# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	10	1.291302e-57	1.6992243017999996e-54	2.675217	353	0.01847297	398	0.0005329603295728643	1.329223	87	113	0.007999264	
GO Biological Process	regulation of DNA-templated transcription in response to stress	14	5.799895e-54	5.451487021785714e-51	2.498997	373	0.0195196	355	0.0002525638006788733	1.334744	92	119	0.008458992	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	16	3.080211e-50	2.5332810343125e-47	2.219859	440	0.0230258	330	0.00013817472372424242	1.3032	117	155	0.01075763	
GO Biological Process	cellular response to topologically incorrect protein	18	6.666801e-48	4.873801908833334e-45	2.362118	368	0.01925794	418	0.000726406077200957	1.291741	104	139	0.009562339	
GO Biological Process	endoplasmic reticulum unfolded protein response	23	2.938395e-46	1.6811452089130436e-43	2.512833	315	0.01648438	537	0.003787669896834264	1.287274	85	114	0.007815373	
GO Biological Process	liver regeneration	25	1.147252e-45	6.0386756271999995e-43	3.449258	189	0.009890627	493	0.002300932025801217	1.529152	31	35	0.002850313	
GO Biological Process	response to topologically incorrect protein	29	1.137631e-42	5.162098734137931e-40	2.078782	432	0.02260715	419	0.0007299074319331741	1.256481	131	180	0.01204487	
GO Biological Process	cellular response to unfolded protein	33	2.30999e-41	9.211260124242424e-39	2.323201	327	0.01711236	465	0.0014868566341935483	1.298414	91	121	0.008367047	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	34	8.222998e-40	3.182542078882353e-37	2.385128	298	0.01559475	857	0.040623153506417736	1.24893	68	94	0.006252299	
GO Biological Process	response to unfolded protein	50	1.001439e-35	2.6355871602000002e-33	2.016676	387	0.02025224	454	0.0012712020073348017	1.262475	117	160	0.01075763	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	51	2.716368e-35	7.008762061176471e-33	2.545792	232	0.01214088	523	0.0033433018462715107	1.350182	61	78	0.00560868	
GO Biological Process	mitochondrial membrane organization	56	6.509339e-33	1.5295784268035714e-30	2.019397	354	0.0185253	635	0.010164985573228345	1.253077	90	124	0.008275101	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	63	2.908103e-32	6.0742424407936506e-30	2.502056	218	0.01140824	897	0.048837978123745816	1.41256	27	33	0.00248253	
GO Biological Process	regulation of mitochondrial membrane permeability	67	1.353485e-31	2.6582849425373136e-29	2.330992	245	0.01282118	654	0.012201179730122323	1.324409	56	73	0.005148952	
GO Biological Process	regulation of membrane permeability	85	4.797327e-29	7.426826587411764e-27	2.175449	260	0.01360615	603	0.007619359968988392	1.321489	62	81	0.005700625	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	95	6.971357e-28	9.656430185578947e-26	2.241826	233	0.01219321	370	0.00032626271671081083	1.331424	91	118	0.008367047	
GO Biological Process	protein targeting to ER	101	1.640479e-27	2.137332986237624e-25	2.328774	212	0.01109425	256	0.000008920635166796876	1.418776	83	101	0.007631482	
GO Biological Process	cotranslational protein targeting to membrane	119	4.080757e-26	4.512494232184874e-24	2.326239	201	0.0105186	277	0.000023887741723826713	1.409357	80	98	0.007355645	
GO Biological Process	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	130	2.821756e-25	2.8562682464615387e-23	2.837889	135	0.007064734	495	0.002330419555919192	1.559385	28	31	0.002574476	
GO Biological Process	regulation of release of cytochrome c from mitochondria	150	1.549878e-23	1.3596563068000002e-21	2.52639	153	0.008006698	772	0.02619097815025907	1.38117	36	45	0.00331004	
GO Cellular Component	mitochondrial ribosome	46	1.433665e-21	5.3855937391304356e-20	2.446202	148	0.007745042	82	0.0022305824780487803	1.340547	66	85	0.006068408	
GO Cellular Component	large ribosomal subunit	48	4.757161e-21	1.71257796e-19	2.065071	208	0.01088492	62	0.000034829986064516126	1.366157	91	115	0.008367047	
GO Cellular Component	endopeptidase complex	53	3.323053e-20	1.083440676226415e-18	2.286212	158	0.008268355	83	0.0023127781012048194	1.376165	55	69	0.005057006	
GO Cellular Component	proteasome complex	56	3.815438e-19	1.1773351542857143e-17	2.24407	155	0.008111361	86	0.0031019649488372093	1.371014	54	68	0.004965061	
GO Cellular Component	peptidase complex	62	4.835016e-18	1.3475657496774192e-16	2.0057	189	0.009890627	78	0.0009273015138461538	1.353703	69	88	0.006344244	
GO Cellular Component	mitochondrial large ribosomal subunit	70	5.764613e-16	1.4230358948571426e-14	2.613966	94	0.004919148	104	0.0099951624	1.38794	41	51	0.003769768	
GO Cellular Component	cleavage furrow	72	7.098717e-16	1.70369208e-14	2.015484	162	0.008477681	121	0.017894839537190083	1.361249	41	52	0.003769768	
GO Cellular Component	spliceosomal snRNP complex	78	8.686528e-15	1.9244000492307693e-13	2.221189	119	0.006227432	112	0.01590485142857143	1.336616	48	62	0.004413387	
GO Cellular Component	endoribonuclease complex	130	9.296747e-10	1.2357522166153846e-8	2.304498	68	0.003558533	116	0.01618038124137931	1.488329	25	29	0.002298639	
GO Cellular Component	platelet dense tubular network	235	0.000005221231	0.00003839271135319149	2.306194	37	0.00193626	140	0.030322425599999998	1.726462	11	11	0.001011401	
GO Cellular Component	U2 snRNP	278	0.00002528343	0.00015715743539568346	2.222478	34	0.001779266	146	0.038633736328767126	1.544729	17	19	0.001563075	
GO Molecular Function	endoribonuclease activity	44	9.295302e-14	8.919264782727274e-12	2.097726	125	0.00654142	90	0.01558753956	1.387335	45	56	0.004137551	
GO Molecular Function	thyroid hormone receptor binding	132	2.82149e-8	9.024493015151515e-7	2.080942	70	0.003663195	91	0.015554307316483518	1.541484	25	28	0.002298639	
GO Molecular Function	aminoacyl-tRNA editing activity	411	0.0001071652	0.0011008551688564477	2.280562	27	0.001412947	102	0.034085178715686275	1.726462	13	13	0.001195292	
Human Phenotype	Abnormal CSF metabolite level	25	1.425284e-16	3.8043680528e-14	2.278067	128	0.006698414	119	0.005205232154033614	1.397612	51	63	0.004689224	
Human Phenotype	Abnormality of mitochondrial metabolism	26	2.778376e-16	7.130808864615384e-14	2.033266	163	0.008530012	123	0.0060267660642276425	1.376165	55	69	0.005057006	
Human Phenotype	Increased CSF lactate	47	2.019837e-13	2.8677387874468084e-11	2.181412	111	0.005808781	164	0.020364270785365856	1.369263	46	58	0.004229496	
Human Phenotype	External ophthalmoplegia	48	2.128057e-13	2.958442575208333e-11	2.275697	101	0.005285468	206	0.04384659855339806	1.456702	27	32	0.00248253	
Human Phenotype	Death in infancy	56	5.569165e-13	6.63625679375e-11	2.022062	128	0.006698414	190	0.03357079180789474	1.356506	44	56	0.004045605	
Mouse Phenotype	dry eyes	111	4.974935e-22	4.2851669851351354e-20	2.957835	109	0.005704118	465	0.0415191462516129	1.618558	15	16	0.001379184	
Mouse Phenotype	increased incidence of corneal inflammation	211	6.468047e-16	2.930852955781991e-14	2.727373	87	0.004552829	412	0.03070932863592233	1.562037	19	21	0.001746966	
Mouse Phenotype	abnormal loop of Henle morphology	269	5.679548e-14	2.0186675995539034e-12	2.668977	78	0.004081846	373	0.021107753054959787	1.726462	13	13	0.001195292	
Mouse Phenotype	decreased type II pneumocyte number	654	2.370255e-7	0.0000034651388463302753	2.166013	55	0.002878225	424	0.03207332158018868	1.726462	12	12	0.001103347