# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	14	9.534109e-43	8.961381452214286e-40	2.853555	232	0.01970443	231	3.439505686190476e-7	1.574065	83	113	0.009472723	
GO Biological Process	regulation of DNA-templated transcription in response to stress	18	3.320669e-38	2.427593520611111e-35	2.609649	240	0.0203839	199	2.3413041642713568e-8	1.602751	89	119	0.0101575	
GO Biological Process	rRNA processing	26	1.300483e-31	6.581944537307692e-29	2.07323	316	0.0268388	79	1.634355795341772e-17	1.598749	188	252	0.02145629	
GO Biological Process	rRNA metabolic process	27	1.344205e-30	6.551256887037037e-28	2.033735	320	0.02717853	83	2.1278166416867468e-17	1.588636	192	259	0.02191281	
GO Biological Process	endoplasmic reticulum unfolded protein response	32	1.345178e-29	5.531624156875e-27	2.524652	195	0.01656192	457	0.0018211960978774615	1.391073	74	114	0.00844556	
GO Biological Process	nuclear-transcribed mRNA catabolic process	38	1.00621e-27	3.484399313157895e-25	2.093494	269	0.02284695	118	2.3747121709322034e-12	1.569372	145	198	0.01654873	
GO Biological Process	cellular response to topologically incorrect protein	39	1.008884e-27	3.404078091282051e-25	2.291872	220	0.01868524	382	0.0004299913380628272	1.387556	90	139	0.01027163	
GO Biological Process	mRNA catabolic process	42	7.842205e-27	2.4570375141666668e-24	2.012721	286	0.02429081	124	6.687410167258065e-12	1.539341	153	213	0.01746177	
GO Biological Process	cellular response to unfolded protein	47	5.042321e-26	1.411742596574468e-23	2.317656	201	0.01707151	452	0.0016870650248008848	1.381441	78	121	0.008902077	
GO Biological Process	response to topologically incorrect protein	48	5.430753e-26	1.4888183068125e-23	2.053974	263	0.02233735	371	0.0003241215635471698	1.34533	113	180	0.0128966	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	50	1.492149e-25	3.9270377382e-23	2.071606	253	0.02148802	412	0.0007324452708737865	1.354931	98	155	0.01118466	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	51	1.986589e-25	5.1257891472549025e-23	2.671407	150	0.01273994	273	0.000008059405485347985	1.62099	59	78	0.006733622	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	53	1.542607e-24	3.8300312288679242e-22	2.514119	161	0.0136742	218	1.1491320090825689e-7	1.580011	87	118	0.00992924	
GO Biological Process	response to unfolded protein	54	1.754269e-24	4.274893661296296e-22	2.063616	244	0.02072363	395	0.0006361200518481012	1.352771	101	160	0.01152705	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	70	2.668277e-21	5.0159795775714285e-19	2.247271	173	0.01469339	558	0.006450971000358422	1.390673	61	94	0.006961881	
GO Biological Process	protein targeting to ER	77	1.763314e-20	3.0134349254545453e-18	2.46028	138	0.01172074	240	8.009905231666667e-7	1.59134	75	101	0.00855969	
GO Biological Process	cotranslational protein targeting to membrane	85	1.576243e-19	2.440209604352941e-17	2.460614	131	0.01112621	214	8.745545188785047e-8	1.640054	75	98	0.00855969	
GO Biological Process	multi-organism metabolic process	93	4.495826e-19	6.36135207892473e-17	2.047599	190	0.01613725	169	7.471818019112426e-10	1.58903	109	147	0.01244008	
GO Biological Process	viral gene expression	96	5.096454e-19	6.985858144374999e-17	2.220382	157	0.01333447	166	5.488836102771084e-10	1.636782	97	127	0.01107053	
GO Biological Process	liver regeneration	97	5.249175e-19	7.121019981958763e-17	2.873092	97	0.008238492	840	0.04129978781309524	1.530717	25	35	0.00285323	
GO Cellular Component	nuclear ubiquitin ligase complex	34	7.196347e-20	3.6574375341176476e-18	3.482709	77	0.006539834	171	0.024293729684210525	1.500103	28	40	0.003195617	
GO Cellular Component	PcG protein complex	36	6.702422e-19	3.21716256e-17	2.507143	122	0.01036181	137	0.0062669729167883215	1.537372	33	46	0.003766263	
GO Cellular Component	proteasome core complex	44	5.071113e-17	1.9915643781818184e-15	5.011558	43	0.003652115	154	0.01323560477922078	1.696545	19	24	0.002168455	
GO Cellular Component	ficolin-1-rich granule lumen	48	1.802071e-16	6.4874556e-15	2.011666	169	0.01435366	115	0.002882903540869565	1.348019	78	124	0.008902077	
GO Cellular Component	catalytic step 2 spliceosome	49	7.203864e-16	2.5404646922448978e-14	2.137856	140	0.01189061	73	0.00003151756010958904	1.517961	68	96	0.007760785	
GO Cellular Component	mitochondrial ribosome	55	1.129e-14	3.5471127272727274e-13	2.494753	93	0.00789876	70	0.000018570830811428572	1.563132	62	85	0.00707601	
GO Cellular Component	endopeptidase complex	56	1.795079e-14	5.539100914285714e-13	2.371891	101	0.008578223	66	0.000007841315781818181	1.646075	53	69	0.006048847	
GO Cellular Component	peptidase complex	57	3.283039e-14	9.952791915789475e-13	2.135698	124	0.01053168	60	0.000001593789984	1.607253	66	88	0.007532527	
GO Cellular Component	proteasome complex	59	9.912666e-14	2.903235058983051e-12	2.326236	99	0.008408357	69	0.00001245128932173913	1.638768	52	68	0.005934718	
GO Cellular Component	methyltransferase complex	60	1.214091e-13	3.49658208e-12	2.010809	137	0.01163581	54	1.08938528e-7	1.648465	70	91	0.007989044	
GO Cellular Component	spliceosomal snRNP complex	61	1.924511e-13	5.451729521311476e-12	2.514378	83	0.007049431	112	0.0013959234514285715	1.520841	44	62	0.005021685	
GO Cellular Component	large ribosomal subunit	66	6.018608e-13	1.5757810036363637e-11	2.03028	126	0.01070155	84	0.00017559582171428571	1.434881	77	115	0.008787948	
GO Cellular Component	small nuclear ribonucleoprotein complex	70	1.003794e-11	2.477937188571428e-10	2.245571	89	0.007559028	120	0.0036827985599999996	1.459727	47	69	0.005364072	
GO Cellular Component	spliceosomal tri-snRNP complex	77	4.852675e-11	1.0890158961038961e-9	3.090322	47	0.003991846	124	0.0046420253419354835	1.699624	23	29	0.002624971	
GO Cellular Component	chromatin silencing complex	80	8.01738e-10	1.7317540800000002e-8	5.247311	22	0.001868524	169	0.022947369656804734	2.143004	8	8	0.0009130336	
GO Cellular Component	intrinsic component of mitochondrial membrane	81	9.05912e-10	1.9326122666666668e-8	2.019298	92	0.007813827	175	0.02625325714285714	1.38471	42	65	0.004793426	
GO Cellular Component	integral component of mitochondrial membrane	85	1.34082e-9	2.725808188235294e-8	2.011276	91	0.007728894	184	0.035233948173913045	1.372862	41	64	0.004679297	
GO Cellular Component	methylosome	87	1.96511e-9	3.9031150344827585e-8	4.7726	23	0.001953457	163	0.016581898601226993	1.96442	11	12	0.001255421	
GO Cellular Component	MLL1 complex	99	4.873032e-8	8.505655854545455e-7	2.552498	44	0.003737048	85	0.0002347276574117647	1.847417	25	29	0.00285323	
GO Cellular Component	Ino80 complex	102	6.873671e-8	0.000001164480734117647	3.778952	24	0.00203839	195	0.045198135138461534	1.741191	13	16	0.00148368	
GO Molecular Function	ribonucleoprotein complex binding	9	2.887094e-20	1.3543678742222223e-17	2.221867	168	0.01426873	52	0.00011380912511538463	1.47215	79	115	0.009016206	
GO Molecular Function	rRNA binding	10	1.198752e-19	5.0611309439999997e-17	3.385493	79	0.006709699	44	0.000048494093504545456	1.678686	47	60	0.005364072	
GO Molecular Function	unfolded protein binding	11	3.552955e-17	1.3636887281818183e-14	2.293218	131	0.01112621	71	0.002574130208732394	1.415191	70	106	0.007989044	
GO Molecular Function	ribonuclease activity	17	8.880561e-14	2.2055134436470586e-11	2.031665	135	0.01146594	80	0.0055038044775	1.407023	65	99	0.007418398	
GO Molecular Function	mRNA 5'-UTR binding	34	5.965974e-10	7.408335949411764e-8	2.893815	46	0.003906914	82	0.00700446276097561	1.850776	19	22	0.002168455	
GO Molecular Function	NF-kappaB binding	40	2.788038e-9	2.942774109e-7	2.536876	53	0.004501444	106	0.022816540366037738	1.683789	22	28	0.002510842	
GO Molecular Function	5S rRNA binding	145	0.00003473277	0.0010113224478620689	3.247113	17	0.001443859	91	0.010562567123076924	2.143004	11	11	0.001255421	
Human Phenotype	Increased serum lactate	1	7.688081e-18	5.1302564513e-14	2.25165	142	0.01206047	30	0.00015050261956666666	1.521533	71	100	0.008103173	
Human Phenotype	Abnormal CSF metabolite level	2	1.564427e-16	5.2197106855e-13	2.686293	93	0.00789876	57	0.002251006602105263	1.564733	46	63	0.005249943	
Human Phenotype	Increased CSF lactate	3	6.554795e-16	1.4580049011666666e-12	2.743008	86	0.00730423	67	0.006078777317761195	1.55183	42	58	0.004793426	
Human Phenotype	Exercise intolerance	7	5.404846e-14	5.152362479714286e-11	2.425991	93	0.00789876	69	0.006262993472173913	1.500103	49	70	0.005592331	
Human Phenotype	Abnormality of mitochondrial metabolism	8	6.877744e-14	5.736898214000001e-11	2.226965	110	0.009342619	37	0.0001987278915945946	1.615017	52	69	0.005934718	
Human Phenotype	Abnormality of the mitochondrion	9	1.273714e-13	9.44388169111111e-11	2.195746	111	0.009427552	41	0.00023591903231707313	1.599707	53	71	0.006048847	
Human Phenotype	Non-medullary thyroid carcinoma	349	0.001766341	0.03377304725787966	2.004008	23	0.001953457	91	0.03579809312747253	2.143004	10	10	0.001141292	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	58	2.098522e-10	3.313132061034483e-8	2.081507	92	0.007813827	49	0.000021675833704081633	1.714403	48	60	0.005478201	
Mouse Phenotype Single KO	increased mammary adenocarcinoma incidence	93	3.262114e-8	0.0000032119546126881724	3.030091	34	0.002887719	179	0.0400950959821229	1.753367	18	22	0.002054325	
Mouse Phenotype Single KO	decreased red blood cell distribution width	378	0.0003212288	0.00778172518941799	2.239311	24	0.00203839	180	0.03999020621333333	1.978157	12	13	0.00136955	
Mouse Phenotype	abnormal cellular replicative senescence	23	9.150193e-16	3.8036954466521735e-13	2.118172	142	0.01206047	57	0.000005184157033157895	1.632765	64	84	0.007304268	
Mouse Phenotype	early cellular replicative senescence	26	2.842272e-15	1.0451908689230768e-12	2.174834	129	0.01095634	65	0.0000220008171	1.643948	56	73	0.006391235	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	56	8.180174e-12	1.3966186359642857e-9	2.838259	58	0.004926108	256	0.029733204889453125	1.64297	23	30	0.002624971	
Mouse Phenotype	spleen atrophy	85	1.992509e-9	2.2412210057647058e-7	2.274294	67	0.005690505	215	0.017262870220465115	1.730888	21	26	0.002396713	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	170	8.478946e-7	0.00004768658982705883	2.665989	33	0.002802786	263	0.03144553643612167	1.804635	16	19	0.001826067	
Mouse Phenotype	abnormal hypoglossal nerve topology	328	0.00006906012	0.0020130603881707318	2.164102	32	0.002717853	310	0.04866040108064516	1.785837	15	18	0.001711938	
Mouse Phenotype	decreased red blood cell distribution width	428	0.0003212288	0.0071758611140186924	2.239311	24	0.00203839	255	0.02947379593411765	1.978157	12	13	0.00136955