# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	DNA replication-dependent nucleosome assembly	1	6.273486e-34	8.2552802274e-30	65.94684	23	0.02634593	15	0.000005992193652866667	7.209978	13	32	0.01228733	
GO Biological Process	nucleosome organization	2	1.303344e-28	8.575351848e-25	6.42998	59	0.06758305	1	1.00027467391e-10	4.151494	40	171	0.03780718	
GO Biological Process	chromatin assembly	3	2.094508e-27	9.187210257333332e-24	6.489811	56	0.06414662	3	6.042283825e-11	4.268419	38	158	0.03591682	
GO Biological Process	chromatin assembly or disassembly	4	2.962781e-27	9.74680879475e-24	6.042443	59	0.06758305	4	1.05025071365e-10	3.988233	40	178	0.03780718	
GO Biological Process	nucleosome assembly	5	3.778009e-27	9.942964086200001e-24	6.877587	53	0.06071019	2	7.804616059e-11	4.499401	36	142	0.03402647	
GO Biological Process	chromatin silencing at rDNA	6	7.021217e-26	1.5398699083833334e-22	28.93229	23	0.02634593	22	0.000022001848	6.408869	13	36	0.01228733	
GO Biological Process	DNA conformation change	7	7.872403e-26	1.4798993011e-22	4.445199	74	0.08476518	8	2.838253195875e-8	2.968466	47	281	0.04442344	
GO Biological Process	protein heterotetramerization	8	1.16838e-24	1.9218390525e-21	15.38541	29	0.03321879	30	0.00003066276843866667	5.646975	14	44	0.01323251	
GO Biological Process	negative regulation of megakaryocyte differentiation	9	1.379561e-24	2.0170714665555555e-21	89.33643	15	0.01718213	76	0.005623645823026316	6.901859	7	18	0.006616257	
GO Biological Process	protein-DNA complex subunit organization	10	1.639426e-23	2.1573206734e-20	4.38882	68	0.07789233	5	5.8927370536e-10	3.336556	47	250	0.04442344	
GO Biological Process	DNA packaging	11	3.931128e-23	4.7027012138181823e-20	5.16586	57	0.0652921	7	1.2322183472714286e-8	3.47818	39	199	0.036862	
GO Biological Process	chromatin silencing	12	7.292404e-22	7.996728686333333e-19	10.26775	32	0.03665521	19	0.000011051475337368421	4.025237	22	97	0.02079395	
GO Biological Process	chromosome organization	13	1.369148e-20	1.3858937332307692e-17	2.854218	101	0.115693	18	0.00001112285675611111	2.057252	67	578	0.06332703	
GO Biological Process	protein-DNA complex assembly	14	2.829673e-20	2.6596905005e-17	4.33135	59	0.06758305	6	4.713735832833333e-9	3.403656	42	219	0.03969754	
GO Biological Process	negative regulation of gene expression, epigenetic	15	3.028208e-20	2.6565459381333336e-17	7.615191	36	0.04123711	13	0.000003607373844153846	3.892026	25	114	0.02362949	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	16	4.843182e-20	3.983214496125e-17	7.502682	36	0.04123711	27	0.00003198387550370371	3.612351	23	113	0.02173913	
GO Biological Process	regulation of gene silencing	17	8.890208e-20	6.881543945411766e-17	6.050891	42	0.04810997	29	0.00003089633373103448	3.386954	25	131	0.02362949	
GO Biological Process	regulation of hematopoietic stem cell differentiation	18	6.074726e-19	4.440962190777778e-16	7.779513	33	0.03780069	34	0.00009118029782058824	3.61845	21	103	0.01984877	
GO Biological Process	gene silencing	20	8.860575e-18	5.82981532125e-15	5.048002	44	0.05040092	31	0.000036222855707096774	2.95794	30	180	0.02835539	
GO Biological Process	protein folding	21	2.325227e-17	1.4570315282380954e-14	4.174487	52	0.05956472	91	0.010976318116043956	2.198822	28	226	0.02646503	
GO Cellular Component	nucleosome	1	7.575815e-31	1.309100832e-27	13.07645	40	0.04581901	1	3.6968849279999995e-15	5.915879	35	105	0.03308129	
GO Cellular Component	DNA packaging complex	2	1.629765e-27	1.4081169600000002e-24	10.61689	40	0.04581901	2	1.900914048e-14	5.546137	35	112	0.03308129	
GO Cellular Component	nuclear nucleosome	3	8.619558e-24	4.964865408e-21	25.88515	22	0.02520046	24	0.00008900172000000001	5.324291	12	40	0.01134216	
GO Cellular Component	chromatin	11	4.211423e-17	6.615762676363636e-15	2.659719	93	0.1065292	3	2.1799411199999998e-10	2.556244	70	486	0.06616257	
GO Cellular Component	protein-DNA complex	13	1.054816e-16	1.402093883076923e-14	4.413684	47	0.05383734	4	2.443110768e-10	3.602243	41	202	0.03875236	
GO Cellular Component	nuclear chromatin	23	4.572018e-14	3.4349770017391305e-12	2.842271	68	0.07789233	16	0.000008075541239999999	2.415027	43	316	0.04064272	
GO Cellular Component	chromosome, telomeric region	24	3.8745e-13	2.78964e-11	4.67709	34	0.03894616	33	0.0033875696290909087	2.444285	23	167	0.02173913	
GO Cellular Component	chromosomal part	25	5.023785e-13	3.4724401919999995e-11	2.00735	120	0.137457	5	1.8618052607999998e-7	1.937242	93	852	0.0879017	
GO Cellular Component	nuclear chromosome, telomeric region	26	2.219025e-12	1.4747981538461538e-10	5.142586	29	0.03321879	41	0.018536066341463413	2.420132	18	132	0.01701323	
GO Cellular Component	nuclear chromosome part	28	3.267362e-12	2.01642912e-10	2.315001	83	0.09507446	26	0.000513031968	1.864538	54	514	0.0510397	
GO Cellular Component	nuclear chromosome	36	7.289703e-11	3.4990574400000003e-9	2.159848	84	0.09621993	29	0.000788778968275862	1.807032	56	550	0.05293006	
GO Cellular Component	coated vesicle membrane	47	5.05451e-9	1.8583389957446807e-7	2.896242	40	0.04581901	39	0.01497190596923077	2.286505	21	163	0.01984877	
GO Cellular Component	coated vesicle	49	1.133351e-7	0.000003996796995918367	2.357715	47	0.05383734	43	0.026151756948837212	1.933595	28	257	0.02646503	
GO Cellular Component	clathrin-coated endocytic vesicle	63	0.000002806015	0.00007696498285714286	3.325918	21	0.02405498	34	0.004026892065882352	3.443571	13	67	0.01228733	
GO Cellular Component	clathrin-coated pit	75	0.00001949359	0.0004491323136	3.243466	18	0.02061856	42	0.02030904822857143	3.042452	12	70	0.01134216	
GO Cellular Component	clathrin-coated vesicle membrane	98	0.0002142089	0.003777071216326531	2.33797	23	0.02634593	44	0.027894463854545457	2.559755	15	104	0.01417769	
GO Cellular Component	inclusion body	109	0.0006376276	0.010108444888073394	2.596521	16	0.01832761	49	0.047011897469387755	2.730406	12	78	0.01134216	
GO Cellular Component	clathrin-coated endocytic vesicle membrane	125	0.002090299	0.028896293376	2.579003	13	0.01489118	32	0.003065904	4.067167	11	48	0.01039698	
GO Molecular Function	nucleosome binding	1	5.807547e-20	2.4519463434e-16	8.431006	33	0.03780069	4	0.003122135224	4.033554	15	66	0.01417769	
GO Molecular Function	nucleosomal DNA binding	2	1.1209e-17	2.3662199e-14	10.56655	25	0.02863688	1	0.0040372423246000004	5.015637	13	46	0.01228733	
GO Molecular Function	chromatin DNA binding	5	1.616987e-11	1.3653838228000002e-8	4.428241	31	0.03550974	7	0.011344429559999999	3.071706	18	104	0.01701323	
GO Molecular Function	peptidyl-prolyl cis-trans isomerase activity	7	3.176978e-11	1.916171588e-8	6.983823	20	0.02290951	12	0.030628375858333334	4.225628	10	42	0.009451796	
GO Molecular Function	cis-trans isomerase activity	9	5.439035e-11	2.551511752222222e-8	6.770152	20	0.02290951	14	0.03995212254285714	4.033554	10	44	0.009451796	
GO Molecular Function	histone binding	12	4.370109e-10	1.5375500165e-7	3.009201	43	0.04925544	10	0.021494269552	2.330498	26	198	0.02457467	
GO Molecular Function	structure-specific DNA binding	15	1.037416e-8	0.0000029199802346666667	3.211121	33	0.03780069	13	0.033490008215384615	2.553617	20	139	0.01890359	
GO Molecular Function	heat shock protein binding	17	1.740529e-8	0.000004322654963529412	3.770231	26	0.02978236	11	0.02931398313818182	2.873427	17	105	0.01606805	
GO Molecular Function	C3HC4-type RING finger domain binding	18	1.846487e-8	0.0000043310378411111105	38.01126	6	0.006872852	15	0.038614637173333334	11.83176	4	6	0.003780718	
Mouse Phenotype Single KO	enlarged spleen	34	1.268334e-7	0.00003415921893529412	2.091004	60	0.06872852	17	0.01646541715882353	1.941148	42	384	0.03969754	
Mouse Phenotype Single KO	abnormal erythropoiesis	101	0.00004248076	0.003851448706138614	2.443412	26	0.02978236	8	0.013122850915	3.065501	19	110	0.01795841	
Mouse Phenotype Single KO	abnormal embryonic erythropoiesis	117	0.00007472168	0.005848089091965812	4.285539	11	0.01260023	28	0.04799036533928571	4.8959	8	29	0.007561437	
Mouse Phenotype Single KO	decreased mean corpuscular hemoglobin	168	0.0003938476	0.02146703853095238	2.958018	14	0.01603666	24	0.04148330847916667	3.343758	13	69	0.01228733	
Mouse Phenotype	decreased immunoglobulin level	38	1.709416e-8	0.000004300980625263157	2.2548	58	0.06643757	63	0.02410866854761905	1.886961	37	348	0.03497164	
Mouse Phenotype	increased myeloid cell number	55	7.813067e-7	0.0001358195156127273	2.118282	51	0.05841924	25	0.00220637590752	2.226184	36	287	0.03402647	
Mouse Phenotype	abnormal platelet morphology	58	9.895881e-7	0.00016312847972586208	2.049345	54	0.06185567	67	0.02518956757164179	1.89589	36	337	0.03402647	
Mouse Phenotype	abnormal erythropoiesis	60	0.000001052452	0.0001677082262	2.56709	34	0.03894616	14	0.0006012644509071429	2.977791	25	149	0.02362949	
Mouse Phenotype	abnormal platelet cell number	73	0.000003583588	0.0004693518475068493	2.095248	46	0.05269187	49	0.016033689682653063	2.06518	32	275	0.03024575	
Mouse Phenotype	abnormal embryonic erythropoiesis	121	0.0000541841	0.004281439504958678	4.10093	12	0.0137457	35	0.009869353176857143	5.15254	9	31	0.008506616	
Mouse Phenotype	thrombocytosis	136	0.00008250055	0.005799909989338235	2.893098	18	0.02061856	89	0.0416770972752809	2.95794	13	78	0.01228733	
Mouse Phenotype	abnormal proerythroblast morphology	142	0.0001055282	0.007105317747887324	2.658832	20	0.02290951	89	0.0416770972752809	2.95794	13	78	0.01228733	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	160	0.0002123486	0.01268915602875	3.533871	12	0.0137457	73	0.033108118939726025	4.095609	9	39	0.008506616	
Mouse Phenotype	abnormal circulating interleukin-10 level	176	0.0003546088	0.01926372009545455	4.241449	9	0.01030928	55	0.017941390336363636	4.563678	9	35	0.008506616	
Mouse Phenotype	abnormal reticulocyte cell number	192	0.0004976189	0.0247798661609375	2.41579	19	0.02176403	36	0.009616480358333334	2.930802	18	109	0.01701323	
Mouse Phenotype	abnormal reticulocyte morphology	198	0.0005607306	0.027076491245454547	2.329635	20	0.02290951	32	0.0065858110078125	2.932218	19	115	0.01795841	
Mouse Phenotype	increased circulating interleukin-10 level	223	0.0008218348	0.03523570638026906	4.752471	7	0.008018328	93	0.046405608861290325	4.77821	7	26	0.006616257	
Mouse Phenotype	decreased mean corpuscular hemoglobin	237	0.00100856	0.04068709772151898	2.574444	15	0.01718213	50	0.0171391117026	3.226843	14	77	0.01323251