# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	13	2.938194e-47	2.9741303727692314e-44	2.693052	284	0.01859612	569	0.013560973916520211	1.287485	78	113	0.007748088	
GO Biological Process	regulation of DNA-templated transcription in response to stress	17	7.165428e-42	5.546462767764706e-39	2.464599	294	0.01925092	551	0.011172449535027223	1.285266	82	119	0.008145426	
GO Biological Process	rRNA metabolic process	18	1.157531e-41	8.462194682777777e-39	2.072588	423	0.02769775	106	6.024807183301887e-12	1.418707	197	259	0.01956889	
GO Biological Process	rRNA processing	19	8.404783e-41	5.820975763e-38	2.078884	411	0.026912	114	2.4551231105263158e-11	1.413706	191	252	0.01897288	
GO Biological Process	liver regeneration	21	3.709923e-40	2.324708417e-37	3.585135	157	0.01028025	404	0.002059384802871287	1.598746	30	35	0.002980034	
GO Biological Process	nuclear-transcribed mRNA catabolic process	28	2.024343e-36	9.513689120357143e-34	2.111982	352	0.02304872	125	1.24881752344e-10	1.450714	154	198	0.01529751	
GO Biological Process	endoplasmic reticulum unfolded protein response	29	3.041757e-36	1.3802234607931035e-33	2.485389	249	0.01630435	265	0.00005970814316603773	1.407083	86	114	0.008542763	
GO Biological Process	mRNA catabolic process	31	7.933524e-36	3.367652977935484e-33	2.040016	376	0.02462022	118	3.9100853330508474e-11	1.444876	165	213	0.01639019	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	35	7.837447e-34	2.9466561449428566e-31	2.588371	215	0.01407805	205	6.618129688780488e-7	1.470033	93	118	0.009238105	
GO Biological Process	cellular response to topologically incorrect protein	36	9.511156e-33	3.4765917167777776e-30	2.232753	278	0.01820325	282	0.00013871825829787232	1.355291	101	139	0.01003278	
GO Biological Process	cellular response to unfolded protein	42	2.16138e-30	6.771809385714286e-28	2.249063	253	0.01656627	253	0.0000391187371229249	1.402756	91	121	0.009039436	
GO Biological Process	cotranslational protein targeting to membrane	50	1.641851e-28	4.3210234618e-26	2.592109	179	0.0117208	191	9.476023254450261e-8	1.541647	81	98	0.008046091	
GO Biological Process	protein targeting to ER	51	1.851336e-28	4.7768098870588235e-26	2.54276	185	0.01211367	175	2.734725186342857e-8	1.551258	84	101	0.008344095	
GO Biological Process	response to unfolded protein	52	3.201522e-28	8.101697691923078e-26	2.00173	307	0.02010215	239	0.00001581571400627615	1.36393	117	160	0.01162213	
GO Biological Process	viral gene expression	56	6.664764e-28	1.566100526357143e-25	2.333297	214	0.01401257	150	6.566803319533334e-9	1.512724	103	127	0.01023145	
GO Biological Process	IRE1-mediated unfolded protein response	57	6.689329e-28	1.5442961458070177e-25	3.048882	134	0.008774227	450	0.003978459893555555	1.44714	45	58	0.004470051	
GO Biological Process	multi-organism metabolic process	60	2.552813e-27	5.598744377833334e-25	2.126961	256	0.0167627	157	1.1476802052866242e-8	1.471861	116	147	0.0115228	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	62	5.878269e-27	1.2476151898548386e-24	2.597624	168	0.01100052	188	7.627936325531915e-8	1.561094	77	92	0.007648753	
GO Biological Process	regulation of mitochondrial membrane permeability	68	1.080034e-25	2.0900246185294117e-23	2.333312	196	0.01283394	324	0.0005090477921604938	1.456391	57	73	0.005662064	
GO Biological Process	viral transcription	71	4.031276e-25	7.471487448450704e-23	2.306241	196	0.01283394	156	1.1133273173076924e-8	1.535079	93	113	0.009238105	
GO Cellular Component	ribosomal subunit	31	1.614894e-31	9.001731716129032e-30	2.157934	288	0.01885804	53	2.413001696603774e-7	1.381259	137	185	0.01360882	
GO Cellular Component	large ribosomal subunit	37	3.948612e-25	1.844108523243243e-23	2.347877	189	0.01237559	74	0.00001972677561081081	1.411067	87	115	0.008642098	
GO Cellular Component	mitochondrial ribosome	45	1.12359e-18	4.3145856000000004e-17	2.502408	121	0.007922996	150	0.011731587840000002	1.316614	60	85	0.005960068	
GO Cellular Component	endopeptidase complex	46	6.986343e-18	2.624434935652174e-16	2.353666	130	0.00851231	188	0.04604028970212765	1.297533	48	69	0.004768054	
GO Cellular Component	peptidase complex	51	5.585095e-17	1.8923616e-15	2.09799	158	0.01034573	125	0.0057600778752	1.335316	63	88	0.006258071	
GO Cellular Component	cytosolic large ribosomal subunit	60	9.968305e-14	2.8708718400000004e-12	2.196894	112	0.007333683	85	0.00006751759510588235	1.528855	50	61	0.004966723	
GO Cellular Component	mitochondrial nucleoid	136	6.874003e-8	8.73402734117647e-7	2.054783	68	0.004452593	168	0.02242224	1.421107	32	42	0.003178703	
GO Cellular Component	pre-autophagosomal structure membrane	161	4.407563e-7	0.000004730601778881988	2.574173	37	0.002422734	186	0.04518132851612903	1.632053	14	16	0.001390682	
GO Cellular Component	ESCRT complex	204	0.000008057583	0.0000682524677647059	2.112806	43	0.00281561	124	0.005049710709677419	1.598746	24	28	0.002384027	
GO Molecular Function	unfolded protein binding	8	5.018168e-30	2.648338162e-27	2.577718	191	0.01250655	51	0.000008994101764705883	1.460489	83	106	0.00824476	
GO Molecular Function	structural constituent of ribosome	10	2.317234e-24	9.783361948e-22	2.041328	250	0.01636983	48	0.0000020849704904166668	1.393146	121	162	0.01201947	
GO Molecular Function	NF-kappaB binding	29	1.646822e-12	2.397545684137931e-10	2.620052	71	0.004649031	114	0.01342016400877193	1.598746	24	28	0.002384027	
GO Molecular Function	thyroid hormone receptor binding	79	1.10859e-8	5.924641746835444e-7	2.268997	61	0.003994238	143	0.047446422657342655	1.532131	23	28	0.002284693	
Human Phenotype	Increased serum lactate	23	8.950166e-18	2.596715552956522e-15	2.078211	170	0.01113148	75	0.0019079183577333332	1.38025	74	100	0.00735075	
Human Phenotype	Abnormal CSF metabolite level	27	6.54245e-17	1.6169544018518518e-14	2.471846	111	0.007268203	110	0.011000234243636364	1.421107	48	63	0.004768054	
Human Phenotype	Increased CSF lactate	31	1.792347e-16	3.858171461612903e-14	2.532759	103	0.006744369	161	0.043977929857142856	1.382823	43	58	0.004271382	
Human Phenotype	Mildly elevated creatine phosphokinase	197	0.000001129742	0.00003826785972588833	2.344774	41	0.002684652	140	0.029301519547857147	1.678683	18	20	0.00178802	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	110	1.413413e-12	1.1766020764545454e-10	2.05826	118	0.007726558	69	0.00016626975366666665	1.554336	50	60	0.004966723	
Mouse Phenotype Single KO	early cellular replicative senescence	131	2.909779e-11	2.033957733053435e-9	2.057185	104	0.006809848	99	0.0009769927032323234	1.54238	43	52	0.004271382	
Mouse Phenotype Single KO	abnormal rostral-caudal body axis extension	247	3.160216e-8	0.000001171582911417004	2.201171	61	0.003994238	189	0.01459787622116402	1.865203	13	13	0.001291348	
Mouse Phenotype	early cellular replicative senescence	54	7.651172e-19	1.354682509111111e-16	2.157608	166	0.01086957	60	0.0000023438679955	1.584145	62	73	0.006158736	
Mouse Phenotype	abnormal cellular replicative senescence	57	3.059412e-18	5.131761075789473e-16	2.058515	179	0.0117208	69	0.0000052659341404347825	1.532131	69	84	0.006854078	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	219	4.831238e-10	2.1091993843835612e-8	2.414527	64	0.004190676	318	0.019694589649056606	1.554336	25	30	0.002483361