# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of transforming growth factor beta2 production 190 0.0001499419 0.010384660326842104 2.602672 20 0.003089757 306 0.005416932452287582 3.071148 8 8 0.001308472 GO Biological Process dosage compensation 310 0.001096839 0.046559046454838715 2.213292 20 0.003089757 468 0.03761862866025641 2.362422 10 13 0.00163559 Human Phenotype Pancreatic islet-cell hyperplasia 82 0.0005714449 0.04650307094756098 2.46862 18 0.002780782 170 0.03163211610705882 2.729909 8 9 0.001308472 Mouse Phenotype Single KO absent outer hair cell stereocilia 7 5.256171e-39 6.875822549571429e-36 8.082403 70 0.01081415 516 0.014300774387209302 2.729909 8 9 0.001308472 Mouse Phenotype Single KO abnormal Reissner membrane morphology 10 1.339701e-35 1.2267642057000001e-32 6.855368 72 0.01112313 438 0.009137404438127853 2.55929 10 12 0.00163559 Mouse Phenotype Single KO abnormal vestibuloocular reflex 25 3.201281e-24 1.17256520468e-21 4.401281 72 0.01112313 656 0.030925869097560975 2.687255 7 8 0.001144913 Mouse Phenotype Single KO abnormal otolith morphology 26 5.339741e-24 1.8806157052692306e-21 3.545741 92 0.01421288 533 0.016199842835272045 1.882317 19 31 0.003107622 Mouse Phenotype Single KO abnormal otolithic membrane morphology 28 2.587468e-23 8.461944455714287e-21 3.434366 93 0.01436737 525 0.014842870835619046 1.861302 20 33 0.003271181 Mouse Phenotype Single KO absent cochlear hair cells 31 2.252861e-19 6.654660702258064e-17 3.310779 80 0.01235903 707 0.0379945041612447 1.996246 13 20 0.002126268 Mouse Phenotype Single KO abnormal cochlear hair cell stereociliary bundle morphology 34 9.809696e-19 2.6419819491764703e-16 2.311136 141 0.02178279 783 0.044636995213282245 1.474151 36 75 0.005888126 Mouse Phenotype Single KO bidirectional circling 40 4.100745e-17 9.387630491250001e-15 2.855662 87 0.01344044 480 0.012147155395625 2.047432 16 24 0.002616945 Mouse Phenotype Single KO abnormal stria vascularis morphology 41 4.567953e-17 1.0202133078292684e-14 2.580621 103 0.01591225 354 0.004420652979096044 1.872651 25 41 0.004088976 Mouse Phenotype Single KO organ of Corti degeneration 42 1.0465e-16 2.281619166666667e-14 2.424808 113 0.01745713 398 0.006803662503768844 1.746339 29 51 0.004743212 Mouse Phenotype Single KO abnormal vestibular saccule morphology 45 4.761148e-16 9.688407163555556e-14 2.301534 120 0.01853854 303 0.002219154222739274 1.869395 28 46 0.004579653 Mouse Phenotype Single KO cochlear degeneration 48 5.056039e-15 9.645447733958334e-13 2.2406 118 0.01822957 563 0.018870007184724688 1.613654 31 59 0.00507033 Mouse Phenotype Single KO abnormal vestibular hair cell morphology 49 9.489315e-15 1.7733399480612243e-12 2.274212 112 0.01730264 283 0.001578771959893993 1.947557 26 41 0.004252535 Mouse Phenotype Single KO abnormal otolith organ morphology 53 5.899031e-14 1.0191967333396227e-11 2.112268 124 0.0191565 352 0.004265905513920454 1.771816 30 52 0.004906771 Mouse Phenotype Single KO head tossing 58 2.242329e-13 3.540173560862069e-11 2.267134 101 0.01560328 330 0.0033363363009090907 1.987214 22 34 0.003598299 Mouse Phenotype Single KO absent pinna reflex 63 9.733271e-13 1.414723215031746e-10 2.079852 116 0.01792059 639 0.028936535575899845 1.559948 32 63 0.005233889 Mouse Phenotype Single KO head bobbing 71 7.55147e-12 9.739269125352112e-10 2.078051 107 0.0165302 317 0.002785903437444795 1.919468 25 40 0.004088976 Mouse Phenotype Single KO abnormal food preference 143 0.000005905074 0.00037813120711888116 2.652678 28 0.00432566 738 0.040555000543360434 2.111414 11 16 0.001799149 Mouse Phenotype Single KO abnormal ureter development 167 0.00001976216 0.0010836053839520959 2.091931 40 0.006179515 549 0.018835999038251363 2.512758 9 11 0.001472031 Mouse Phenotype Single KO abnormal entorhinal cortex morphology 222 0.0001488214 0.006138547566666666 3.119746 15 0.002317318 759 0.04410912422529644 3.071148 5 5 0.0008177952 Mouse Phenotype absent outer hair cell stereocilia 6 5.256171e-39 8.3757084885e-36 8.082403 70 0.01081415 654 0.011780985255963302 2.729909 8 9 0.001308472 Mouse Phenotype abnormal Reissner membrane morphology 15 2.533537e-29 1.6148764837999998e-26 5.02868 77 0.01189557 740 0.01870129015945946 2.252175 11 15 0.001799149 Mouse Phenotype abnormal otolith morphology 21 2.017931e-23 9.187351567142859e-21 3.41964 94 0.01452186 665 0.012235047797142856 1.861302 20 33 0.003271181 Mouse Phenotype abnormal otolithic membrane morphology 25 1.164431e-22 4.4532499164e-20 3.30561 95 0.01467635 563 0.006792475742984015 1.876813 22 36 0.003598299 Mouse Phenotype abnormal vestibuloocular reflex 27 4.949176e-22 1.7525582124444443e-19 3.718897 79 0.01220454 913 0.03422788781270537 2.111414 11 16 0.001799149 Mouse Phenotype bidirectional circling 33 4.100745e-17 1.1880976650000001e-14 2.855662 87 0.01344044 625 0.00974060453232 2.047432 16 24 0.002616945 Mouse Phenotype organ of Corti degeneration 37 2.067505e-16 5.342544677027027e-14 2.400407 113 0.01745713 648 0.010398123093055555 1.68044 29 53 0.004743212 Mouse Phenotype abnormal stria vascularis morphology 39 4.370138e-16 1.0713561389230769e-13 2.490295 103 0.01591225 589 0.007840510224448217 1.785551 25 43 0.004088976 Mouse Phenotype abnormal cochlear hair cell stereociliary bundle morphology 41 6.858227e-16 1.5993050816341463e-13 2.038672 156 0.02410011 953 0.03630507334312697 1.433202 42 90 0.00686948 Mouse Phenotype absent cochlear hair cells 43 3.556665e-15 7.908203270930233e-13 2.497735 96 0.01483084 613 0.00942366161598695 2.008058 17 26 0.002780504 Mouse Phenotype abnormal utricle morphology 45 8.316434e-15 1.766965010533333e-12 2.182308 123 0.01900201 732 0.018147822918032786 1.65842 27 50 0.004416094 Mouse Phenotype cochlear degeneration 48 1.058854e-14 2.10910481125e-12 2.215778 118 0.01822957 908 0.03397367622356828 1.535574 31 62 0.00507033 Mouse Phenotype head tossing 53 1.396635e-13 2.519476836792453e-11 2.275093 102 0.01575776 402 0.0013966899068656718 2.018183 23 35 0.003761858 Mouse Phenotype abnormal vestibular hair cell morphology 62 2.951139e-12 4.550941932096774e-10 2.014763 120 0.01853854 369 0.0009891339027642276 1.894964 29 47 0.004743212 Mouse Phenotype abnormal white fat cell number 145 0.000004054552 0.0002673487701517241 2.129692 45 0.006951954 1021 0.04553203846718903 1.869395 14 23 0.002289827 Mouse Phenotype abnormal food preference 151 0.000005905074 0.00037389677161589404 2.652678 28 0.00432566 913 0.03422788781270537 2.111414 11 16 0.001799149