# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	10	8.776362e-42	1.15488147558e-38	2.776624	237	0.01917321	309	0.00006664833346925566	1.481411	77	113	0.008915133	
GO Biological Process	regulation of DNA-templated transcription in response to stress	15	9.134329e-39	8.013242354066667e-36	2.578936	249	0.020144	269	0.000016996448125650558	1.498063	82	119	0.009494037	
GO Biological Process	rRNA metabolic process	22	4.217054e-31	2.5223733448181815e-28	2.015854	333	0.02693957	155	4.2871453191612904e-9	1.435356	171	259	0.01979854	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	24	2.236981e-30	1.2265180407916667e-27	4.486346	90	0.007280964	716	0.01743814139357542	1.721098	19	24	0.002199838	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	25	3.493822e-30	1.83900814792e-27	2.152614	276	0.02232829	423	0.0007023620916312058	1.360515	97	155	0.01123075	
GO Biological Process	regulation of necrotic cell death	26	5.32389e-30	2.6945026350000003e-27	5.553381	72	0.005824771	549	0.004065956026047359	1.771423	22	27	0.002547181	
GO Biological Process	rRNA processing	30	1.109786e-29	4.8678913246666666e-27	2.006023	321	0.02596877	162	1.0253346588888889e-8	1.432092	166	252	0.01921964	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	33	1.360056e-28	5.423326334545454e-26	2.748111	162	0.01310574	436	0.0008355204433944954	1.50509	54	78	0.006252171	
GO Biological Process	response to topologically incorrect protein	34	1.884067e-28	7.291893427352941e-26	2.082896	280	0.02265189	341	0.00015443043518181818	1.364801	113	180	0.01308325	
GO Biological Process	endoplasmic reticulum unfolded protein response	38	6.900085e-28	2.389426803026316e-25	2.429426	197	0.01593722	488	0.0020707609116188525	1.392135	73	114	0.008452009	
GO Biological Process	cellular response to topologically incorrect protein	40	1.430469e-27	4.70588539275e-25	2.252496	227	0.01836421	393	0.0004468906895419847	1.391998	89	139	0.0103045	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	42	2.833016e-27	8.87610893904762e-25	2.412761	195	0.01577542	620	0.007794901321129032	1.387672	60	94	0.006946857	
GO Biological Process	cellular response to unfolded protein	49	4.074181e-26	1.094125464877551e-23	2.284477	208	0.01682712	355	0.00022635337087042255	1.437368	80	121	0.009262475	
GO Biological Process	response to unfolded protein	50	7.002025e-26	1.8427929394999998e-23	2.070345	257	0.0207912	317	0.00008347559014195585	1.399525	103	160	0.01192544	
GO Biological Process	regulation of receptor catabolic process	70	2.629728e-22	4.943512964571428e-20	4.991875	58	0.004692177	711	0.017021808718424753	2.174019	9	9	0.001042028	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	77	5.729578e-21	9.791625571688312e-19	2.335232	157	0.01270124	459	0.0011825230708714595	1.400215	76	118	0.008799352	
GO Biological Process	protein targeting to ER	81	2.789576e-20	4.5318556276543205e-18	2.411372	142	0.01148774	284	0.00002952547381584507	1.528271	71	101	0.008220447	
GO Biological Process	regulation of necroptotic process	82	2.819111e-20	4.523985566951219e-18	5.343388	49	0.003964081	823	0.03243013964763062	1.739215	16	20	0.001852495	
GO Biological Process	cotranslational protein targeting to membrane	95	4.960202e-19	6.870662959789473e-17	2.397438	134	0.01084055	356	0.0002274913504241573	1.486319	67	98	0.007757323	
GO Biological Process	mitochondrial translational elongation	100	1.433102e-18	1.8858189218e-16	2.550039	116	0.009384354	547	0.004053792332541134	1.432295	56	85	0.006483733	
GO Cellular Component	ribosomal subunit	37	1.485098e-27	6.935809037837837e-26	2.203256	238	0.01925411	72	0.0000182716608	1.386671	118	185	0.01366215	
GO Cellular Component	large ribosomal subunit	42	1.302062e-22	5.357055085714285e-21	2.425007	158	0.01278214	85	0.00021520349364705882	1.436743	76	115	0.008799352	
GO Cellular Component	mitochondrial ribosome	44	1.219469e-20	4.789187345454545e-19	2.810656	110	0.008898956	142	0.021093087549295772	1.355565	53	85	0.00613639	
GO Cellular Component	nuclear ubiquitin ligase complex	45	3.076378e-19	1.181329152e-17	3.360404	78	0.006310169	119	0.008915135354621849	1.576164	29	40	0.003357647	
GO Cellular Component	PcG protein complex	48	1.373613e-16	4.9450068e-15	2.348935	120	0.009707952	132	0.013680366545454544	1.512361	32	46	0.00370499	
GO Cellular Component	endopeptidase complex	53	1.334832e-13	4.3520560301886795e-12	2.281623	102	0.00825176	145	0.026232696496551723	1.386331	44	69	0.005094361	
GO Cellular Component	peptidase complex	56	1.863194e-13	5.749284342857143e-12	2.067089	126	0.01019335	98	0.0009383360914285714	1.457581	59	88	0.006831076	
GO Cellular Component	proteasome complex	58	6.826643e-13	2.0338688110344827e-11	2.238149	100	0.00808996	154	0.03488524550649351	1.374747	43	68	0.004978581	
GO Cellular Component	DNA-directed RNA polymerase III complex	61	1.670571e-12	4.7323716196721306e-11	4.762548	32	0.002588787	155	0.03988584092903226	1.716331	15	19	0.001736714	
GO Cellular Component	cytosolic large ribosomal subunit	82	7.484489e-10	1.5772191453658537e-8	2.084164	86	0.006957366	102	0.0015682574117647059	1.532505	43	61	0.004978581	
GO Cellular Component	U2 snRNP	119	6.265868e-8	9.098672188235293e-7	3.132597	31	0.002507888	155	0.03988584092903226	1.716331	15	19	0.001736714	
GO Cellular Component	intraciliary transport particle	152	6.276686e-7	0.000007135600926315788	2.344906	43	0.003478683	152	0.030955062315789473	1.562576	23	32	0.002662962	
GO Cellular Component	pronucleus	202	0.00001820405	0.00015572573465346534	2.490635	28	0.002265189	136	0.018051793411764706	1.88415	13	15	0.001505152	
GO Cellular Component	anaphase-promoting complex	214	0.00002635084	0.00021277687626168224	2.484979	27	0.002184289	133	0.01478514478195489	1.75992	17	21	0.001968276	
GO Molecular Function	structural constituent of ribosome	7	6.80608e-24	4.105038537142857e-21	2.158882	214	0.01731252	70	0.00013106354600000002	1.395666	104	162	0.01204122	
GO Molecular Function	rRNA binding	9	2.54011e-23	1.1915938244444445e-20	3.592096	88	0.007119165	121	0.03431982849256199	1.449346	40	60	0.004631238	
GO Molecular Function	RNA polymerase III activity	29	7.974215e-12	1.1609357148275862e-9	4.765138	30	0.002426988	117	0.02671780474188034	1.902266	14	16	0.001620933	
GO Molecular Function	L-serine transmembrane transporter activity	83	2.49011e-8	0.0000012666559542168675	4.14806	23	0.001860691	109	0.016377072152293577	2.174019	10	10	0.001157809	
Human Phenotype	Increased serum lactate	15	1.630032e-16	7.251469024e-14	2.159827	143	0.01156864	53	0.0008846286562075471	1.478333	68	100	0.007873104	
Mouse Phenotype Single KO	expanded mesangial matrix	17	8.891567e-22	4.789416412882353e-19	2.613456	132	0.01067875	222	0.026264148647747752	1.614985	26	35	0.003010305	
Mouse Phenotype Single KO	abnormal mesangial matrix morphology	18	5.3296e-21	2.7112859555555557e-18	2.536041	134	0.01084055	238	0.030826128647478992	1.586446	27	37	0.003126085	
Mouse Phenotype Single KO	decreased spongiotrophoblast size	209	6.700503e-8	0.0000029357179890430624	2.554793	43	0.003478683	110	0.00155348505	2.05324	17	18	0.001968276	
Mouse Phenotype Single KO	cardia bifida	373	0.00001299501	0.0003190222696246649	2.133911	40	0.003235984	235	0.02885052737787234	1.902266	14	16	0.001620933	
Mouse Phenotype Single KO	abnormal antigen presentation via MHC class I	394	0.00001924826	0.00044735105791878177	3.035891	20	0.001617992	192	0.015716764797395835	2.018732	13	14	0.001505152	
Mouse Phenotype Single KO	abnormal level of surface class I molecules	508	0.0001016564	0.0018324166433070865	3.091078	16	0.001294394	269	0.04594128173605948	1.992851	11	12	0.00127359	
Mouse Phenotype	expanded mesangial matrix	29	2.709708e-21	8.93362696137931e-19	2.347103	158	0.01278214	433	0.04579690294919168	1.464135	33	49	0.003820771	
Mouse Phenotype	dry eyes	30	9.851333e-21	3.1396198271e-18	3.439899	82	0.006633767	356	0.019884822773595504	1.902266	14	16	0.001620933	
Mouse Phenotype	abnormal mesangial matrix morphology	31	1.107431e-20	3.415531545483871e-18	2.297284	160	0.01294394	447	0.04958576298657718	1.449346	34	51	0.003936552	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	251	4.082484e-8	0.0000015550848415936256	2.377194	51	0.00412588	444	0.04777937479729729	1.59428	22	30	0.002547181	
Mouse Phenotype	decreased spongiotrophoblast size	272	1.117075e-7	0.000003926600762867647	2.506253	43	0.003478683	236	0.00407269025720339	1.945175	17	19	0.001968276	
Mouse Phenotype	decreased level of surface class I molecules	376	0.000002589545	0.00006584744613031915	4.208913	16	0.001294394	395	0.032666935572151896	1.992851	11	12	0.00127359	
Mouse Phenotype	abnormal antigen presentation via MHC class I	404	0.000004055294	0.00009597194538118812	3.163504	22	0.001779791	221	0.003417232917828054	2.038143	15	16	0.001736714	
Mouse Phenotype	abnormal level of surface class I molecules	493	0.00002076181	0.0004026443517444219	3.247545	18	0.001456193	308	0.010229720552922077	2.018732	13	14	0.001505152