# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	1	3.95328e-174	5.202121152e-170	17.4375	203	0.07384503	2	6.55275104275e-31	5.276226	63	92	0.02585146	
GO Biological Process	cotranslational protein targeting to membrane	2	3.657585e-171	2.40650805075e-167	16.49208	205	0.07457257	1	1.6636186795999998e-31	5.189058	66	98	0.02708248	
GO Biological Process	protein targeting to ER	3	8.75672e-167	3.840989282666667e-163	15.6534	205	0.07457257	6	5.9841583288333335e-30	4.958641	65	101	0.02667214	
GO Biological Process	translational initiation	4	8.833442e-166	2.90598158195e-162	11.60755	239	0.08694071	5	5.1562041374e-30	4.256589	79	143	0.03241691	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	5	2.984177e-159	7.853757028599999e-156	13.91145	208	0.07566388	11	1.4602087716363637e-24	4.24426	65	118	0.02667214	
GO Biological Process	viral gene expression	6	6.517397e-159	1.4293737853833334e-155	13.02315	215	0.07821026	10	1.20160513688e-25	4.186162	69	127	0.0283135	
GO Biological Process	viral transcription	7	1.721035e-158	3.235299937857143e-155	13.66206	209	0.07602765	9	6.015231845222222e-27	4.500245	66	113	0.02708248	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	8	3.905297e-158	6.423725402875e-155	13.8542	207	0.07530011	3	2.7201372442666667e-30	4.916502	67	105	0.02749282	
GO Biological Process	protein localization to endoplasmic reticulum	9	6.564572e-155	9.59813366088889e-152	12.12917	218	0.07930156	4	5.70312704875e-30	4.535988	73	124	0.02995486	
GO Biological Process	multi-organism metabolic process	10	5.232553e-146	6.8855164927e-143	10.3854	225	0.08184794	13	1.9328809718461538e-22	3.721446	71	147	0.02913418	
GO Biological Process	protein targeting to membrane	11	3.561709e-135	4.260775339181818e-132	10.17933	211	0.07675518	12	7.418424630416667e-24	3.967482	69	134	0.0283135	
GO Biological Process	translation	12	4.86319e-130	5.332893100833333e-127	5.367898	324	0.117861	30	2.587730509e-18	2.423336	117	372	0.04800985	
GO Biological Process	nuclear-transcribed mRNA catabolic process	13	1.174601e-127	1.1889672737692307e-124	7.866484	236	0.0858494	19	1.952043459263158e-21	3.229859	83	198	0.03405827	
GO Biological Process	mRNA catabolic process	14	1.399205e-127	1.3151527567857141e-124	7.414844	246	0.08948709	16	1.598063502375e-21	3.147098	87	213	0.03569963	
GO Biological Process	RNA catabolic process	15	3.49288e-125	3.064187194666667e-122	6.712923	260	0.09457985	15	1.3657664691333333e-21	3.005256	94	241	0.03857201	
GO Biological Process	peptide biosynthetic process	16	4.17473e-120	3.433454504375e-117	4.863237	328	0.1193161	33	2.842941338848485e-18	2.378318	121	392	0.04965121	
GO Biological Process	viral life cycle	17	8.422399e-119	6.519432261235294e-116	5.425024	294	0.106948	22	5.936590737e-21	2.740692	106	298	0.0434961	
GO Biological Process	mRNA metabolic process	18	7.343204e-118	5.368290079777777e-115	3.533561	450	0.1636959	44	1.7163217905e-17	1.999316	171	659	0.07016824	
GO Biological Process	rRNA processing	19	5.761455e-115	3.9902624392105266e-112	6.715951	239	0.08694071	45	2.0004636388666665e-17	2.721198	89	252	0.03652031	
GO Biological Process	ncRNA processing	20	1.462502e-113	9.622531909e-111	5.086593	298	0.1084031	110	1.6742004296363636e-12	2.101354	108	396	0.04431678	
GO Cellular Component	intracellular ribonucleoprotein complex	1	1.034464e-161	1.7875537920000002e-158	3.922939	538	0.1957075	16	1.45410228e-18	1.902577	201	814	0.08247846	
GO Cellular Component	ribonucleoprotein complex	2	1.771253e-161	1.530362592e-158	3.917945	538	0.1957075	15	1.0527637248e-18	1.905022	202	817	0.0828888	
GO Cellular Component	ribosomal subunit	3	2.211935e-157	1.27407456e-154	10.19842	245	0.08912332	8	1.2170731679999999e-23	3.415174	82	185	0.03364793	
GO Cellular Component	cytosolic ribosome	4	3.061517e-156	1.322575344e-153	11.92163	222	0.08075664	1	1.866563136e-33	4.953192	72	112	0.02954452	
GO Cellular Component	ribosome	5	2.957034e-140	1.0219509503999999e-137	7.694151	263	0.09567115	12	3.2316523200000003e-21	2.970982	91	236	0.03734099	
GO Cellular Component	cytosolic part	6	2.249204e-109	6.47770752e-107	5.997048	249	0.09057839	17	2.5753847717647058e-18	2.79305	87	240	0.03569963	
GO Cellular Component	cytosolic large ribosomal subunit	7	7.365681e-103	1.818270966857143e-100	14.38422	132	0.04801746	7	9.371210605714286e-24	5.55768	44	61	0.01805499	
GO Cellular Component	large ribosomal subunit	8	7.20803e-91	1.55693448e-88	9.937961	144	0.05238268	28	3.631783885714286e-14	3.349985	50	115	0.02051703	
GO Cellular Component	nucleosome	9	1.651322e-85	3.1705382400000005e-83	12.35425	119	0.04328847	2	7.905414239999999e-28	4.69636	64	105	0.0262618	
GO Cellular Component	DNA packaging complex	10	1.159162e-75	2.003031936e-73	10.03053	119	0.04328847	5	6.112689407999999e-26	4.402837	64	112	0.0262618	
GO Cellular Component	small ribosomal subunit	11	4.144323e-75	6.510354676363636e-73	11.27648	110	0.04001455	42	3.626650285714286e-10	3.531442	33	72	0.01354124	
GO Cellular Component	cytosolic small ribosomal subunit	14	1.62417e-69	2.0046898285714286e-67	13.72772	91	0.03310295	30	4.204476287999999e-12	4.728047	27	44	0.0110792	
GO Cellular Component	nuclear nucleosome	17	2.65621e-65	2.699959341176471e-63	24.28739	65	0.02364496	43	1.4021032186046512e-9	4.430355	23	40	0.009437833	
GO Cellular Component	protein-DNA complex	18	5.781723e-65	5.550454079999999e-63	5.099634	171	0.06220444	9	2.16431616e-23	3.280332	86	202	0.03528929	
GO Cellular Component	chromatin	22	4.432879e-50	3.48182496e-48	2.661093	293	0.1065842	11	5.984577687272728e-22	2.330514	147	486	0.06032007	
GO Cellular Component	chromosome, telomeric region	25	9.769862e-48	6.7529286144e-46	5.285934	121	0.04401601	53	0.00003203931749433962	2.076188	45	167	0.01846533	
GO Cellular Component	catalytic step 2 spliceosome	28	2.719172e-43	1.678117577142857e-41	6.213314	95	0.03455802	61	0.0017420217285245903	2.167021	27	96	0.0110792	
GO Cellular Component	focal adhesion	29	6.512136e-43	3.8803348303448277e-41	2.62094	258	0.09385231	32	1.89137808e-11	2.038973	104	393	0.04267542	
GO Cellular Component	nuclear chromosome, telomeric region	30	1.077663e-42	6.20733888e-41	5.687802	101	0.03674063	48	0.00000160807968	2.393209	41	132	0.01682396	
GO Cellular Component	cell-substrate adherens junction	31	1.13636e-42	6.334290580645162e-41	2.612159	258	0.09385231	35	2.8982968868571426e-11	2.023526	104	396	0.04267542	
GO Molecular Function	RNA binding	1	3.989821e-179	1.6845024261999998e-175	2.761693	887	0.3226628	1	1.9377780952e-32	1.829812	389	1638	0.1596225	
GO Molecular Function	structural constituent of ribosome	2	1.660426e-145	3.5051592859999995e-142	10.25185	226	0.08221171	3	5.756411311333334e-23	3.614675	76	162	0.03118588	
GO Molecular Function	structural molecule activity	4	3.732311e-78	3.9394542605000003e-75	2.902933	394	0.1433248	11	9.970874785454547e-10	1.718295	157	704	0.06442347	
GO Molecular Function	nucleosomal DNA binding	6	8.662545e-60	6.095544165e-57	11.54333	86	0.0312841	32	0.00004282674098125	3.349985	20	46	0.008206812	
GO Molecular Function	rRNA binding	8	2.536435e-55	1.33860357125e-52	13.39883	73	0.02655511	49	0.03636634347755102	2.31149	18	60	0.00738613	
GO Molecular Function	nucleosome binding	9	5.971004e-51	2.801064320888889e-48	7.707767	95	0.03455802	21	0.0000028897800676190477	3.152031	27	66	0.0110792	
GO Molecular Function	mRNA binding	10	6.337969e-46	2.6758905118000003e-43	3.53875	179	0.06511459	9	1.1707976597777778e-11	2.634859	66	193	0.02708248	
GO Molecular Function	chromatin DNA binding	11	5.608217e-42	2.1525356521818183e-39	5.035377	111	0.04037832	17	8.438983270588235e-7	2.74119	37	104	0.0151826	
GO Molecular Function	histone binding	13	1.542607e-38	5.009912887692308e-36	3.44472	155	0.05638414	10	4.2118118918e-11	2.568322	66	198	0.02708248	
GO Molecular Function	miRNA binding	15	7.674761e-37	2.160189396133333e-34	9.98011	57	0.02073481	50	0.038902951924	3.210402	10	24	0.004103406	
GO Molecular Function	structure-specific DNA binding	16	7.294556e-36	1.9248509645e-33	3.862712	125	0.04547108	14	6.041461852857143e-8	2.605276	47	139	0.01928601	
GO Molecular Function	cadherin binding	19	2.918958e-32	6.486231934736842e-30	2.618122	194	0.07057112	12	5.3411642416666664e-9	2.103658	83	304	0.03405827	
GO Molecular Function	ribonucleoprotein complex binding	23	1.023917e-25	1.8795554669565216e-23	4.361629	77	0.02801019	46	0.025266852704347822	1.942991	29	115	0.01189988	
GO Molecular Function	single-stranded DNA binding	24	2.062572e-20	3.62840791e-18	3.400286	81	0.02946526	48	0.0347297498	1.983456	26	101	0.01066886	
GO Molecular Function	single-stranded RNA binding	25	1.158924e-19	1.9571908511999998e-17	3.496328	75	0.02728265	51	0.04029403121960785	2.092707	22	81	0.009027493	
GO Molecular Function	mRNA 5'-UTR binding	26	1.525011e-19	2.476383246923077e-17	8.622082	32	0.0116406	36	0.0004773270058333333	4.202708	12	22	0.004924087	
GO Molecular Function	mRNA 3'-UTR binding	30	3.331597e-17	4.688667511333334e-15	3.490252	65	0.02364496	37	0.00052338023	2.685064	23	66	0.009437833	
GO Molecular Function	ubiquitin-protein transferase inhibitor activity	43	6.354899e-14	6.239624087906977e-12	19.29318	14	0.005092761	44	0.018844944977272727	6.420804	5	6	0.002051703	
GO Molecular Function	double-stranded RNA binding	69	2.458636e-10	1.5044001727536228e-8	3.009049	45	0.01636959	52	0.042717911826923076	2.218096	19	66	0.007796471	
GO Molecular Function	translation regulator activity	84	1.815536e-8	9.125229752380952e-7	3.097385	34	0.01236813	45	0.019015118657777778	2.687779	15	43	0.006155109	
Mouse Phenotype Single KO	abnormal cell cycle	11	1.114424e-12	9.277073243636365e-10	2.019533	122	0.04437977	20	0.004667121446000001	1.788072	55	237	0.02256873	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	35	1.936149e-9	5.065518969428571e-7	5.232647	21	0.007639142	33	0.02342632257666667	3.531442	11	24	0.004513746	
Mouse Phenotype Single KO	abnormal neural plate morphology	244	0.0002317186	0.008696095164754098	2.287798	24	0.008730447	23	0.008935026357391306	3.698383	12	25	0.004924087	
Mouse Phenotype Single KO	enlarged lung	260	0.0002952276	0.010397688973846153	2.131688	27	0.009821753	38	0.04807906947368421	3.081986	12	30	0.004924087	
Mouse Phenotype	macrocytic anemia	34	7.492456e-10	2.1069227004705884e-7	3.910634	30	0.01091306	44	0.011254724631136363	3.684983	11	23	0.004513746	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	37	1.562486e-9	4.0375482827027026e-7	4.820601	23	0.008366679	39	0.009769917656153846	3.338818	13	30	0.005334428	
Mouse Phenotype	thin external granule cell layer	47	1.015007e-8	0.0000020647833887234043	2.945177	38	0.01382321	47	0.017173954387021278	3.531442	11	24	0.004513746