# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of mRNA stability	46	1.157775e-24	3.3119915706521736e-22	2.0295	256	0.02278594	279	0.001457979939749104	1.377305	91	151	0.01107595	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	64	2.011628e-22	4.136095758125e-20	2.281511	177	0.01575434	609	0.04713017932676519	1.314621	65	113	0.007911392	
GO Biological Process	protein targeting to ER	97	5.865281e-19	7.956828111237113e-17	2.428845	130	0.01157098	602	0.04565539094684386	1.335047	59	101	0.00718111	
GO Biological Process	regulation of DNA-templated transcription in response to stress	99	7.115663e-19	9.45808175929293e-17	2.073926	182	0.01619938	542	0.02950174964206642	1.325159	69	119	0.008398247	
GO Biological Process	regulation of cholesterol metabolic process	148	1.63469e-15	1.4534382236486485e-13	2.49421	99	0.008811749	286	0.0016111106623776226	1.638602	38	53	0.004625122	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	158	8.074007e-15	6.724421399556962e-13	2.220991	119	0.0105919	538	0.0283751821802974	1.406412	48	78	0.005842259	
GO Biological Process	regulation of cholesterol biosynthetic process	165	1.370121e-14	1.0926922569090908e-12	2.577275	87	0.007743658	312	0.0031712848372115387	1.686857	31	42	0.003773126	
GO Biological Process	regulation of cellular amino acid metabolic process	178	9.550033e-14	7.0600496767977525e-12	2.658177	77	0.006853583	585	0.03919526243589744	1.447432	38	60	0.004625122	
GO Biological Process	negative regulation of cyclin-dependent protein kinase activity	248	1.233533e-10	6.545185785080645e-9	2.566076	61	0.005429462	466	0.017128417997639485	1.758014	20	26	0.002434275	
GO Biological Process	negative regulation of Notch signaling pathway	307	2.654143e-9	1.1376504148859935e-7	2.212041	70	0.00623053	365	0.006819289426849315	1.731378	25	33	0.003042843	
GO Biological Process	modification by symbiont of host morphology or physiology	312	3.073973e-9	1.2964875226602562e-7	2.048591	83	0.007387628	307	0.002882286922899023	1.653282	34	47	0.004138267	
GO Biological Process	intracellular protein transmembrane transport	347	7.38834e-9	2.801820347550432e-7	2.047381	79	0.007031598	470	0.017380933560000002	1.510009	37	56	0.004503408	
GO Biological Process	positive regulation of viral transcription	374	1.612299e-8	5.672792123262032e-7	2.210837	63	0.005607477	618	0.04879900168446602	1.523612	28	42	0.003407984	
GO Biological Process	gene silencing by miRNA	384	2.01731e-8	6.912964138020834e-7	2.06201	73	0.006497552	277	0.0011982704163537904	1.714064	33	44	0.004016553	
GO Biological Process	multivesicular body organization	569	0.000001560161	0.00003608112231810194	2.286348	42	0.003738318	351	0.005317368198860399	1.769356	24	31	0.00292113	
GO Biological Process	negative regulation of cyclin-dependent protein serine/threonine kinase activity	590	0.000002082103	0.00004643795487627118	2.167557	46	0.004094348	592	0.04235184139527027	1.714064	18	24	0.002190847	
GO Biological Process	multivesicular body assembly	591	0.000002083789	0.00004639691954483926	2.285143	41	0.00364931	387	0.008632409408010336	1.752154	23	30	0.002799416	
GO Biological Process	multi-organism membrane organization	792	0.00003008947	0.0004999335047095959	2.032411	41	0.00364931	599	0.044044886525876466	1.62191	22	31	0.002677702	
GO Biological Process	regulation of apoptotic cell clearance	1444	0.001861393	0.016962652691828256	2.277219	17	0.001513129	583	0.03836216410291595	2.077653	10	11	0.001217137	
GO Biological Process	regulation of aerobic respiration	1778	0.006008248	0.04446711779077615	2.071401	16	0.001424121	556	0.03173870331294964	2.285419	8	8	0.0009737098	
GO Cellular Component	PcG protein complex	32	7.098659e-25	3.83327586e-23	2.842786	132	0.011749	56	0.0009903587657142858	1.689223	34	46	0.004138267	
GO Cellular Component	ribosomal subunit	33	2.087813e-20	1.0932548072727272e-18	2.057405	202	0.01797953	118	0.043478998779661014	1.235361	100	185	0.01217137	
GO Cellular Component	methyltransferase complex	35	7.485294e-18	3.695596580571428e-16	2.230331	145	0.0129061	107	0.031552327177570096	1.356183	54	91	0.006572541	
GO Cellular Component	endopeptidase complex	36	1.622842e-16	7.7896416e-15	2.534904	103	0.009167779	58	0.0011089162924137932	1.556734	47	69	0.005720545	
GO Cellular Component	proteasome core complex	37	2.704012e-16	1.2628466854054053e-14	5.00771	41	0.00364931	103	0.03196521506796116	1.714064	18	24	0.002190847	
GO Cellular Component	peptidase complex	38	5.769097e-16	2.6234209515789472e-14	2.256208	125	0.01112595	61	0.0015739377521311474	1.480328	57	88	0.006937683	
GO Cellular Component	proteasome complex	42	1.02101e-15	4.200726857142857e-14	2.487087	101	0.008989764	62	0.001635462255483871	1.546019	46	68	0.005598832	
GO Cellular Component	mitochondrial ribosome	43	2.016078e-15	8.101820427906978e-14	2.586327	92	0.008188696	126	0.04969193142857142	1.344364	50	85	0.006085686	
GO Cellular Component	proteasome core complex, beta-subunit complex	60	1.474101e-11	4.2454108799999997e-10	6.517701	22	0.001958166	99	0.029665885090909092	2.077653	10	11	0.001217137	
GO Cellular Component	septin cytoskeleton	61	1.68467e-11	4.772311081967213e-10	4.345488	32	0.002848242	119	0.0445257971092437	2.285419	7	7	0.0008519961	
GO Cellular Component	cytoplasmic stress granule	62	2.5004e-11	6.968856774193547e-10	2.290138	82	0.00729862	95	0.02656256134736842	1.541329	29	43	0.003529698	
GO Cellular Component	ESCRT complex	90	2.165699e-8	4.15814208e-7	2.738407	41	0.00364931	83	0.016477941513253012	1.714064	21	28	0.002555988	
GO Cellular Component	I-kappaB/NF-kappaB complex	188	0.00005673059	0.0005214386144680851	3.253853	16	0.001424121	119	0.0445257971092437	2.285419	7	7	0.0008519961	
GO Cellular Component	CD40 receptor complex	212	0.0001781387	0.0014519984603773583	2.938916	16	0.001424121	99	0.029665885090909092	2.077653	10	11	0.001217137	
GO Cellular Component	ESCRT I complex	228	0.0003130025	0.0023722294736842103	2.690242	17	0.001513129	124	0.049561952516129035	2.056877	9	10	0.001095424	
GO Molecular Function	mRNA 3'-UTR binding	12	5.256499e-20	1.8494115648333333e-17	2.207265	168	0.01495327	81	0.0074552076	1.523612	44	66	0.005355404	
GO Molecular Function	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	243	0.0001046122	0.0018175831621399178	2.853789	18	0.001602136	102	0.03337472373529411	2.094967	11	12	0.001338851	
Human Phenotype	Increased serum lactate	13	7.780758e-14	3.993922933384616e-11	2.093794	126	0.01121495	61	0.008755448579672132	1.439814	63	100	0.007667965	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	15	1.094223e-20	6.679866674e-18	2.154075	184	0.01637739	261	0.03517894860536398	1.376166	56	93	0.006815969	
Mouse Phenotype Single KO	abnormal transitional stage T2 B cell morphology	19	1.117883e-19	5.3876077005263157e-17	4.179277	61	0.005429462	204	0.017726910615686275	1.999741	14	16	0.001703992	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning, complete penetrance	38	1.088768e-14	2.623644362105263e-12	2.004767	150	0.01335113	65	0.00015393170578461535	1.636854	53	74	0.006450828	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	72	4.991907e-11	6.348735055416667e-9	2.269587	81	0.007209613	180	0.01212013906611111	1.828335	20	25	0.002434275	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	170	9.762437e-8	0.000005258507976999999	2.487959	44	0.003916333	186	0.014646296574193548	1.869888	18	22	0.002190847	
Mouse Phenotype Single KO	absent hypoglossal canal	190	2.098281e-7	0.000010112610061578947	4.324992	19	0.001691144	286	0.04293666072027972	2.285419	8	8	0.0009737098	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	261	0.000004526687	0.00015881560482375478	2.102016	46	0.004094348	212	0.019025412513207548	1.80929	19	24	0.002312561	
Mouse Phenotype Single KO	abnormal stapedial artery morphology	313	0.00001655093	0.00048420723964856223	2.270308	34	0.003026257	284	0.042901576774647884	1.88211	14	17	0.001703992	
Mouse Phenotype Single KO	abnormal gastrulation movements	713	0.002386814	0.030653654695652174	2.286857	16	0.001424121	286	0.04293666072027972	2.285419	8	8	0.0009737098	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	13	1.525774e-25	1.1221480933846153e-22	3.406575	104	0.009256787	187	0.0009618289307486631	1.891381	24	29	0.00292113	
Mouse Phenotype	decreased circulating free fatty acid level	21	2.490996e-22	1.134114893142857e-19	2.023177	232	0.02064976	271	0.0059154612608856095	1.382774	72	119	0.008763389	
Mouse Phenotype	decreased transitional stage T2 B cell number	42	1.064804e-17	2.4239502485714283e-15	3.043728	82	0.00729862	248	0.004925071572580645	1.845915	21	26	0.002555988	
Mouse Phenotype	abnormal transitional stage T1 B cell morphology	77	2.293456e-13	2.8477575085714285e-11	2.670253	74	0.00658656	455	0.02892784565274725	1.692903	20	27	0.002434275	
Mouse Phenotype	decreased transitional stage T1 B cell number	94	2.985162e-12	3.0362908385106383e-10	3.474402	45	0.00400534	448	0.028396426098214283	1.88211	14	17	0.001703992	
Mouse Phenotype	abnormal vitelline vein morphology	118	4.991907e-11	4.044713798898305e-9	2.269587	81	0.007209613	290	0.007854747236896551	1.828335	20	25	0.002434275	
Mouse Phenotype	abnormal sublingual gland morphology	181	6.759418e-9	3.570541187734807e-7	2.904304	40	0.003560303	406	0.01898789873275862	2.094967	11	12	0.001338851	
Mouse Phenotype	absent segment of posterior cerebral artery	234	9.762437e-8	0.000003988831630641025	2.487959	44	0.003916333	307	0.009265150893811075	1.869888	18	22	0.002190847	
Mouse Phenotype	absent hypoglossal canal	254	2.098281e-7	0.000007898293165748032	4.324992	19	0.001691144	451	0.028429410904656317	2.285419	8	8	0.0009737098	
Mouse Phenotype	abnormal stapedial artery morphology	267	3.556015e-7	0.000012733730117977529	2.318468	46	0.004094348	276	0.0062871542499999995	1.942606	17	20	0.002069133	
Mouse Phenotype	absent stapedial artery	274	4.916913e-7	0.000017157155179927006	2.314939	45	0.00400534	323	0.01052803150866873	1.924563	16	19	0.00194742	
Mouse Phenotype	abnormal cerebral artery morphology	361	0.000004526687	0.00011988823935457063	2.102016	46	0.004094348	346	0.012171495648554914	1.80929	19	24	0.002312561