# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	7	5.734773e-33	1.0780553986714286e-29	3.024476	161	0.02088468	238	0.0002753821527142857	1.630165	60	113	0.009810334	
GO Biological Process	regulation of DNA-templated transcription in response to stress	14	4.454599e-29	4.1870048743571427e-26	2.74019	165	0.02140355	229	0.00019104609708733622	1.62537	63	119	0.01030085	
GO Biological Process	regulation of PERK-mediated unfolded protein response	21	3.027727e-26	1.897231409190476e-23	7.647893	48	0.006226489	374	0.010226017230213904	2.763129	9	10	0.00147155	
GO Biological Process	rRNA metabolic process	24	1.919135e-24	1.0522457277083333e-21	2.145175	221	0.02866779	99	3.297217400202021e-8	1.57656	133	259	0.02174624	
GO Biological Process	rRNA processing	27	4.895405e-24	2.3858753479629633e-21	2.154392	215	0.02788948	112	7.019488788660715e-8	1.571621	129	252	0.02109222	
GO Biological Process	mRNA catabolic process	31	4.817551e-23	2.0449726970645162e-20	2.171176	202	0.02620314	205	0.00007104171796585367	1.484624	103	213	0.01684107	
GO Biological Process	RNA catabolic process	32	4.987202e-23	2.0508309724375002e-20	2.07156	225	0.02918666	179	0.000012048968511731845	1.490485	117	241	0.01913015	
GO Biological Process	nuclear-transcribed mRNA catabolic process	34	3.812298e-22	1.4754714524117646e-19	2.210845	186	0.02412764	221	0.00012987409021719457	1.488555	96	198	0.01569653	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	36	2.521335e-21	9.216179795833332e-19	2.761316	117	0.01517707	254	0.0006114536578346457	1.602995	59	113	0.009646828	
GO Biological Process	regulation of receptor catabolic process	39	2.050321e-20	6.917993343333333e-18	6.07217	44	0.005707614	452	0.023519039942035396	2.729017	8	9	0.001308044	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	43	7.647907e-20	2.340437400302326e-17	2.828839	104	0.01349073	234	0.0002377906654957265	1.771237	45	78	0.00735775	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	48	8.777014e-19	2.4061818172083334e-16	2.125992	170	0.02205215	245	0.0003742799331142857	1.525168	77	155	0.01258993	
GO Biological Process	protein targeting to ER	56	1.259673e-17	2.9600066083928572e-15	2.69567	99	0.01284213	376	0.010377925843882979	1.519873	50	101	0.008175278	
GO Biological Process	regulation of mRNA stability	60	5.81693e-17	1.2757496978333333e-14	2.010357	174	0.02257102	142	9.76595185e-7	1.687563	83	151	0.01357096	
GO Biological Process	protein localization to endoplasmic reticulum	65	1.141206e-16	2.3103276544615386e-14	2.361012	119	0.0154365	350	0.006602411698857142	1.485553	60	124	0.009810334	
GO Biological Process	regulation of hematopoietic stem cell differentiation	69	3.094193e-16	5.900939954637681e-14	2.589562	97	0.0125827	323	0.00489564910123839	1.549976	52	103	0.008502289	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	73	5.278008e-16	9.51415168109589e-14	3.382715	63	0.008172266	295	0.0025914527217288136	2.269237	17	23	0.002779595	
GO Biological Process	regulation of cellular amino acid metabolic process	79	2.888238e-15	4.810927068607596e-13	3.219943	64	0.008301985	442	0.020782300460633486	1.63741	32	60	0.005232178	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	84	6.329537e-15	9.91552111702381e-13	2.410512	101	0.01310157	363	0.008122093681818182	1.520452	52	105	0.008502289	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	96	3.902016e-14	5.34860714e-12	2.361136	99	0.01284213	372	0.009416495503225807	1.483036	57	118	0.009319817	
GO Cellular Component	ribosomal subunit	34	5.427024e-16	2.7582051388235292e-14	2.122656	143	0.01854975	57	0.00044273269894736845	1.460393	88	185	0.01438849	
GO Cellular Component	mitochondrial ribosome	35	1.265402e-14	6.247470445714286e-13	2.908901	71	0.009210014	82	0.003974385248780488	1.589251	44	85	0.007194245	
GO Cellular Component	catalytic step 2 spliceosome	38	1.415155e-13	6.435231157894736e-12	2.308934	99	0.01284213	42	0.000021199371428571427	1.758937	55	96	0.008992806	
GO Cellular Component	endopeptidase complex	42	7.842963e-13	3.226819062857143e-11	2.618316	73	0.009469451	61	0.0009825189875409834	1.735299	39	69	0.006376717	
GO Cellular Component	peptidase complex	45	1.125277e-12	4.32106368e-11	2.341176	89	0.01154495	55	0.00020093416494545454	1.709512	49	88	0.008011772	
GO Cellular Component	proteasome complex	46	2.029967e-12	7.62561516521739e-11	2.583908	72	0.009339733	66	0.0016010056145454546	1.715669	38	68	0.006213211	
GO Cellular Component	large ribosomal subunit	48	1.4659e-11	5.277239999999999e-10	2.214899	90	0.01167467	83	0.004802692857831325	1.495027	56	115	0.009156311	
GO Cellular Component	mitochondrial large ribosomal subunit	51	1.071721e-10	3.631242917647059e-9	3.101876	45	0.005837333	85	0.006049496244705883	1.745768	29	51	0.004741661	
GO Cellular Component	preribosome	56	3.918962e-9	1.2092797028571428e-7	2.217346	68	0.008820859	102	0.020126490352941177	1.535072	38	76	0.006213211	
GO Cellular Component	spliceosomal snRNP complex	61	4.999432e-8	0.0000014162325403278689	2.359656	51	0.006615644	93	0.011289997625806451	1.634109	33	62	0.005395683	
GO Cellular Component	cytoplasmic stress granule	71	1.88446e-7	0.000004586404056338028	2.197944	54	0.0070048	78	0.0034469590153846153	1.856366	26	43	0.004251145	
GO Cellular Component	MHC class I peptide loading complex	75	4.179039e-7	0.000009628505856	35.36687	5	0.0006485926	133	0.04757945359398496	3.070144	5	5	0.0008175278	
GO Cellular Component	proteasome accessory complex	122	0.00001113244	0.0001576791501639344	2.801281	24	0.003113244	95	0.011629594610526315	2.046763	16	24	0.002616089	
GO Cellular Component	proteasome regulatory particle	207	0.0005287747	0.0044141192347826085	2.353515	20	0.00259437	108	0.022568255999999995	2.046763	14	21	0.002289078	
GO Cellular Component	very-low-density lipoprotein particle	212	0.0005882674	0.004794934279245283	2.332875	20	0.00259437	128	0.039732619500000003	1.995594	13	20	0.002125572	
GO Cellular Component	3M complex	235	0.001165073	0.008567004868085107	4.480845	7	0.0009080296	133	0.04757945359398496	3.070144	5	5	0.0008175278	
GO Molecular Function	unfolded protein binding	9	1.064597e-16	4.994142815555556e-14	2.620149	98	0.01271241	57	0.004865138000701754	1.564036	54	106	0.0088293	
GO Molecular Function	ribonucleoprotein complex binding	10	1.091689e-15	4.609110958000001e-13	2.322911	115	0.01491763	41	0.0010600628492682927	1.601814	60	115	0.009810334	
GO Molecular Function	ribonuclease activity	18	1.922917e-11	4.510308652222222e-9	2.160589	94	0.01219354	25	0.00033016394647999997	1.705635	55	99	0.008992806	
GO Molecular Function	endoribonuclease activity	33	7.298223e-9	9.337302274545455e-7	2.371119	57	0.007393955	75	0.020117970733333334	1.699544	31	56	0.005068672	
Human Phenotype	Increased serum lactate	4	1.464433e-11	2.44304035225e-8	2.203839	91	0.01180438	52	0.005633170792115384	1.596475	52	100	0.008502289	
Human Phenotype	Abnormality of mitochondrial metabolism	46	1.322234e-8	0.0000019181016265217393	2.133515	69	0.008950577	69	0.02310677117826087	1.646309	37	69	0.006049706	
Human Phenotype	Abnormality of the mitochondrion	52	3.135701e-8	0.0000040239486101923075	2.084655	69	0.008950577	82	0.04083651396585365	1.599934	37	71	0.006049706	
Human Phenotype	Progressive microcephaly	70	3.255962e-7	0.00003103862060857143	2.049718	61	0.007912829	57	0.007079075464035088	1.842086	30	50	0.004905167	
Human Phenotype	Dysphonia	80	7.863815e-7	0.00006559404686874999	2.62879	34	0.004410429	74	0.027548398391891892	2.135752	16	23	0.002616089	
Human Phenotype	3-Methylglutaconic aciduria	205	0.0001945469	0.006332738847317074	2.625378	19	0.002464652	81	0.036114564339506175	2.558453	10	12	0.001635056	
Human Phenotype	Basal cell carcinoma	220	0.0002607726	0.007909707089999999	2.228913	25	0.003242963	61	0.014592166340983606	2.232832	16	22	0.002616089	
Mouse Phenotype Single KO	disorganized mitochondrial cristae	28	2.134016e-13	6.978994468571428e-11	10.12404	19	0.002464652	33	0.003711040740909091	3.070144	10	10	0.001635056	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	88	1.306807e-7	0.000013598217839772726	2.10788	61	0.007912829	48	0.006680945292291667	1.790917	35	60	0.005722695	
Mouse Phenotype Single KO	early cellular replicative senescence	91	2.665873e-7	0.000026825713253846154	2.155265	55	0.007134518	74	0.020425950681081082	1.771237	30	52	0.004905167	
Mouse Phenotype Single KO	decreased level of surface class I molecules	125	0.00000271828	0.00019913031968	5.601581	12	0.001556622	85	0.03131046546235294	2.763129	9	10	0.00147155	
Mouse Phenotype Single KO	abnormal antigen presentation via MHC class I	146	0.000006732859	0.00042227938262328767	3.89432	16	0.002075496	107	0.047027630573831775	2.412256	11	14	0.001798561	
Mouse Phenotype Single KO	abnormal level of surface class I molecules	200	0.00003381506	0.0015482225220999999	4.027068	13	0.001686341	98	0.04096126993367347	2.558453	10	12	0.001635056	
Mouse Phenotype Single KO	increased mitochondria size	222	0.00006975086	0.002877065878468468	2.011622	38	0.004929303	84	0.030302933064285713	2.011474	19	29	0.003106606	
Mouse Phenotype Single KO	abnormal mitochondrial chromosome morphology	263	0.0001831145	0.00637558736311787	2.166882	28	0.003632118	68	0.016633353845588235	2.302608	15	20	0.002452583	
Mouse Phenotype	dry eyes	29	3.740354e-15	1.2331560204827587e-12	3.632295	54	0.0070048	149	0.03989820700268456	2.302608	12	16	0.001962067	
Mouse Phenotype	early cellular replicative senescence	76	9.338108e-9	0.0000011747585603684212	2.03418	79	0.01024776	32	0.0003105108043125	1.850498	44	73	0.007194245	
Mouse Phenotype	decreased level of surface class I molecules	86	3.48341e-8	0.000003872660815116279	6.326985	15	0.001945778	78	0.004491736961923076	2.814299	11	12	0.001798561	
Mouse Phenotype	abnormal antigen presentation via MHC class I	97	1.725878e-7	0.000017011463461855672	4.380815	19	0.002464652	93	0.009040282238387097	2.494492	13	16	0.002125572	
Mouse Phenotype	abnormal level of surface class I molecules	111	7.759279e-7	0.00006683465452162163	4.628691	16	0.002075496	88	0.006860082688636363	2.631552	12	14	0.001962067	
Mouse Phenotype	abnormal mitochondrial chromosome morphology	290	0.0002326785	0.007671169443103449	2.072303	30	0.003891555	146	0.03973630183561644	2.007402	17	26	0.002779595	
Mouse Phenotype	disorganized mitochondrial cristae	308	0.0003653383	0.011340907423051948	2.425631	20	0.00259437	108	0.014816433822222223	2.597814	11	13	0.001798561