# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 49 6.349646e-50 1.7052039125306122e-47 2.213426 437 0.03390225 446 0.010771600395739909 1.25899 130 248 0.01662829 GO Biological Process gene silencing 79 4.93628e-33 8.222342850632911e-31 2.214487 285 0.02211016 485 0.015686073352371134 1.294285 97 180 0.01240727 GO Biological Process nucleosome organization 83 6.466306e-32 1.0251821765542169e-29 2.15527 292 0.02265322 476 0.01367922281932773 1.306223 93 171 0.01189563 GO Biological Process chromatin assembly or disassembly 115 8.386077e-27 9.59585976026087e-25 2.004563 289 0.02242048 487 0.016030601834086243 1.295334 96 178 0.01227936 GO Biological Process mitochondrial membrane organization 128 4.248056e-25 4.3672006956249996e-23 2.080361 246 0.01908456 346 0.002963650583786127 1.413942 73 124 0.009337426 GO Biological Process nucleosome assembly 139 2.649873e-24 2.508609986115108e-22 2.082907 237 0.01838635 530 0.02281468687849057 1.319279 78 142 0.009976976 GO Biological Process transport along microtubule 140 2.782306e-24 2.6151689038571426e-22 2.023888 254 0.0197052 620 0.04048183821935484 1.313465 70 128 0.008953697 GO Biological Process positive regulation of histone methylation 161 9.127528e-23 7.460195090186335e-21 2.815499 122 0.009464701 553 0.024685546334538882 1.673958 23 33 0.002941929 GO Biological Process cellular response to topologically incorrect protein 184 5.343495e-21 3.82147014701087e-19 2.036351 214 0.01660202 506 0.018456974636758897 1.330474 77 139 0.009849066 GO Biological Process organelle transport along microtubule 187 7.698798e-21 5.4175659295187165e-19 2.306752 160 0.01241272 493 0.016515596652332657 1.492006 41 66 0.005244308 GO Biological Process endoplasmic reticulum unfolded protein response 219 4.40459e-19 2.6465753337899543e-17 2.105029 178 0.01380915 652 0.04513034455368098 1.327291 63 114 0.008058327 GO Biological Process cellular response to unfolded protein 230 1.053415e-18 6.026907819565217e-17 2.022206 192 0.01489527 521 0.021228697395585413 1.349752 68 121 0.008697877 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 242 7.91964e-18 4.3063860644628096e-16 2.501018 115 0.008921645 388 0.005973836676030927 1.601177 36 54 0.004604758 GO Biological Process regulation of megakaryocyte differentiation 248 1.551594e-17 8.232832841129033e-16 2.190993 148 0.01148177 426 0.009147658010093897 1.485302 47 76 0.006011768 GO Biological Process axonal transport 284 1.399421e-16 6.484148217957747e-15 2.643218 96 0.007447634 579 0.0315993726044905 1.601177 26 39 0.003325659 GO Biological Process regulation of membrane permeability 305 8.362346e-16 3.6078724922622955e-14 2.009443 162 0.01256788 549 0.024363469041894355 1.423268 48 81 0.006139678 GO Biological Process negative regulation of transcription from RNA polymerase II promoter in response to stress 321 5.274365e-15 2.1621610291277257e-13 3.772609 51 0.003956555 404 0.0070447585938118815 2.217014 12 13 0.001534919 GO Biological Process regulation of mitochondrial membrane permeability 325 6.905563e-15 2.7960093389846155e-13 2.045162 145 0.01124903 645 0.04375190006511628 1.414738 43 73 0.005500128 GO Biological Process positive regulation of mRNA metabolic process 450 4.486411e-12 1.3119262744222222e-10 2.085333 109 0.008456168 570 0.028023775775438596 1.524197 33 52 0.004221028 GO Biological Process positive regulation of mRNA catabolic process 462 6.218107e-12 1.7710837665151515e-10 2.434909 77 0.005973623 635 0.04295342129448819 1.729271 18 25 0.002302379 GO Cellular Component axon cytoplasm 67 7.533062e-17 1.9428553934328353e-15 2.654528 97 0.007525213 95 0.015333740867368419 1.621191 27 40 0.003453569 GO Cellular Component organelle membrane contact site 79 1.21711e-14 2.6622355443037974e-13 2.996956 68 0.005275407 107 0.02363571319626168 1.951434 13 16 0.001662829 GO Cellular Component RISC complex 163 2.478819e-7 0.000002627852289570552 2.877638 32 0.002482545 72 0.0037449504 2.401765 10 10 0.0012791 GO Cellular Component cytoplasmic dynein complex 172 6.929946e-7 0.000006962178306976743 2.003301 61 0.004732351 114 0.047532323368421045 1.746738 16 22 0.002046559 GO Cellular Component RNAi effector complex 211 0.00001283476 0.0001051112098578199 2.369355 32 0.002482545 100 0.01844180352 2.183423 10 11 0.0012791 GO Molecular Function protein-glutamic acid ligase activity 561 0.002697591 0.020301656331550805 2.005078 21 0.00162917 79 0.02004234170886076 2.401765 9 9 0.00115119 Mouse Phenotype Single KO abnormal erythropoiesis 22 3.543495e-53 1.4748992597727275e-50 2.437718 383 0.02971296 91 0.000037731589564835166 1.572064 72 110 0.009209517 Mouse Phenotype Single KO decreased erythrocyte cell number 34 1.054029e-45 2.8387481038235293e-43 2.042747 480 0.03723817 233 0.005984193821030043 1.331264 97 175 0.01240727 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 46 5.908847e-40 1.1762459125869566e-37 2.101196 391 0.03033359 103 0.00012868109842718446 1.427335 104 175 0.01330263 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 64 2.020796e-31 2.8913170268750003e-29 2.473364 216 0.01675718 181 0.001558827476519337 1.676704 37 53 0.004732668 Mouse Phenotype Single KO decreased erythroid progenitor cell number 73 2.462635e-27 3.089088862328767e-25 2.361736 204 0.01582622 211 0.0038236542054976303 1.64827 35 51 0.004476848 Mouse Phenotype Single KO abnormal megakaryocyte progenitor cell morphology 76 6.109471e-27 7.361108677236842e-25 2.101287 259 0.0200931 232 0.005734788334051724 1.47381 54 88 0.006907137 Mouse Phenotype Single KO abnormal platelet activation 82 1.735083e-25 1.937579881829268e-23 2.257037 208 0.01613654 422 0.044914065144549764 1.384547 49 85 0.006267588 Mouse Phenotype Single KO extramedullary hematopoiesis 83 3.245473e-25 3.5805778627710844e-23 2.114057 238 0.01846393 377 0.029606256949602117 1.348359 64 114 0.008186237 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 95 3.590894e-23 3.4612438271578946e-21 2.389739 167 0.01295578 357 0.024936906696918764 1.461944 42 69 0.005372218 Mouse Phenotype Single KO abnormal reticulocyte cell number 107 4.472485e-22 3.82752758364486e-20 2.241237 181 0.01404189 328 0.018937357191463413 1.4537 46 76 0.005883858 Mouse Phenotype Single KO abnormal erythrocyte physiology 124 7.502855e-21 5.540616389919354e-19 2.814424 111 0.008611327 405 0.037865981180246915 1.547804 29 45 0.003709389 Mouse Phenotype Single KO decreased circulating alanine transaminase level 128 2.606293e-20 1.864517578203125e-18 2.037999 206 0.01598138 431 0.04545339337354988 1.409036 44 75 0.005628038 Mouse Phenotype Single KO abnormal reticulocyte morphology 147 1.558988e-18 9.711328650340135e-17 2.058069 182 0.01411947 426 0.04525520521361502 1.393617 47 81 0.006011768 Mouse Phenotype Single KO increased spleen white pulp amount 155 3.908931e-18 2.3092955591612904e-16 3.470821 70 0.005430566 388 0.032901974219072164 1.829916 16 21 0.002046559 Mouse Phenotype Single KO absent hypoglossal nerve 236 1.878834e-13 7.290035143220338e-12 3.849582 44 0.003413499 298 0.01368222961342282 2.08153 13 15 0.001662829 Mouse Phenotype Single KO prolonged estrous cycle 390 1.127889e-9 2.648225531538462e-8 2.055887 87 0.006749418 314 0.015114666682165608 1.726269 23 32 0.002941929 Mouse Phenotype Single KO abnormal thrombopoiesis 508 7.285764e-8 0.0000013133019871653543 2.615153 41 0.00318076 371 0.02634140630188679 2.183423 10 11 0.0012791 Mouse Phenotype abnormal erythropoiesis 15 1.528812e-62 9.744647688e-60 2.393147 468 0.03630721 116 0.0000012551169781034484 1.547446 96 149 0.01227936 Mouse Phenotype abnormal mean corpuscular hemoglobin 49 3.670462e-43 7.161895343265305e-41 2.097599 425 0.0329713 161 0.00001325709850621118 1.448891 111 184 0.014198 Mouse Phenotype abnormal embryonic erythropoiesis 75 3.301198e-33 4.2083672104000005e-31 3.309775 143 0.01109387 704 0.04035513398863636 1.627002 21 31 0.002686109 Mouse Phenotype decreased erythroid progenitor cell number 79 3.072618e-31 3.7186456579746836e-29 2.248841 260 0.02017067 225 0.0002675706615466667 1.611711 51 76 0.006523408 Mouse Phenotype abnormal embryonic erythrocyte morphology 80 1.038629e-30 1.2412914836250001e-28 3.011672 151 0.01171451 744 0.04927869193145161 1.539593 25 39 0.003197749 Mouse Phenotype abnormal embryonic hematopoiesis 83 4.047325e-30 4.662225822289157e-28 2.326716 233 0.01807603 306 0.0014869289071568629 1.614301 41 61 0.005244308 Mouse Phenotype abnormal megakaryocyte progenitor cell morphology 85 3.800374e-29 4.274750095764706e-27 2.014036 312 0.02420481 410 0.005240584647804878 1.386385 71 123 0.009081607 Mouse Phenotype abnormal platelet physiology 87 1.183375e-28 1.3004883189655174e-26 2.036801 298 0.0231187 491 0.010923193251934827 1.346444 74 132 0.009465336 Mouse Phenotype abnormal reticulocyte cell number 96 8.507954e-27 8.473390436875e-25 2.135593 248 0.01923972 623 0.026677445966292138 1.344107 61 109 0.007802507 Mouse Phenotype decreased mean corpuscular hemoglobin 98 4.913103e-26 4.793283447244898e-24 2.324789 200 0.0155159 398 0.004678540823366835 1.497204 48 77 0.006139678 Mouse Phenotype abnormal proerythroblast morphology 120 2.292392e-22 1.826463326e-20 2.043845 227 0.01761055 600 0.023516920804999997 1.416426 46 78 0.005883858 Mouse Phenotype microcytosis 125 5.741549e-22 4.39159599912e-20 4.063988 71 0.005508146 734 0.047531169833787475 1.70125 17 24 0.002174469 Mouse Phenotype decreased mean corpuscular volume 126 6.356843e-22 4.823633009761905e-20 2.029759 226 0.01753297 381 0.004030192369291338 1.427464 63 106 0.008058327 Mouse Phenotype decreased circulating alanine transaminase level 134 5.1662e-21 3.686122253731343e-19 2.018191 219 0.01698991 520 0.012891892437115384 1.424303 51 86 0.006523408 Mouse Phenotype increased spleen white pulp amount 146 3.68293e-20 2.4118146390410956e-18 2.936072 100 0.007757952 382 0.00409315170078534 1.766004 25 34 0.003197749 Mouse Phenotype pancytopenia 186 2.690342e-17 1.3829225732258064e-15 2.803981 91 0.007059736 686 0.03754476476676385 1.65639 20 29 0.002558199 Mouse Phenotype lymph node hyperplasia 189 3.666468e-17 1.854767224761905e-15 2.336386 126 0.009775019 683 0.03699685644070279 1.528396 28 44 0.003581479 Mouse Phenotype microcytic anemia 222 7.905652e-16 3.404772016756757e-14 2.950898 76 0.005896043 529 0.014030201792438564 1.739209 21 29 0.002686109 Mouse Phenotype decreased DN1 thymic pro-T cell number 257 8.993211e-15 3.345684450233463e-13 3.14216 64 0.004965089 563 0.01812402180106572 2.183423 10 11 0.0012791 Mouse Phenotype interstitial pneumonia 267 1.881669e-14 6.738066407865168e-13 2.887956 71 0.005508146 522 0.013571984197126437 1.855909 17 22 0.002174469