# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process cellular response to xenobiotic stimulus 377 1.684677e-28 5.88028239867374e-27 2.063183 289 0.01221213 352 0.001411053401903409 1.307843 85 109 0.007591997 GO Biological Process xenobiotic metabolic process 399 1.24256e-27 4.097956651629073e-26 2.056159 282 0.01191633 365 0.0016894490395068494 1.309748 82 105 0.007324044 GO Biological Process platelet-derived growth factor receptor signaling pathway 486 2.054035e-24 5.561532215020576e-23 2.122303 229 0.009676738 392 0.0025260207742602045 1.524652 30 33 0.002679528 GO Biological Process regulation of pri-miRNA transcription from RNA polymerase II promoter 653 7.379851e-20 1.4871586417917304e-18 2.09406 189 0.007986478 749 0.03398432095994659 1.44579 25 29 0.00223294 GO Biological Process bile acid metabolic process 663 1.135925e-19 2.2545455618401206e-18 2.230138 162 0.006845553 711 0.027274905452883264 1.405152 31 37 0.002768846 GO Biological Process negative regulation of sodium ion transport 694 6.578531e-19 1.247361519149856e-17 2.500773 123 0.005197549 682 0.023168252498533725 1.677117 13 13 0.001161129 GO Biological Process polyol biosynthetic process 1383 4.063965e-11 3.8667907039045556e-10 2.053849 103 0.004352419 596 0.01367329390352349 1.497426 25 28 0.00223294 GO Biological Process intracellular lipid transport 1397 5.459406e-11 5.142471263707946e-10 2.084611 98 0.004141137 849 0.048574394828032975 1.467477 21 24 0.00187567 GO Biological Process membrane raft organization 1616 8.038102e-10 6.545382686757426e-9 2.092853 85 0.003591802 700 0.02613467633142857 1.524652 20 22 0.001786352 GO Biological Process pyrimidine-containing compound transmembrane transport 2113 1.136928e-7 7.080376503549456e-7 2.10509 62 0.002619903 838 0.047287337585918854 1.572297 15 16 0.001339764 GO Molecular Function C-acyltransferase activity 116 1.292253e-15 4.703355315517242e-14 2.535025 97 0.00409888 83 0.023741959192771087 1.593261 19 20 0.001697035 GO Molecular Function cAMP response element binding 308 1.605936e-8 2.2013836987012987e-7 2.197143 64 0.002704416 103 0.049219338174757286 1.677117 13 13 0.001161129 Human Phenotype Glycosuria 68 3.655502e-18 3.5872301244117646e-16 2.497174 118 0.004986267 82 0.03327408444390244 1.503622 26 29 0.002322258 Mouse Phenotype Single KO increased liver triglyceride level 99 1.578825e-44 1.4603333863636364e-42 2.226497 387 0.01635326 666 0.03878852952852852 1.263283 58 77 0.005180422 Mouse Phenotype Single KO abnormal hepatocyte physiology 103 3.599531e-43 3.200087899708738e-41 2.032867 463 0.01956476 679 0.03946440435051546 1.23577 70 95 0.006252233 Mouse Phenotype Single KO abnormal mammary gland physiology 146 8.485605e-36 5.32210171130137e-34 2.030903 382 0.01614198 554 0.020993695223826714 1.285064 59 77 0.005269739 Mouse Phenotype Single KO abnormal lactation 221 2.228841e-29 9.235066532579185e-28 2.056023 301 0.01271921 703 0.04318150729018492 1.284043 49 64 0.004376563 Mouse Phenotype Single KO kinked neural tube 229 7.931365e-29 3.171506956550218e-27 2.110648 277 0.01170505 730 0.04557201821506849 1.315386 40 51 0.003572705 Mouse Phenotype Single KO abnormal branching of the mammary ductal tree 238 2.402129e-28 9.242140862605042e-27 2.127735 267 0.01128248 716 0.0438357739650838 1.368174 31 38 0.002768846 Mouse Phenotype Single KO impaired wound healing 256 2.61309e-27 9.34690044140625e-26 2.472813 187 0.007901965 538 0.020135698345724908 1.430482 29 34 0.002590211 Mouse Phenotype Single KO increased bone ossification 279 1.018149e-25 3.3416453021505376e-24 2.665032 153 0.006465244 698 0.042860925888252153 1.509405 18 20 0.001607717 Mouse Phenotype Single KO decreased tumor growth/size 292 4.773683e-25 1.4970073709246577e-23 2.049397 256 0.01081766 675 0.039259721799999994 1.3112 43 55 0.003840657 Mouse Phenotype Single KO expanded mesangial matrix 427 4.36729e-19 9.36563806323185e-18 2.026957 196 0.008282273 680 0.03988332696617647 1.389611 29 35 0.002590211 Mouse Phenotype abnormal lymph organ development 202 2.199262e-39 1.0409477218811881e-37 2.628429 246 0.0103951 840 0.032168860925 1.437529 24 28 0.002143623 Mouse Phenotype impaired wound healing 318 1.153279e-29 3.4674529933962267e-28 2.172941 267 0.01128248 790 0.026229054375949364 1.317735 44 56 0.003929975 Mouse Phenotype abnormal Paneth cell morphology 415 7.466463e-25 1.7201651263373494e-23 2.093831 241 0.01018382 511 0.004869860735812133 1.456444 33 38 0.002947481 Mouse Phenotype conotruncal ridge hypoplasia 442 1.244801e-23 2.692656642760181e-22 2.57032 149 0.006296218 879 0.03676683093856655 1.677117 11 11 0.0009824937 Mouse Phenotype bowed tibia 635 3.859365e-18 5.810927364566929e-17 2.032867 184 0.007775195 873 0.03578102945017182 1.509405 18 20 0.001607717 Mouse Phenotype abnormal Paneth cell number 762 6.512873e-16 8.171860728740157e-15 2.038615 158 0.006676527 964 0.046094999281120326 1.458362 20 23 0.001786352 Mouse Phenotype abnormal urine magnesium level 802 2.713146e-15 3.234462457107232e-14 2.906337 75 0.003169237 969 0.04700204373684211 1.565309 14 15 0.001250447 Mouse Phenotype increased bile salt level 886 5.491845e-14 5.926357792889391e-13 2.389302 96 0.004056624 709 0.01874775899576869 1.524652 20 22 0.001786352 Mouse Phenotype abnormal bile secretion 919 1.772273e-13 1.843819603155604e-12 2.283584 101 0.004267906 969 0.04700204373684211 1.565309 14 15 0.001250447 Mouse Phenotype increased urine uric acid level 957 6.301182e-13 6.2952561235109725e-12 2.723089 69 0.002915698 879 0.03676683093856655 1.677117 11 11 0.0009824937