# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	16	2.685319e-53	2.2085070450625e-50	2.215017	467	0.03392663	445	0.0008011704860449439	1.273577	149	248	0.01682095	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	35	1.169382e-41	4.396542210857142e-39	5.013554	112	0.008136578	738	0.02478362137262873	1.678158	19	24	0.002144954	
GO Biological Process	response to topologically incorrect protein	58	3.309819e-35	7.509294520862069e-33	2.157692	323	0.02346531	215	0.000001020343963627907	1.436739	122	180	0.01377286	
GO Biological Process	cellular response to topologically incorrect protein	68	9.261021e-33	1.792143754985294e-30	2.307891	259	0.01881584	217	0.0000011846847586175116	1.49452	98	139	0.01106345	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	73	5.006408e-32	9.024564776986301e-30	2.419769	230	0.01670904	589	0.006331822597792869	1.350655	72	113	0.008128246	
GO Biological Process	endoplasmic reticulum unfolded protein response	74	6.999668e-32	1.2447112325945945e-29	2.458486	222	0.01612786	283	0.000024398729626148408	1.487564	80	114	0.009031384	
GO Biological Process	response to unfolded protein	76	1.627473e-31	2.8178838430263155e-29	2.134071	295	0.02143117	255	0.000007779796894901961	1.430851	108	160	0.01219237	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	78	2.872356e-31	4.845811872307692e-29	2.108148	301	0.02186705	278	0.000018972002450359713	1.422303	104	155	0.0117408	
GO Biological Process	cellular response to unfolded protein	85	2.228476e-29	3.4499430216470586e-27	2.298035	233	0.01692699	261	0.000010948751842145594	1.489101	85	121	0.009595846	
GO Biological Process	regulation of DNA-templated transcription in response to stress	90	7.437346e-29	1.0874226223777778e-26	2.241484	241	0.01750817	500	0.00220930214474	1.371622	77	119	0.008692707	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	93	2.735112e-28	3.870036430967742e-26	2.511109	188	0.01365783	392	0.0003657654827295918	1.419174	79	118	0.008918492	
GO Biological Process	viral gene expression	104	6.877956e-27	8.702598365769231e-25	2.383099	197	0.01431166	443	0.000780877932302483	1.385367	83	127	0.009370061	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	114	1.370777e-25	1.5822854862280702e-23	2.277776	205	0.01489284	452	0.0009542158600221238	1.443254	64	94	0.007225107	
GO Biological Process	Fc-gamma receptor signaling pathway involved in phagocytosis	115	5.24152e-25	5.997666233043478e-23	2.256743	204	0.0148202	432	0.0006516239325925926	1.522658	51	71	0.005757507	
GO Biological Process	multi-organism metabolic process	116	6.834871e-25	7.75345409387931e-23	2.12937	231	0.01678169	447	0.0008668737061297539	1.355505	94	147	0.01061188	
GO Biological Process	Fc-gamma receptor signaling pathway	117	7.401783e-25	8.324791666410256e-23	2.244866	205	0.01489284	501	0.0022072594040918165	1.469713	52	75	0.0058704	
GO Biological Process	Fc receptor mediated stimulatory signaling pathway	118	1.151794e-24	1.284445529322034e-22	2.221356	208	0.01511079	442	0.0007753312571493212	1.509979	52	73	0.0058704	
GO Biological Process	viral transcription	127	1.410234e-22	1.4612022996850393e-20	2.297635	176	0.01278605	361	0.00018727039479501386	1.444451	77	113	0.008692707	
GO Biological Process	cotranslational protein targeting to membrane	143	2.7009e-21	2.485394622377623e-19	2.409968	150	0.0108972	370	0.0002447170338783784	1.470867	68	98	0.007676676	
GO Biological Process	positive regulation of mRNA metabolic process	162	1.871297e-19	1.5200245199382715e-17	2.418573	135	0.009807483	530	0.003272891583018868	1.549069	38	52	0.004289907	
GO Cellular Component	PcG protein complex	41	3.83376e-21	1.6157895804878049e-19	2.478485	141	0.01024337	120	0.00913328496	1.520711	33	46	0.003725446	
GO Cellular Component	nuclear ubiquitin ligase complex	52	3.175287e-16	1.0551722953846155e-14	2.978963	77	0.005593898	128	0.013812848999999999	1.53684	29	40	0.003273877	
GO Cellular Component	cytoplasmic stress granule	53	5.391482e-16	1.7578265841509434e-14	2.439094	107	0.007773338	140	0.028103809371428572	1.478915	30	43	0.003386769	
GO Cellular Component	COPI-coated vesicle	61	1.414909e-14	4.008135659016394e-13	3.292075	59	0.004286233	141	0.028983486638297876	1.658957	18	23	0.002032061	
GO Cellular Component	vesicle coat	72	4.260905e-13	1.0226172e-11	2.090368	119	0.008645114	88	0.0012777961090909091	1.579443	38	51	0.004289907	
GO Cellular Component	COPI vesicle coat	101	9.067874e-11	1.5514144823762374e-9	3.169872	44	0.003196513	127	0.012089874444094489	1.956719	12	13	0.001354708	
GO Cellular Component	DNA polymerase complex	131	6.489859e-9	8.560668970992366e-8	3.061109	37	0.002687977	107	0.004579821757009345	1.884248	16	18	0.001806277	
GO Cellular Component	platelet dense tubular network	179	0.000001580973	0.000015262130413407823	2.682363	31	0.002252089	155	0.038147796232258065	1.927072	10	11	0.001128923	
GO Cellular Component	platelet dense tubular network membrane	182	0.00000184711	0.000017537396043956045	2.768411	29	0.002106793	130	0.015348029538461538	2.119779	9	9	0.001016031	
GO Cellular Component	zonula adherens	267	0.0001030711	0.0006670668943820224	2.605963	21	0.001525608	142	0.02979927481690141	2.119779	8	8	0.0009031384	
GO Molecular Function	SUMO transferase activity	20	1.351949e-18	2.853964339e-16	3.806507	64	0.004649473	138	0.03071272484057971	1.785077	16	19	0.001806277	
GO Molecular Function	peptidyl-prolyl cis-trans isomerase activity	70	6.389331e-11	3.853679354571428e-9	2.103899	95	0.006901562	119	0.014540905050420168	1.564599	31	42	0.003499661	
GO Molecular Function	cis-trans isomerase activity	87	3.038522e-10	1.4745563085057473e-8	2.03953	95	0.006901562	148	0.042767462175675675	1.49348	31	44	0.003499661	
GO Molecular Function	cAMP response element binding	337	0.0001701706	0.0021319295940652816	2.006724	34	0.002470033	134	0.027995949668656716	1.956719	12	13	0.001354708	
Human Phenotype	Nevus	108	1.673392e-9	1.0339393348148148e-7	2.210104	72	0.005230657	97	0.018414865835051544	1.727227	22	27	0.002483631	
Human Phenotype	Basal cell carcinoma	226	4.596451e-7	0.000013571733417256637	2.296851	46	0.003341809	80	0.013601158837500002	1.830718	19	22	0.002144954	
Human Phenotype	Aplasia of the uterus	377	0.00003092422	0.0005473668967108753	2.229332	33	0.002397385	166	0.0464157398493976	2.119779	9	9	0.001016031	
Mouse Phenotype Single KO	decreased circulating total protein level	10	9.628764e-32	8.817059194800001e-29	2.767036	179	0.013004	350	0.01687364576057143	1.461916	40	58	0.004515692	
Mouse Phenotype Single KO	extramedullary hematopoiesis	34	8.574051e-25	2.3091936766764703e-22	2.062852	248	0.01801671	290	0.006501277387241379	1.357402	73	114	0.008241138	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	39	1.817321e-23	4.2669765120512816e-21	2.187465	204	0.0148202	216	0.001061417545462963	1.599833	40	53	0.004515692	
Mouse Phenotype Single KO	abnormal chromosome number	78	1.08528e-15	1.2740908923076922e-13	2.077942	148	0.01075191	285	0.005636962449473684	1.477422	46	66	0.005193046	
Mouse Phenotype Single KO	increased integument system tumor incidence	100	4.811585e-14	4.4059683845e-12	2.032248	138	0.01002543	194	0.00033479299468556703	1.53405	55	76	0.006209077	
Mouse Phenotype Single KO	abnormal vascular branching morphogenesis	106	1.29713e-13	1.1205490009433961e-11	2.078946	126	0.009153651	317	0.011732474133123028	1.681204	23	29	0.002596523	
Mouse Phenotype Single KO	increased skin tumor incidence	119	8.354721e-13	6.428922705630252e-11	2.332418	91	0.00661097	334	0.014131167390119761	1.541657	32	44	0.003612554	
Mouse Phenotype Single KO	increased hemangiosarcoma incidence	218	1.622265e-9	6.814257158256881e-8	2.356293	63	0.004576825	412	0.0308925841723301	1.678158	19	24	0.002144954	
Mouse Phenotype Single KO	myelofibrosis	253	9.61098e-9	3.478566950988142e-7	3.333357	32	0.002324737	488	0.04594980723565574	2.119779	8	8	0.0009031384	
Mouse Phenotype Single KO	increased circulating interferon-gamma level	256	1.193808e-8	4.27019525625e-7	2.090703	73	0.005303305	369	0.020003650136314364	1.528213	31	43	0.003499661	
Mouse Phenotype Single KO	abnormal white fat cell number	282	4.732644e-8	0.0000015367667059574467	2.190995	60	0.004358881	445	0.03727740620898876	1.766482	15	18	0.001693385	
Mouse Phenotype Single KO	decreased white fat cell number	350	3.600983e-7	0.000009421200380285713	2.636903	36	0.002615329	440	0.036399324736363634	1.943131	11	12	0.001241815	
Mouse Phenotype Single KO	multiple persisting craniopharyngeal ducts	415	0.000002187475	0.00004826676765060241	2.1435	47	0.003414457	453	0.038396918130242826	1.837142	13	15	0.0014676	
Mouse Phenotype	decreased circulating total protein level	25	1.126794e-31	4.3093109736e-29	2.754066	180	0.01307664	517	0.007979002172727272	1.473067	41	59	0.004628584	
Mouse Phenotype	abnormal embryonic erythropoiesis	32	6.827683e-29	2.03998366134375e-26	3.03436	140	0.01017072	706	0.027969933577903682	1.572739	23	31	0.002596523	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	37	2.169841e-27	5.606986432702703e-25	2.801552	150	0.0108972	849	0.04998585396466431	1.467539	27	39	0.003048092	
Mouse Phenotype	abnormal embryonic hematopoiesis	63	2.116175e-21	3.2115474880952383e-19	2.038547	218	0.01583727	307	0.00020032403402931595	1.598522	46	61	0.005193046	
Mouse Phenotype	decreased transitional stage T1 B cell number	93	2.089496e-17	2.1481366941935483e-15	3.781078	60	0.004358881	387	0.001396014703875969	1.995086	16	17	0.001806277	
Mouse Phenotype	early cellular replicative senescence	98	2.834793e-16	2.7656587625510204e-14	2.119832	147	0.01067926	355	0.000701393344056338	1.509979	52	73	0.0058704	
Mouse Phenotype	abnormal cellular replicative senescence	99	7.14274e-16	6.898155266666668e-14	2.0287	159	0.01155104	369	0.0010441210534146341	1.463657	58	84	0.006547753	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	101	2.134241e-15	2.0203443763366337e-13	2.539832	95	0.006901562	508	0.007644256642913385	1.681204	23	29	0.002596523	
Mouse Phenotype	pancytopenia	103	3.282178e-15	3.0466896949514566e-13	2.596886	90	0.006538322	663	0.022877641556561086	1.608108	22	29	0.002483631	
Mouse Phenotype	absent spleen germinal center	129	1.193396e-13	8.845007097674418e-12	2.961351	64	0.004649473	426	0.002696125691549296	1.683354	27	34	0.003048092	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	135	3.638236e-13	2.576679584888889e-11	2.804443	67	0.004867417	465	0.004870147225806452	1.695823	24	30	0.002709415	
Mouse Phenotype	increased fibroblast apoptosis	152	1.318689e-12	8.294727321710525e-11	2.20256	101	0.00733745	583	0.012561874826758149	1.50151	34	48	0.003838338	
Mouse Phenotype	increased hemangioma incidence	176	1.495911e-11	8.126366517613636e-10	2.421113	75	0.005448602	706	0.027969933577903682	1.572739	23	31	0.002596523	
Mouse Phenotype	increased circulating interferon-gamma level	197	6.844901e-11	3.322035454873097e-9	2.182675	87	0.006320378	619	0.016468351400646203	1.467539	36	52	0.004064123	
Mouse Phenotype	abnormal transitional stage T1 B cell morphology	222	3.526577e-10	1.5188109322972973e-8	2.238366	76	0.00552125	472	0.0054222618686440675	1.727227	22	27	0.002483631	
Mouse Phenotype	abnormal thymus cell ratio	243	6.659916e-10	2.6203891718518517e-8	2.100145	85	0.006175082	753	0.03289507125099602	1.589834	21	28	0.002370738	
Mouse Phenotype	decreased transitional stage T2 B cell number	291	6.257991e-9	2.056104878041237e-7	2.151034	71	0.005158009	697	0.0267436944964132	1.630599	20	26	0.002257846	
Mouse Phenotype	abnormal extensor digitorum longus morphology	323	1.900435e-8	5.625405273993808e-7	3.10136	34	0.002470033	676	0.024737135698224853	1.943131	11	12	0.001241815	
Mouse Phenotype	ectopic cortical neuron	398	1.342094e-7	0.0000032240604859296486	2.903087	33	0.002397385	632	0.01746781084651899	2.119779	9	9	0.001016031	
Mouse Phenotype	myelofibrosis	402	1.519076e-7	0.0000036129068746268657	2.886863	33	0.002397385	632	0.01746781084651899	2.119779	9	9	0.001016031