# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	16	6.129265e-49	5.0409373834375005e-46	2.690596	295	0.01857917	428	0.0010260124567056076	1.370137	79	113	0.008245486	
GO Biological Process	regulation of DNA-templated transcription in response to stress	22	8.585766e-45	5.135458854272728e-42	2.491481	309	0.01946089	374	0.00037164147419786097	1.3834	84	119	0.008767352	
GO Biological Process	mRNA catabolic process	31	4.41928e-41	1.8759130812903227e-38	2.103056	403	0.02538103	137	2.9505743737226276e-10	1.45376	158	213	0.01649097	
GO Biological Process	nuclear-transcribed mRNA catabolic process	41	1.821113e-38	5.844884382195122e-36	2.123711	368	0.02317672	168	3.39405152375e-9	1.445117	146	198	0.01523849	
GO Biological Process	rRNA processing	42	2.036283e-38	6.379868570714286e-36	2.019002	415	0.02613679	180	1.0691585152222222e-8	1.384315	178	252	0.01857844	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	49	4.832281e-37	1.2977139934489795e-34	2.131189	351	0.02210606	286	0.00001433536858951049	1.390837	110	155	0.01148106	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	61	3.19299e-33	6.887959903278689e-31	2.535901	219	0.01379267	249	0.000002322458333694779	1.478167	89	118	0.009289218	
GO Biological Process	liver regeneration	63	5.983652e-33	1.2498234391746032e-30	3.228668	147	0.009258093	478	0.002549681783556485	1.623848	29	35	0.003026824	
GO Biological Process	viral gene expression	70	2.066401e-31	3.884538679857143e-29	2.401551	229	0.01442247	161	2.0306200510559008e-9	1.558594	101	127	0.0105417	
GO Biological Process	multi-organism metabolic process	74	5.345915e-31	9.506337227702702e-29	2.189627	274	0.01725658	175	6.680779183428572e-9	1.506525	113	147	0.01179418	
GO Biological Process	regulation of necrotic cell death	82	4.777325e-29	7.666441423780488e-27	4.803666	80	0.005038418	431	0.0011431733173085847	1.742059	24	27	0.002504958	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	86	5.494448e-28	8.407144329302324e-26	2.244365	233	0.01467439	494	0.0031384001898785425	1.376041	66	94	0.006888634	
GO Biological Process	RNA phosphodiester bond hydrolysis	87	6.11261e-28	9.245498274712643e-26	2.17202	250	0.01574506	463	0.002002404745788337	1.326191	90	133	0.009393591	
GO Biological Process	cotranslational protein targeting to membrane	88	7.203387e-28	1.0771519265113635e-25	2.534964	182	0.0114624	252	0.000002851119277579365	1.519858	76	98	0.007932366	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	90	1.061047e-27	1.5513686081111113e-25	2.482761	188	0.01184028	562	0.008396586973487543	1.381922	55	78	0.005740528	
GO Biological Process	translational elongation	92	1.251635e-27	1.7902461918478261e-25	2.37722	204	0.01284797	219	3.1173430652968036e-7	1.522357	87	112	0.009080472	
GO Biological Process	viral transcription	94	3.030106e-27	4.241826048297872e-25	2.342713	207	0.01303691	204	6.202695905294117e-8	1.543572	89	113	0.009289218	
GO Biological Process	protein targeting to ER	96	5.909494e-27	8.100315786041666e-25	2.458933	186	0.01171432	233	8.435602364377683e-7	1.532926	79	101	0.008245486	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	99	7.646576e-27	1.0163767028686868e-24	2.557971	172	0.0108326	254	0.00000322747839996063	1.533769	72	92	0.007514873	
GO Biological Process	cellular response to topologically incorrect protein	111	6.072822e-25	7.199303125945947e-23	2.023938	262	0.01650082	621	0.01527911196714976	1.268946	90	139	0.009393591	
GO Cellular Component	ribosomal subunit	37	1.547935e-30	7.229274810810811e-29	2.111608	293	0.01845321	44	1.431861250909091e-9	1.461917	138	185	0.01440351	
GO Cellular Component	mitochondrial ribosome	43	3.293263e-23	1.3234322009302325e-21	2.685385	135	0.00850233	66	0.00003224767418181818	1.498683	65	85	0.006784261	
GO Cellular Component	ficolin-1-rich granule lumen	47	6.166128e-22	2.2670359965957448e-20	2.02131	229	0.01442247	63	0.000020323381028571428	1.422447	90	124	0.009393591	
GO Cellular Component	very-low-density lipoprotein particle	48	1.040434e-21	3.7455624000000005e-20	4.020889	71	0.004471596	139	0.021307943136690648	1.665844	17	20	0.001774345	
GO Cellular Component	large ribosomal subunit	50	3.7467e-20	1.2948595199999998e-18	2.150732	180	0.01133644	58	0.0000014514246620689655	1.482644	87	115	0.009080472	
GO Cellular Component	high-density lipoprotein particle	55	9.440038e-18	2.9658883025454546e-16	3.699948	63	0.003967754	132	0.014005191272727273	1.596887	22	27	0.002296211	
GO Cellular Component	mitochondrial large ribosomal subunit	69	8.429244e-15	2.110975888695652e-13	2.710811	81	0.005101398	103	0.0028542550368932038	1.498683	39	51	0.004070556	
GO Cellular Component	protein-lipid complex	71	1.487428e-14	3.620106456338028e-13	2.293914	109	0.006864844	145	0.0259366483862069	1.446531	31	42	0.00323557	
GO Cellular Component	plasma lipoprotein particle	78	7.390548e-14	1.637290633846154e-12	2.284732	104	0.006549943	168	0.04801122514285715	1.420867	29	40	0.003026824	
GO Cellular Component	endopeptidase complex	87	3.268025e-12	6.490973793103448e-11	2.037452	117	0.007368686	72	0.000225766392	1.505366	53	69	0.005531782	
GO Cellular Component	proteasome complex	92	6.512299e-12	1.2231796382608697e-10	2.021179	116	0.007305706	77	0.0003208216020779221	1.498683	52	68	0.005427408	
GO Cellular Component	small ribosomal subunit	94	9.211903e-12	1.6934221685106382e-10	2.023321	114	0.007179746	104	0.0032692131692307687	1.415423	52	72	0.005427408	
GO Cellular Component	spherical high-density lipoprotein particle	146	7.501751e-9	8.878784745205479e-8	4.435892	23	0.001448545	164	0.04834539395121951	1.959816	8	8	0.0008349859	
GO Cellular Component	zonula adherens	157	1.603585e-8	1.7649648917197452e-7	3.334963	31	0.001952387	164	0.04834539395121951	1.959816	8	8	0.0008349859	
GO Cellular Component	U12-type spliceosomal complex	208	0.000001103249	0.000009165453230769231	2.293454	43	0.00270815	140	0.021346514742857144	1.582929	21	26	0.002191838	
GO Cellular Component	Lewy body	246	0.000009106189	0.00006396542517073171	2.838076	24	0.001511525	164	0.04834539395121951	1.959816	8	8	0.0008349859	
GO Cellular Component	HFE-transferrin receptor complex	358	0.0005637447	0.0027210917363128494	2.150059	24	0.001511525	164	0.04834539395121951	1.959816	8	8	0.0008349859	
GO Molecular Function	structural constituent of ribosome	10	1.556087e-27	6.569799314e-25	2.096931	267	0.01681572	13	1.829063284e-9	1.512204	125	162	0.01304665	
GO Molecular Function	ribonucleoprotein complex binding	13	1.970203e-24	6.398613127692308e-22	2.157544	220	0.01385565	80	0.00461313399625	1.346309	79	115	0.008245486	
GO Molecular Function	unfolded protein binding	14	3.667432e-24	1.1059927074285714e-21	2.349529	181	0.01139942	100	0.026285589364000002	1.312707	71	106	0.0074105	
GO Molecular Function	exonuclease activity	19	2.943996e-18	6.54186900631579e-16	2.165883	159	0.01001386	103	0.028693248972815534	1.366714	53	76	0.005531782	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	114	3.435778e-8	0.0000012724433961403508	2.081927	69	0.004345635	41	0.0001370817495609756	1.824657	27	29	0.002818077	
GO Molecular Function	proteasome binding	140	1.2663e-7	0.0000038187989999999995	2.632666	39	0.002456229	91	0.014402118876923078	1.959816	12	12	0.001252479	
Human Phenotype	Abnormality of transition element cation homeostasis	36	1.513558e-13	2.805547926111111e-11	3.221966	56	0.003526893	142	0.018839368676760563	1.621917	24	29	0.002504958	
Human Phenotype	Abnormality of reticulocytes	66	5.389349e-11	5.448958466212121e-9	2.418236	71	0.004471596	126	0.013101355109523809	1.603486	27	33	0.002818077	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	33	1.204504e-22	3.3423160993939396e-20	2.004637	242	0.01524121	169	0.008892389791715978	1.369764	65	93	0.006784261	
Mouse Phenotype Single KO	pale liver	36	9.032267e-22	2.297457469972222e-19	2.135313	199	0.01253306	174	0.009483152341954024	1.396369	57	80	0.005949275	
Mouse Phenotype Single KO	absent hypoglossal nerve	133	3.219566e-13	2.216659087368421e-11	3.480279	49	0.003086031	135	0.0027916192991111113	1.959816	15	15	0.001565599	
Mouse Phenotype	decreased circulating free fatty acid level	18	4.645365e-33	2.4674630425e-30	2.067131	335	0.02109838	196	0.0005152525339285714	1.3834	84	119	0.008767352	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	49	3.844836e-21	7.50213816244898e-19	3.265839	90	0.00566822	315	0.007378047656190476	1.63318	25	30	0.002609331	
Mouse Phenotype	absent hypoglossal nerve	166	3.219566e-13	1.854353646144578e-11	3.480279	49	0.003086031	230	0.0017108511597391306	1.959816	15	15	0.001565599	
Mouse Phenotype	increased liver adenoma incidence	289	8.633756e-10	2.8563093811764705e-8	2.342087	66	0.004156695	281	0.004575693853024912	1.679843	24	28	0.002504958	
Mouse Phenotype	distorted hair follicle pattern	638	0.00001127765	0.00016900566089341694	2.252863	36	0.002267288	380	0.015315423716842106	1.959816	11	11	0.001148106	
Mouse Phenotype	decreased brain cholesterol level	888	0.0002499015	0.002690662434121622	2.093759	29	0.001826427	441	0.02587685734013605	1.959816	10	10	0.001043732