# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 19 1.712543e-36 1.186071228263158e-33 4.429464 110 0.02398604 288 0.023480170268055555 1.640543 40 114 0.009960159 GO Biological Process nucleosome organization 73 1.650141e-25 2.9745486875342465e-23 2.821478 136 0.02965547 121 0.0005960254860330578 1.695228 62 171 0.01543825 GO Biological Process regulation of gene expression, epigenetic 80 2.009405e-24 3.305220049375e-22 2.4202 170 0.03706934 302 0.027662034987748343 1.413976 75 248 0.0186753 GO Biological Process DNA replication-dependent nucleosome assembly 84 1.201777e-23 1.88264089797619e-21 15.28285 28 0.006105539 364 0.042009745989010985 2.191663 15 32 0.00373506 GO Biological Process nucleosome assembly 85 1.984991e-23 3.0729995963529412e-21 2.914892 118 0.02573048 116 0.0004883257255344827 1.778025 54 142 0.01344622 GO Biological Process blood coagulation 89 4.479645e-23 6.6233312983146064e-21 2.014978 238 0.05189708 209 0.007998896479425838 1.421 93 306 0.02315737 GO Biological Process coagulation 90 5.087213e-23 7.43807065188889e-21 2.012911 238 0.05189708 225 0.00960253169111111 1.411773 93 308 0.02315737 GO Biological Process chromatin assembly or disassembly 95 1.048124e-22 1.451817233263158e-20 2.631931 135 0.02943742 189 0.0032475075212698413 1.602294 61 178 0.01518924 GO Biological Process chromatin assembly 111 5.674211e-21 6.7267515809909905e-19 2.669375 121 0.02638465 177 0.00239798389960452 1.657156 56 158 0.01394422 GO Biological Process protein-DNA complex subunit organization 125 2.817452e-20 2.9659880694399996e-18 2.162379 176 0.03837767 203 0.006408541253842364 1.477473 79 250 0.01967131 GO Biological Process platelet aggregation 132 1.895346e-19 1.8894589404545454e-17 4.244581 59 0.01286524 350 0.037992852785714286 2.05268 18 41 0.004482072 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell differentiation 148 1.575014e-18 1.4003790017567566e-16 4.050377 59 0.01286524 241 0.015420813693360996 2.517603 14 26 0.003486056 GO Biological Process platelet activation 158 4.459103e-18 3.7137554668987337e-16 2.270267 140 0.03052769 183 0.0027693863333879782 1.691156 51 141 0.0126992 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell activation 181 6.943157e-17 5.047790218950276e-15 3.408265 66 0.01439163 282 0.023022720420212767 2.337774 15 30 0.00373506 GO Biological Process myeloid cell differentiation 191 2.534559e-16 1.7461917215183245e-14 2.006691 166 0.03619712 376 0.04558904052393617 1.444279 59 191 0.01469124 GO Biological Process DNA packaging 196 3.878168e-16 2.603714934285714e-14 2.225552 129 0.02812909 272 0.021710845423161765 1.480199 63 199 0.01568725 GO Biological Process regulation of CD4-positive, alpha-beta T cell activation 203 7.147313e-16 4.633078412167488e-14 2.897801 78 0.01700829 368 0.04304748725271739 1.948145 20 48 0.00498008 GO Biological Process protein-DNA complex assembly 209 1.007878e-15 6.345773493779905e-14 2.068298 148 0.03227213 224 0.009586031897767857 1.494467 70 219 0.01743028 GO Biological Process regulation of megakaryocyte differentiation 220 1.806565e-15 1.0805722197727271e-13 2.995922 72 0.01569996 146 0.0011766994112328768 2.030172 33 76 0.008217131 GO Biological Process regulation of CD4-positive, alpha-beta T cell differentiation 222 2.405255e-15 1.425709484009009e-13 3.125471 67 0.01460968 310 0.03000729544354839 2.103997 18 40 0.004482072 GO Cellular Component nucleosome 36 7.620702e-21 3.65793696e-19 4.107278 66 0.01439163 37 0.016315435070270272 1.692103 38 105 0.009462151 GO Cellular Component DNA packaging complex 47 5.627716e-17 2.069083669787234e-15 3.385264 67 0.01460968 42 0.02924004342857143 1.628093 39 112 0.009711155 GO Cellular Component nuclear pore outer ring 167 0.00001076297 0.00011136773748502995 5.342243 11 0.002398604 48 0.047469420000000005 3.272883 7 10 0.001743028 GO Molecular Function nucleosomal DNA binding 43 3.360224e-11 3.2992710995348832e-9 3.379268 42 0.009158308 73 0.03636423637260274 2.032847 20 46 0.00498008 GO Molecular Function RNA polymerase II core binding 112 5.643365e-7 0.0000212734705625 2.818321 31 0.006759703 75 0.04269469916266666 2.337774 14 28 0.003486056 Mouse Phenotype Single KO decreased erythroid progenitor cell number 5 8.429943e-51 1.54385976102e-47 4.718327 145 0.03161797 74 0.0013943599012162162 2.291935 25 51 0.0062251 Mouse Phenotype Single KO abnormal T cell physiology 16 2.26966e-41 1.29895478875e-38 2.034994 421 0.09180113 80 0.001567672676875 1.362588 153 525 0.03809761 Mouse Phenotype Single KO abnormal erythropoiesis 17 2.346838e-40 1.264117386235294e-37 3.220149 180 0.03924989 15 0.000008659506294666667 2.125249 50 110 0.0124502 Mouse Phenotype Single KO decreased T cell proliferation 23 1.156927e-36 4.606078495217391e-34 2.90201 190 0.04143044 207 0.03778440081352657 1.527346 49 150 0.0122012 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 24 3.870745e-36 1.4768504985416668e-33 3.20056 162 0.0353249 58 0.0005874662298448277 2.035238 37 85 0.009213147 Mouse Phenotype Single KO decreased myeloid cell number 27 5.141547e-35 1.7437461436666667e-32 2.171155 308 0.06716092 133 0.007678089420300752 1.425659 93 305 0.02315737 Mouse Phenotype Single KO abnormal T cell activation 35 5.022805e-34 1.3141092967142857e-31 2.296586 266 0.05800262 196 0.03557673435255102 1.375161 85 289 0.02116534 Mouse Phenotype Single KO abnormal T cell proliferation 38 5.419383e-33 1.3059286876578948e-30 2.336534 249 0.05429568 193 0.03503188270984456 1.39729 78 261 0.01942231 Mouse Phenotype Single KO abnormal third pharyngeal arch artery morphology 69 3.887542e-27 5.15916262231884e-25 6.854405 54 0.01177497 214 0.03990593642476635 3.117032 8 12 0.001992032 Mouse Phenotype Single KO autoimmune response 92 9.322322e-23 9.278750277608695e-21 2.031273 230 0.05015264 215 0.040188292708837205 1.341925 95 331 0.02365538 Mouse Phenotype Single KO abnormal self tolerance 95 1.803659e-22 1.738537417157895e-20 2.01303 232 0.05058875 195 0.035664988833333335 1.347906 96 333 0.02390438 Mouse Phenotype Single KO abnormal immune tolerance 96 2.426826e-22 2.314838091875e-20 2.004583 233 0.0508068 206 0.03745958006407767 1.341799 97 338 0.02415339 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 98 3.211693e-22 3.000966612346939e-20 2.386523 158 0.03445268 96 0.0025033139520833332 1.629762 61 175 0.01518924 Mouse Phenotype Single KO abnormal neutrophil morphology 105 2.183081e-21 1.9038545444761904e-19 2.040792 213 0.0464457 187 0.03291661403529412 1.385966 83 280 0.02066733 Mouse Phenotype Single KO abnormal thymus development 121 1.016122e-19 7.689776160330579e-18 5.960014 43 0.009376363 168 0.023925371445833336 2.922217 10 16 0.00249004 Mouse Phenotype Single KO thrombocytopenia 151 1.929257e-17 1.169947440331126e-15 2.179486 147 0.03205408 194 0.035566217529381446 1.527957 50 153 0.0124502 Mouse Phenotype Single KO abnormal interleukin-1 beta secretion 172 9.874785e-16 5.2571747816860474e-14 2.978844 74 0.01613607 199 0.03614405945226131 1.803426 27 70 0.006723108 Mouse Phenotype Single KO lymph node hyperplasia 213 6.373948e-14 2.7401991472300467e-12 3.632305 49 0.01068469 171 0.025251155776023396 2.424358 14 27 0.003486056 Mouse Phenotype Single KO abnormal myelopoiesis 280 5.794786e-11 1.895101978642857e-9 2.031023 103 0.02245966 85 0.0019242681394117647 1.827714 43 110 0.01070717 Mouse Phenotype Single KO abnormal spleen red pulp morphology 296 1.599003e-10 4.946645429391892e-9 2.058732 95 0.02071522 173 0.025923964547976876 1.679566 37 103 0.009213147 Mouse Phenotype decreased erythroid progenitor cell number 12 1.529064e-45 1.218281742e-42 3.889773 160 0.03488879 126 0.0009906683266666667 2.030172 33 76 0.008217131 Mouse Phenotype abnormal erythropoiesis 13 2.497161e-43 1.8365658708461539e-40 3.032668 211 0.04600959 17 1.6257631258235295e-7 2.071048 66 149 0.01643426 Mouse Phenotype thymus hypoplasia 19 2.869249e-39 1.4438362994210524e-36 2.443166 273 0.059529 300 0.023802982737999998 1.43698 67 218 0.01668327 Mouse Phenotype increased myeloid cell number 25 1.107673e-37 4.2361846212e-35 2.308748 292 0.06367205 161 0.0027615564827329193 1.4662 90 287 0.02241036 Mouse Phenotype decreased T cell proliferation 26 6.416789e-37 2.3596507549615383e-34 2.504209 245 0.05342346 247 0.014291651191093118 1.470712 67 213 0.01668327 Mouse Phenotype abnormal erythroid progenitor cell morphology 31 1.780506e-36 5.4914251180645155e-34 2.963737 183 0.03990406 103 0.0004975187022815534 1.846645 47 119 0.01170319 Mouse Phenotype abnormal proerythroblast morphology 34 8.234596e-36 2.315616834e-33 3.542983 140 0.03052769 331 0.029550826839879155 1.738345 29 78 0.007221116 Mouse Phenotype abnormal T cell proliferation 37 1.89769e-35 4.9037335378378384e-33 2.15488 317 0.06912342 427 0.04910688576814988 1.29594 102 368 0.02539841 Mouse Phenotype abnormal T cell activation 39 4.288624e-35 1.0513726683076922e-32 2.063325 346 0.07544701 379 0.03751764149604221 1.291777 113 409 0.02813745 Mouse Phenotype decreased myeloid cell number 47 1.083027e-33 2.2031534355319145e-31 2.020204 349 0.07610118 216 0.008818561791666667 1.356266 114 393 0.02838645 Mouse Phenotype abnormal platelet physiology 48 9.056575e-33 1.8039565328124998e-30 3.035347 158 0.03445268 268 0.017586949342164176 1.593937 45 132 0.01120518 Mouse Phenotype anemia 56 2.542257e-31 4.3404498530357147e-29 2.010385 328 0.07152202 30 0.00000816554018 1.571085 125 372 0.0311255 Mouse Phenotype decreased erythrocyte cell number 60 3.967007e-30 6.3214256545e-28 2.267264 241 0.05255124 378 0.0369186126984127 1.396592 69 231 0.01718127 Mouse Phenotype abnormal erythrocyte cell number 66 2.217438e-29 3.212261320909091e-27 2.008557 308 0.06716092 220 0.009239759091818182 1.399686 94 314 0.02340637 Mouse Phenotype abnormal third pharyngeal arch artery morphology 93 9.451842e-24 9.717103372258065e-22 4.749204 65 0.01417357 248 0.014425301393951612 2.671742 12 21 0.002988048 Mouse Phenotype abnormal mean corpuscular hemoglobin 105 9.117398e-22 8.302042121714286e-20 2.302823 166 0.03619712 113 0.0007510253495044248 1.651688 65 184 0.01618526 Mouse Phenotype abnormal spleen B cell follicle morphology 129 6.354815e-19 4.709952419767442e-17 2.164859 163 0.03554296 392 0.04175042357908163 1.429313 59 193 0.01469124 Mouse Phenotype increased spleen white pulp amount 132 8.014573e-19 5.805100943409091e-17 4.456351 54 0.01177497 302 0.024050138302649005 2.200258 16 34 0.003984064 Mouse Phenotype decreased mean corpuscular hemoglobin 147 1.64931e-17 1.072724687755102e-15 2.875114 88 0.01918884 307 0.02507228367850163 1.760921 29 77 0.007221116 Mouse Phenotype extramedullary hematopoiesis 153 5.913719e-17 3.695494598627451e-15 2.130532 150 0.03270824 214 0.008856667042990653 1.54961 58 175 0.01444223