003479125	115	0.013024352346086955	2.2226	14	19	0.002248996	
GO Molecular Function	histone methyltransferase activity (H3-K36 specific)	375	0.004089721	0.046044805498666665	2.299957	14	0.001739563	139	0.040260809755395685	3.016386	6	6	0.0009638554	
Human Phenotype	Laryngomalacia	1	2.746765e-18	1.8329162845e-14	4.957537	47	0.00583996	54	0.009500007799814815	2.585473	12	14	0.001927711	
Human Phenotype	Deep plantar creases	310	0.0005804621	0.012494914817096777	2.280531	21	0.002609344	65	0.014935036356923077	3.016386	8	8	0.001285141	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	23	3.947536e-16	1.571634224e-13	2.274159	124	0.01540755	73	2.4443808694520547e-7	2.219604	39	53	0.00626506	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	26	8.412953e-16	2.962977331576923e-13	2.895561	78	0.009691849	228	0.0007722459560526316	2.068379	24	35	0.003855422	
Mouse Phenotype Single KO	abnormal embryonic erythropoiesis	27	9.442398e-16	3.2023717957777775e-13	3.042787	72	0.008946322	279	0.0027985629964157707	2.080266	20	29	0.003212851	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	29	1.797405e-15	5.675461236206896e-13	2.747289	83	0.01031312	342	0.010588903116374268	1.659012	33	60	0.005301205	
Mouse Phenotype Single KO	extramedullary hematopoiesis	36	2.83551e-14	7.212434741666667e-12	2.020194	142	0.01764414	409	0.02465713673838631	1.428814	54	114	0.008674699	
Mouse Phenotype Single KO	abnormal lymph node secondary follicle morphology	112	8.088342e-9	6.612941758392856e-7	2.588198	48	0.005964215	434	0.03238328741935484	1.930487	16	25	0.002570281	
Mouse Phenotype Single KO	decreased fetal cardiomyocyte proliferation	300	0.00001199185	0.00036603123483333334	2.72061	25	0.003106362	256	0.001723660025703125	3.016386	9	9	0.001445783	
Mouse Phenotype Single KO	thin ventricle myocardium compact layer	410	0.00006646986	0.0014845475805365853	2.199174	31	0.003851889	421	0.028452930558194773	2.467952	9	11	0.001445783	
Mouse Phenotype Single KO	abnormal memory T cell physiology	579	0.0004852552	0.007674407368566494	2.262076	22	0.002733598	329	0.008886386992097263	2.306648	13	17	0.002088353	
Mouse Phenotype Single KO	enlarged inguinal lymph nodes	664	0.001069631	0.014750920281626506	2.402039	17	0.002112326	486	0.0470067812037037	2.639337	7	8	0.001124498	
Mouse Phenotype	abnormal cellular replicative senescence	27	2.326354e-21	8.237877997777777e-19	2.684195	123	0.0152833	282	0.00006195616151063829	1.759558	49	84	0.007871486	
Mouse Phenotype	early cellular replicative senescence	37	2.723799e-18	7.038443848378378e-16	2.639102	107	0.01329523	313	0.00016612460488178913	1.776775	43	73	0.006907631	
Mouse Phenotype	decreased fibroblast proliferation	44	1.078034e-17	2.3425188804545455e-15	2.083966	167	0.0207505	173	4.0642363033526014e-7	1.740222	75	130	0.01204819	
Mouse Phenotype	abnormal embryonic hematopoiesis	72	1.002957e-13	1.3318433162500002e-11	2.063204	129	0.01602883	199	0.0000025786146722110552	2.027407	41	61	0.006586345	
Mouse Phenotype	abnormal embryonic erythropoiesis	80	4.694588e-13	5.6106194835000003e-11	2.669069	72	0.008946322	542	0.006028007637453874	1.946055	20	31	0.003212851	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	86	1.465676e-12	1.629456771627907e-10	2.491669	78	0.009691849	514	0.004772259682879377	1.856237	24	39	0.003855422	
Mouse Phenotype	increased Leydig cell tumor incidence	94	5.223188e-12	5.312648985957447e-10	12.2149	15	0.001863817	686	0.018473886848396504	3.016386	6	6	0.0009638554	
Mouse Phenotype	decreased vascular endothelial cell number	110	8.405921e-11	7.3062736982727275e-9	3.339209	41	0.005094433	833	0.0374870741092437	2.413108	8	10	0.001285141	
Mouse Phenotype	hyperchromasia	146	3.024947e-9	1.98092590869863e-7	5.380421	20	0.002485089	686	0.018473886848396504	3.016386	6	6	0.0009638554	
Mouse Phenotype	abnormal thymus development	168	1.081424e-8	6.154461228571429e-7	2.173071	67	0.00832505	552	0.006227605847826087	1.976253	19	29	0.003052209	
Mouse Phenotype	increased T-helper 2 cell number	184	2.381343e-8	0.0000012373924142934783	4.004795	24	0.002982107	833	0.0374870741092437	2.413108	8	10	0.001285141	
Mouse Phenotype	decreased transitional stage T2 B cell number	205	6.680307e-8	0.0000031156300110731705	2.435426	47	0.00583996	626	0.01166946472571885	1.972252	17	26	0.002730924	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	208	7.13398e-8	0.000003279229941346154	2.332061	51	0.006336978	682	0.018460734884164224	1.872239	18	29	0.002891566	
Mouse Phenotype	decreased embryonic epiblast cell proliferation	212	8.668585e-8	0.000003909450055896226	3.402538	27	0.003354871	792	0.030117693238636365	2.639337	7	8	0.001124498	
Mouse Phenotype	abnormal transitional stage T1 B cell morphology	230	1.479927e-7	0.0000061519921943478264	2.367575	47	0.00583996	701	0.019471610717546363	1.899206	17	27	0.002730924	
Mouse Phenotype	increased insulinoma incidence	236	1.773245e-7	0.000007183896375	8.237787	11	0.001366799	875	0.043711373166857144	3.016386	5	5	0.0008032129	
Mouse Phenotype	abnormal keratinocyte apoptosis	241	2.284883e-7	0.000009064633345643154	3.010226	30	0.003727634	634	0.01233861225615142	2.056627	15	22	0.002409639	
Mouse Phenotype	decreased spongiotrophoblast size	247	2.70335e-7	0.000010464262894736842	2.864653	32	0.003976143	740	0.022777958436486487	2.063843	13	19	0.002088353	
Mouse Phenotype	increased cellular sensitivity to hydroxyurea	248	2.773904e-7	0.000010694071025806452	6.328453	13	0.001615308	686	0.018473886848396504	3.016386	6	6	0.0009638554	
Mouse Phenotype	increased keratinocyte apoptosis	255	3.448877e-7	0.000012931259998823529	3.56353	23	0.002857853	716	0.020908865438547485	2.320297	10	13	0.001606426