# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	33	1.074379e-195	4.284167654848485e-193	2.126604	1952	0.02205849	763	0.0050905496644823075	1.10409	147	155	0.009114018	
GO Biological Process	endoplasmic reticulum unfolded protein response	42	2.175911e-180	6.817336392619046e-178	2.397873	1392	0.01573024	856	0.010515979492873832	1.113116	109	114	0.006758014	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	57	2.827653e-159	6.527909794210527e-157	2.263292	1383	0.01562853	419	0.000020268270662052507	1.153874	112	113	0.006944014	
GO Biological Process	cellular response to topologically incorrect protein	58	4.301407e-157	9.759002536724138e-155	2.140105	1544	0.0174479	688	0.002893866840406977	1.113924	133	139	0.008246016	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	59	1.887741e-156	4.21030234220339e-154	2.290051	1325	0.0149731	1006	0.023512085239562622	1.114637	90	94	0.005580011	
GO Biological Process	cellular response to unfolded protein	62	6.557086e-154	1.3916886237741936e-151	2.193861	1430	0.01615965	769	0.005338919446553966	1.11607	116	121	0.007192014	
GO Biological Process	cellular response to epidermal growth factor stimulus	63	6.737419e-153	1.407265025730159e-150	2.608988	1006	0.01136826	1093	0.037086540634949684	1.164176	38	38	0.002356005	
GO Biological Process	IRE1-mediated unfolded protein response	75	2.377362e-146	4.1711608743999995e-144	2.999998	764	0.008633549	971	0.020898917809474768	1.144104	57	58	0.003534007	
GO Biological Process	response to epidermal growth factor	77	2.346571e-145	4.010198414155844e-143	2.494512	1038	0.01172987	989	0.022282497936299293	1.164176	42	42	0.002604005	
GO Biological Process	regulation of DNA-templated transcription in response to stress	84	1.539577e-140	2.4118206836904763e-138	2.096328	1449	0.01637436	385	0.000009253747174285714	1.154393	118	119	0.007316015	
GO Biological Process	regulation of mitochondrial membrane permeability	110	1.031569e-124	1.2340378609999998e-122	2.249691	1095	0.012374	713	0.003564411365918654	1.148229	72	73	0.004464009	
GO Biological Process	positive regulation of mRNA metabolic process	150	1.796753e-114	1.5762315151333333e-112	2.416111	867	0.009797496	1116	0.04113284083333333	1.141788	51	52	0.003162006	
GO Biological Process	regulation of membrane permeability	173	5.693526e-105	4.3306999210404625e-103	2.052522	1136	0.01283732	806	0.007309267773076923	1.135431	79	81	0.00489801	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	184	8.026636e-102	5.740353430652173e-100	2.11924	1020	0.01152647	475	0.00008842864621894736	1.144445	116	118	0.007192014	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	243	4.700535e-87	2.5454460932098763e-85	2.101805	887	0.0100235	654	0.0019263381628899083	1.149251	77	78	0.00477401	
GO Biological Process	cotranslational protein targeting to membrane	259	2.96778e-84	1.507838494980695e-82	2.11428	846	0.009560186	396	0.0000108037018260101	1.164176	98	98	0.006076012	
GO Biological Process	regulation of cholesterol metabolic process	260	4.097343e-84	2.073728328346154e-82	2.280638	713	0.008057226	1083	0.03702088419298245	1.142211	52	53	0.003224006	
GO Biological Process	protein targeting to ER	306	1.511631e-75	6.500507297058823e-74	2.01625	850	0.009605388	377	0.000007173578238461538	1.164176	101	101	0.006262013	
GO Biological Process	mitochondrial transmembrane transport	307	1.83879e-75	7.881640915309446e-74	2.031551	833	0.00941328	984	0.022356378740853663	1.122098	80	83	0.00496001	
GO Biological Process	apoptotic mitochondrial changes	308	2.913587e-75	1.2448016666558441e-73	2.003061	861	0.009729693	949	0.018646095007376184	1.144445	58	59	0.003596007	
GO Cellular Component	cleavage furrow	64	3.478181e-86	9.391088700000001e-85	2.176122	810	0.00915337	159	0.003963927667924529	1.164176	52	52	0.003224006	
GO Cellular Component	PcG protein complex	70	4.86821e-80	1.2017524114285715e-78	2.138189	782	0.008836957	175	0.008988878262857143	1.164176	46	46	0.002852006	
GO Cellular Component	mitochondrial ribosome	109	8.143237e-51	1.290964544587156e-49	2.016569	565	0.006384758	101	0.00004055338835643565	1.164176	85	85	0.005270011	
GO Cellular Component	nuclear ubiquitin ligase complex	126	1.463731e-45	2.007402514285714e-44	2.280792	379	0.004282873	200	0.0196244208	1.164176	40	40	0.002480005	
GO Cellular Component	mitochondrial large ribosomal subunit	152	2.137736e-37	2.4302682947368423e-36	2.137745	356	0.004022963	163	0.004503479676073619	1.164176	51	51	0.003162006	
GO Molecular Function	unfolded protein binding	18	8.795103e-114	2.062940270333333e-111	2.273232	976	0.01102925	116	0.0036210368803448276	1.131228	103	106	0.006386013	
Human Phenotype	Abnormal CSF metabolite level	100	1.02423e-47	6.834686789999999e-46	2.021511	526	0.00594404	308	0.0014762311751623377	1.164176	63	63	0.003906008	
Mouse Phenotype Single KO	pale liver	92	1.960431e-95	1.9512681159782607e-93	2.033125	1056	0.01193328	350	0.013332458569428572	1.135072	78	80	0.00483601	
Mouse Phenotype Single KO	abnormal lymph node B cell domain morphology	165	2.353898e-71	1.3063420597575758e-69	2.05668	763	0.008622248	419	0.03142662731026253	1.164176	43	43	0.002666005