# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process nucleosome assembly 1 1.222383e-50 1.6085337897000002e-46 5.851836 117 0.05165563 18 1.5770593624444447e-8 2.697497 49 142 0.02039967 GO Biological Process nucleosome organization 2 1.102622e-47 7.254701449e-44 5.166647 123 0.05430464 33 4.034677002424243e-7 2.377171 52 171 0.02164863 GO Biological Process chromatin assembly 3 7.058913e-46 3.0962745389000005e-42 5.226078 117 0.05165563 37 5.192374245135136e-7 2.424333 49 158 0.02039967 GO Biological Process chromatin assembly or disassembly 4 2.765122e-44 9.096560099500001e-41 4.815778 122 0.05386313 53 0.000003401174453207547 2.23977 51 178 0.02123231 GO Biological Process negative regulation of gene expression, epigenetic 5 1.491749e-41 3.9259850182e-38 6.848628 84 0.03708609 8 4.8476686831249994e-9 3.017179 44 114 0.01831807 GO Biological Process DNA replication-dependent nucleosome assembly 6 3.713284e-41 8.143850692666667e-38 37.57432 34 0.01501104 73 0.00006987789520547944 3.908618 16 32 0.006661116 GO Biological Process regulation of gene expression, epigenetic 7 5.263241e-41 9.89414118842857e-38 3.97784 138 0.06092715 44 9.296020034545454e-7 2.080393 66 248 0.0274771 GO Biological Process regulation of gene silencing 8 5.120335e-40 8.422311033125e-37 5.441794 98 0.04326711 81 0.0003032537037901234 2.207922 37 131 0.01540383 GO Biological Process gene silencing 9 1.050293e-39 1.5356450652222222e-36 4.819915 109 0.04812362 23 1.5748862839130433e-7 2.3886 55 180 0.02289759 GO Biological Process DNA packaging 10 1.630184e-38 2.1451591256e-35 4.226679 121 0.05342163 61 0.000022600431495081965 2.081977 53 199 0.02206495 GO Biological Process DNA conformation change 11 1.76897e-38 2.1161705663636364e-35 3.496089 151 0.06666667 96 0.0006784291049687501 1.752619 63 281 0.02622814 GO Biological Process DNA replication-independent nucleosome assembly 12 2.191317e-38 2.4029617002499998e-35 9.577059 61 0.02693157 176 0.015716578753977275 2.507415 17 53 0.007077435 GO Biological Process DNA replication-independent nucleosome organization 13 5.570366e-38 5.638495861076924e-35 9.41552 61 0.02693157 191 0.01864329227591623 2.460982 17 54 0.007077435 GO Biological Process protein-DNA complex assembly 14 3.953104e-37 3.7156353954285716e-34 3.763301 133 0.05871965 51 0.000003331685926862745 2.106013 59 219 0.02456286 GO Biological Process protein-DNA complex subunit organization 15 1.075724e-36 9.436968077333334e-34 3.532428 142 0.06269316 59 0.000014560580702372882 1.969943 63 250 0.02622814 GO Biological Process chromatin silencing at rDNA 16 1.718546e-34 1.413396675875e-31 18.42403 38 0.01677704 48 0.0000026933728800208334 4.125763 19 36 0.007910075 GO Biological Process chromatin silencing 18 6.862162e-32 5.016621653222223e-29 7.420323 60 0.02649007 32 4.0443516213437496e-7 2.901242 36 97 0.01498751 GO Biological Process negative regulation of megakaryocyte differentiation 22 3.117895e-28 1.8649263775e-25 48.20617 21 0.009271523 165 0.011793582284242423 3.908618 9 18 0.003746878 GO Biological Process chromosome organization 27 4.616142e-26 2.249770836222222e-23 2.243774 206 0.09094923 211 0.02559713625971564 1.379512 102 578 0.04246461 GO Biological Process protein heterotetramerization 28 4.010925e-25 1.8849915026785717e-22 8.588282 42 0.01854305 146 0.005338154748013699 2.842631 16 44 0.006661116 GO Cellular Component nucleosome 8 1.352734e-41 2.92190544e-39 8.820111 70 0.03090508 1 1.874664e-13 3.573593 48 105 0.01998335 GO Cellular Component DNA packaging complex 16 5.026745e-36 5.4288846e-34 7.16113 70 0.03090508 2 2.1813356160000003e-12 3.350244 48 112 0.01998335 GO Cellular Component nuclear nucleosome 24 5.684624e-31 4.09292928e-29 16.32588 36 0.01589404 26 0.00019759394215384613 3.322325 17 40 0.007077435 GO Cellular Component nuclear chromatin 29 1.488674e-27 8.870443696551725e-26 2.625972 163 0.07196468 15 1.0480443264e-7 1.979047 80 316 0.03330558 GO Cellular Component chromatin 32 4.573902e-24 2.46990708e-22 2.193572 199 0.08785872 13 6.072827372307693e-8 1.785418 111 486 0.04621149 GO Cellular Component protein-DNA complex 35 6.275372e-22 3.098240804571429e-20 3.293752 91 0.0401766 6 4.7791987199999995e-9 2.39935 62 202 0.02581182 GO Cellular Component nuclear chromosome part 36 8.662762e-22 4.15812576e-20 2.107052 196 0.08653422 25 0.00012803152896 1.566489 103 514 0.04288093 GO Cellular Component nuclear chromosome 40 5.219459e-20 2.254806288e-18 2.001895 202 0.08918322 24 0.00006617234880000001 1.563447 110 550 0.04579517 GO Cellular Component hemoglobin complex 61 3.139531e-13 8.893622242622951e-12 29.69905 11 0.004856512 39 0.010827550523076922 4.560054 7 12 0.002914238 GO Cellular Component ESC/E(Z) complex 108 0.000001362541 0.000021800656 3.974497 18 0.00794702 33 0.007743487418181818 3.908618 9 18 0.003746878 GO Cellular Component P-body 155 0.000186944 0.002084124077419355 2.095229 30 0.01324503 45 0.022030978559999997 2.072038 22 83 0.009159034 GO Cellular Component Barr body 165 0.0003900441 0.004084825483636364 6.500846 6 0.002649007 47 0.044100287999999994 6.253789 4 5 0.001665279 GO Molecular Function nucleosome binding 1 3.751276e-41 1.5837887272e-37 7.582322 77 0.03399558 27 0.02275450027407407 2.368859 20 66 0.008326395 GO Molecular Function cadherin binding 5 1.554448e-23 1.3125758912000002e-20 2.48965 152 0.06710817 2 0.00002138681543 1.928594 75 304 0.03122398 GO Molecular Function histone binding 17 1.966833e-13 4.8846876035294114e-11 2.400594 89 0.0392936 19 0.007861361777894737 1.816125 46 198 0.01915071 Mouse Phenotype Single KO abnormal platelet activation 8 4.563984e-39 5.224050186e-36 5.681303 92 0.0406181 134 0.021499173613432836 2.115252 23 85 0.009575354 Mouse Phenotype Single KO abnormal platelet aggregation 9 8.423499e-39 8.570442260333334e-36 5.779099 90 0.0397351 167 0.03322035130598803 2.10464 21 78 0.008742714 Mouse Phenotype Single KO abnormal platelet physiology 12 1.512827e-33 1.1544130699166665e-30 4.421436 100 0.04415011 124 0.01707416435403226 1.989842 28 110 0.01165695 Mouse Phenotype Single KO abnormal hemostasis 31 1.582132e-22 4.673413781935484e-20 2.676917 128 0.05651214 126 0.018174457494444445 1.670046 47 220 0.01956703 Mouse Phenotype Single KO abnormal blood coagulation 33 3.233969e-22 8.97377397969697e-20 2.66614 127 0.05607064 146 0.024250878230821917 1.649508 46 218 0.01915071 Mouse Phenotype Single KO thrombocytopenia 38 1.060957e-19 2.5566271707894736e-17 2.911886 97 0.04282561 66 0.004910707635454546 1.941536 38 153 0.01582015 Mouse Phenotype Single KO abnormal platelet morphology 52 1.551353e-17 2.731872965576923e-15 2.323329 127 0.05607064 112 0.0157391660625 1.616346 55 266 0.02289759 Mouse Phenotype Single KO abnormal platelet cell number 53 1.912245e-17 3.303854238679245e-15 2.47374 112 0.04944812 49 0.0026285131124489792 1.826457 50 214 0.02081599 Mouse Phenotype Single KO decreased myeloid cell number 66 9.419604e-15 1.3068986943636362e-12 2.026722 142 0.06269316 13 0.00042988719866153845 1.79412 70 305 0.02914238 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 143 1.453195e-9 9.305529101398601e-8 2.201947 72 0.03178808 175 0.035212034776000004 1.697457 38 175 0.01582015 Mouse Phenotype Single KO abnormal interleukin-6 secretion 162 5.083716e-9 2.8735547785185183e-7 2.220059 66 0.02913907 174 0.034299659082758616 1.742696 35 157 0.01457119 Mouse Phenotype Single KO decreased T cell proliferation 172 1.061821e-8 5.652962149418606e-7 2.133832 69 0.03046358 41 0.002008481416121951 2.032481 39 150 0.01623647 Mouse Phenotype Single KO abnormal erythropoiesis 191 5.098637e-8 0.0000024444093721989527 2.173304 60 0.02649007 48 0.002480682808125 2.203039 31 110 0.01290591 Mouse Phenotype Single KO decreased white adipose tissue amount 237 6.814744e-7 0.000026330215530801692 2.301244 44 0.01942605 95 0.011339546852631579 2.345171 21 70 0.008742714 Mouse Phenotype Single KO increased integument system tumor incidence 239 7.454079e-7 0.000028559414812970708 2.774388 31 0.01368653 151 0.025147026170860926 2.160026 21 76 0.008742714 Mouse Phenotype Single KO increased skin tumor incidence 250 0.000001106402 0.000040525292456 3.426854 22 0.009713024 79 0.006865106061139241 2.842631 16 44 0.006661116 Mouse Phenotype Single KO abnormal liver sinusoid morphology 342 0.00004090178 0.0010951391797076023 2.327874 29 0.01280353 100 0.013324964219 2.368859 20 66 0.008326395 Mouse Phenotype Single KO decreased erythroid progenitor cell number 400 0.0002275084 0.005208236047 2.042432 31 0.01368653 60 0.005054016905333333 2.759024 18 51 0.007493755 Mouse Phenotype abnormal platelet activation 5 4.054655e-38 7.753311291000001e-35 5.391169 94 0.0415011 271 0.02297842758597786 1.954309 25 100 0.01040799 Mouse Phenotype abnormal platelet aggregation 6 5.379606e-38 8.572402161e-35 5.435034 93 0.0410596 260 0.021978951828461542 1.99589 24 94 0.009991674 Mouse Phenotype abnormal platelet physiology 9 5.444983e-33 5.7843869403333335e-30 4.123092 106 0.04679912 204 0.01069870275882353 1.895087 32 132 0.01332223 Mouse Phenotype abnormal hemostasis 35 5.94558e-19 1.6241625822857141e-16 2.274388 144 0.06357616 178 0.008874052892696629 1.595906 59 289 0.02456286 Mouse Phenotype abnormal blood coagulation 36 1.111603e-18 2.9522323008333335e-16 2.265097 143 0.06313466 212 0.011131903869339621 1.57979 58 287 0.02414654 Mouse Phenotype thrombocytopenia 49 1.750262e-15 3.415154077959184e-13 2.414143 103 0.04547461 243 0.017067683407407407 1.661635 44 207 0.01831807 Mouse Phenotype abnormal somite shape 56 2.025149e-14 3.4575802837499998e-12 3.734496 49 0.02163355 297 0.0291819328979798 2.680195 12 35 0.004995837 Mouse Phenotype atherosclerotic lesions 57 2.028697e-14 3.4028722836842107e-12 2.968386 67 0.02958057 190 0.009858981145263158 2.008097 28 109 0.01165695 Mouse Phenotype arteriosclerosis 66 8.181244e-14 1.1851647558181817e-11 2.850948 68 0.03002208 186 0.009382908383870969 1.988595 29 114 0.01207327 Mouse Phenotype abnormal platelet cell number 70 9.685195e-14 1.3228592770714287e-11 2.106711 120 0.05298013 150 0.0047217597656 1.648726 58 275 0.02414654 Mouse Phenotype decreased inflammatory response 101 3.109733e-11 2.9437779418811877e-9 2.085751 98 0.04326711 222 0.013478852314864865 1.553093 60 302 0.02497918 Mouse Phenotype decreased mean corpuscular hemoglobin 161 8.733993e-9 5.186689880310559e-7 2.778354 42 0.01854305 332 0.037853525304216866 2.030451 20 77 0.008326395 Mouse Phenotype abnormal mean corpuscular hemoglobin 162 9.109897e-9 5.376526247962964e-7 2.0785 74 0.03267108 252 0.01828724123095238 1.699399 40 184 0.01665279 Mouse Phenotype abnormal interleukin-6 secretion 171 1.583668e-8 8.854648975438595e-7 2.073333 72 0.03178808 313 0.035336814527156556 1.628591 40 192 0.01665279 Mouse Phenotype abnormal erythropoiesis 176 2.267056e-8 0.00000123155241 2.066173 71 0.03134658 87 0.0008327811230344827 2.046122 39 149 0.01623647 Mouse Phenotype abnormal circulating tumor necrosis factor level 180 2.53199e-8 0.0000013449086883333333 2.378418 52 0.02295806 279 0.02433823143763441 1.766909 33 146 0.01373855 Mouse Phenotype increased pre-B cell number 196 5.522252e-8 0.0000026937883353061225 3.291745 29 0.01280353 350 0.043052527388571425 2.53532 12 37 0.004995837 Mouse Phenotype glomerulonephritis 205 8.31976e-8 0.0000038802548956097565 2.287988 52 0.02295806 307 0.03226283148859935 1.824022 28 120 0.01165695 Mouse Phenotype abnormal splenic cell ratio 233 3.500731e-7 0.000014365016777253217 2.629705 36 0.01589404 325 0.03774250348615385 2.178574 17 61 0.007077435 Mouse Phenotype decreased white adipose tissue amount 306 0.000005710319 0.00017841947699019607 2.020734 49 0.02163355 124 0.0030533716601612903 2.258313 26 90 0.01082431