# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process liver regeneration 28 1.394963e-43 6.555827898928572e-41 4.25928 139 0.01221334 774 0.030677913325581396 1.645662 23 35 0.003067485 GO Biological Process negative regulation of sequence-specific DNA binding transcription factor activity 63 5.118451e-36 1.069106296968254e-33 2.084647 357 0.03136807 430 0.002427592517534884 1.405273 78 139 0.01040277 GO Biological Process response to hydrogen peroxide 85 1.009184e-30 1.562335559529412e-28 2.283349 247 0.02170284 610 0.01079753979032787 1.401471 61 109 0.008135503 GO Biological Process cellular response to epidermal growth factor stimulus 91 9.220745e-30 1.3333602577472527e-27 2.984416 148 0.01300413 562 0.00829814969252669 1.713446 26 38 0.003467591 GO Biological Process response to epidermal growth factor 104 6.75687e-28 8.549389647115384e-26 2.821556 151 0.01326773 583 0.00929404595883362 1.669512 28 42 0.003734329 GO Biological Process cellular response to reactive oxygen species 108 3.203326e-27 3.903015447592592e-25 2.123791 255 0.02240576 543 0.0072183827786372005 1.398216 67 120 0.008935716 GO Biological Process cellular response to hydrogen peroxide 110 4.252827e-27 5.087540953909091e-25 2.611413 167 0.01467358 620 0.01146871371548387 1.534874 38 62 0.005068018 GO Biological Process animal organ regeneration 129 5.632024e-25 5.745101071007752e-23 2.20889 213 0.0187154 410 0.0018892437280731708 1.545844 50 81 0.006668445 GO Biological Process negative regulation of ossification 184 3.173472e-21 2.269549893913043e-19 2.037072 216 0.018979 433 0.002648554172517321 1.574111 44 70 0.005868232 GO Biological Process regulation of glucose metabolic process 202 2.561127e-20 1.6684094154950496e-18 2.029305 208 0.01827607 870 0.04719428461609196 1.354349 53 98 0.007068552 GO Biological Process regulation of cellular response to insulin stimulus 207 7.629352e-20 4.849982752077295e-18 2.204518 167 0.01467358 468 0.0038532532457264956 1.56984 42 67 0.005601494 GO Biological Process negative regulation of cellular response to insulin stimulus 252 5.728153e-18 2.9911414812301585e-16 2.547901 112 0.009840963 670 0.017948436057313433 1.721684 22 32 0.002934116 GO Biological Process negative regulation of insulin receptor signaling pathway 258 8.680862e-18 4.4275760875193794e-16 2.544921 111 0.009753097 657 0.016557875564079148 1.752987 21 30 0.002800747 GO Biological Process regulation of insulin receptor signaling pathway 260 1.571763e-17 7.954934352692308e-16 2.21706 144 0.01265267 538 0.007020659143866171 1.63544 32 49 0.004267805 GO Biological Process cellular response to hexose stimulus 270 5.680384e-17 2.768450853925926e-15 2.084603 160 0.01405852 361 0.0011313692652631577 1.620409 44 68 0.005868232 GO Biological Process cellular response to monosaccharide stimulus 288 2.069395e-16 9.455266946180556e-15 2.052809 160 0.01405852 401 0.0017277120535411472 1.596924 44 69 0.005868232 GO Biological Process regulation of pri-miRNA transcription from RNA polymerase II promoter 303 6.594552e-16 2.863950817425743e-14 2.442077 106 0.009313769 580 0.009018414016724137 1.813435 21 29 0.002800747 GO Biological Process cholesterol efflux 317 1.047783e-15 4.3494563082018933e-14 3.547224 58 0.005096213 615 0.011182002538373984 1.878201 18 24 0.00240064 GO Biological Process cellular response to glucose stimulus 363 7.905835e-15 2.8659196353994487e-13 2.002739 152 0.01335559 465 0.003802464258494624 1.579615 41 65 0.005468125 GO Biological Process high-density lipoprotein particle remodeling 498 1.305723e-12 3.450202601807229e-11 4.096066 38 0.003338898 824 0.039380894584951455 1.915028 13 17 0.001733796 GO Cellular Component PcG protein complex 85 5.291065e-11 1.0756423905882353e-9 2.083478 98 0.008610843 80 0.0275870664 1.578778 29 46 0.003867698 GO Molecular Function cadherin binding 3 3.809375e-61 5.361060416666666e-58 2.056894 631 0.05544328 23 9.492764992173913e-7 1.408651 171 304 0.02280608 GO Molecular Function NF-kappaB binding 60 5.188989e-12 3.651318593e-10 2.87207 58 0.005096213 83 0.037206624250602414 1.788763 20 28 0.002667378 GO Molecular Function sugar transmembrane transporter activity 122 2.248634e-8 7.781748154098361e-7 2.293956 57 0.005008347 60 0.006084813248333333 1.808638 26 36 0.003467591 GO Molecular Function monosaccharide transmembrane transporter activity 276 0.00002825091 0.00043215703630434784 2.038334 41 0.003602495 79 0.027929486630379752 1.878201 18 24 0.00240064 Human Phenotype Hypotelorism 27 3.403097e-16 8.410691215185186e-14 2.145438 142 0.01247694 73 0.03239611696438356 1.713446 26 38 0.003467591 Human Phenotype Foot acroosteolysis 759 0.001406951 0.012369675919631094 2.120752 21 0.001845181 90 0.04782530944111111 2.504268 8 8 0.001066951 Mouse Phenotype Single KO abnormal osteoblast differentiation 23 3.3225e-40 1.3227883695652172e-37 3.022521 199 0.01748528 360 0.006545052232777778 1.669512 30 45 0.004001067 Mouse Phenotype Single KO cortical renal glomerulopathies 42 2.812772e-33 6.132512667619047e-31 2.141249 309 0.02715051 294 0.001876470816292517 1.420331 76 134 0.01013604 Mouse Phenotype Single KO pale kidney 43 3.482811e-33 7.4167675179069765e-31 3.468979 134 0.01177401 313 0.0033209337907348243 1.858005 23 31 0.003067485 Mouse Phenotype Single KO abnormal glomerular mesangium morphology 78 5.220696e-27 6.12896324e-25 2.392841 196 0.01722169 615 0.04128937457235772 1.441851 38 66 0.005068018 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 154 1.582405e-20 9.409144535714287e-19 2.2177 171 0.01502504 461 0.01650549845900217 1.559261 33 53 0.004401174 Mouse Phenotype Single KO abnormal cervical atlas morphology 155 1.637578e-20 9.674388223225807e-19 2.391838 146 0.0128284 568 0.03314127879225352 1.558211 28 45 0.003734329 Mouse Phenotype Single KO abnormal B cell apoptosis 164 3.330544e-20 1.8596214273170733e-18 2.509047 131 0.01151041 344 0.005362530858139535 1.733724 27 39 0.00360096 Mouse Phenotype Single KO increased B cell proliferation 218 6.148996e-18 2.5828603840366973e-16 2.257668 142 0.01247694 382 0.008216396315968585 1.550261 39 63 0.005201387 Mouse Phenotype Single KO decreased hepatocyte proliferation 267 4.646276e-16 1.593481248389513e-14 2.779322 85 0.007468588 490 0.021852339551020408 1.803073 18 25 0.00240064 Mouse Phenotype Single KO persistence of hyaloid vascular system 283 1.357837e-15 4.393538307067137e-14 2.132907 138 0.01212547 498 0.0229840516124498 1.593625 28 44 0.003734329 Mouse Phenotype Single KO abnormal neural fold morphology 310 1.4428e-14 4.261845032258064e-13 2.047368 141 0.01238907 457 0.015722869557986872 1.598469 30 47 0.004001067 Mouse Phenotype Single KO abnormal cervical axis morphology 432 1.057404e-11 2.2413538027777775e-10 2.061619 108 0.0094895 533 0.029393781018761726 1.669512 22 33 0.002934116 Mouse Phenotype Single KO bowed tibia 442 1.706946e-11 3.536313240271493e-10 2.221739 89 0.007820051 400 0.01006587116725 2.062338 14 17 0.001867165 Mouse Phenotype Single KO abnormal vascular endothelial cell development 532 3.723491e-10 6.409023888533834e-9 2.039073 94 0.00825938 522 0.02808069481226054 1.696439 21 31 0.002800747 Mouse Phenotype Single KO absent incisors 604 2.855762e-9 4.329505402980132e-8 2.013709 87 0.007644319 645 0.04923957407906977 1.788763 15 21 0.002000533 Mouse Phenotype Single KO loss of dopaminergic neurons 645 8.700968e-9 1.2352676585426355e-7 2.473801 52 0.004569019 371 0.007699082190296495 2.295579 11 12 0.001467058 Mouse Phenotype Single KO abnormal osteocyte morphology 664 1.515815e-8 2.0904093305722893e-7 2.817321 40 0.00351463 554 0.031194907272563178 2.003414 12 15 0.001600427 Mouse Phenotype Single KO decreased total retina thickness 795 1.870464e-7 0.0000021544451381132073 2.032769 65 0.005711273 631 0.04623666793660856 1.581643 24 38 0.003200854 Mouse Phenotype Single KO decreased urine calcium level 1305 0.00006446484 0.00045234064358620687 2.44787 25 0.002196644 437 0.01351608612654462 2.504268 8 8 0.001066951 Mouse Phenotype Single KO absent Langerhans cell 1729 0.001390681 0.007365220310584153 2.500935 15 0.001317986 524 0.028243962641221376 2.504268 7 7 0.0009335823 Mouse Phenotype decreased interscapular fat pad weight 27 1.2052e-48 4.267747111111111e-46 6.369691 106 0.009313769 942 0.03890940297133758 1.967639 11 14 0.001467058 Mouse Phenotype extramedullary hematopoiesis 32 6.230624e-46 1.861593627e-43 2.23783 391 0.0343555 409 0.001009284640415648 1.37377 96 175 0.01280341 Mouse Phenotype abnormal interscapular fat pad morphology 69 1.160199e-34 1.6076322665217392e-32 3.239945 154 0.01353132 985 0.04578103821928933 1.640727 19 29 0.002534009 Mouse Phenotype thick epidermis 86 1.787173e-32 1.9868791922093022e-30 2.212557 280 0.02460241 522 0.004052625832183908 1.412664 66 117 0.008802347 Mouse Phenotype decreased circulating free fatty acid level 87 1.97404e-32 2.1694018896551723e-30 2.272702 264 0.02319656 858 0.029894695171328672 1.325789 63 119 0.008402241 Mouse Phenotype abnormal osteoblast differentiation 95 1.191167e-31 1.1988155459999999e-29 2.278389 256 0.02249363 669 0.011827477209865472 1.495085 40 67 0.005334756 Mouse Phenotype dry eyes 131 1.130589e-27 8.251573609923664e-26 4.100601 90 0.007907917 992 0.04626064790927419 1.878201 12 16 0.001600427 Mouse Phenotype pale kidney 152 8.2925e-26 5.216091611842105e-24 2.706249 149 0.013092 650 0.01119045328246154 1.613861 29 45 0.003867698 Mouse Phenotype abnormal lung saccule morphology 180 6.874359e-24 3.6514303554999997e-22 2.406721 170 0.01493718 716 0.01565855445670391 1.627774 26 40 0.003467591 Mouse Phenotype increased B cell proliferation 186 1.246569e-23 6.407766779032258e-22 2.371545 173 0.01520077 558 0.005712918533870967 1.484011 48 81 0.006401707 Mouse Phenotype absent heart 228 8.436737e-21 3.537879055131579e-19 4.414835 61 0.00535981 796 0.02266890278517588 2.003414 12 15 0.001600427 Mouse Phenotype abnormal cervical atlas morphology 242 2.888615e-20 1.1412416535123968e-18 2.336774 151 0.01326773 824 0.023956094974514563 1.512011 32 53 0.004267805 Mouse Phenotype abnormal brown fat cell morphology 261 3.973197e-19 1.4554688320689656e-17 2.091477 181 0.0159037 745 0.01695731259865772 1.520448 34 56 0.004534543 Mouse Phenotype abnormal axillary lymph node morphology 263 4.576855e-19 1.663852116159696e-17 2.712663 107 0.009401634 793 0.022564116737704917 1.821286 16 22 0.002133902 Mouse Phenotype abnormal embryonic hematopoiesis 294 2.684442e-17 8.729914953061225e-16 2.013168 178 0.0156401 675 0.011956887448888889 1.518982 37 61 0.004934649 Mouse Phenotype abnormal mesenchymal cell proliferation involved in lung development 312 8.152429e-17 2.498249156057692e-15 2.698796 94 0.00825938 847 0.02783619114757969 1.915028 13 17 0.001733796 Mouse Phenotype abnormal thymus development 321 1.408197e-16 4.194321344859813e-15 2.477025 108 0.0094895 985 0.04578103821928933 1.640727 19 29 0.002534009 Mouse Phenotype abnormal kidney inner medulla morphology 326 1.69655e-16 4.975679309815951e-15 3.282425 68 0.00597487 938 0.038182913568230274 2.226016 8 9 0.001066951 Mouse Phenotype abnormal ileum morphology 400 9.535756e-15 2.2792840779e-13 2.350965 105 0.009225903 907 0.034070902845644985 1.565167 25 40 0.003334222 Mouse Phenotype decreased hepatocyte proliferation 465 2.380976e-13 4.895593878709677e-12 2.279683 100 0.008786574 706 0.015187228682719546 1.647545 25 38 0.003334222