# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	14	4.28919e-29	4.031532229285714e-26	3.229388	128	0.02118504	328	0.02263080808109756	1.55101	46	114	0.009416581	
GO Biological Process	cellular response to unfolded protein	21	1.294001e-26	8.108456742380953e-24	2.965994	132	0.02184707	258	0.008581544942635659	1.58835	50	121	0.01023541	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	22	1.75604e-26	1.0503513800000001e-23	2.600864	163	0.02697782	263	0.0090770031486692	1.512724	61	155	0.01248721	
GO Biological Process	cellular response to topologically incorrect protein	25	1.715121e-25	9.0277108956e-23	2.801497	138	0.02284012	294	0.013991391791156462	1.520931	55	139	0.01125896	
GO Biological Process	response to unfolded protein	45	1.192239e-21	3.4863717779999997e-19	2.439181	148	0.0244952	286	0.012270744494755246	1.489475	62	160	0.01269191	
GO Biological Process	response to topologically incorrect protein	49	2.882409e-21	7.7407387818367345e-19	2.358925	155	0.02565376	298	0.01453165149932886	1.452105	68	180	0.01392016	
GO Biological Process	macromolecular complex disassembly	53	6.172901e-21	1.5326264954528301e-18	2.282494	163	0.02697782	78	0.000001588844146705128	1.73072	86	191	0.01760491	
GO Biological Process	mitochondrial transport	57	7.741133e-21	1.7871152481929825e-18	2.099482	195	0.03227408	53	5.7723641824528304e-8	1.720868	107	239	0.02190379	
GO Biological Process	response to endoplasmic reticulum stress	63	2.977404e-20	6.2189935295238095e-18	2.010338	210	0.0347567	266	0.009236475244736843	1.402045	89	244	0.01821904	
GO Biological Process	mitochondrial translation	65	4.656409e-20	9.426720927846153e-18	3.081706	92	0.01522675	94	0.000021261570256382976	1.903942	53	107	0.01084954	
GO Biological Process	mitochondrial translational termination	66	6.180673e-20	1.2322950910151517e-17	3.450764	78	0.01290963	100	0.00003479030371899999	1.988176	45	87	0.009211873	
GO Biological Process	protein complex disassembly	69	8.814677e-20	1.6810483281594204e-17	2.387277	140	0.02317114	71	4.933257205352112e-7	1.837292	76	159	0.01555783	
GO Biological Process	mRNA catabolic process	70	9.7364e-20	1.8303041085714284e-17	2.221652	162	0.02681231	207	0.0025412896009178744	1.479776	82	213	0.01678608	
GO Biological Process	negative regulation of response to endoplasmic reticulum stress	73	1.909139e-19	3.441419191917809e-17	3.674921	70	0.01158557	362	0.03551805668867403	1.921904	20	40	0.004094166	
GO Biological Process	nuclear-transcribed mRNA catabolic process	75	2.934124e-19	5.1480183621333333e-17	2.274856	150	0.02482622	194	0.0016308660913917524	1.514227	78	198	0.01596725	
GO Biological Process	mitochondrial translational elongation	76	3.066295e-19	5.309128408552632e-17	3.418026	76	0.01257862	105	0.00004356329560095238	1.989736	44	85	0.009007165	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	78	6.952468e-19	1.172917005282051e-16	2.890858	95	0.01572327	133	0.00027328304486466166	1.759031	54	118	0.01105425	
GO Biological Process	translational elongation	84	4.027916e-18	6.309922219523809e-16	2.847982	93	0.01539225	89	0.000006661368201011236	1.921904	56	112	0.01146366	
GO Biological Process	cellular response to insulin stimulus	87	5.888284e-18	8.906198753563219e-16	2.083846	169	0.02797087	323	0.022444365207430338	1.480385	57	148	0.01166837	
GO Biological Process	translational termination	90	1.280486e-17	1.8722128082222223e-15	3.027347	82	0.01357167	101	0.000035109241268316834	1.942134	48	95	0.009825998	
GO Cellular Component	mitochondrial ribosome	33	6.832268e-23	3.577623970909091e-21	3.972844	76	0.01257862	40	0.000001397075904	2.080178	46	85	0.009416581	
GO Cellular Component	ribosomal subunit	36	2.097519e-22	1.0068091200000001e-20	2.594666	137	0.02267461	38	9.419910063157895e-7	1.724519	83	185	0.01699079	
GO Cellular Component	ribosome	38	2.0851e-21	9.48171789473684e-20	2.262809	170	0.02813638	32	1.5062166e-7	1.677594	103	236	0.02108495	
GO Cellular Component	small ribosomal subunit	45	2.063178e-12	7.92260352e-11	2.845147	61	0.01009599	60	0.0009063817919999999	1.868518	35	72	0.00716479	
GO Cellular Component	large ribosomal subunit	47	7.863687e-12	2.8911598161702127e-10	2.417795	77	0.01274412	73	0.003998528087671233	1.604372	48	115	0.009825998	
GO Cellular Component	mitochondrial large ribosomal subunit	50	3.103389e-11	1.0725312383999998e-9	3.517947	40	0.006620324	90	0.01849914048	1.808851	24	51	0.004912999	
GO Cellular Component	catalytic step 2 spliceosome	53	3.784487e-11	1.2338855728301886e-9	2.32107	78	0.01290963	97	0.021873451546391753	1.561547	39	96	0.007983623	
GO Cellular Component	mitochondrial small ribosomal subunit	59	2.976591e-10	8.717880081355934e-9	4.205068	29	0.004799735	69	0.002791441252173913	2.33374	17	28	0.003480041	
GO Cellular Component	peptidase complex	67	2.902209e-9	7.485100226865673e-8	2.248724	67	0.01108904	86	0.015277925134883722	1.616146	37	88	0.007574207	
GO Cellular Component	transcription factor AP-1 complex	90	1.204655e-7	0.0000023129376	6.81704	13	0.002151605	93	0.022110298838709675	3.843808	5	5	0.001023541	
GO Cellular Component	Ino80 complex	98	3.62399e-7	0.000006390055836734694	4.909344	16	0.00264813	79	0.009052337984810126	2.642618	11	16	0.002251791	
GO Cellular Component	signal recognition particle, endoplasmic reticulum targeting	120	0.000003652086	0.00005259003840000001	6.75162	10	0.001655081	104	0.027963376615384616	3.294692	6	7	0.00122825	
GO Cellular Component	transcription elongation factor complex	130	0.000006023593	0.00008006745156923078	2.040156	48	0.007944389	87	0.015420743503448273	1.784625	26	56	0.005322416	
GO Cellular Component	MLL1 complex	155	0.00005108324	0.0005694957336774194	2.600063	23	0.003806687	117	0.04008308676923077	1.988176	15	29	0.003070624	
GO Cellular Component	zonula adherens	167	0.00008366671	0.0008657249992814372	3.675258	13	0.002151605	83	0.010346614438554216	3.363332	7	8	0.001432958	
GO Cellular Component	nuclear stress granule	185	0.000135774	0.0012682025513513513	6.458137	7	0.001158557	93	0.022110298838709675	3.843808	5	5	0.001023541	
GO Cellular Component	U1 snRNP	236	0.001229347	0.00900132040677966	2.445607	16	0.00264813	121	0.04584024119008265	2.225362	11	19	0.002251791	
GO Cellular Component	ESCRT III complex	240	0.001419552	0.010220774399999999	3.010922	11	0.001820589	126	0.049957426285714285	2.562538	8	12	0.001637666	
GO Molecular Function	cadherin binding	3	4.91666e-35	6.919379506666668e-32	2.087666	340	0.05627276	6	1.910398003e-11	1.770175	140	304	0.02865916	
GO Molecular Function	structural constituent of ribosome	6	2.540626e-18	1.7877538286666665e-15	2.476676	120	0.01986097	11	0.0000011091194000000002	1.826995	77	162	0.01576254	
GO Molecular Function	nuclear hormone receptor binding	7	4.343977e-18	2.620038699142857e-15	2.036726	180	0.02979146	62	0.026854208051612902	1.515077	54	137	0.01105425	
GO Molecular Function	steroid hormone receptor binding	11	3.220974e-15	1.2362683843636365e-12	2.136018	133	0.02201258	61	0.023892173416393443	1.659826	38	88	0.007778915	
GO Molecular Function	ribonucleoprotein complex binding	18	5.497702e-13	1.2895165468888888e-10	2.345273	91	0.01506124	37	0.001750384145945946	1.704645	51	115	0.01044012	
GO Molecular Function	ATP-dependent RNA helicase activity	65	0.000001118239	0.00007263392396923076	2.023485	57	0.009433962	34	0.001584758744117647	1.950589	34	67	0.006960082	
GO Molecular Function	RNA helicase activity	67	0.0000015124	0.00009530377313432836	2.003031	57	0.009433962	39	0.0020759335835897432	1.921904	34	68	0.006960082	
GO Molecular Function	SNAP receptor activity	152	0.0001018703	0.0028295816223684214	2.015293	36	0.005958292	54	0.011646926477777776	2.062531	22	41	0.004503582	
Mouse Phenotype Single KO	prenatal lethality prior to heart atrial septation	147	2.458417e-8	0.0000015314098278231295	2.230633	60	0.009930487	43	0.01642842676209302	1.921904	29	58	0.00593654	
Mouse Phenotype Single KO	lethality, complete penetrance	236	0.000001346339	0.000052239094165254234	2.025149	56	0.009268454	42	0.015699286237380955	2.460037	16	25	0.003275333	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	178	2.458417e-8	0.0000013205014009550562	2.230633	60	0.009930487	66	0.011175593594090908	1.921904	29	58	0.00593654