# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of canonical Wnt signaling pathway 83 0.00001927666 0.003056163481204819 2.209547 35 0.02565982 369 0.023342611021138212 1.977259 25 122 0.01284687 GO Biological Process regulation of proteasomal ubiquitin-dependent protein catabolic process 85 0.00002320938 0.003593085075529412 2.189174 35 0.02565982 224 0.0021374563169642854 2.265423 27 115 0.01387461 GO Biological Process regulation of proteasomal protein catabolic process 86 0.00002331338 0.003567218225813954 2.06409 40 0.02932551 270 0.004059533954666667 2.018096 32 153 0.01644399 GO Biological Process regulation of ER-associated ubiquitin-dependent protein catabolic process 89 0.00003974572 0.0058765610053932585 6.583739 8 0.005865103 402 0.03428289392288557 5.360569 5 9 0.002569373 GO Biological Process mitochondrial RNA processing 100 0.00006693937 0.0088085516983 6.104723 8 0.005865103 336 0.015086844412797618 4.502878 7 15 0.003597122 GO Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process 101 0.00007099429 0.00924964219910891 2.373177 26 0.01906158 236 0.0025710834818644065 2.532869 21 80 0.01079137 GO Biological Process mitochondrial tRNA processing 113 0.0001422994 0.01657095402300885 6.399404 7 0.005131965 368 0.02337326253125 4.824512 6 12 0.003083248 GO Biological Process embryonic placenta development 115 0.0001535018 0.01756461031478261 2.085829 31 0.02272727 467 0.04743737784582441 2.059904 19 89 0.009763618 GO Biological Process regulation of DNA replication 116 0.0001635936 0.018558001572413794 2.050519 32 0.02346041 466 0.04729463200429184 1.913168 23 116 0.01181912 GO Biological Process positive regulation of proteasomal protein catabolic process 118 0.0001792624 0.019990795945762713 2.160508 28 0.02052786 268 0.003977498751902985 2.336079 23 95 0.01181912 GO Biological Process forebrain neuroblast division 144 0.0005077636 0.04640042508611111 4.505699 8 0.005865103 355 0.01886659578028169 6.03064 5 8 0.002569373 GO Molecular Function NAD binding 14 0.00007313516 0.02205547468 3.041541 17 0.01246334 51 0.03552853564313726 2.58456 15 56 0.007708119 GO Molecular Function enhancer binding 17 0.0001072285 0.026630513352941178 2.000039 36 0.02639296 28 0.001122254494357143 2.45777 27 106 0.01387461 GO Molecular Function enhancer sequence-specific DNA binding 20 0.0001864356 0.03935655516 2.035127 32 0.02346041 38 0.005263695171052632 2.412256 23 92 0.01181912 Mouse Phenotype Single KO abnormal vestibuloocular reflex 9 4.722456e-9 0.000004804836621333334 5.511774 19 0.01392962 264 0.01765421040151515 6.03064 5 8 0.002569373 Mouse Phenotype Single KO abnormal cranial ganglia morphology 20 3.370876e-7 0.00015433555765999998 2.015097 62 0.04545455 83 0.00019094562538554214 2.222199 38 165 0.01952724 Mouse Phenotype Single KO abnormal utricle morphology 21 3.705552e-7 0.00016157971268571428 3.137473 27 0.01979472 252 0.01458038223293651 2.96893 12 39 0.006166495 Mouse Phenotype Single KO abnormal cochlear inner hair cell morphology 22 4.290694e-7 0.0001785903861727273 2.237429 48 0.03519062 202 0.007967297174257426 2.184685 24 106 0.01233299 Mouse Phenotype Single KO abnormal semicircular canal morphology 26 8.346774e-7 0.00029396695968461536 2.30075 43 0.03152493 64 0.00007312087701875001 3.385622 20 57 0.01027749 Mouse Phenotype Single KO abnormal inner ear canal morphology 31 0.00000164818 0.0004868511051612904 2.239219 43 0.03152493 84 0.00019099234552380953 3.163614 20 61 0.01027749 Mouse Phenotype Single KO bidirectional circling 37 0.000003765052 0.0009317994909189189 3.271133 21 0.01539589 404 0.047689882658415846 3.216341 8 24 0.004110997 Mouse Phenotype Single KO abnormal vestibular saccule morphology 38 0.000004075109 0.0009819940292894735 2.639523 29 0.021261 278 0.019240349129856116 2.726898 13 46 0.00668037 Mouse Phenotype Single KO abnormal otolith organ morphology 39 0.00000536069 0.0012586625212820514 2.505996 31 0.02272727 203 0.007947486603448276 2.783372 15 52 0.007708119 Mouse Phenotype Single KO abnormal placenta labyrinth morphology 41 0.000006292811 0.0014054456177317073 2.058953 46 0.03372434 153 0.0026872473343137254 2.054308 33 155 0.01695786 Mouse Phenotype Single KO abnormal vestibular labyrinth morphology 44 0.00001321333 0.002749874154772727 2.166954 38 0.02785924 213 0.0090193440657277 2.412256 19 76 0.009763618 Mouse Phenotype Single KO abnormal inner ear vestibule morphology 57 0.00005387381 0.00865478031877193 2.123947 34 0.02492669 273 0.017879555694505493 2.377296 17 69 0.008735868 Mouse Phenotype Single KO abnormal hippocampus development 90 0.0002775846 0.028242690913333333 2.931876 15 0.01099707 155 0.0028060882124516127 4.57059 9 19 0.004624872 Mouse Phenotype Single KO abnormal otic vesicle morphology 99 0.0003568902 0.033010541024242425 2.489489 19 0.01392962 112 0.0007540450200446429 4.135296 12 28 0.006166495 Mouse Phenotype Single KO abnormal habituation to a new environment 102 0.0003857736 0.034632635835294114 6.510674 6 0.004398827 270 0.017894073545925922 7.719219 4 5 0.002055498 Mouse Phenotype abnormal vestibuloocular reflex 5 2.351749e-9 0.0000044970144378 4.914744 22 0.01612903 282 0.0026632999544680853 4.824512 8 16 0.004110997 Mouse Phenotype abnormal semicircular canal morphology 23 0.000001644697 0.0006836933920434783 2.170514 46 0.03372434 98 0.000011244857954081632 3.312351 23 67 0.01181912 Mouse Phenotype abnormal semicircular canal ampulla morphology 24 0.000001880272 0.0007490533579999999 2.694347 30 0.02199413 294 0.003025537474285714 3.216341 13 39 0.00668037 Mouse Phenotype abnormal crista ampullaris morphology 26 0.000002227908 0.0008192703226153846 2.917591 26 0.01906158 578 0.029331609638408307 2.837948 10 34 0.005138746 Mouse Phenotype abnormal utricle morphology 28 0.000002411594 0.0008234732226428572 2.61014 31 0.02272727 228 0.0011092059960526317 3.087688 16 50 0.008221994 Mouse Phenotype abnormal inner ear canal morphology 31 0.000003044861 0.0009390940651935484 2.119161 46 0.03372434 120 0.000030427579734999998 3.12574 23 71 0.01181912 Mouse Phenotype bidirectional circling 34 0.000003765052 0.001058754769764706 3.271133 21 0.01539589 605 0.0332508191107438 3.216341 8 24 0.004110997 Mouse Phenotype decreased fibroblast proliferation 38 0.0000050948 0.0012818784947368422 2.429751 33 0.02419355 571 0.028353254338003505 1.855581 25 130 0.01284687 Mouse Phenotype abnormal vestibular saccule morphology 44 0.00001137639 0.0024720378361363636 2.333991 33 0.02419355 225 0.0010563222263999998 2.982425 17 55 0.008735868 Mouse Phenotype abnormal cerebellar granule cell morphology 47 0.00001688579 0.0034350008125531915 2.287403 33 0.02419355 134 0.00008690071385820895 3.03255 22 70 0.01130524 Mouse Phenotype abnormal fibroblast proliferation 54 0.00003863374 0.006840318298888888 2.016231 40 0.02932551 635 0.038392142801574804 1.702769 30 170 0.01541624 Mouse Phenotype abnormal otolith organ morphology 57 0.00006324542 0.010608587028421051 2.079979 35 0.02565982 214 0.0007185064693457943 2.864554 19 64 0.009763618 Mouse Phenotype head tossing 78 0.0001255789 0.015393075165384617 2.434547 23 0.01686217 617 0.03494550148784441 2.756864 10 35 0.005138746 Mouse Phenotype decreased brain weight 84 0.0001596634 0.018173116278571426 2.142226 29 0.021261 613 0.03443744304078303 2.014631 19 91 0.009763618 Mouse Phenotype abnormal habituation to a new environment 105 0.000371225 0.033802687857142855 5.452062 7 0.005131965 591 0.030998460654822334 4.824512 5 10 0.002569373 Mouse Phenotype abnormal cochlear outer hair cell number 107 0.0003887056 0.03473284337943925 2.026498 29 0.021261 651 0.04262173369585254 2.322913 13 54 0.00668037 Mouse Phenotype abnormal nonassociative learning 121 0.0005130809 0.040541871776033064 3.683941 10 0.007331378 435 0.011555996062068967 3.859609 8 20 0.004110997 Mouse Phenotype abnormal otic vesicle morphology 125 0.0005887997 0.0450361114536 2.220814 22 0.01612903 128 0.0000523336722234375 4.135296 15 35 0.007708119 Mouse Phenotype thin myocardium compact layer 126 0.000613252 0.04653414580952381 2.317518 20 0.01466276 541 0.02429775280036969 2.508746 13 50 0.00668037