# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	negative regulation of gene expression, epigenetic	14	5.574088e-47	5.239244570857142e-44	4.381757	145	0.0237277	238	0.0030035561253781515	1.591121	54	114	0.009660107	
GO Biological Process	regulation of gene expression, epigenetic	15	3.056084e-46	2.6810006237333333e-43	2.777778	260	0.04254623	73	1.0940307877671233e-9	1.693061	125	248	0.02236136	
GO Biological Process	gene silencing	29	4.112664e-28	1.866156744e-25	2.687897	164	0.02683685	117	4.044312928119658e-7	1.698178	91	180	0.01627907	
GO Biological Process	ncRNA processing	32	1.384088e-26	5.6916293725e-24	2.050145	267	0.0436917	112	2.569136137053571e-7	1.467457	173	396	0.03094812	
GO Biological Process	multi-organism metabolic process	43	1.55848e-24	4.769311237209303e-22	2.782325	134	0.02192767	97	4.832772983402061e-8	1.828046	80	147	0.01431127	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	44	1.802982e-24	5.392145485909091e-22	3.219255	107	0.01750941	65	3.6298656118461537e-10	2.04958	72	118	0.01288014	
GO Biological Process	ribosome biogenesis	45	9.278165e-24	2.7131416274444442e-21	2.073263	231	0.03780069	157	0.000005790866043248408	1.466328	141	323	0.02522361	
GO Biological Process	viral gene expression	46	9.455421e-24	2.7048670638913047e-21	3.051813	112	0.01832761	122	6.71438406442623e-7	1.824987	69	127	0.01234347	
GO Biological Process	mRNA catabolic process	47	2.570818e-23	7.197743417446808e-21	2.345716	173	0.02830961	37	1.7266464485945948e-13	1.892414	120	213	0.02146691	
GO Biological Process	rRNA metabolic process	49	8.964551e-22	2.40743931855102e-19	2.216332	181	0.02961872	188	0.00005081334551010638	1.478494	114	259	0.02039356	
GO Biological Process	viral transcription	50	9.733901e-22	2.56176806518e-19	3.028792	103	0.01685485	115	2.719125412521739e-7	1.902462	64	113	0.01144902	
GO Biological Process	RNA catabolic process	51	3.451616e-21	8.90584606745098e-19	2.160298	186	0.03043692	39	3.668044257179487e-13	1.825865	131	241	0.0234347	
GO Biological Process	rRNA processing	54	5.102524e-21	1.2434095058518519e-18	2.212127	175	0.02863688	190	0.00006695840796736843	1.479574	111	252	0.01985689	
GO Biological Process	cotranslational protein targeting to membrane	60	4.045661e-20	8.872808849833333e-18	3.184686	88	0.01440026	153	0.00000410300974254902	1.885172	55	98	0.009838998	
GO Biological Process	nuclear-transcribed mRNA catabolic process	62	6.212891e-20	1.3186360107903227e-17	2.294154	153	0.02503682	48	8.059536593333334e-12	1.86613	110	198	0.019678	
GO Biological Process	protein targeting to ER	64	9.701293e-20	1.994676790421875e-17	3.091432	90	0.01472754	110	2.363304960272727e-7	1.962208	59	101	0.01055456	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	67	3.03996e-19	5.970572185074627e-17	3.20722	83	0.01358207	143	0.00000230300076006993	1.935096	53	92	0.009481216	
GO Biological Process	ribonucleoprotein complex export from nucleus	71	6.340925e-19	1.1752145362676054e-16	2.722992	105	0.01718213	192	0.00006838135347447917	1.692953	63	125	0.01127013	
GO Biological Process	translational initiation	73	1.81082e-18	3.2641890931506845e-16	2.534329	116	0.01898216	145	0.000002607154554275862	1.738241	74	143	0.01323792	
GO Biological Process	mitochondrial transport	74	2.141981e-18	3.8089632404054054e-16	2.011907	189	0.03092784	172	0.000022450631104651164	1.51789	108	239	0.01932021	
GO Cellular Component	ribosomal subunit	26	1.09619e-27	7.285447384615384e-26	2.808798	150	0.0245459	33	1.150096581818182e-8	1.743066	96	185	0.01717352	
GO Cellular Component	nucleosome	33	7.74609e-22	4.0561344000000004e-20	3.689428	79	0.01292751	101	0.013561537330693069	1.503568	47	105	0.008407871	
GO Cellular Component	ribosome	34	1.184628e-21	6.0206976e-20	2.26358	172	0.02814597	42	5.988219428571429e-7	1.579885	111	236	0.01985689	
GO Cellular Component	DNA packaging complex	43	9.026123e-19	3.627241986976744e-17	3.147151	83	0.01358207	95	0.010770654922105263	1.499569	50	112	0.008944544	
GO Cellular Component	cytosolic ribosome	45	3.791701e-18	1.456013184e-16	2.608968	108	0.01767305	31	7.294501161290322e-9	1.979431	66	112	0.0118068	
GO Cellular Component	spliceosomal complex	52	4.926092e-15	1.6369782646153846e-13	2.030743	148	0.02421862	49	0.000002264838112653061	1.625339	90	186	0.01610018	
GO Cellular Component	large ribosomal subunit	54	6.989912e-15	2.23677184e-13	2.638859	85	0.01390934	55	0.00003212270312727273	1.72333	59	115	0.01055456	
GO Cellular Component	mitochondrial membrane part	55	1.402126e-14	4.4052249600000003e-13	2.003151	148	0.02421862	65	0.0002301389745230769	1.473538	93	212	0.01663685	
GO Cellular Component	small ribosomal subunit	57	4.183048e-14	1.2681240252631579e-12	2.997483	65	0.01063656	81	0.0020636315733333333	1.72617	37	72	0.006618962	
GO Cellular Component	mitochondrial protein complex	59	9.139232e-12	2.676710660338983e-10	2.032175	112	0.01832761	68	0.0005084490070588236	1.52304	73	161	0.01305903	
GO Cellular Component	intrinsic component of endoplasmic reticulum membrane	61	1.250376e-11	3.5420487344262294e-10	2.021255	112	0.01832761	90	0.00451953408	1.477022	62	141	0.01109123	
GO Cellular Component	cytosolic small ribosomal subunit	62	1.669441e-11	4.652893625806451e-10	3.189461	47	0.007691049	76	0.0011351238821052632	1.984884	26	44	0.004651163	
GO Cellular Component	integral component of endoplasmic reticulum membrane	63	1.711535e-11	4.694495999999999e-10	2.024841	110	0.01800033	87	0.003438422068965517	1.495628	61	137	0.01091234	
GO Cellular Component	cytosolic large ribosomal subunit	64	2.090926e-11	5.645500200000001e-10	2.79415	57	0.009327442	54	0.0000173065312	2.037447	37	61	0.006618962	
GO Cellular Component	catalytic step 2 spliceosome	66	6.332408e-11	1.657939549090909e-9	2.294863	78	0.01276387	83	0.0027831084722891564	1.609537	46	96	0.00822898	
GO Cellular Component	precatalytic spliceosome	67	7.010046e-11	1.8079641026865673e-9	4.343264	30	0.00490918	86	0.0032697698232558143	2.159379	18	28	0.003220036	
GO Cellular Component	ficolin-1-rich granule lumen	69	2.106893e-10	5.276392904347827e-9	2.086999	91	0.01489118	99	0.013280530036363637	1.462805	54	124	0.009660107	
GO Cellular Component	spliceosomal snRNP complex	79	5.494266e-9	1.2017837529113924e-7	2.684863	46	0.00752741	96	0.011548810799999998	1.679517	31	62	0.005545617	
GO Cellular Component	nuclear pore outer ring	80	5.936629e-9	1.2823118639999997e-7	6.19586	17	0.002781869	110	0.02355827956363636	2.687227	8	10	0.001431127	
GO Cellular Component	intrinsic component of mitochondrial membrane	84	2.420672e-8	4.979668114285714e-7	2.325878	55	0.009000164	72	0.0010133311199999999	1.808711	35	65	0.006261181	
GO Molecular Function	ribonucleoprotein complex binding	7	6.517264e-25	3.930841229714286e-22	3.032267	119	0.01947308	39	0.0035976116676923074	1.606495	55	115	0.009838998	
GO Molecular Function	structural constituent of ribosome	9	1.089377e-21	5.110388548888889e-19	2.632365	129	0.02110947	16	0.00000514376815	1.700252	82	162	0.01466905	
GO Molecular Function	mRNA 5'-UTR binding	80	0.000006043618	0.00031895193995	2.908947	24	0.003927344	40	0.0041598954355	2.442934	16	22	0.002862254	
GO Molecular Function	cAMP response element binding	132	0.0001136321	0.003634505501515152	2.658904	20	0.003272787	59	0.043386402637288136	2.583872	10	13	0.001788909	
Human Phenotype	Abnormality of reticulocytes	12	1.111634e-9	6.181611401666667e-7	3.274354	37	0.006054656	2	0.042880931555	2.239356	22	33	0.003935599	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	2	2.853091e-16	1.3062877143500001e-12	3.275582	67	0.01096384	42	0.0025513843866666664	2.207365	23	35	0.00411449	
Mouse Phenotype Single KO	abnormal erythropoiesis	3	6.8938e-16	2.1042175533333334e-12	2.054077	153	0.02503682	28	0.00012563191426785716	1.771127	58	110	0.01037567	
Mouse Phenotype Single KO	abnormal embryonic erythropoiesis	4	4.304684e-15	9.854497846999999e-12	3.339381	60	0.00981836	68	0.009812656012794118	2.200746	19	29	0.003398927	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	36	7.945913e-11	2.0211312594722222e-8	2.149636	89	0.0145639	36	0.0009206274834444444	2.028096	32	53	0.005724508	
Mouse Phenotype Single KO	decreased erythroid progenitor cell number	38	1.026131e-10	2.472705675526316e-8	2.148941	88	0.01440026	87	0.016363411645977013	1.844176	28	51	0.005008945	
Mouse Phenotype Single KO	increased integument system tumor incidence	109	4.843948e-7	0.00004069360718899082	2.023445	61	0.009982	107	0.0338230397411215	1.635319	37	76	0.006618962	
Mouse Phenotype Single KO	absent hypoglossal nerve	123	0.0000011447	0.00008521965772357723	3.690893	20	0.003272787	123	0.04629089074878048	2.463292	11	15	0.0019678	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	14	1.125628e-15	7.687235220000001e-13	3.029032	72	0.01178203	63	0.00031562940138095245	2.239356	26	39	0.004651163	
Mouse Phenotype	abnormal embryonic erythropoiesis	20	3.368077e-14	1.61010920985e-11	3.075697	63	0.01030928	134	0.004647953145671642	2.167119	20	31	0.003577818	
Mouse Phenotype	decreased erythroid progenitor cell number	29	3.248851e-13	1.0711125658965516e-10	2.116333	116	0.01898216	106	0.0022554065266981132	1.767913	40	76	0.007155635	
Mouse Phenotype	decreased mean corpuscular volume	55	3.012072e-11	5.236076434909091e-9	2.027031	107	0.01750941	216	0.0225809706125	1.521072	48	106	0.008586762	
Mouse Phenotype	increased circulating iron level	128	1.186325e-7	0.00000886129166015625	2.270166	52	0.008509246	191	0.016295347916230368	1.87481	24	43	0.004293381	
Mouse Phenotype	absent hypoglossal nerve	175	0.0000011447	0.00006253986685714286	3.690893	20	0.003272787	226	0.0263052427579646	2.463292	11	15	0.0019678	
Mouse Phenotype	absent segment of posterior cerebral artery	196	0.00000315476	0.00015389112428571428	2.806824	27	0.004418262	253	0.03890779037549408	2.137567	14	22	0.002504472	
Mouse Phenotype	dry eyes	432	0.0005260571	0.011642666511805554	2.121354	25	0.004090983	110	0.0026451393065454547	2.729215	13	16	0.002325581	
Mouse Phenotype	increased kidney tumor incidence	474	0.0008129024	0.016396961701265825	2.547326	16	0.002618229	182	0.012804879194505495	2.519275	12	16	0.002146691	
Mouse Phenotype	decreased spleen red pulp amount	513	0.00122786	0.022884150994152048	2.026548	24	0.003927344	176	0.011031878364204547	2.239356	16	24	0.002862254