# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	57	4.081178e-12	9.421793210877194e-10	3.677172	41	0.02	173	0.0019496070145664738	2.180819	30	118	0.01370489	
GO Biological Process	negative regulation of cyclin-dependent protein serine/threonine kinase activity	62	2.934781e-11	6.228835996612904e-9	5.939636	23	0.01121951	351	0.037224527857264954	3.216709	9	24	0.004111466	
GO Biological Process	regulation of cellular response to transforming growth factor beta stimulus	64	4.733561e-11	9.73264518734375e-9	2.61177	61	0.0297561	382	0.045504442057591625	1.93423	23	102	0.01050708	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	69	2.136863e-10	4.075214524202899e-8	3.80122	33	0.01609756	217	0.006252865725345622	2.23771	24	92	0.01096391	
GO Biological Process	protein targeting to ER	77	1.043144e-9	1.782692454025974e-7	3.481405	34	0.01658537	249	0.00978221034939759	2.12324	25	101	0.01142074	
GO Biological Process	cotranslational protein targeting to membrane	78	1.063169e-9	1.7936206244871796e-7	3.560051	33	0.01609756	271	0.014235289662730627	2.100708	24	98	0.01096391	
GO Biological Process	protein localization to endoplasmic reticulum	80	2.825447e-9	4.647507134125e-7	2.984389	40	0.0195122	202	0.004550608248168317	2.075296	30	124	0.01370489	
GO Biological Process	rRNA metabolic process	81	3.037272e-9	4.934254598518519e-7	2.299615	63	0.03073171	385	0.045951228000000004	1.556605	47	259	0.02147099	
GO Biological Process	nuclear-transcribed mRNA catabolic process	83	3.305837e-9	5.241145672650602e-7	2.458398	55	0.02682927	242	0.009262870229752066	1.77623	41	198	0.01873001	
GO Biological Process	mRNA catabolic process	86	6.553264e-9	0.000001002725592744186	2.344314	58	0.02829268	220	0.0063745425936363636	1.771958	44	213	0.0201005	
GO Biological Process	RNA catabolic process	87	8.972392e-9	0.0000013571000727356322	2.215844	64	0.03121951	232	0.007686637002586206	1.708459	48	241	0.02192782	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	92	2.496251e-8	0.0000035704529248913043	3.051483	34	0.01658537	289	0.0160505286083045	2.042355	25	105	0.01142074	
GO Biological Process	termination of RNA polymerase II transcription	107	1.844229e-7	0.00002268056954299065	3.686384	23	0.01121951	324	0.02952403195462963	2.23771	18	69	0.008222933	
GO Biological Process	mammary gland epithelium development	118	4.43462e-7	0.00004945352930508474	2.338353	44	0.02146341	163	0.0018263965429447854	2.859296	18	54	0.008222933	
GO Biological Process	metanephric tubule morphogenesis	134	0.000001186686	0.00011653433637313434	4.757944	15	0.007317073	287	0.015808466072125438	5.146734	6	10	0.002740978	
GO Biological Process	RNA 3'-end processing	147	0.000002449079	0.00021923422150340135	2.717695	29	0.01414634	360	0.041502206652777776	1.924013	24	107	0.01096391	
GO Biological Process	cellular response to epidermal growth factor stimulus	170	0.000007187016	0.0005563173149647059	2.79875	25	0.01219512	190	0.0036064497307368415	3.160275	14	38	0.006395614	
GO Biological Process	positive regulation of neural precursor cell proliferation	176	0.000008831722	0.0006603217602159092	2.369352	33	0.01609756	197	0.0042659594325888325	2.859296	16	48	0.007309274	
GO Biological Process	positive regulation of protein homooligomerization	177	0.000009314922	0.0006925144553559322	6.047819	10	0.004878049	170	0.0019548127972941177	6.004523	7	10	0.003197807	
GO Biological Process	notochord formation	200	0.00002195696	0.0014446581832	7.172773	8	0.003902439	248	0.009776808025000002	8.577889	4	4	0.001827318	
GO Cellular Component	nuclear matrix	19	2.597988e-10	2.3628017178947367e-8	2.543834	59	0.02878049	26	0.007747840246153845	2.144472	26	104	0.01187757	
GO Cellular Component	transcriptional repressor complex	28	9.680847e-7	0.000059744655771428576	2.293967	43	0.02097561	28	0.0094670208	2.273657	22	83	0.01005025	
GO Cellular Component	cytosolic ribosome	29	0.000001277707	0.00007613371365517242	2.520412	35	0.01707317	32	0.0223608168	1.991296	26	112	0.01187757	
GO Cellular Component	SWI/SNF superfamily-type complex	41	0.000004547637	0.00019166626185365853	2.579448	30	0.01463415	33	0.0234534528	2.26361	19	72	0.008679762	
GO Cellular Component	cytosolic small ribosomal subunit	53	0.00005890651	0.001920574514716981	3.236665	16	0.007804878	40	0.04846387680000001	2.534376	13	44	0.005938785	
GO Cellular Component	compact myelin	64	0.0001662918	0.0044898786	3.640375	12	0.005853659	34	0.023989468235294117	4.288945	7	14	0.003197807	
GO Cellular Component	histone methyltransferase complex	72	0.0003287712	0.0078905088	2.275543	23	0.01121951	38	0.033056580884210526	2.23771	18	69	0.008222933	
GO Molecular Function	histone deacetylase binding	16	8.154854e-8	0.0000215186209925	2.287973	52	0.02536585	49	0.04774931214285714	1.985623	25	108	0.01142074	
GO Molecular Function	RNA polymerase II distal enhancer sequence-specific DNA binding	32	0.000001156099	0.0001525328118125	2.457214	37	0.01804878	35	0.005749870629142857	2.501884	21	72	0.009593422	
GO Molecular Function	enhancer binding	33	0.000001305019	0.00016696333993939394	2.033102	55	0.02682927	31	0.00034128468903225803	2.427705	30	106	0.01370489	
GO Molecular Function	histone methyltransferase activity	53	0.00001798546	0.0014327285305660376	2.438489	29	0.01414634	44	0.02754758085909091	2.471595	17	59	0.007766103	
GO Molecular Function	SNAP receptor activity	55	0.00001937121	0.0014870045203636364	3.134845	19	0.009268293	38	0.015035841931578949	2.929035	14	41	0.006395614	
GO Molecular Function	pre-mRNA binding	92	0.0003239817	0.014867942797826087	2.512843	19	0.009268293	42	0.01690741114761905	3.013853	13	37	0.005938785	
Mouse Phenotype Single KO	vertebral transformation	21	1.267734e-7	0.000055279239228571425	2.619523	39	0.01902439	38	0.002841072507631579	2.424186	26	92	0.01187757	
Mouse Phenotype Single KO	decreased mortality induced by ionizing radiation	25	5.316568e-7	0.000194735252704	9.850328	9	0.004390244	99	0.03398151600606061	6.127064	5	7	0.002284148	
Mouse Phenotype	absent hypoglossal canal	16	1.432769e-8	0.000008561690255625	12.4753	10	0.004878049	226	0.03745273840884956	5.361181	5	8	0.002284148	
Mouse Phenotype	dry eyes	18	4.092457e-8	0.000021737767431666666	4.806016	19	0.009268293	250	0.048707979084	3.752827	7	16	0.003197807	
Mouse Phenotype	sacral vertebral transformation	23	1.928815e-7	0.00008018000093478261	7.233735	12	0.005853659	87	0.005206948074137931	4.084709	10	21	0.004568296	
Mouse Phenotype	thoracic vertebral transformation	24	2.175046e-7	0.000086648395025	3.32324	26	0.01268293	91	0.005399079889450549	2.708807	18	57	0.008222933	
Mouse Phenotype	decreased mortality induced by ionizing radiation	37	0.000001352451	0.00034948064894594597	8.782897	9	0.004390244	226	0.03745273840884956	5.361181	5	8	0.002284148	
Mouse Phenotype	vertebral transformation	63	0.00002635635	0.003999889878571429	2.01679	42	0.0204878	47	0.0006301929724468085	2.405016	30	107	0.01370489	
Mouse Phenotype	abnormal rib development	76	0.00005253913	0.006609560814868421	3.011205	18	0.008780488	132	0.014886904347727273	3.119233	12	33	0.005481955	
Mouse Phenotype	abnormal liver sinusoid morphology	106	0.0002010611	0.018135331859433963	2.05679	31	0.01512195	190	0.024257278517368423	2.199459	20	78	0.009136592	
Mouse Phenotype	abnormal ureter development	109	0.0002295428	0.020134483585321102	2.335833	23	0.01121951	89	0.005289002322134831	3.774271	11	25	0.005025126	
Mouse Phenotype	abnormal Mullerian duct morphology	140	0.0004193184	0.02863645158857143	2.151445	25	0.01219512	237	0.04525737674683545	2.534376	13	44	0.005938785	
Mouse Phenotype	enlarged liver sinusoidal spaces	141	0.0004214294	0.02857649995319149	2.393081	20	0.009756098	77	0.003863304578181818	3.138252	15	41	0.006852444	
Mouse Phenotype	fusion of vertebral arches	158	0.0005942622	0.035960385406329114	2.098746	25	0.01219512	232	0.040325442063362076	2.382747	15	54	0.006852444