# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	20	5.876927e-30	3.86672411965e-27	2.548501	194	0.01759797	555	0.013062744878738737	1.374164	65	113	0.00826972	
GO Biological Process	regulation of DNA-templated transcription in response to stress	26	8.889408e-27	4.499066148923077e-24	2.345887	202	0.01832366	499	0.007251394848096192	1.385179	69	119	0.008778626	
GO Biological Process	macromolecular complex disassembly	27	3.020393e-26	1.4720500550740742e-23	2.049155	267	0.02421988	149	5.353460956375839e-8	1.525914	122	191	0.01552163	
GO Biological Process	IRE1-mediated unfolded protein response	28	6.649915e-26	3.1252225530357143e-23	3.372689	107	0.009706096	566	0.014191821081095407	1.523973	37	58	0.004707379	
GO Biological Process	protein complex disassembly	29	5.069397e-25	2.300282590448276e-22	2.140188	229	0.02077286	188	0.0000018904086410106384	1.517497	101	159	0.01284987	
GO Biological Process	response to topologically incorrect protein	30	1.07778e-24	4.72750234e-22	2.060255	247	0.02240566	212	0.00000843441001981132	1.459902	110	180	0.01399491	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	35	3.521591e-23	1.3240175991142856e-20	2.508607	152	0.0137881	608	0.022858265154605262	1.353023	64	113	0.008142494	
GO Biological Process	regulation of hematopoietic stem cell differentiation	39	5.135379e-23	1.7327295451538463e-20	2.613615	140	0.01269956	615	0.023921671211382115	1.368417	59	103	0.007506361	
GO Biological Process	endoplasmic reticulum unfolded protein response	41	7.11571e-23	2.283795802195122e-20	2.350719	170	0.0154209	268	0.00006925463858208956	1.529754	73	114	0.009287532	
GO Biological Process	cellular response to topologically incorrect protein	47	3.628757e-22	1.0159747524042552e-19	2.169638	195	0.01768868	270	0.00007139751735555555	1.478044	86	139	0.01094148	
GO Biological Process	mitochondrial translational termination	61	8.307863e-21	1.7921831019180327e-18	2.764184	114	0.01034107	327	0.0002812575283639144	1.565162	57	87	0.007251908	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	62	8.484242e-21	1.8007119431935483e-18	2.418314	145	0.01315312	166	2.74390278933735e-7	1.63986	81	118	0.01030534	
GO Biological Process	regulation of PERK-mediated unfolded protein response	63	1.179136e-20	2.4628969244444445e-18	5.459533	49	0.004444848	704	0.045867601059659084	2.150038	9	10	0.001145038	
GO Biological Process	translational elongation	64	1.209629e-20	2.48711062671875e-18	2.416897	144	0.01306241	217	0.000011482676809216589	1.578401	74	112	0.009414758	
GO Biological Process	mitochondrial translational elongation	65	1.973005e-20	3.994272737692307e-18	2.760713	112	0.01015965	323	0.0002651229283869969	1.573884	56	85	0.007124682	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	67	2.253126e-20	4.425206721492538e-18	2.510774	132	0.01197388	661	0.03351436047503783	1.408857	46	78	0.005852417	
GO Biological Process	mitochondrial translation	71	6.128869e-20	1.1359124953661971e-17	2.460083	134	0.0121553	255	0.00003662116673490196	1.562852	70	107	0.008905852	
GO Biological Process	cellular protein complex disassembly	78	2.197703e-19	3.707637663717949e-17	2.150864	172	0.01560232	256	0.0000386199995640625	1.516782	80	126	0.01017812	
GO Biological Process	telomere organization	83	7.293894e-19	1.1563897728433736e-16	2.257789	150	0.01360668	261	0.00004824345017356322	1.531366	75	117	0.009541985	
GO Biological Process	cellular response to unfolded protein	84	9.113923e-19	1.4277394375833333e-16	2.118196	172	0.01560232	320	0.00025106681152499996	1.480743	75	121	0.009541985	
GO Cellular Component	endopeptidase complex	36	2.308477e-22	1.1080689599999999e-20	2.884403	115	0.01043179	76	0.00020978076884210526	1.627243	47	69	0.005979644	
GO Cellular Component	PRC1 complex	37	7.850614e-22	3.666448916756757e-20	8.040343	38	0.003447025	177	0.04086926969491525	1.990776	10	12	0.001272265	
GO Cellular Component	proteasome complex	39	1.867612e-21	8.274957784615385e-20	2.835841	113	0.01025036	79	0.00033231124253164555	1.616042	46	68	0.005852417	
GO Cellular Component	ribosomal subunit	40	5.831193e-21	2.519075376e-19	2.086404	201	0.01823295	46	4.915280973913044e-8	1.523751	118	185	0.01501272	
GO Cellular Component	catalytic step 2 spliceosome	41	9.809547e-21	4.134365174634146e-19	2.397466	147	0.01333454	47	8.614524868085107e-8	1.717044	69	96	0.008778626	
GO Cellular Component	peptidase complex	43	2.079142e-20	8.355249711627907e-19	2.483343	135	0.01224601	70	0.00010829371062857142	1.574523	58	88	0.007379135	
GO Cellular Component	mitochondrial ribosome	44	6.195721e-20	2.433228610909091e-18	2.893682	101	0.009161829	103	0.0018142909514563107	1.489569	53	85	0.006743003	
GO Cellular Component	PcG protein complex	49	4.031433e-18	1.4216971885714287e-16	2.524073	115	0.01043179	65	0.00006525712246153847	1.817665	35	46	0.004452926	
GO Cellular Component	large ribosomal subunit	51	1.245738e-16	4.220853458823529e-15	2.254455	131	0.01188316	77	0.0002920872062337662	1.474905	71	115	0.009033079	
GO Cellular Component	nuclear ubiquitin ligase complex	52	1.631685e-16	5.422214769230769e-15	3.284886	68	0.00616836	101	0.0014411425900990099	1.731975	29	40	0.003689567	
GO Cellular Component	spliceosomal snRNP complex	54	2.298021e-15	7.3536672e-14	2.717795	84	0.007619739	94	0.0006186258382978725	1.618308	42	62	0.005343511	
GO Cellular Component	mitochondrial large ribosomal subunit	57	6.290145e-15	1.9069071157894736e-13	3.133171	65	0.005896226	185	0.04592726036756757	1.452095	31	51	0.00394402	
GO Cellular Component	small nuclear ribonucleoprotein complex	61	1.365432e-13	3.867977862295081e-12	2.425293	90	0.008164006	97	0.0013350939513402061	1.557999	45	69	0.005725191	
GO Cellular Component	methyltransferase complex	64	8.526949e-13	2.30227623e-11	2.006528	128	0.01161103	67	0.00007630149062686567	1.57512	60	91	0.007633588	
GO Cellular Component	U5 snRNP	69	2.190534e-11	5.485859060869565e-10	3.635294	39	0.003537736	137	0.010063873261313869	1.845992	17	22	0.00216285	
GO Cellular Component	methylosome	109	3.119693e-7	0.000004945715141284404	4.21081	19	0.001723512	177	0.04086926969491525	1.990776	10	12	0.001272265	
GO Cellular Component	U2 snRNP	116	6.612329e-7	0.000009850090096551726	3.059293	27	0.002449202	189	0.04600213028571429	1.760265	14	19	0.00178117	
GO Cellular Component	mitochondrial nucleoid	119	9.323109e-7	0.00001353809441344538	2.134932	51	0.00462627	57	0.000007477977600000001	1.933897	34	42	0.0043257	
GO Cellular Component	precatalytic spliceosome	120	9.74227e-7	0.0000140288688	2.648391	33	0.002993469	183	0.04613314308196721	1.621061	19	28	0.002417303	
GO Cellular Component	ESCRT complex	132	0.000001859905	0.00002434784727272727	2.450476	36	0.003265602	100	0.0014498279424000002	1.877017	22	28	0.002798982	
GO Molecular Function	ribonucleoprotein complex binding	7	6.834963e-22	4.122459112285714e-19	2.330652	165	0.01496734	46	0.00020974703256521738	1.516452	73	115	0.009287532	
GO Molecular Function	unfolded protein binding	9	5.529162e-19	2.5937913293333337e-16	2.430536	130	0.01179245	42	0.00011273805552380951	1.555059	69	106	0.008778626	
GO Molecular Function	ribonuclease activity	19	1.43544e-12	3.1896987789473685e-10	2.009154	125	0.0113389	80	0.0029690170054999998	1.471968	61	99	0.007760814	
GO Molecular Function	rRNA binding	21	4.648395e-12	9.345487471428572e-10	2.791962	61	0.005533382	82	0.00462188261097561	1.592621	40	60	0.005089059	
GO Molecular Function	endoribonuclease activity	49	2.925839e-8	0.00000252099842	2.06536	71	0.006440493	91	0.01004656449010989	1.578401	37	56	0.004707379	
GO Molecular Function	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	64	9.276267e-8	0.0000061194373865625	2.195738	57	0.005170537	105	0.03393064582857143	1.634532	26	38	0.003307888	
GO Molecular Function	mismatch repair complex binding	207	0.00007419821	0.0015133567276328502	3.329668	15	0.001360668	108	0.0367760671962963	2.388931	8	8	0.001017812	
Human Phenotype	Increased serum lactate	5	8.247192e-20	1.1006702443200001e-16	2.387902	141	0.01279028	36	0.000006608846519444444	1.648363	69	100	0.008778626	
Human Phenotype	Increased CSF lactate	7	1.84923e-19	1.7628445414285716e-16	3.065885	90	0.008164006	74	0.0007441037050810812	1.688727	41	58	0.005216285	
Human Phenotype	Abnormal CSF metabolite level	8	3.38785e-19	2.82589038125e-16	2.93075	95	0.008617562	72	0.0005968807578055555	1.66846	44	63	0.005597964	
Human Phenotype	Glycosuria	24	7.57502e-13	2.1061711858333332e-10	2.862033	63	0.005714804	165	0.03417206092969697	1.729916	21	29	0.002671756	
Human Phenotype	Progressive external ophthalmoplegia	33	1.384521e-11	2.7996692827272726e-9	3.945718	36	0.003265602	137	0.023097347445255476	2.070407	13	15	0.001653944	
Mouse Phenotype Single KO	expanded mesangial matrix	48	1.179854e-10	2.2508173079166665e-8	2.086813	94	0.008526851	68	0.0031203070011764705	1.84289	27	35	0.003435115	
Mouse Phenotype Single KO	increased embryonic epiblast cell apoptosis	181	0.00001360661	0.0006883741865745856	2.484873	29	0.002630624	124	0.02906306998951613	2.388931	9	9	0.001145038	
Mouse Phenotype	decreased platelet dense granule number	376	0.0007234327	0.018395585225265958	2.009906	27	0.002449202	153	0.014068542823529413	2.090315	14	16	0.00178117