# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process platelet activation 107 6.028185e-19 7.413540786448599e-17 2.245448 151 0.03019396 354 0.036180421445480226 1.542642 46 141 0.01158398 GO Biological Process positive regulation of peptidase activity 133 3.892987e-17 3.85171548368421e-15 2.130589 152 0.03039392 355 0.036804844497746486 1.499291 52 164 0.01309494 GO Biological Process regulation of cellular response to insulin stimulus 148 2.709729e-16 2.409278642635135e-14 2.703729 90 0.0179964 328 0.02943526279085366 1.834953 26 67 0.006547469 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell differentiation 173 3.766541e-15 2.8649660704624273e-13 3.525402 56 0.01119776 252 0.013013582606349208 2.546133 14 26 0.00352556 GO Biological Process regulation of CD4-positive, alpha-beta T cell differentiation 174 4.591889e-15 3.4726820316666666e-13 2.994442 70 0.0139972 316 0.025537525551582282 2.127839 18 40 0.004532863 GO Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 276 2.803919e-12 1.336839497137681e-10 3.014362 55 0.0109978 167 0.003494763280179641 2.50334 18 34 0.004532863 GO Biological Process regulation of CD4-positive, alpha-beta T cell activation 298 7.492502e-12 3.308517913355705e-10 2.48699 73 0.01459708 362 0.03774913605801105 1.970222 20 48 0.005036515 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell activation 301 9.221013e-12 4.0312063145182726e-10 2.79395 59 0.01179764 209 0.006604917647368421 2.521884 16 30 0.004029212 GO Biological Process JAK-STAT cascade 311 1.318534e-11 5.578967493890675e-10 2.571766 67 0.01339732 329 0.030162955807902733 2.012141 20 47 0.005036515 GO Biological Process regulation of endoplasmic reticulum unfolded protein response 314 1.440314e-11 6.036016536942675e-10 3.476285 42 0.00839832 97 0.0008524514154226805 3.083825 15 23 0.003777386 GO Biological Process regulation of alpha-beta T cell activation 393 1.531824e-10 5.129076848854962e-9 2.098889 91 0.01819636 380 0.04208064666578947 1.742091 28 76 0.007051121 GO Biological Process regulation of alpha-beta T cell differentiation 453 7.061154e-10 2.051163918013245e-8 2.171032 78 0.01559688 289 0.019226532940830453 1.977386 23 55 0.005791992 GO Biological Process positive regulation of alpha-beta T cell differentiation 473 1.618534e-9 4.502809493868922e-8 2.351123 63 0.01259748 288 0.019171689782291668 2.182399 18 39 0.004532863 GO Biological Process cellular protein complex localization 727 2.208732e-7 0.000003997896064374141 2.889645 32 0.00639872 252 0.013013582606349208 2.546133 14 26 0.00352556 GO Biological Process regulation of T-helper cell differentiation 729 2.305601e-7 0.000004161783752949245 2.464645 42 0.00839832 261 0.014144972106896551 2.364266 16 32 0.004029212 GO Biological Process regulation of IRE1-mediated unfolded protein response 756 3.60825e-7 0.0000062805504960317464 3.821703 21 0.00419916 205 0.006315830228439025 3.546399 9 12 0.002266432 GO Biological Process negative regulation of smooth muscle cell proliferation 879 0.000001938712 0.0000290233347076223 2.093618 50 0.009998 351 0.03513978985099715 2.115396 17 38 0.004281038 GO Biological Process negative regulation of B cell activation 1065 0.00001431999 0.000176935914 2.12197 40 0.0079984 324 0.027518535371913577 2.287999 15 31 0.003777386 GO Biological Process PERK-mediated unfolded protein response 1090 0.00001819052 0.00021960463548623854 3.584553 16 0.00319936 344 0.03293752019127907 3.152355 8 12 0.002014606 GO Biological Process positive regulation of T-helper cell differentiation 1238 0.00005286876 0.0005619547761227787 2.337464 28 0.00559888 232 0.010078222860775862 2.837119 12 20 0.003021909 Mouse Phenotype Single KO abnormal T cell physiology 19 2.837824e-48 1.367681808842105e-45 2.078888 469 0.09378124 113 0.00519483254902655 1.332996 148 525 0.03727021 Mouse Phenotype Single KO abnormal granulocyte morphology 27 7.499442e-40 2.5434218664444445e-37 2.040579 405 0.0809838 180 0.021447632231666666 1.310069 128 462 0.03223369 Mouse Phenotype Single KO abnormal granulocyte number 30 2.16857e-38 6.619198496666668e-36 2.056844 383 0.07658468 252 0.04340450703571428 1.290586 119 436 0.02996726 Mouse Phenotype Single KO abnormal neutrophil cell number 33 2.635007e-36 7.311745181515152e-34 2.441635 253 0.05058988 255 0.043574931117647056 1.376214 78 268 0.01964241 Mouse Phenotype Single KO abnormal erythropoiesis 35 1.099943e-34 2.8777651574285715e-32 2.92012 178 0.03559288 24 0.000011476048404166666 2.106346 49 110 0.01233946 Mouse Phenotype Single KO decreased myeloid cell number 36 3.094741e-34 7.871817593611111e-32 2.100877 325 0.064987 172 0.017454945627906976 1.395304 90 305 0.02266432 Mouse Phenotype Single KO abnormal platelet activation 38 3.023835e-33 7.2866466039473685e-31 3.579987 128 0.02559488 217 0.035149275314285716 1.724523 31 85 0.007806598 Mouse Phenotype Single KO abnormal neutrophil morphology 39 1.834801e-32 4.308018655641026e-30 2.275601 259 0.05178964 254 0.04329548568897638 1.367897 81 280 0.02039788 Mouse Phenotype Single KO abnormal platelet aggregation 42 5.669121e-32 1.2360033570714286e-29 3.577125 123 0.02459508 220 0.035263715219090906 1.758044 29 78 0.007302946 Mouse Phenotype Single KO abnormal platelet physiology 49 3.476535e-30 6.496863468367347e-28 2.98374 149 0.02979404 141 0.011154154688652483 1.719466 40 110 0.01007303 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 58 1.025556e-27 1.61914074e-25 2.260246 223 0.04459108 221 0.03531317495972851 1.395007 77 261 0.01939058 Mouse Phenotype Single KO abnormal platelet morphology 59 2.258527e-27 3.5053104642372884e-25 2.112801 255 0.0509898 176 0.018699202732386365 1.422115 80 266 0.02014606 Mouse Phenotype Single KO abnormal blood coagulation 61 4.84133e-27 7.267550624590164e-25 2.196355 231 0.04619076 91 0.002828555036923077 1.561717 72 218 0.01813145 Mouse Phenotype Single KO abnormal hemostasis 64 7.917509e-27 1.132822342390625e-24 2.188005 231 0.04619076 100 0.0036091106776 1.54752 72 220 0.01813145 Mouse Phenotype Single KO abnormal self tolerance 83 2.424517e-24 2.674855683012048e-22 2.013075 253 0.05058988 258 0.04337351469767442 1.334781 94 333 0.02367162 Mouse Phenotype Single KO abnormal immune tolerance 85 3.57849e-24 3.855086227058823e-22 2.003913 254 0.05078984 266 0.0461297644924812 1.329025 95 338 0.02392344 Mouse Phenotype Single KO decreased circulating alanine transaminase level 94 1.426205e-22 1.3893360835106384e-20 2.90695 114 0.02279544 231 0.03798666095584415 1.765319 28 75 0.007051121 Mouse Phenotype Single KO abnormal body temperature 108 6.119451e-21 5.188501185833333e-19 2.584196 128 0.02559488 109 0.004947829533027522 1.807968 39 102 0.009821204 Mouse Phenotype Single KO increased body temperature 114 1.308469e-19 1.0510219853508773e-17 4.280951 59 0.01179764 128 0.0080829554390625 2.43591 17 33 0.004281038 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 115 1.779375e-19 1.4168466847826086e-17 2.216184 160 0.0319936 193 0.02402375483108808 1.51313 56 175 0.01410224 Mouse Phenotype abnormal erythropoiesis 29 7.217458e-39 2.379521239241379e-36 2.807367 213 0.04259148 20 0.000005763437727 1.967577 62 149 0.0156132 Mouse Phenotype decreased myeloid cell number 30 2.336826e-37 7.447464461999999e-35 2.03304 383 0.07658468 194 0.009603447882989691 1.359603 113 393 0.02845631 Mouse Phenotype abnormal platelet physiology 37 1.944732e-34 5.025292608648648e-32 2.994866 170 0.0339932 155 0.00546365318883871 1.683644 47 132 0.01183581 Mouse Phenotype abnormal neutrophil cell number 47 7.448527e-32 1.5152205669574468e-29 2.085844 307 0.06138772 223 0.01371983349013453 1.366318 102 353 0.02568623 Mouse Phenotype abnormal circulating cytokine level 52 3.396003e-31 6.244073977500001e-29 2.180778 272 0.05438912 272 0.027826548819485295 1.347 96 337 0.02417527 Mouse Phenotype abnormal circulating interleukin level 66 7.51268e-28 1.0883141436363636e-25 2.265761 223 0.04459108 341 0.04845259653079179 1.369266 75 259 0.01888693 Mouse Phenotype abnormal mean corpuscular hemoglobin 101 3.4117e-23 3.2296300693069307e-21 2.289824 180 0.0359928 158 0.005929807235696203 1.567611 61 184 0.01536137 Mouse Phenotype abnormal body temperature 116 7.163871e-21 5.904635399224138e-19 2.354579 152 0.03039392 155 0.00546365318883871 1.683644 47 132 0.01183581 Mouse Phenotype decreased erythroid progenitor cell number 122 5.410837e-20 4.24041086532787e-18 2.630652 118 0.02359528 198 0.010116151256060607 1.866526 30 76 0.007554772 Mouse Phenotype extramedullary hematopoiesis 144 3.885954e-18 2.58011154125e-16 2.123056 163 0.03259348 279 0.03129238880537634 1.48611 55 175 0.01385042 Mouse Phenotype increased body temperature 146 4.466632e-18 2.9250320926027397e-16 3.797625 62 0.01239752 143 0.004901518858951049 2.431816 18 35 0.004532863 Mouse Phenotype decreased mean corpuscular hemoglobin 152 1.433689e-17 9.018092453289474e-16 2.78633 93 0.01859628 162 0.0063542406 1.903695 31 77 0.007806598 Mouse Phenotype abnormal erythroid progenitor cell morphology 162 3.983346e-17 2.3509117966666665e-15 2.168297 146 0.02919416 292 0.03487508996917809 1.589422 40 119 0.01007303 Mouse Phenotype abnormal spleen red pulp morphology 167 8.867059e-17 5.076524017904192e-15 2.10345 153 0.03059388 232 0.014812684212931033 1.565942 51 154 0.01284311 Mouse Phenotype decreased insulin secretion 173 1.560064e-16 8.621833470520232e-15 2.014719 167 0.03339332 254 0.020779546152755908 1.58794 45 134 0.01133216 Mouse Phenotype decreased circulating leptin level 175 2.128213e-16 1.1627339710285712e-14 2.229319 131 0.02619476 75 0.0006090351900800001 1.883044 45 113 0.01133216 Mouse Phenotype increased bleeding time 219 2.241896e-14 9.787565139726026e-13 2.332387 103 0.02059588 222 0.013753985163513513 1.742091 35 95 0.008813901 Mouse Phenotype abnormal iron level 230 6.985438e-14 2.9038162051304345e-12 2.24739 107 0.02139572 307 0.039417511534201956 1.541151 44 135 0.01108033 Mouse Phenotype abnormal lipolysis 232 7.700251e-14 3.1733663711637934e-12 3.452569 52 0.01039792 261 0.023582356691954024 2.172569 17 37 0.004281038 Mouse Phenotype abnormal iron homeostasis 242 1.366024e-13 5.396923745454545e-12 2.185683 111 0.02219556 276 0.028463353345652177 1.55366 46 140 0.01158398