# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	2	1.164964e-45	7.664880638e-42	2.169507	408	0.06621227	32	3.7383049451874995e-14	1.585284	243	555	0.04685692	
GO Biological Process	ribonucleoprotein complex biogenesis	10	1.128081e-36	1.4844417878999999e-33	2.073824	362	0.05874716	36	1.8231662910000002e-13	1.634902	205	454	0.0395295	
GO Biological Process	ncRNA processing	15	1.85679e-32	1.628899974e-29	2.177859	286	0.0464135	55	1.7450118796909093e-10	1.600061	175	396	0.0337447	
GO Biological Process	translation	21	1.90424e-27	1.1932330552380952e-24	2.04735	277	0.04495294	60	1.0696935747833334e-9	1.596227	164	372	0.0316236	
GO Biological Process	rRNA processing	22	5.474847e-27	3.2747050760454547e-24	2.406933	192	0.03115871	116	3.421805102586207e-7	1.623572	113	252	0.02178943	
GO Biological Process	ribosome biogenesis	23	2.614412e-26	1.4957846742608695e-23	2.136211	240	0.03894839	115	3.396708640521739e-7	1.546929	138	323	0.0266101	
GO Biological Process	rRNA metabolic process	24	3.468722e-26	1.901871366583333e-23	2.355855	194	0.03148328	123	4.7232401078048784e-7	1.607651	115	259	0.02217509	
GO Biological Process	protein targeting to ER	26	1.248603e-23	6.319371875769231e-21	3.338366	98	0.01590393	119	3.85703449e-7	2.007522	56	101	0.0107983	
GO Biological Process	protein localization to endoplasmic reticulum	29	4.806628e-23	2.181048891448276e-20	2.904113	117	0.01898734	151	0.000003110339671125828	1.839554	63	124	0.01214809	
GO Biological Process	cotranslational protein targeting to membrane	32	1.682579e-22	6.9190803315625e-20	3.337778	93	0.0150925	148	0.0000025446918656081082	1.958139	53	98	0.01021982	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	35	1.177741e-21	4.427969662571428e-19	3.372282	88	0.01428108	158	0.000004727266643987342	1.967777	50	92	0.009641342	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	37	3.236273e-21	1.150976119108108e-18	3.015682	101	0.01639078	112	2.621176457321429e-7	2.000011	58	105	0.01118396	
GO Biological Process	nucleic acid phosphodiester bond hydrolysis	38	3.269067e-21	1.1320434908684212e-18	2.043704	212	0.03440441	206	0.00027897495211165046	1.450898	111	277	0.02140378	
GO Biological Process	multi-organism metabolic process	39	1.009256e-20	3.405333257435897e-18	2.594563	126	0.02044791	102	1.8728353235294118e-7	1.847301	75	147	0.01446201	
GO Biological Process	viral gene expression	40	1.321016e-20	4.345812386e-18	2.864418	106	0.01720221	107	2.193112144953271e-7	1.910138	67	127	0.0129194	
GO Biological Process	viral transcription	45	4.809352e-20	1.406361399288889e-17	2.916237	100	0.0162285	87	4.149791989425287e-8	2.018626	63	113	0.01214809	
GO Biological Process	tRNA metabolic process	48	1.513219e-19	4.148426837708334e-17	2.292757	150	0.02434275	152	0.000003818505457434211	1.666676	87	189	0.01677594	
GO Biological Process	mRNA catabolic process	49	2.603024e-19	6.990447513469387e-17	2.191834	163	0.02645245	159	0.0000060148969666037736	1.61487	95	213	0.01831855	
GO Biological Process	nuclear-transcribed mRNA catabolic process	54	8.118002e-18	1.978236820703704e-15	2.200814	148	0.02401818	156	0.000004575620487179487	1.645777	90	198	0.01735442	
GO Biological Process	ribonucleoprotein complex export from nucleus	57	2.233453e-17	5.156141759122806e-15	2.623299	102	0.01655307	140	0.0000017847326117142858	1.853803	64	125	0.01234092	
GO Cellular Component	intracellular ribonucleoprotein complex	10	6.978871e-68	1.2059489088e-65	2.10143	646	0.1048361	19	4.524938981052632e-21	1.57016	353	814	0.06806788	
GO Cellular Component	ribonucleoprotein complex	11	1.09985e-67	1.7277643636363636e-65	2.098754	646	0.1048361	20	4.440241152e-21	1.568826	354	817	0.0682607	
GO Cellular Component	ribosomal subunit	31	2.92647e-21	1.631271019354839e-19	2.525566	136	0.02207076	48	0.0000272067804	1.604855	82	185	0.0158118	
GO Cellular Component	spliceosomal complex	32	3.878588e-20	2.09443752e-18	2.231658	164	0.02661474	44	0.000008241727418181818	1.635159	84	186	0.01619745	
GO Cellular Component	ribosome	35	7.834026e-19	3.867770550857143e-17	2.153485	165	0.02677702	45	0.00001298686464	1.549541	101	236	0.01947551	
GO Cellular Component	catalytic step 2 spliceosome	36	9.590222e-18	4.603306559999999e-16	2.771892	95	0.01541707	53	0.0005749398339622642	1.734923	46	96	0.008870035	
GO Cellular Component	large ribosomal subunit	40	4.063536e-15	1.7554475519999998e-13	2.647807	86	0.01395651	76	0.004146845305263158	1.574222	50	115	0.009641342	
GO Cellular Component	methyltransferase complex	46	3.352956e-12	1.2595452104347827e-10	2.355765	84	0.01363194	55	0.000629999266909091	1.750673	44	91	0.008484381	
GO Cellular Component	nucleosome	49	7.863626e-12	2.77313178122449e-10	2.778906	60	0.009737098	88	0.01074816589090909	1.551733	45	105	0.008677208	
GO Cellular Component	DNA packaging complex	50	1.228859e-11	4.246936704e-10	2.557048	68	0.01103538	75	0.0040396170240000005	1.58406	49	112	0.009448515	
GO Cellular Component	nuclear chromosome, telomeric region	56	1.286323e-10	3.969225257142857e-9	2.160601	86	0.01395651	90	0.012447454080000002	1.481199	54	132	0.01041265	
GO Cellular Component	outer mitochondrial membrane protein complex	57	1.720858e-10	5.216916884210526e-9	5.706648	22	0.003570269	82	0.006377942634146342	2.655187	11	15	0.002121095	
GO Cellular Component	mitochondrial nucleoid	58	2.873039e-10	8.559674813793102e-9	3.145434	42	0.006815969	89	0.011448221339325841	1.896562	22	42	0.004242191	
GO Cellular Component	mitochondrial outer membrane translocase complex	74	5.455228e-9	1.2738694572972972e-7	5.827919	18	0.00292113	99	0.04192950109090909	2.633243	8	11	0.001542615	
GO Cellular Component	small ribosomal subunit	84	2.887447e-8	5.939890971428571e-7	2.378139	52	0.008438819	91	0.013508134892307693	1.659492	33	72	0.006363286	
GO Cellular Component	histone methyltransferase complex	85	3.020051e-8	6.139586032941177e-7	2.139452	65	0.01054852	79	0.0059474172759493675	1.731644	33	69	0.006363286	
GO Cellular Component	transcription factor TFIID complex	87	5.702664e-8	0.0000011326670565517241	2.757174	38	0.006166829	98	0.04223547624489796	1.862079	18	35	0.003470883	
GO Cellular Component	aminoacyl-tRNA synthetase multienzyme complex	92	1.179892e-7	0.0000022161449739130433	4.492378	19	0.003083414	92	0.016386834365217394	2.715532	9	12	0.001735442	
GO Cellular Component	peptidase complex	99	6.235304e-7	0.000010883439709090908	2.007476	61	0.009899383	78	0.005629245784615384	1.645777	40	88	0.007713074	
GO Cellular Component	endopeptidase complex	100	6.557726e-7	0.000011331750528	2.198729	49	0.007951964	94	0.028013747744680854	1.626696	31	69	0.005977632	
GO Molecular Function	ribonucleoprotein complex binding	7	2.671484e-21	1.6112864925714285e-18	2.830278	112	0.01817592	53	0.014528810128301886	1.574222	50	115	0.009641342	
GO Molecular Function	structural constituent of ribosome	8	2.623144e-17	1.384364246e-14	2.408208	119	0.01931191	23	0.00011573507937391303	1.653904	74	162	0.01426919	
GO Molecular Function	rRNA binding	10	4.169558e-13	1.7603873876e-10	3.684764	45	0.007302824	48	0.0059565084275	1.8707	31	60	0.005977632	
GO Molecular Function	tRNA binding	25	1.086298e-8	0.0000018345400624	2.478956	51	0.008276534	22	0.00006142284583636363	2.228129	32	52	0.006170459	
GO Molecular Function	ligase activity, forming carbon-nitrogen bonds	26	1.387269e-8	0.00000225271143	2.233875	62	0.01006167	55	0.01602128481090909	1.84327	28	55	0.005399152	
GO Molecular Function	proteasome binding	57	0.000002744606	0.00020329344792982459	3.478847	20	0.003245699	79	0.04662622884050633	2.715532	9	12	0.001735442	
GO Molecular Function	aminoacyl-tRNA ligase activity	66	0.000006943471	0.0004441717357878788	2.273432	37	0.006004544	76	0.03893897269473684	1.850585	23	45	0.004435017	
GO Molecular Function	thyroid hormone receptor binding	169	0.0003773404	0.009426811649704143	2.212532	24	0.003894839	62	0.01686883075806452	2.198288	17	28	0.003278056	
Human Phenotype	Abnormal CNS myelination	1	3.164252e-22	2.1115053596e-18	2.684855	128	0.02077248	26	0.00001351641045423077	1.824838	63	125	0.01214809	
Human Phenotype	Increased serum lactate	2	2.688399e-18	8.9698432635e-15	2.848018	94	0.01525479	54	0.000535379856537037	1.774148	49	100	0.009448515	
Human Phenotype	Exercise intolerance	4	9.559234e-18	1.59471921205e-14	3.439202	69	0.01119766	61	0.0007653798633934426	1.913804	37	70	0.007134593	
Human Phenotype	Lactic acidosis	5	2.820269e-17	3.7639310073999996e-14	2.346864	125	0.02028562	40	0.00009451972518250001	1.717855	65	137	0.01253374	
Human Phenotype	Leukodystrophy	8	1.610406e-14	1.34327990475e-11	3.236898	60	0.009737098	60	0.0006906757414333333	2.100012	29	50	0.005591978	
Human Phenotype	Abnormality of the mitochondrion	9	6.595532e-14	4.890220559555555e-11	2.759208	73	0.0118468	64	0.00111983887890625	1.886849	37	71	0.007134593	
Human Phenotype	Abnormality of mitochondrial metabolism	10	1.774509e-13	1.1841298557e-10	2.746511	71	0.01152223	68	0.0013347589744117647	1.889066	36	69	0.006941766	
Human Phenotype	Increased CSF lactate	11	1.845191e-12	1.1193599584545454e-9	3.169088	52	0.008438819	100	0.016155766745	1.810355	29	58	0.005591978	
Human Phenotype	Abnormal CSF metabolite level	12	6.816344e-12	3.7904552926666666e-9	2.980345	54	0.008763389	123	0.03018988352113821	1.724147	30	63	0.005784805	
Human Phenotype	Decreased liver function	22	9.680126e-10	2.9361582180909094e-7	2.004316	93	0.0150925	41	0.00009706176343658538	1.846562	51	100	0.009834169	
Human Phenotype	Hepatic failure	38	2.328822e-8	0.000004089534001578947	2.155082	65	0.01054852	31	0.0000261140751483871	2.160746	37	62	0.007134593	
Human Phenotype	Acute encephalopathy	47	5.159085e-8	0.000007324803022340426	3.231845	30	0.004868549	83	0.006109571274819278	2.413806	16	24	0.003085229	
Human Phenotype	Acute necrotizing encephalopathy	52	6.744066e-8	0.000008654452388076924	3.780512	24	0.003894839	85	0.007641601651176472	2.534497	14	20	0.002699576	
Human Phenotype	Abnormal mitochondria in muscle tissue	59	2.168079e-7	0.00002452134096101695	3.540457	24	0.003894839	134	0.04238819076119403	2.20391	14	23	0.002699576	
Human Phenotype	Cerebral edema	125	0.00002091071	0.00111629734264	2.212183	35	0.005679974	84	0.00708903215702381	2.219145	19	31	0.00366371