# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ribonucleoprotein complex biogenesis	1	5.414814e-30	7.1253537426e-26	2.06663	295	0.05854336	35	1.4127085071714286e-11	1.689326	172	454	0.0408454	
GO Biological Process	nuclear-transcribed mRNA catabolic process	3	2.546332e-24	1.1169060929333334e-20	2.636738	145	0.02877555	120	0.000012950078943333334	1.73407	77	198	0.01828544	
GO Biological Process	mRNA catabolic process	5	7.990395e-23	2.1029121560999998e-19	2.482986	151	0.02996626	112	0.000009195654888928572	1.716624	82	213	0.01947281	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6	1.805807e-22	3.9604357188333336e-19	3.356815	92	0.01825759	153	0.00008621484377777776	1.889422	50	118	0.01187366	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	9	1.447684e-21	2.1166748617777778e-18	2.9889	104	0.02063902	295	0.011857971900338984	1.657341	42	113	0.009973878	
GO Biological Process	RNA catabolic process	11	3.0858e-21	3.691458381818182e-18	2.295918	163	0.03234769	115	0.000011160421378347827	1.6652	90	241	0.0213726	
GO Biological Process	rRNA metabolic process	12	4.093816e-21	4.489210395333333e-18	2.331437	157	0.03115698	150	0.00008390019614733334	1.583905	92	259	0.02184754	
GO Biological Process	rRNA processing	13	7.598811e-21	7.69175030376923e-18	2.345479	153	0.03036317	151	0.00008345755010331125	1.592513	90	252	0.0213726	
GO Biological Process	ribosome biogenesis	15	2.08225e-20	1.8266885166666667e-17	2.089833	192	0.0381028	101	0.0000012628941148415842	1.615193	117	323	0.02778437	
GO Biological Process	IRE1-mediated unfolded protein response	16	7.337182e-20	6.034373621125e-17	4.206464	61	0.01210558	372	0.03343507344892473	1.845118	24	58	0.005699359	
GO Biological Process	regulation of DNA-templated transcription in response to stress	23	2.323155e-18	1.3291476802173915e-15	2.667717	105	0.02083747	321	0.018747959349532706	1.611248	43	119	0.01021135	
GO Biological Process	protein refolding	32	5.742342e-17	2.3613586993125002e-14	9.350413	26	0.005159754	217	0.0011029819223502305	2.972691	14	21	0.003324626	
GO Biological Process	endoplasmic reticulum unfolded protein response	33	6.483816e-17	2.5854707498181814e-14	2.752885	91	0.01805914	298	0.014604520565771814	1.642803	42	114	0.009973878	
GO Biological Process	macromolecular complex disassembly	37	2.53834e-16	9.027571908108107e-14	2.21632	132	0.02619567	119	0.000011941604514285714	1.75093	75	191	0.0178105	
GO Biological Process	cotranslational protein targeting to membrane	40	4.287326e-16	1.41042307085e-13	3.116091	71	0.0140901	142	0.00006023768555985916	2.002016	44	98	0.01044882	
GO Biological Process	protein targeting to ER	41	5.662448e-16	1.8173695910243904e-13	3.040941	73	0.014487	209	0.0007883638750239234	1.854253	42	101	0.009973878	
GO Biological Process	viral transcription	42	7.208783e-16	2.2585803689761903e-13	2.852924	80	0.01587617	140	0.00005269695436785715	1.933564	49	113	0.01163619	
GO Biological Process	ribonucleoprotein complex subunit organization	44	1.215425e-15	3.634949448863637e-13	2.047825	151	0.02996626	82	2.3693421402439024e-7	1.812786	87	214	0.02066018	
GO Biological Process	multi-organism metabolic process	45	1.388758e-15	4.061037004888889e-13	2.492908	99	0.01964676	186	0.00038685917708602155	1.729014	57	147	0.01353598	
GO Biological Process	response to unfolded protein	46	1.719295e-15	4.918304979347827e-13	2.292328	116	0.02302044	207	0.0006841497597101448	1.672138	60	160	0.0142484	
GO Cellular Component	ribosomal subunit	22	1.909241e-18	1.4996220218181815e-16	2.566112	113	0.02242508	52	0.00021312364430769234	1.638997	68	185	0.01614818	
GO Cellular Component	ribosome	24	7.327471e-18	5.275779119999999e-16	2.250373	141	0.02798174	44	0.000024734878690909094	1.624903	86	236	0.0204227	
GO Cellular Component	large ribosomal subunit	34	5.874482e-13	2.985619087058823e-11	2.673151	71	0.0140901	60	0.001127853216	1.74484	45	115	0.0106863	
GO Cellular Component	cytosolic ribosome	40	3.961226e-10	1.7112496320000002e-8	2.22652	76	0.01508236	61	0.0012018463790163935	1.751764	44	112	0.01044882	
GO Cellular Component	prespliceosome	45	3.961349e-8	0.0000015211580160000003	4.381085	21	0.004167494	100	0.04481481600000001	2.335685	11	21	0.002612206	
GO Cellular Component	proteasome complex	53	8.216684e-8	0.0000026789490475471698	2.470648	45	0.008930343	82	0.021089628878048782	1.7705	27	68	0.006411779	
GO Cellular Component	endopeptidase complex	54	8.345341e-8	0.00000267050912	2.469252	45	0.008930343	86	0.026065975813953486	1.74484	27	69	0.006411779	
GO Cellular Component	U2 snRNP	60	2.749958e-7	0.00000791987904	4.461949	18	0.003572137	70	0.003971677165714286	2.816233	12	19	0.002849679	
GO Cellular Component	U1 snRNP	63	3.226672e-7	0.000008850300342857144	3.848773	21	0.004167494	79	0.019073187159493674	2.581547	11	19	0.002612206	
GO Cellular Component	mitochondrial outer membrane translocase complex	64	4.674988e-7	0.000012622467600000001	5.543019	14	0.002778329	63	0.0013719423085714285	3.648302	9	11	0.00213726	
GO Cellular Component	mitochondrial nucleoid	65	4.872613e-7	0.000012953654252307691	2.839033	31	0.006152014	73	0.006561720197260273	2.12335	20	42	0.004749466	
GO Cellular Component	methyltransferase complex	69	7.254092e-7	0.00001816676953043478	2.023401	59	0.01170867	96	0.03342186	1.617013	33	91	0.007836618	
GO Cellular Component	catalytic step 2 spliceosome	71	9.473294e-7	0.000023056129622535213	2.033784	57	0.01131177	84	0.025401147428571427	1.62569	35	96	0.008311565	
GO Cellular Component	cytosolic large ribosomal subunit	74	0.000001045057	0.000024403493189189188	2.37795	40	0.007938083	80	0.01908363456	1.827474	25	61	0.005936832	
GO Cellular Component	outer mitochondrial membrane protein complex	75	0.000001209257	0.00002786128128	4.758028	15	0.002976781	74	0.007213949318918919	2.972691	10	15	0.002374733	
GO Cellular Component	preribosome	79	0.000002424033	0.00005302188637974683	2.194982	44	0.008731891	89	0.02705848017977528	1.701474	29	76	0.006886725	
GO Cellular Component	U2-type spliceosomal complex	136	0.0001909642	0.0024263686588235295	2.195697	27	0.005358206	101	0.0467807923960396	1.981794	16	36	0.003799573	
GO Cellular Component	Lewy body	152	0.0004765097	0.0054171629052631575	3.726183	10	0.001984521	98	0.04093958204081633	3.344277	6	8	0.00142484	
GO Molecular Function	unfolded protein binding	9	3.747296e-14	1.7578981902222223e-11	2.8632	70	0.01389165	60	0.017949340433333336	1.682655	40	106	0.009498931	
GO Molecular Function	structural constituent of ribosome	10	5.941046e-14	2.5083096212e-11	2.375722	96	0.0190514	30	0.0005058953799333334	1.706545	62	162	0.01472334	
GO Molecular Function	ribonucleoprotein complex binding	11	6.448656e-12	2.475111421090909e-9	2.410366	78	0.01547926	65	0.026595248381538462	1.628517	42	115	0.009973878	
GO Molecular Function	DNA polymerase binding	13	9.324091e-11	3.028177861692308e-8	7.056988	19	0.003770589	71	0.03913031066760563	2.786897	10	16	0.002374733	
GO Molecular Function	deoxyribonucleotide binding	17	1.299428e-9	3.2271676564705883e-7	16.14004	10	0.001984521	69	0.034646863985507245	4.459036	5	5	0.001187366	
GO Molecular Function	disordered domain specific binding	56	0.00000432623	0.00032616684035714283	2.423694	34	0.006747371	40	0.0020083283485000003	2.589118	18	31	0.004274519	
GO Molecular Function	protein carboxyl O-methyltransferase activity	78	0.00004088117	0.0022128243556410257	5.075316	10	0.001984521	50	0.010712767696	4.459036	6	6	0.00142484	
GO Molecular Function	ubiquitin-specific protease binding	82	0.00005044367	0.0025972338382926827	3.638697	14	0.002778329	71	0.03913031066760563	2.786897	10	16	0.002374733	
GO Molecular Function	O-methyltransferase activity	92	0.00008718206	0.004000898449130435	2.895007	18	0.003572137	70	0.035869762177142855	2.54802	12	21	0.002849679	
Human Phenotype	Abnormal CNS myelination	12	4.948811e-9	0.0000027519513169166668	2.052004	80	0.01587617	5	0.009779450994199999	1.783614	50	125	0.01187366	
Mouse Phenotype Single KO	absent hypoglossal nerve	72	0.000001154869	0.0001468768810138889	4.028487	18	0.003572137	37	0.0009004310737297297	3.567229	12	15	0.002849679	
Mouse Phenotype Single KO	heterochrony	263	0.0009616109	0.033480878369961976	2.2933	19	0.003770589	79	0.02602696428227848	2.885258	11	17	0.002612206	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	46	1.067868e-9	2.2195404234782606e-7	3.658926	32	0.006350466	124	0.016822857077419356	2.378152	16	30	0.003799573	
Mouse Phenotype	absent hypoglossal nerve	83	0.000001154869	0.00013303256034939758	4.028487	18	0.003572137	56	0.0006211754382857142	3.567229	12	15	0.002849679	
Mouse Phenotype	abnormal thymus topology	155	0.00004744393	0.0029265252563225805	5.588475	9	0.001786069	158	0.03426423375	4.459036	5	5	0.001187366	
Mouse Phenotype	heterochrony	289	0.0009616109	0.03181301666055363	2.2933	19	0.003770589	125	0.017174760847200002	2.885258	11	17	0.002612206