# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	16	2.461246e-47	2.0242210071249998e-44	2.139013	449	0.02581498	143	1.2790032682517485e-12	1.45654	170	213	0.0165225	
GO Biological Process	nuclear-transcribed mRNA catabolic process	17	4.808944e-47	3.7224055350588237e-44	2.202141	418	0.02403266	150	3.1883809593999996e-12	1.465497	159	198	0.0154534	
GO Biological Process	RNA catabolic process	22	2.533103e-44	1.5151410171363635e-41	2.003642	491	0.02822975	154	9.307317975974026e-12	1.416047	187	241	0.01817475	
GO Biological Process	rRNA metabolic process	23	4.610573e-44	2.6378491350869564e-41	2.030654	472	0.02713735	167	6.038579211916167e-11	1.388096	197	259	0.01914666	
GO Biological Process	rRNA processing	25	2.773734e-43	1.4599826282400001e-40	2.038556	459	0.02638993	173	8.628090077456647e-11	1.390445	192	252	0.01866071	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	28	4.433589e-37	2.0836284875357144e-34	2.558143	242	0.01391364	256	6.8144087109375e-7	1.453781	94	118	0.00913597	
GO Biological Process	protein targeting to ER	43	4.676845e-31	1.4312233338372092e-28	2.510258	208	0.01195883	247	3.156416299311741e-7	1.499719	83	101	0.008066868	
GO Biological Process	mitochondrial membrane organization	44	2.259942e-30	6.7587674495454545e-28	2.024345	323	0.01857069	257	7.224787662645914e-7	1.442306	98	124	0.009524735	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	45	3.824493e-30	1.1183667419333335e-27	2.198122	264	0.01517852	425	0.0004239560427529412	1.356606	84	113	0.008164059	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	49	4.637253e-29	1.2453390250408162e-26	2.552386	188	0.01080895	279	0.000002964505269928315	1.487738	75	92	0.007289338	
GO Biological Process	cotranslational protein targeting to membrane	50	5.484793e-29	1.44348782174e-26	2.492171	196	0.0112689	264	0.0000010097399146969696	1.489762	80	98	0.007775294	
GO Biological Process	viral gene expression	54	5.650045e-28	1.3768322621296297e-25	2.240235	234	0.01345369	220	2.341977810090909e-8	1.480085	103	127	0.01001069	
GO Biological Process	multi-organism metabolic process	55	9.757368e-28	2.3344946456727275e-25	2.057264	282	0.01621342	209	4.728061440095694e-9	1.464933	118	147	0.01146856	
GO Biological Process	protein localization to endoplasmic reticulum	62	1.388592e-26	2.9471745367741936e-24	2.145679	244	0.01402863	257	7.224787662645914e-7	1.442306	98	124	0.009524735	
GO Biological Process	viral transcription	63	1.850995e-26	3.86622908015873e-24	2.252302	218	0.01253378	217	9.339154541935484e-9	1.518107	94	113	0.00913597	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	65	2.867234e-26	5.80460495476923e-24	2.263733	214	0.0123038	243	2.3506798966666666e-7	1.494728	86	105	0.008358441	
GO Biological Process	regulation of DNA-templated transcription in response to stress	67	4.361155e-26	8.565438603731344e-24	2.024198	275	0.01581096	383	0.0001717494813994778	1.364885	89	119	0.008650015	
GO Biological Process	endoplasmic reticulum unfolded protein response	71	1.006399e-25	1.865240062112676e-23	2.120957	242	0.01391364	377	0.00013749800705039787	1.376723	86	114	0.008358441	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	74	2.722371e-25	4.8410378363513514e-23	2.408522	181	0.01040649	294	0.000006098261047278911	1.552577	57	67	0.005539897	
GO Biological Process	IRE1-mediated unfolded protein response	82	3.058805e-24	4.908635975e-22	2.737019	137	0.007876732	538	0.002122375730836431	1.447381	46	58	0.004470794	
GO Cellular Component	ribosomal subunit	35	5.251637e-37	2.592808210285714e-35	2.184264	332	0.01908814	51	9.616438588235294e-8	1.38105	140	185	0.01360676	
GO Cellular Component	large ribosomal subunit	36	9.100679e-36	4.368325920000001e-34	2.552413	234	0.01345369	86	0.00005682120111627907	1.380621	87	115	0.008455632	
GO Cellular Component	ficolin-1-rich granule lumen	39	7.590299e-25	3.363086326153846e-23	2.046691	254	0.01460358	71	0.000008756469633802818	1.398154	95	124	0.009233162	
GO Cellular Component	mitochondrial ribosome	44	2.471802e-22	9.707440581818184e-21	2.560432	141	0.00810671	163	0.01032696053006135	1.309676	61	85	0.005928662	
GO Cellular Component	spliceosomal snRNP complex	50	4.992545e-20	1.725423552e-18	2.563374	125	0.007186799	127	0.002486869568503937	1.412871	48	62	0.004665176	
GO Cellular Component	nuclear ubiquitin ligase complex	51	6.552782e-20	2.2202367247058824e-18	2.969941	97	0.005576956	109	0.0008359777056880734	1.551215	34	40	0.0033045	
GO Cellular Component	outer mitochondrial membrane protein complex	53	1.087907e-18	3.546987350943396e-17	4.686793	51	0.002932214	174	0.015959331310344826	1.703295	14	15	0.001360676	
GO Cellular Component	endopeptidase complex	54	6.829708e-18	2.18550656e-16	2.257414	142	0.008164204	118	0.0018067352949152544	1.40178	53	69	0.005151132	
GO Cellular Component	cytosolic large ribosomal subunit	59	1.284667e-16	3.762550128813559e-15	2.256233	131	0.007531766	102	0.00045942047999999997	1.46595	49	61	0.004762368	
GO Cellular Component	proteasome complex	60	1.694459e-16	4.88004192e-15	2.195064	138	0.007934226	123	0.0024560878829268293	1.395557	52	68	0.005053941	
GO Cellular Component	small nuclear ribonucleoprotein complex	62	2.377307e-16	6.6257846709677415e-15	2.237472	131	0.007531766	141	0.004071210893617021	1.375331	52	69	0.005053941	
GO Cellular Component	PcG protein complex	66	2.050248e-14	5.367922036363637e-13	2.017144	145	0.008336687	159	0.008899260860377359	1.428229	36	46	0.003498882	
GO Cellular Component	mitochondrial intermembrane space	77	2.755717e-13	6.184258410389609e-12	2.000592	135	0.007761743	115	0.0016831080626086956	1.380417	59	78	0.005734279	
GO Cellular Component	mitochondrial nucleoid	97	5.476956e-11	9.756886564948453e-10	2.228732	84	0.004829529	170	0.012133436611764708	1.433896	33	42	0.003207309	
GO Cellular Component	endoribonuclease complex	123	4.599564e-9	6.461826497560976e-8	2.308461	62	0.003564652	205	0.04635993038048781	1.447381	23	29	0.002235397	
GO Cellular Component	cytoplasmic exosome (RNase complex)	127	7.329247e-9	9.972392768503937e-8	4.117425	25	0.00143736	197	0.041196028751269036	1.684577	12	13	0.001166294	
GO Cellular Component	prespliceosome	138	4.256942e-8	5.330431721739129e-7	2.598967	43	0.002472259	185	0.027556770940540543	1.56425	18	21	0.001749441	
GO Cellular Component	mRNA cleavage factor complex	187	0.000002286466	0.00002112841309090909	2.226974	43	0.002472259	160	0.00939500316	1.642463	18	20	0.001749441	
GO Cellular Component	anaphase-promoting complex	197	0.000004445351	0.00003899272349238578	2.354727	36	0.002069798	147	0.006150114220408163	1.651153	19	21	0.001846632	
GO Cellular Component	proteasome accessory complex	200	0.000005321992	0.00004598201088	2.172793	42	0.002414765	190	0.03045214383157895	1.520799	20	24	0.001943824	
GO Molecular Function	structural constituent of ribosome	8	1.74158e-30	9.191188449999999e-28	2.107859	294	0.01690335	54	0.000009396819396296299	1.363086	121	162	0.01176013	
GO Molecular Function	unfolded protein binding	9	1.155319e-29	5.419729797777777e-27	2.452979	207	0.01190134	137	0.03367655186861314	1.274028	74	106	0.007192147	
GO Molecular Function	ribonucleoprotein complex binding	10	2.593426e-28	1.0949444572e-25	2.202385	246	0.01414362	70	0.0004363739777714286	1.364752	86	115	0.008358441	
GO Molecular Function	protein transporter activity	13	4.407202e-21	1.4313236033846154e-18	2.001808	225	0.01293624	61	0.00011117418849180326	1.425749	75	96	0.007289338	
GO Molecular Function	SUMO transferase activity	55	1.895231e-9	1.454848233090909e-7	2.541804	54	0.003104697	143	0.042506948377622374	1.632858	17	19	0.00165225	
GO Molecular Function	RNA polymerase III activity	171	0.000002209979	0.000054564510748538015	2.93499	26	0.001494854	133	0.029660854693233082	1.710899	15	16	0.001457868	
Human Phenotype	Increased serum lactate	1	2.078192e-27	1.3867775216e-23	2.307813	215	0.01236129	36	0.00002092884501388889	1.459967	80	100	0.007775294	
Human Phenotype	Abnormality of transition element cation homeostasis	2	1.49558e-20	4.99000267e-17	3.781697	72	0.004139596	118	0.019857134509322034	1.57324	25	29	0.002429779	
Human Phenotype	Abnormality of iron homeostasis	10	1.971964e-18	1.3158915772e-15	3.730598	65	0.003737136	135	0.03546939728	1.596839	21	24	0.002041015	
Human Phenotype	Abnormal CSF metabolite level	12	1.1208e-17	6.2325820000000004e-15	2.405055	123	0.00707181	79	0.003494186368734177	1.44838	50	63	0.004859559	
Human Phenotype	Increased CSF lactate	15	1.247807e-15	5.551077407333333e-13	2.375039	110	0.006324383	110	0.016112710729090908	1.415916	45	58	0.004373603	
Mouse Phenotype Single KO	thin ventricle myocardium compact layer	101	3.195944e-9	2.897550416633663e-7	2.232134	68	0.003909619	266	0.0459238352669173	1.824959	11	11	0.001069103	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	20	9.624639e-18	4.6010586739499994e-15	2.915119	88	0.005059507	353	0.027245599801699712	1.520799	25	30	0.002429779	
Mouse Phenotype	absent segment of posterior cerebral artery	33	2.114598e-15	6.126567114545454e-13	2.848943	78	0.004484563	417	0.04246883852517986	1.576101	19	22	0.001846632	
Mouse Phenotype	abnormal sublingual gland morphology	132	5.485679e-9	3.9733770393181815e-7	2.485745	53	0.003047203	329	0.02123297871155015	1.824959	12	12	0.001166294