# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of DNA-templated transcription in response to stress	21	4.888069e-23	3.062957141476191e-20	2.964514	113	0.02315574	308	0.04202054497954545	1.555828	43	119	0.009860124	
GO Biological Process	rRNA processing	25	1.00249e-21	5.276706364e-19	2.406069	152	0.03114754	63	0.0000015260922578412698	1.691511	99	252	0.02270122	
GO Biological Process	rRNA metabolic process	31	2.996614e-21	1.2720143105161291e-18	2.361399	154	0.03155738	69	0.000003355083481449275	1.662418	100	259	0.02293052	
GO Biological Process	response to endoplasmic reticulum stress	35	4.209467e-20	1.5826393215142857e-17	2.133454	180	0.03688525	310	0.04428640225806452	1.376401	78	244	0.01788581	
GO Biological Process	protein targeting to ER	46	9.507233e-19	2.7196886749347826e-16	3.312077	77	0.01577869	72	0.000004242377528611111	2.088886	49	101	0.01123596	
GO Biological Process	mitochondrial transport	47	1.070084e-18	2.996007522553191e-16	2.159502	162	0.03319672	62	0.0000015501616118064518	1.711456	95	239	0.02178399	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	55	1.171226e-17	2.8022114425454545e-15	3.053874	81	0.01659836	57	8.141948870877192e-7	2.132329	52	105	0.01192387	
GO Biological Process	ribosome biogenesis	56	1.42624e-17	3.351409314285714e-15	2.011814	179	0.03668033	55	5.675507803090909e-7	1.626288	122	323	0.02797524	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	59	3.906107e-17	8.711942714067796e-15	3.338814	69	0.01413934	70	0.0000035679124614285715	2.152832	46	92	0.01054804	
GO Biological Process	cotranslational protein targeting to membrane	64	2.8691e-16	5.899138578125001e-14	3.172301	70	0.01434426	71	0.000004059458830985916	2.108897	48	98	0.01100665	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	65	3.504778e-16	7.095288261846154e-14	2.938723	78	0.01598361	178	0.0029633166091011234	1.714968	47	118	0.01077734	
GO Biological Process	protein localization to endoplasmic reticulum	67	5.188834e-16	1.0191024866567165e-13	2.726772	87	0.01782787	79	0.000009641924110759494	1.944493	56	124	0.01284109	
GO Biological Process	protein-lipid complex assembly	68	8.52256e-16	1.6492406917647057e-13	4.827309	41	0.008401639	230	0.011398222816521739	2.375539	16	29	0.003668883	
GO Biological Process	viral gene expression	70	2.540645e-15	4.776049650714286e-13	2.763868	81	0.01659836	92	0.000022510200194565216	1.89856	56	127	0.01284109	
GO Biological Process	translational initiation	71	3.036072e-15	5.62699597859155e-13	2.544371	93	0.01905738	94	0.000026772503460638295	1.836682	61	143	0.01398762	
GO Biological Process	protein-lipid complex subunit organization	79	2.409517e-14	4.013523316835444e-12	3.458928	54	0.01106557	254	0.016802670112204723	2.015417	22	47	0.005044715	
GO Biological Process	intrinsic apoptotic signaling pathway	80	3.047343e-14	5.012498317125001e-12	2.012361	142	0.02909836	210	0.005982280664857143	1.583373	57	155	0.0130704	
GO Biological Process	plasma lipoprotein particle assembly	83	3.654476e-14	5.793885504096386e-12	5.008358	35	0.007172131	285	0.03208853085192982	2.318434	14	26	0.003210273	
GO Biological Process	viral transcription	87	7.748074e-14	1.1719184570804596e-11	2.724937	74	0.01516393	110	0.00007491537131	1.905161	50	113	0.01146526	
GO Biological Process	protein refolding	92	1.916147e-13	2.740715040543478e-11	8.169673	22	0.004508197	227	0.009689116622907489	2.665411	13	21	0.002980968	
GO Cellular Component	ribosome	28	9.251851e-20	5.70971376e-18	2.356654	143	0.02930328	26	2.9116574030769227e-9	1.824434	100	236	0.02293052	
GO Cellular Component	ribosomal subunit	31	3.719569e-18	2.0733597522580647e-16	2.579375	110	0.02254098	33	1.5881697163636364e-7	1.838635	79	185	0.01811511	
GO Cellular Component	cytosolic ribosome	41	7.054518e-12	2.9732212448780487e-10	2.389817	79	0.01618852	38	0.000002535404362105263	1.999058	52	112	0.01192387	
GO Cellular Component	large ribosomal subunit	43	7.696635e-12	3.092973320930232e-10	2.604741	67	0.01372951	46	0.0006877808139130434	1.759706	47	115	0.01077734	
GO Cellular Component	preribosome	46	7.887565e-11	2.9629809391304347e-9	2.781612	54	0.01106557	65	0.005221128073846154	1.812911	32	76	0.007337767	
GO Cellular Component	catalytic step 2 spliceosome	48	4.428609e-10	1.59429924e-8	2.394793	65	0.01331967	97	0.04159082226804124	1.569773	35	96	0.008025682	
GO Cellular Component	mitochondrial ribosome	49	7.111307e-10	2.507824182857143e-8	2.912469	45	0.009221311	63	0.004705928228571428	1.77292	35	85	0.008025682	
GO Cellular Component	endoplasmic reticulum-Golgi intermediate compartment	52	9.82945e-10	3.2664018461538465e-8	2.076206	85	0.01741803	84	0.019545821485714286	1.576181	41	112	0.009401513	
GO Cellular Component	ficolin-1-rich granule lumen	61	2.077524e-8	5.885182740983606e-7	2.067787	72	0.0147541	76	0.015569000336842106	1.562539	45	124	0.01031873	
GO Cellular Component	MLL1 complex	63	4.086346e-8	0.0000011208263314285714	3.639069	26	0.005327869	79	0.017186642065822783	2.227068	15	29	0.003439578	
GO Cellular Component	small ribosomal subunit	65	5.290424e-8	0.0000014064388726153847	2.540905	44	0.009016393	48	0.00072023472	1.973429	33	72	0.007567072	
GO Cellular Component	methyltransferase complex	66	5.5439e-8	0.0000014514938181818182	2.160152	61	0.0125	92	0.03130696486956522	1.60871	34	91	0.007796377	
GO Cellular Component	small-subunit processome	68	7.05042e-8	0.0000017916361411764707	3.436251	27	0.005532787	81	0.01928923093333333	2.091322	17	35	0.003898188	
GO Cellular Component	cytosolic small ribosomal subunit	75	2.786299e-7	0.000006419632896	2.804308	33	0.006762295	59	0.002817502828474576	2.152832	22	44	0.005044715	
GO Cellular Component	very-low-density lipoprotein particle	78	2.960029e-7	0.000006557602707692307	3.869537	21	0.004303279	69	0.011341384904347825	2.583398	12	20	0.002751662	
GO Cellular Component	cytosolic large ribosomal subunit	80	4.806937e-7	0.00001038298392	2.455428	40	0.008196721	73	0.014287489841095891	1.835201	26	61	0.005961935	
GO Cellular Component	cytochrome complex	100	0.000004852463	0.00008385056063999999	2.53084	31	0.006352459	81	0.01928923093333333	2.091322	17	35	0.003898188	
GO Cellular Component	transcription factor TFIID complex	109	0.00001065857	0.00016897255926605505	2.565314	28	0.005737705	102	0.047574991058823526	1.968303	16	35	0.003668883	
GO Cellular Component	mitochondrial intermembrane space	116	0.00001574829	0.00023459521655172413	2.112708	40	0.008196721	80	0.01751010264	1.711225	31	78	0.007108461	
GO Cellular Component	glycogen granule	123	0.00002400007	0.00033717171512195117	5.411708	10	0.00204918	75	0.015542360064	4.305664	5	5	0.001146526	
GO Molecular Function	structural constituent of ribosome	7	2.162573e-16	1.304340458e-13	2.555341	100	0.0204918	9	0.0000023513673731111114	1.88705	71	162	0.01628067	
GO Molecular Function	unfolded protein binding	8	2.735107e-15	1.44345271925e-12	2.998724	71	0.01454918	47	0.04893099476170213	1.624779	40	106	0.009172208	
GO Molecular Function	rRNA binding	15	1.65286e-11	4.652249946666667e-9	3.82561	37	0.007581967	44	0.04253570005000001	1.865788	26	60	0.005961935	
GO Molecular Function	ribonucleoprotein complex binding	17	2.211984e-11	5.4935273223529415e-9	2.393173	75	0.01536885	12	0.00015689835101666668	1.909468	51	115	0.01169457	
GO Molecular Function	heat shock protein binding	34	1.347765e-8	0.0000016736070088235294	2.023409	78	0.01598361	25	0.015158464455200001	1.722266	42	105	0.009630819	
GO Molecular Function	sterol transporter activity	159	0.0001270977	0.0033748835811320756	2.294601	26	0.005327869	41	0.03451571499512195	2.296354	16	30	0.003668883	
GO Molecular Function	sulfurtransferase activity	261	0.001608131	0.02601352138697318	3.163016	10	0.00204918	36	0.025030162183333333	3.229248	9	12	0.002063747	
Human Phenotype	Increased serum lactate	7	2.121827e-12	2.0227073672857144e-9	2.639769	69	0.01413934	10	0.015348734125	1.808379	42	100	0.009630819	
Human Phenotype	Papule	16	1.036331e-11	4.322147976875e-9	6.282604	23	0.004713115	28	0.037305668653571426	4.305664	6	6	0.001375831	
Human Phenotype	Abnormality of nitrogen compound homeostasis	21	2.244519e-10	7.132226327142857e-8	2.330672	71	0.01454918	21	0.025281578831904766	1.906794	31	70	0.007108461	
Human Phenotype	Azotemia	26	1.139016e-9	2.9233283723076925e-7	2.270198	69	0.01413934	27	0.03826488504074074	1.872028	30	69	0.006879156	
Human Phenotype	Hyperammonemia	40	4.977792e-8	0.000008304201504	2.613393	42	0.008606557	5	0.015095153451999998	2.443755	21	37	0.004815409	
Human Phenotype	Hepatic failure	95	0.000008726604	0.0006129750367578947	2.009526	48	0.009836066	25	0.030589512455999997	1.944493	28	62	0.006420546	
Mouse Phenotype Single KO	increased integument system tumor incidence	170	5.032857e-7	0.00002710933620529412	2.160018	52	0.01065574	28	0.009253472265357141	1.926218	34	76	0.007796377