# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process DNA replication-dependent nucleosome assembly 1 2.24166e-59 2.9498003940000003e-55 66.59807 41 0.0266061 90 0.00001818177567888889 5.080357 14 32 0.008658009 GO Biological Process chromatin silencing 2 2.528461e-55 1.66360091495e-51 13.26967 73 0.04737184 7 1.6629667451428572e-11 4.309699 36 97 0.02226345 GO Biological Process negative regulation of gene expression, epigenetic 3 3.379126e-52 1.4821973011333336e-48 9.82661 82 0.0532122 2 4.6790351112e-13 4.278195 42 114 0.02597403 GO Biological Process chromatin silencing at rDNA 4 1.58925e-49 5.2282351875e-46 31.3559 44 0.02855289 84 0.000015225656980595237 4.838435 15 36 0.009276438 GO Biological Process protein heterotetramerization 5 1.124906e-45 2.9605276108e-42 16.22992 54 0.03504218 66 0.0000014387159376818183 4.750464 18 44 0.01113173 GO Biological Process DNA conformation change 6 1.727923e-44 3.7896231261666667e-41 4.458023 131 0.08500973 42 8.570957995238095e-8 2.396833 58 281 0.03586889 GO Biological Process negative regulation of megakaryocyte differentiation 7 3.030882e-43 5.697625176857143e-40 91.09881 27 0.01752109 160 0.004868167115375 5.160998 8 18 0.004947434 GO Biological Process regulation of gene expression, epigenetic 8 6.002429e-42 9.873245401375e-39 4.829906 114 0.07397794 17 1.018827060352941e-9 2.715767 58 248 0.03586889 GO Biological Process chromatin assembly 9 2.168593e-41 3.1707239207777776e-38 6.04009 92 0.05970149 12 3.2385220130000005e-10 3.307285 45 158 0.02782931 GO Biological Process gene silencing 10 1.863693e-39 2.4524336187e-36 5.84953 90 0.05840363 35 1.5172172851714287e-8 2.903061 45 180 0.02782931 GO Biological Process nucleosome assembly 11 2.227564e-39 2.6647740614545458e-36 6.248716 85 0.05515899 27 4.371868180740741e-9 3.271055 40 142 0.02473717 GO Biological Process nucleosome organization 12 2.501487e-39 2.74308895275e-36 5.680114 92 0.05970149 19 1.0592724894210527e-9 3.123762 46 171 0.02844774 GO Biological Process chromatin assembly or disassembly 13 8.787022e-39 8.894494038307692e-36 5.45381 94 0.06099935 14 4.2704244750000005e-10 3.131392 48 178 0.0296846 GO Biological Process positive regulation of gene expression, epigenetic 14 9.879507e-38 9.286030900928571e-35 10.02447 58 0.0376379 110 0.0000789432933590909 3.193367 22 80 0.01360544 GO Biological Process regulation of megakaryocyte differentiation 15 1.385055e-36 1.215062583e-33 8.049017 65 0.0421804 20 1.0238267837e-9 4.430988 29 76 0.01793445 GO Biological Process regulation of hematopoietic stem cell differentiation 16 1.246629e-35 1.0252744381875001e-32 8.280218 62 0.04023361 135 0.0016849212485925925 2.593026 23 103 0.01422387 GO Biological Process regulation of hematopoietic progenitor cell differentiation 17 2.114229e-35 1.6365376124117648e-32 7.674304 65 0.0421804 126 0.000290590197 2.671844 26 113 0.01607916 GO Biological Process protein-DNA complex assembly 18 2.290669e-34 1.6746062983888888e-31 4.325299 104 0.06748864 23 1.7019301354782608e-9 2.810269 53 219 0.03277675 GO Biological Process protein-DNA complex subunit organization 19 3.050129e-34 2.1124551321578943e-31 4.058574 111 0.07203115 15 4.89146348e-10 2.74049 59 250 0.03648732 GO Biological Process DNA packaging 20 5.343685e-34 3.5158775457500006e-31 4.774879 93 0.06035042 45 1.2127588807333333e-7 2.684238 46 199 0.02844774 GO Cellular Component nucleosome 1 6.627756e-63 1.1452762368000001e-59 14.63082 79 0.05126541 3 3.4156690560000003e-20 5.197862 47 105 0.02906617 GO Cellular Component DNA packaging complex 2 2.882891e-56 2.4908178239999997e-53 11.8789 79 0.05126541 4 7.31737152e-19 4.872996 47 112 0.02906617 GO Cellular Component nuclear nucleosome 3 2.814924e-51 1.6213962240000003e-48 30.66178 46 0.02985075 23 8.346412800000001e-8 5.22551 18 40 0.01113173 GO Cellular Component protein-DNA complex 9 2.451459e-37 4.7068012799999996e-35 5.10724 96 0.06229721 12 1.9778256e-13 3.219236 56 202 0.03463203 GO Cellular Component chromatin 14 4.655165e-32 5.745803657142857e-30 2.770515 171 0.1109669 10 1.8317370239999998e-14 2.389351 100 486 0.06184292 GO Cellular Component chromosome, telomeric region 21 1.811036e-25 1.4902239085714285e-23 5.065494 65 0.0421804 56 0.03263966742857143 1.877429 27 167 0.01669759 GO Cellular Component chromosome 22 2.187642e-25 1.7182933527272726e-23 2.015418 245 0.1589877 21 4.751484891428571e-9 1.715039 144 975 0.0890538 GO Cellular Component nuclear chromatin 24 1.741436e-24 1.25383392e-22 2.88887 122 0.07916937 18 3.27640416e-11 2.535585 69 316 0.04267161 GO Cellular Component chromosomal part 26 4.058938e-23 2.69763264e-21 2.04695 216 0.1401687 19 6.360922610526316e-10 1.81271 133 852 0.08225108 GO Cellular Component nuclear chromosome part 32 8.897719e-18 4.80476826e-16 2.212141 140 0.0908501 30 0.00000797560704 1.807353 80 514 0.04947434 GO Cellular Component cytosolic ribosome 36 3.272815e-16 1.5709512e-14 4.40669 46 0.02985075 31 0.000010514066167741936 2.903061 28 112 0.01731602 GO Cellular Component nuclear chromosome 37 4.90889e-16 2.2925843027027025e-14 2.083011 143 0.09279689 33 0.000016225642472727273 1.752393 83 550 0.05132962 GO Cellular Component cytosolic part 38 7.145737e-16 3.249429877894737e-14 3.050483 71 0.04607398 32 0.000010455507 2.22568 46 240 0.02844774 GO Cellular Component ribosomal subunit 40 3.048289e-15 1.316860848e-13 3.78712 51 0.03309539 47 0.009121597276595745 1.945836 31 185 0.0191713 GO Cellular Component ribosome 49 4.225651e-12 1.4901887608163264e-10 2.922571 56 0.03634004 57 0.03249073515789474 1.722155 35 236 0.02164502 GO Cellular Component small ribosomal subunit 50 3.468004e-11 1.1985421824e-9 4.93761 27 0.01752109 44 0.0011048804509090908 2.903061 18 72 0.01113173 GO Cellular Component cytosolic small ribosomal subunit 52 8.083137e-11 2.686088603076923e-9 5.920409 22 0.01427644 34 0.000017520491858823532 4.222635 16 44 0.009894867 GO Cellular Component myelin sheath 84 0.00001166108 0.00023988507428571426 2.109042 41 0.0266061 49 0.01013116878367347 2.007055 28 162 0.01731602 GO Cellular Component nuclear euchromatin 104 0.0001739693 0.0028905668307692305 3.219255 14 0.00908501 55 0.02660589661090909 3.715918 8 25 0.004947434 GO Cellular Component euchromatin 106 0.0001840972 0.003001131713207547 3.050632 15 0.009733939 59 0.042875721762711864 3.166976 9 33 0.005565863 GO Molecular Function nucleosomal DNA binding 1 3.063994e-36 1.2936182668e-32 11.97222 50 0.03244646 15 0.00019555622850666666 4.039042 16 46 0.009894867 GO Molecular Function nucleosome binding 2 3.297055e-28 6.960083105e-25 7.526281 52 0.03374432 21 0.001539205894952381 3.166976 18 66 0.01113173 GO Molecular Function chromatin DNA binding 8 5.094002e-22 2.6883595555e-19 4.774558 59 0.03828683 16 0.000485165588625 2.791405 25 104 0.01546073 GO Molecular Function structure-specific DNA binding 10 7.818685e-21 3.301048807e-18 3.858801 70 0.04542505 11 0.0000782608727090909 2.673323 32 139 0.01978973 GO Molecular Function histone binding 11 1.163443e-18 4.465505769090908e-16 3.171643 80 0.05191434 9 0.00004719618993333333 2.404556 41 198 0.0253556 GO Molecular Function protein heterodimerization activity 14 2.282781e-16 6.884215272857143e-14 2.013254 158 0.1025308 5 2.8881764716e-8 2.04922 90 510 0.05565863 GO Molecular Function structural constituent of ribosome 15 4.648228e-16 1.3083212410666667e-13 4.046095 50 0.03244646 27 0.0075933686407407405 2.150416 30 162 0.01855288 GO Molecular Function cadherin binding 20 2.330922e-11 4.920576342e-9 2.16672 90 0.05840363 40 0.04785083918 1.68072 44 304 0.02721088 GO Molecular Function DNA-(apurinic or apyrimidinic site) lyase activity 40 1.779423e-7 0.000018781809765 8.216113 11 0.007138222 39 0.04412571336923077 5.359498 6 13 0.003710575 Mouse Phenotype Single KO abnormal erythropoiesis 47 9.45158e-9 0.0000018414493204255318 2.555501 48 0.0311486 4 0.000018388897392250002 3.166976 30 110 0.01855288 Mouse Phenotype Single KO abnormal platelet morphology 61 2.068059e-8 0.0000031044616824590163 2.016666 75 0.0486697 26 0.003103924693115385 1.964478 45 266 0.02782931 Mouse Phenotype Single KO abnormal incidence of induced tumors 66 4.500874e-8 0.0000062446216996969696 2.098129 65 0.0421804 35 0.009667191412 2.019521 36 207 0.02226345 Mouse Phenotype Single KO lordosis 74 1.026294e-7 0.000012699694808108107 4.305875 20 0.01297859 57 0.028768868198245614 3.745885 10 31 0.006184292 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 135 0.000002269621 0.00015394755182962963 2.992432 25 0.01622323 42 0.01241245957595238 2.860988 17 69 0.0105133 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 177 0.00001239725 0.0006413650748587571 2.022798 45 0.02920182 34 0.009651036309411764 2.123382 32 175 0.01978973 Mouse Phenotype Single KO improved central nervous system regeneration 209 0.00003293093 0.0014428159139234452 8.116053 7 0.004542505 62 0.03769340218064516 9.289796 4 5 0.002473717 Mouse Phenotype Single KO extramedullary hematopoiesis 234 0.00006360327 0.002488953604230769 2.229006 30 0.01946788 44 0.019468733079318182 2.342821 23 114 0.01422387 Mouse Phenotype Single KO hyperchromasia 283 0.000250005 0.008089384399293286 9.205494 5 0.003244646 40 0.012547425035 11.61224 4 4 0.002473717 Mouse Phenotype Single KO embryonic lethality between implantation and placentation, complete penetrance 295 0.0003229254 0.010023823348474575 2.511394 19 0.01232966 67 0.03957736036268657 2.959984 13 51 0.008039579 Mouse Phenotype Single KO decreased erythroid progenitor cell number 441 0.0022236 0.04617121360544218 2.033624 21 0.01362751 22 0.0013825775533181817 3.643057 16 51 0.009894867 Mouse Phenotype abnormal pre-B cell morphology 8 1.544001e-15 1.845274195125e-12 3.031597 70 0.04542505 79 0.018957514492405063 2.182753 25 133 0.01546073 Mouse Phenotype abnormal incidence of induced tumors 61 7.490411e-9 0.000001174029829032787 2.013376 80 0.05191434 46 0.0022742688345652176 1.965149 44 260 0.02721088 Mouse Phenotype abnormal erythropoiesis 68 1.308919e-8 0.000001840378611617647 2.352537 55 0.03569111 7 0.000012820885779428571 2.805643 36 149 0.02226345 Mouse Phenotype poikilocytosis 69 1.342868e-8 0.000001860747963478261 5.470303 18 0.01168073 103 0.030158382972815534 3.275249 11 39 0.006802721 Mouse Phenotype transmission ratio distortion 85 8.400296e-8 0.000009448850594823529 3.853013 23 0.01492537 87 0.021384715051724137 3.452289 11 37 0.006802721 Mouse Phenotype lordosis 127 0.000001234399 0.00009292983337795275 3.521438 21 0.01362751 87 0.021384715051724137 3.452289 11 37 0.006802721 Mouse Phenotype extramedullary hematopoiesis 130 0.000001279714 0.00009411804272307693 2.11348 50 0.03244646 66 0.012685242175454546 2.057026 31 175 0.0191713 Mouse Phenotype abnormal mean corpuscular hemoglobin 168 0.000005200015 0.0002959365679464286 2.022926 49 0.03179753 39 0.0015802205064615385 2.208851 35 184 0.02164502 Mouse Phenotype decreased mean corpuscular hemoglobin 179 0.000009578125 0.0005116002967877096 2.625232 27 0.01752109 49 0.004052468874489796 2.865359 19 77 0.01175015 Mouse Phenotype microcytic anemia 263 0.00008865685 0.0032229967408745246 3.897374 12 0.007787151 114 0.043661539365789474 3.6038 9 29 0.005565863 Mouse Phenotype hyperchromasia 272 0.00009776171 0.003436395990110294 8.429908 6 0.003893576 51 0.004918131532352941 9.676871 5 6 0.003092146 Mouse Phenotype increased red blood cell distribution width 276 0.0001114754 0.003861653258695652 2.226608 28 0.01817002 109 0.038331540165137616 2.375232 18 88 0.01113173 Mouse Phenotype embryonic lethality between implantation and placentation, complete penetrance 312 0.000216566 0.006636498480769231 2.521828 20 0.01297859 85 0.019550231565882353 2.955844 14 55 0.008658009