# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	124	2.183554e-37	2.317208635967742e-35	2.432999	268	0.0168004	677	0.0023416994460856723	1.324181	80	113	0.007968921	
GO Biological Process	regulation of DNA-templated transcription in response to stress	134	6.109119e-36	5.999246038880597e-34	2.303359	287	0.01799147	653	0.001959947607182236	1.320286	84	119	0.008367367	
GO Biological Process	cellular response to epidermal growth factor stimulus	181	1.891245e-29	1.37496646160221e-27	2.61839	182	0.01140923	739	0.005122716790121787	1.525857	31	38	0.003087957	
GO Biological Process	positive regulation of mRNA metabolic process	193	3.251558e-28	2.2169560477720207e-26	2.643521	171	0.01071966	932	0.016320082653433474	1.402804	39	52	0.003884849	
GO Biological Process	response to epidermal growth factor	196	9.193775e-28	6.172494144132653e-26	2.492979	187	0.01172267	844	0.010497113599170615	1.469604	33	42	0.00328718	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	228	9.741296e-25	5.622180441403508e-23	2.37923	181	0.01134654	850	0.010829144865882353	1.342855	56	78	0.005578245	
GO Biological Process	liver regeneration	327	1.258333e-19	5.0637320938837916e-18	2.601559	119	0.00745988	736	0.004845991268206522	1.549764	29	35	0.002888734	
GO Biological Process	viral gene expression	342	6.530322e-19	2.512646409298246e-17	2.025064	194	0.01216148	1194	0.047262179598827475	1.222391	83	127	0.008267756	
GO Biological Process	regulation of cellular amino acid metabolic process	375	8.145567e-18	2.85833376408e-16	2.601566	107	0.006707623	942	0.017648146751592358	1.371631	44	60	0.004382907	
GO Biological Process	negative regulation of response to endoplasmic reticulum stress	383	1.957316e-17	6.724888053263708e-16	2.40603	121	0.007585256	1193	0.047076272864207874	1.402804	30	40	0.002988345	
GO Biological Process	regulation of mitochondrial membrane permeability	389	3.02357e-17	1.0228061087403598e-15	2.017301	177	0.01109579	567	0.0007905623173721341	1.434832	56	73	0.005578245	
GO Biological Process	regulation of pri-miRNA transcription from RNA polymerase II promoter	444	7.78641e-16	2.30768849527027e-14	2.186102	133	0.008337513	899	0.014294588034037818	1.547922	24	29	0.002390676	
GO Biological Process	regulation of cell aging	472	2.872985e-15	8.009663054025424e-14	2.223318	123	0.007710632	1215	0.04997239096049383	1.415442	28	37	0.002789122	
GO Biological Process	protein-lipid complex subunit organization	484	4.034568e-15	1.0969190147107439e-13	2.273057	116	0.007271815	1071	0.031164505160597576	1.392855	35	47	0.003486403	
GO Biological Process	protein-lipid complex assembly	565	9.416447e-14	2.1931155057168145e-12	2.701389	75	0.004701605	899	0.014294588034037818	1.547922	24	29	0.002390676	
GO Biological Process	actin polymerization or depolymerization	604	4.524749e-13	9.85780994884106e-12	2.053876	124	0.00777332	1175	0.04393916650382978	1.39193	32	43	0.003187568	
GO Biological Process	regulation of cellular senescence	615	6.11894e-13	1.3092541700813009e-11	2.141248	111	0.006958375	1063	0.029750803061147694	1.496324	24	30	0.002390676	
GO Biological Process	intracellular transport of virus	636	1.476011e-12	3.0539038913522015e-11	2.029491	122	0.007647944	1020	0.02552993071176471	1.344354	46	64	0.00458213	
GO Biological Process	plasma lipoprotein particle organization	705	8.897188e-12	1.6606822254184396e-10	2.146906	99	0.006206118	1083	0.033447322630655585	1.402804	33	44	0.00328718	
GO Biological Process	regulation of fatty acid biosynthetic process	729	1.429408e-11	2.5801892828532236e-10	2.067826	106	0.006644935	1038	0.027616481439306357	1.438773	30	39	0.002988345	
GO Cellular Component	cortical actin cytoskeleton	78	2.754066e-17	6.101315446153846e-16	2.033201	174	0.01090772	117	0.018658855384615387	1.371631	44	60	0.004382907	
GO Cellular Component	PcG protein complex	100	1.118744e-13	1.933189632e-12	2.032511	134	0.008400201	150	0.041347376639999996	1.382474	34	46	0.003386792	
GO Cellular Component	very-low-density lipoprotein particle	154	2.14691e-9	2.4090003116883116e-8	2.705737	48	0.003009027	148	0.038707106594594594	1.589845	17	20	0.001693396	
GO Cellular Component	fibrinogen complex	230	0.000001472392	0.000011062145113043479	2.408678	38	0.002382146	149	0.04132478367785235	1.870405	9	9	0.0008965036	
GO Cellular Component	nucleotide-activated protein kinase complex	306	0.0001022561	0.0005774462117647058	2.425493	24	0.001504514	130	0.025312581415384616	1.870405	10	10	0.0009961152	
GO Molecular Function	peptide disulfide oxidoreductase activity	75	5.518317e-12	3.1064445832000004e-10	3.814423	39	0.002444835	100	0.012268236935999998	1.870405	13	13	0.00129495	
GO Molecular Function	C-acyltransferase activity	107	4.245481e-10	1.6751795123364487e-8	2.442545	63	0.003949348	108	0.02298667118148148	1.683365	18	20	0.001793007	
GO Molecular Function	cadherin binding involved in cell-cell adhesion	169	7.360718e-8	0.0000018388728636686387	2.027151	70	0.004388164	72	0.000741753211388889	1.870405	18	18	0.001793007	
Human Phenotype	Abnormality of the umbilical cord	79	4.505192e-10	3.805461546329114e-8	2.572551	57	0.00357322	188	0.04144181462765958	1.745712	14	15	0.001394561	
Mouse Phenotype Single KO	abnormal cell adhesion	96	2.561153e-24	2.442966460520833e-22	2.148588	221	0.01385406	532	0.011983678116729323	1.394879	44	59	0.004382907	
Mouse Phenotype Single KO	decreased mean corpuscular volume	108	5.46739e-23	4.635637984259259e-21	2.055715	231	0.01448094	658	0.028384626454407296	1.288502	62	90	0.006175914	
Mouse Phenotype Single KO	spontaneous skin ulceration	163	3.58773e-18	2.0155118779141104e-16	2.789249	97	0.006080742	618	0.021150032546925563	1.571141	21	25	0.002091842	
Mouse Phenotype Single KO	abnormal fibroblast migration	170	1.15369e-17	6.214317252941177e-16	2.007498	184	0.0115346	568	0.01615104566549296	1.459829	32	41	0.003187568	
Mouse Phenotype Single KO	abnormal branching of the mammary ductal tree	176	1.996738e-17	1.0388710151136365e-15	2.045238	173	0.01084504	731	0.03985186528043776	1.427415	29	38	0.002888734	
Mouse Phenotype Single KO	decreased fibroblast cell migration	198	3.517699e-16	1.6268469567171718e-14	2.002635	168	0.01053159	747	0.04138018879919679	1.442884	27	35	0.002689511	
Mouse Phenotype Single KO	increased liver adenoma incidence	481	2.465554e-10	4.693779205405406e-9	2.591065	58	0.003635908	512	0.010516345919140625	1.683365	18	20	0.001793007	
Mouse Phenotype Single KO	abnormal acute phase protein level	522	1.045359e-9	1.833783977586207e-8	2.3305	66	0.004137412	512	0.010516345919140625	1.683365	18	20	0.001793007	
Mouse Phenotype Single KO	microcytosis	856	0.000001231311	0.000013171863115654206	2.258743	44	0.002758275	659	0.02841811726403642	1.603205	18	21	0.001793007	
Mouse Phenotype	abnormal cell adhesion	123	6.413305e-27	4.985171471951219e-25	2.053992	274	0.01717653	379	0.0002760306108443272	1.452025	59	76	0.005877079	
Mouse Phenotype	increased liver adenoma incidence	192	2.081867e-20	1.03670470765625e-18	3.17894	90	0.005641926	499	0.0011395342037074149	1.670005	25	28	0.002490288	
Mouse Phenotype	spontaneous skin ulceration	231	5.752391e-18	2.380892222987013e-16	2.436891	122	0.007647944	1105	0.036928415052488686	1.402804	30	40	0.002988345	
Mouse Phenotype	increased cellular sensitivity to oxidative stress	501	1.865977e-11	3.560999220958084e-10	2.117422	99	0.006206118	906	0.018798192357615894	1.402804	36	48	0.003586015	
Mouse Phenotype	abnormal acute phase protein level	745	1.081963e-8	1.3885433883221476e-7	2.108595	72	0.004513541	694	0.006373789676368876	1.636605	21	24	0.002091842	
Mouse Phenotype	microcytic anemia	820	3.788213e-8	4.416963962560976e-7	2.102099	67	0.0042001	1064	0.03277278065131579	1.483425	23	29	0.002291065	
Mouse Phenotype	abnormal kidney inner medulla morphology	898	1.511482e-7	0.0000016092738755011138	2.100782	61	0.003823972	1039	0.03278996021751684	1.870405	9	9	0.0008965036	
Mouse Phenotype	decreased Clara cell number	903	1.604474e-7	0.0000016988234677740863	2.018138	67	0.0042001	1039	0.03278996021751684	1.870405	9	9	0.0008965036	
Mouse Phenotype	ovary hypoplasia	974	4.521473e-7	0.000004438378167659138	2.611057	36	0.00225677	1039	0.03278996021751684	1.870405	9	9	0.0008965036	
Mouse Phenotype	microcytosis	1009	6.736692e-7	0.000006383499723686818	2.220103	48	0.003009027	694	0.006373789676368876	1.636605	21	24	0.002091842