# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA processing	17	5.90295e-25	4.569230532352942e-22	2.20205	213	0.02850642	179	0.00007499034746927374	1.46052	115	252	0.01960116	
GO Biological Process	rRNA metabolic process	19	5.098667e-24	3.5312294238421054e-21	2.153129	215	0.02877409	192	0.00010589136397395833	1.44576	117	259	0.01994205	
GO Biological Process	mRNA catabolic process	24	1.99779e-20	1.0953716087499999e-17	2.10697	190	0.02542827	258	0.001354534926007752	1.427428	95	213	0.01619226	
GO Biological Process	nuclear-transcribed mRNA catabolic process	25	2.259635e-20	1.1893814786e-17	2.1706	177	0.02368844	267	0.0016199798476779026	1.438583	89	198	0.01516959	
GO Biological Process	cellular response to epidermal growth factor stimulus	36	2.953748e-17	1.0796769425555556e-14	2.795005	91	0.0121788	465	0.017086109702365588	1.852888	22	38	0.003749787	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	41	3.864993e-16	1.2404742167560975e-13	2.509847	102	0.01365096	411	0.010422004840875911	1.491732	55	118	0.009374467	
GO Biological Process	cotranslational protein targeting to membrane	51	5.104075e-15	1.3169514299019607e-12	2.604606	88	0.0117773	583	0.03590700618524871	1.469591	45	98	0.007670019	
GO Biological Process	translational elongation	59	2.602851e-14	5.8052400523728815e-12	2.401982	97	0.0129818	450	0.015321058790666666	1.48592	52	112	0.008863133	
GO Biological Process	chylomicron assembly	75	6.951637e-13	1.2196878837733334e-10	5.678275	28	0.003747323	361	0.007409209578947369	2.880399	9	10	0.001534004	
GO Biological Process	mitochondrial translation	86	1.426192e-12	2.1822395962790695e-10	2.356495	87	0.01164347	622	0.043880589535369774	1.435713	48	107	0.008181353	
GO Biological Process	translational termination	93	2.370928e-12	3.354735650752688e-10	2.418117	81	0.01084047	481	0.01948255061060291	1.515999	45	95	0.007670019	
GO Biological Process	ribonucleoprotein complex export from nucleus	94	2.567562e-12	3.5943136551063834e-10	2.163379	102	0.01365096	385	0.009007803755324674	1.485006	58	125	0.009885802	
GO Biological Process	protein-lipid complex assembly	97	3.329305e-12	4.5165282984536084e-10	3.460323	45	0.006022484	463	0.017026890522894172	1.986482	18	29	0.003068007	
GO Biological Process	ribonucleoprotein complex localization	98	4.048042e-12	5.43552904877551e-10	2.127797	104	0.01391863	372	0.007961789277419355	1.48682	59	127	0.01005625	
GO Biological Process	RNA phosphodiester bond hydrolysis	108	7.279423e-12	8.86943770898148e-10	2.049301	111	0.01485546	390	0.009272205925384617	1.467872	61	133	0.01039714	
GO Biological Process	plasma lipoprotein particle assembly	121	1.998215e-11	2.1731000979338843e-9	3.64481	39	0.005219486	564	0.03216115595744681	1.969503	16	26	0.002727118	
GO Biological Process	rRNA 3'-end processing	130	4.20949e-11	4.2609753007692305e-9	8.654236	17	0.002275161	493	0.021490010945030426	2.618544	9	11	0.001534004	
GO Biological Process	viral gene expression	131	4.298705e-11	4.3180655797709925e-9	2.117088	95	0.01271413	573	0.03499481035602094	1.411219	56	127	0.009544912	
GO Biological Process	RNA 3'-end processing	132	4.402092e-11	4.3884188354545456e-9	2.21115	86	0.01150964	456	0.015937176560526314	1.495534	50	107	0.008522243	
GO Biological Process	liver regeneration	134	4.711487e-11	4.6267505547014925e-9	2.707029	58	0.007762313	427	0.012678249648711944	1.920266	21	35	0.003579342	
GO Cellular Component	large ribosomal subunit	31	2.791676e-18	1.5561342348387097e-16	2.666011	105	0.01405246	52	0.00044595260307692304	1.614137	58	115	0.009885802	
GO Cellular Component	ribosomal subunit	32	9.227317e-18	4.982751179999999e-16	2.220612	145	0.01940578	59	0.0018886410305084748	1.435874	83	185	0.01414692	
GO Cellular Component	mitochondrial large ribosomal subunit	42	1.040345e-12	4.280276571428572e-11	3.413613	48	0.006423983	91	0.048719459868131865	1.631598	26	51	0.004431566	
GO Cellular Component	cytosolic large ribosomal subunit	76	5.787757e-8	0.000001315953170526316	2.245113	56	0.007494647	90	0.0491417664	1.573988	30	61	0.005113346	
GO Cellular Component	Flemming body	166	0.0001611476	0.001677488269879518	2.089461	31	0.004148822	78	0.01816653489230769	2.087246	15	23	0.002556673	
GO Molecular Function	structural constituent of ribosome	10	1.129305e-14	4.7679257099999995e-12	2.1362	128	0.01713062	62	0.009927127312903227	1.442175	73	162	0.01244247	
GO Molecular Function	ribonucleoprotein complex binding	13	1.473674e-11	4.786039713846154e-9	2.104831	101	0.01351713	80	0.030603541702499997	1.474987	53	115	0.009033578	
GO Molecular Function	ribonuclease activity	18	4.200132e-11	9.851642946666668e-9	2.157978	91	0.0121788	67	0.015405057158208956	1.55173	48	99	0.008181353	
GO Molecular Function	exonuclease activity	40	3.420271e-8	0.0000036100960404999997	2.055205	71	0.009502141	76	0.02714563231842105	1.600222	38	76	0.006476905	
GO Molecular Function	acetyl-CoA C-acyltransferase activity	295	0.0008772153	0.012554586429152543	3.436677	10	0.00133833	90	0.04357639255777778	3.200443	6	6	0.001022669	
Human Phenotype	Increased serum lactate	1	2.484373e-15	1.6578221029e-11	2.473631	99	0.01324946	65	0.000025377388201538458	1.792248	56	100	0.009544912	
Human Phenotype	Abnormality of mitochondrial metabolism	6	1.252718e-14	1.3932312023333333e-11	2.647804	83	0.01110814	138	0.0016434762457246375	1.762563	38	69	0.006476905	
Human Phenotype	Abnormality of the mitochondrion	8	4.18801e-14	3.49332384125e-11	2.587167	83	0.01110814	162	0.0032317985704320984	1.712913	38	71	0.006476905	
Human Phenotype	Lactic acidosis	9	9.83582e-14	7.292714095555556e-11	2.043792	132	0.01766595	102	0.00033755808824509803	1.588541	68	137	0.01159025	
Human Phenotype	Abnormal CSF metabolite level	11	2.287297e-13	1.3875575346363638e-10	2.91298	64	0.00856531	253	0.024782498630830038	1.625622	32	63	0.005454236	
Human Phenotype	Increased CSF lactate	16	2.833128e-12	1.1815914465e-9	2.915035	58	0.007762313	316	0.04611744087341773	1.600222	29	58	0.004942901	
Human Phenotype	Abnormality of lipid metabolism	21	1.081201e-11	3.4356448919047616e-9	2.02082	113	0.01512313	224	0.016264415696875	1.46687	55	120	0.009374467	
Human Phenotype	Hepatic failure	39	3.478157e-9	5.951215810512821e-7	2.105358	77	0.01030514	197	0.008830966904568529	1.703462	33	62	0.00562468	
Human Phenotype	Ectropion	118	0.000004902348	0.0002772319339322034	2.410521	34	0.004550321	206	0.011352084924757281	2.092597	17	26	0.002897563	
Human Phenotype	Acute encephalopathy	122	0.000007013546	0.0003836179709672131	2.576393	29	0.003881156	288	0.03606844546527778	2.000277	15	24	0.002556673	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	276	0.0002601003	0.006288584427173912	2.563684	19	0.002542827	317	0.0475125178170347	2.200305	11	16	0.001874893	
Human Phenotype	Thickened ribs	332	0.000513322	0.010317462969879518	3.20897	12	0.001605996	251	0.02469579198924303	3.200443	6	6	0.001022669	
Human Phenotype	Ependymoma	352	0.0005691037	0.010788718721875	3.640819	10	0.00133833	291	0.038672993134020624	2.800388	7	8	0.001193114	
Human Phenotype	Non-medullary thyroid carcinoma	437	0.001442617	0.022028794601830666	2.334037	17	0.002275161	312	0.045579092375	2.560355	8	10	0.001363559	
Mouse Phenotype Single KO	prenatal lethality prior to heart atrial septation	44	1.649538e-9	3.4329135150000003e-7	2.19454	73	0.009769807	111	0.001219326321081081	1.876122	34	58	0.005795125	
Mouse Phenotype Single KO	spontaneous skin ulceration	71	7.284144e-8	0.000009394493888450706	2.578358	42	0.005620985	152	0.010309366279605263	2.176301	17	25	0.002897563	
Mouse Phenotype	pale lung	35	1.210836e-11	3.307657998857143e-9	5.662795	25	0.003345824	374	0.023746919010962566	3.200443	6	6	0.001022669	
Mouse Phenotype	spontaneous skin ulceration	61	1.246147e-9	1.953182207704918e-7	2.473333	58	0.007762313	417	0.03525977574100719	1.760244	22	40	0.003749787	
Mouse Phenotype	increased renal carcinoma incidence	66	1.620139e-9	2.3469922695454546e-7	5.921766	19	0.002542827	460	0.044293972167391296	2.560355	8	10	0.001363559	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	67	1.649538e-9	2.3539153459701495e-7	2.19454	73	0.009769807	172	0.0008216078588372093	1.876122	34	58	0.005795125	
Mouse Phenotype	dry eyes	114	6.214098e-8	0.0000052116658752631575	2.706532	39	0.005219486	467	0.0462096437601713	2.200305	11	16	0.001874893	
Mouse Phenotype	increased liver adenoma incidence	191	0.000001345248	0.0000673398750157068	2.563876	34	0.004550321	230	0.0030533107540434783	2.171729	19	28	0.003238452	
Mouse Phenotype	abnormal primitive streak elongation	225	0.000004482317	0.00019046859038666667	2.014593	51	0.006825482	326	0.012203757183128834	2.24031	14	20	0.002386228