# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	19	4.192887e-55	2.903905264894737e-52	2.165222	509	0.03316393	295	0.0015964159788474576	1.234544	164	248	0.01630543	
GO Biological Process	gene silencing	51	4.665234e-35	1.2037218471764707e-32	2.140441	328	0.02137086	481	0.019078555631808734	1.223838	118	180	0.01173195	
GO Biological Process	mRNA catabolic process	55	3.720372e-34	8.901159117818183e-32	2.00832	372	0.02423769	95	4.3945076117894746e-11	1.446169	165	213	0.01640485	
GO Biological Process	response to topologically incorrect protein	56	5.188891e-34	1.219296726232143e-31	2.066953	345	0.0224785	199	0.00002985986718241206	1.337925	129	180	0.01282561	
GO Biological Process	macromolecular complex disassembly	57	1.085624e-33	2.5062677571929824e-31	2.012074	365	0.0237816	241	0.00021141921000414937	1.299969	133	191	0.0132233	
GO Biological Process	nuclear-transcribed mRNA catabolic process	66	8.830642e-33	1.760642698151515e-30	2.041821	342	0.02228303	117	1.0901573550000002e-9	1.433154	152	198	0.01511235	
GO Biological Process	chromatin assembly or disassembly	79	1.590389e-31	2.649104917848101e-29	2.003925	344	0.02241334	251	0.00041193290098804784	1.300518	124	178	0.01232849	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	82	3.277241e-31	5.25917247792683e-29	2.041467	325	0.0211754	434	0.012302294523502304	1.252611	104	155	0.01034003	
GO Biological Process	cellular response to topologically incorrect protein	83	5.179121e-31	8.211090751686747e-29	2.18973	274	0.01785249	232	0.00015994344773275862	1.356504	101	139	0.01004176	
GO Biological Process	endoplasmic reticulum unfolded protein response	84	7.095656e-31	1.1115683012380953e-28	2.343966	236	0.0153766	250	0.000405879248888	1.37559	84	114	0.008351561	
GO Biological Process	response to unfolded protein	88	2.247904e-30	3.361382810909091e-28	2.043722	315	0.02052385	204	0.000041307487855392154	1.353482	116	160	0.01153311	
GO Biological Process	regulation of DNA-templated transcription in response to stress	93	2.959847e-29	4.188024373440861e-27	2.177126	261	0.01700547	502	0.023037395767131475	1.270728	81	119	0.008053291	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	104	6.9617e-28	8.808558682692308e-26	2.226807	236	0.0153766	589	0.04675750160101867	1.255595	76	113	0.007556174	
GO Biological Process	multi-organism metabolic process	108	1.089752e-27	1.3277820896296295e-25	2.132963	258	0.01681001	186	0.000014757224222580645	1.384279	109	147	0.01083714	
GO Biological Process	cellular response to unfolded protein	112	5.971388e-27	7.015847740357142e-25	2.158316	244	0.01589784	262	0.00057269223629771	1.357725	88	121	0.008749254	
GO Biological Process	mitochondrial membrane organization	118	4.411718e-26	4.91981331881356e-24	2.002875	282	0.01837373	258	0.0005313787813953488	1.354988	90	124	0.008948101	
GO Biological Process	translational elongation	128	3.46663e-25	3.56385813828125e-23	2.3267	193	0.01257493	191	0.000020522411254973823	1.433491	86	112	0.008550408	
GO Biological Process	viral gene expression	141	2.258043e-24	2.1073466551063827e-22	2.2241	205	0.01335679	222	0.00009577381009009008	1.381779	94	127	0.009345794	
GO Biological Process	viral transcription	150	1.018156e-22	8.931943202666667e-21	2.224571	190	0.01237946	185	0.000014621818456756756	1.437326	87	113	0.008649831	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	156	5.392059e-22	4.5483400244230773e-20	2.216174	185	0.01205369	247	0.0002725195869311741	1.376423	87	118	0.008649831	
GO Cellular Component	ribosomal subunit	37	5.427159e-35	2.5346299329729728e-33	2.229261	299	0.01948137	49	2.421684088163265e-7	1.382495	137	185	0.013621	
GO Cellular Component	large ribosomal subunit	42	3.517173e-27	1.447065462857143e-25	2.410418	195	0.01270524	66	0.0000564527650909091	1.396096	86	115	0.008550408	
GO Cellular Component	ficolin-1-rich granule lumen	43	4.92402e-26	1.9787689674418602e-24	2.15503	236	0.0153766	89	0.0022131719191011237	1.309822	87	124	0.008649831	
GO Cellular Component	mitochondrial ribosome	48	4.876999e-24	1.75571964e-22	2.757539	134	0.008730779	86	0.0015498857972093022	1.383682	63	85	0.006263671	
GO Cellular Component	nuclear chromosome, telomeric region	69	2.789833e-19	6.986712208695652e-18	2.017326	200	0.01303101	122	0.011458426072131147	1.258724	89	132	0.008848678	
GO Cellular Component	mitochondrial large ribosomal subunit	89	4.037373e-15	7.838854543820225e-14	2.769798	80	0.005212406	170	0.04376116291764706	1.354397	37	51	0.003678664	
GO Cellular Component	intrinsic component of mitochondrial membrane	91	1.561582e-14	2.9652897758241755e-13	2.138398	127	0.008274694	100	0.0041146012800000005	1.407334	49	65	0.004871744	
GO Cellular Component	cytosolic large ribosomal subunit	92	2.703696e-14	5.0782464e-13	2.225052	114	0.007427678	92	0.0023954550260869563	1.43841	47	61	0.004672897	
GO Cellular Component	integral component of mitochondrial membrane	97	9.749049e-14	1.7367378012371133e-12	2.102442	124	0.008079229	103	0.005689040714563108	1.400154	48	64	0.004772321	
GO Cellular Component	pronucleus	105	8.407596e-13	1.3836500845714286e-11	3.438706	48	0.003127443	131	0.015784554503816793	1.742414	14	15	0.001391927	
GO Cellular Component	small ribosomal subunit	121	4.712794e-11	6.730337216528927e-10	2.001384	109	0.007101903	105	0.006202066834285715	1.374225	53	72	0.005269437	
GO Cellular Component	spliceosomal snRNP complex	123	5.718645e-11	8.033998829268292e-10	2.138024	92	0.005994266	75	0.00018295598592	1.505542	50	62	0.004971167	
GO Cellular Component	INO80-type complex	125	1.386617e-10	1.9168593407999998e-9	3.284876	41	0.002671358	163	0.03904148849079755	1.542199	19	23	0.001889044	
GO Cellular Component	intrinsic component of mitochondrial outer membrane	143	3.075529e-9	3.716443434965035e-8	2.642737	49	0.003192598	163	0.03904148849079755	1.542199	19	23	0.001889044	
GO Cellular Component	precatalytic spliceosome	157	2.217654e-8	2.440831918471338e-7	2.593988	45	0.002931978	136	0.02009550917647059	1.533502	23	28	0.002286737	
GO Cellular Component	endoribonuclease complex	171	1.487026e-7	0.000001502678905263158	2.236297	53	0.003453219	166	0.039193840192771084	1.480623	23	29	0.002286737	
GO Cellular Component	spliceosomal tri-snRNP complex	224	0.000004325174	0.000033365628	2.168935	43	0.002801668	127	0.013769139401574804	1.544998	24	29	0.00238616	
GO Cellular Component	RISC complex	243	0.000008776197	0.00006240851199999999	2.416781	32	0.002084962	141	0.023783517957446806	1.866872	10	10	0.0009942334	
GO Cellular Component	U2 snRNP	272	0.00003390791	0.00021541495764705883	2.360167	29	0.001889497	128	0.013847409	1.670359	17	19	0.001690197	
GO Cellular Component	platelet dense tubular network membrane	273	0.00003515355	0.0002225103824175824	2.397259	28	0.001824342	161	0.03890133704347826	1.866872	9	9	0.0008948101	
GO Molecular Function	structural constituent of ribosome	9	2.625519e-28	1.2316601353333334e-25	2.136843	263	0.01713578	30	0.000019897638626666665	1.371344	119	162	0.01183138	
GO Molecular Function	ribonucleoprotein complex binding	10	7.972945e-25	3.366177379e-22	2.191466	216	0.01407349	22	0.0000018601423855454546	1.477264	91	115	0.009047524	
GO Molecular Function	rRNA binding	16	6.010843e-21	1.586111196625e-18	3.123134	95	0.006189732	99	0.022071895274747472	1.400154	45	60	0.004474051	
GO Molecular Function	nucleosome binding	20	2.625557e-19	5.542550827000001e-17	2.252473	155	0.01009904	94	0.01997270548723404	1.386011	49	66	0.004871744	
GO Molecular Function	snRNA binding	88	9.223505e-9	4.425186148863636e-7	2.445645	53	0.003453219	88	0.014432935786363637	1.522975	31	38	0.003082124	
GO Molecular Function	SUMO transferase activity	121	7.575952e-8	0.0000026434437474380168	2.453742	46	0.002997133	108	0.040098601370370364	1.670359	17	19	0.001690197	
GO Molecular Function	telomerase RNA binding	213	0.000005375906	0.00010655903817840376	2.034655	49	0.003192598	115	0.047426166556521744	1.612299	19	22	0.001889044	
Human Phenotype	Abnormal mitochondria in muscle tissue	69	1.316418e-9	1.273109755652174e-7	2.783657	47	0.003062288	126	0.04175676355079365	1.623367	20	23	0.001988467	
Human Phenotype	Progressive macrocephaly	86	8.803828e-9	6.831156307441861e-7	2.645712	46	0.002997133	108	0.02957083105925926	1.633513	21	24	0.00208789	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	18	6.444461e-26	3.278440520944445e-23	2.783622	143	0.009317175	223	0.04428953460538116	1.493498	28	35	0.002783854	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	32	1.776687e-21	5.084100893437501e-19	2.058018	214	0.01394318	156	0.0172997448525641	1.444184	41	53	0.004076357	
Mouse Phenotype Single KO	absent hypoglossal nerve	43	8.439621e-20	1.797246732488372e-17	4.335249	59	0.003844149	115	0.006795633449304348	1.866872	15	15	0.00149135	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	60	2.962167e-17	4.5207605365000005e-15	3.145759	76	0.004951785	139	0.01374847790647482	1.697156	20	22	0.001988467	
Mouse Phenotype Single KO	increased circulating interferon-gamma level	91	2.170494e-14	2.1840894019780218e-12	2.440155	95	0.006189732	177	0.024378567284180787	1.476131	34	43	0.003380394	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	105	1.704313e-13	1.4863232515238094e-11	2.609121	78	0.005082095	179	0.024483096478212292	1.633513	21	24	0.00208789	
Mouse Phenotype	abnormal platelet aggregation	7	1.963768e-40	2.682226549714286e-37	2.457993	285	0.01856919	285	0.023900054396842105	1.310783	66	94	0.006561941	
Mouse Phenotype	abnormal platelet physiology	11	9.075471e-35	7.888234384636362e-32	2.055022	358	0.02332551	254	0.016125981602362206	1.272867	90	132	0.008948101	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	35	9.893538e-24	2.7026319090857143e-21	2.5461	152	0.00990357	221	0.008411932197285067	1.531793	32	39	0.003181547	
Mouse Phenotype	decreased platelet aggregation	48	4.267602e-22	8.500529733750001e-20	2.237959	182	0.01185822	308	0.028195267935389613	1.348297	52	72	0.005170014	
Mouse Phenotype	absent hypoglossal nerve	66	8.439621e-20	1.222594187590909e-17	4.335249	59	0.003844149	193	0.0042278598337305694	1.866872	15	15	0.00149135	
Mouse Phenotype	increased circulating interferon-gamma level	73	7.381276e-19	9.667449292602741e-17	2.58757	115	0.007492833	339	0.034191151327433625	1.400154	39	52	0.00387751	
Mouse Phenotype	absent segment of posterior cerebral artery	87	2.962167e-17	3.2553193893103454e-15	3.145759	76	0.004951785	229	0.00871332758515284	1.697156	20	22	0.001988467	
Mouse Phenotype	abnormal cerebral artery morphology	130	1.704313e-13	1.253456661e-11	2.609121	78	0.005082095	261	0.017531899466666667	1.633513	21	24	0.00208789	
Mouse Phenotype	abnormal circulating interleukin-1 beta level	158	4.699428e-12	2.8437488043037974e-10	2.06116	112	0.007297368	241	0.011203861472614108	1.433491	43	56	0.004275204	
Mouse Phenotype	increased fibroblast apoptosis	162	5.821078e-12	3.4355139974074076e-10	2.092737	107	0.006971592	228	0.008738984638157895	1.47794	38	48	0.003778087	
Mouse Phenotype	increased circulating interleukin-1 beta level	186	5.588012e-11	2.872418426451613e-9	2.181118	88	0.005733646	169	0.002160178961360947	1.607584	31	36	0.003082124	
Mouse Phenotype	decreased spongiotrophoblast size	238	7.908651e-10	3.177084546680672e-8	2.58179	55	0.003583529	323	0.030362361529411762	1.670359	17	19	0.001690197