# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA processing	40	2.309663e-60	7.598213854249999e-58	2.045723	636	0.04359748	113	3.494099953893805e-14	1.38525	283	396	0.02921441	
GO Biological Process	ribosome biogenesis	47	1.316072e-54	3.6847215846808505e-52	2.079141	553	0.03790787	97	4.832250693195876e-16	1.452278	242	323	0.02498193	
GO Biological Process	rRNA processing	54	4.119379e-49	1.003831634462963e-46	2.234607	422	0.02892789	118	6.140388630677965e-14	1.476854	192	252	0.01982038	
GO Biological Process	rRNA metabolic process	56	1.161249e-48	2.728727784107143e-46	2.205673	430	0.02947628	114	3.6219027830701754e-14	1.474359	197	259	0.02033653	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	63	2.067309e-42	4.318050655714286e-40	2.873578	228	0.01562928	139	2.9844460529496405e-12	1.642687	100	118	0.01032311	
GO Biological Process	nuclear-transcribed mRNA catabolic process	65	7.220903e-39	1.4618440396461538e-36	2.185883	348	0.02385522	111	1.4520458591891892e-14	1.546781	158	198	0.01631052	
GO Biological Process	mRNA catabolic process	68	1.743266e-37	3.373476072647059e-35	2.095908	369	0.02529476	120	1.4441037506666667e-13	1.510655	166	213	0.01713637	
GO Biological Process	translational initiation	83	1.007428e-33	1.5971981990361444e-31	2.352094	257	0.01761722	174	6.744241604827586e-10	1.53172	113	143	0.01166512	
GO Biological Process	viral gene expression	86	8.112013e-33	1.241232314732558e-30	2.511187	220	0.01508089	155	1.759213126516129e-11	1.60259	105	127	0.01083927	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	97	5.890063e-30	7.990447321340206e-28	2.751795	170	0.01165341	197	6.913945670558375e-9	1.622332	77	92	0.007948797	
GO Biological Process	cotranslational protein targeting to membrane	103	3.623606e-28	4.629420519805826e-26	2.622688	173	0.01185906	199	8.040711067839196e-9	1.602123	81	98	0.008361722	
GO Biological Process	protein targeting to ER	108	5.669019e-27	6.907279724166667e-25	2.532482	176	0.01206471	231	1.2188412667532467e-7	1.554535	81	101	0.008361722	
GO Biological Process	multi-organism metabolic process	113	2.469143e-26	2.8753497997345134e-24	2.131011	245	0.01679463	169	4.3641815713609465e-10	1.529599	116	147	0.01197481	
GO Biological Process	viral transcription	131	4.126128e-25	4.144711324580152e-23	2.340466	190	0.0130244	202	9.290547146039604e-9	1.560989	91	113	0.009394033	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	134	1.004125e-24	9.860657369402984e-23	2.345865	186	0.01275021	225	7.937994220888889e-8	1.550697	84	105	0.008671415	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	136	2.127454e-24	2.0584681754411764e-22	2.164129	218	0.01494379	475	0.0006626700640421052	1.372298	80	113	0.008258491	
GO Biological Process	protein localization to endoplasmic reticulum	143	2.174713e-23	2.0011921934965032e-21	2.170321	207	0.01418974	192	3.93768476734375e-9	1.54757	99	124	0.01021988	
GO Biological Process	regulation of DNA-templated transcription in response to stress	150	2.779109e-22	2.438019688733333e-20	2.027268	231	0.01583493	520	0.0010367798959615385	1.351973	83	119	0.008568184	
GO Biological Process	ribosomal small subunit biogenesis	190	3.737808e-18	2.5887271301052633e-16	2.354941	132	0.009048533	397	0.00020508980994962217	1.501555	55	71	0.005677712	
GO Biological Process	retrograde transport, endosome to Golgi	218	1.222095e-15	7.376856928899082e-14	2.025917	157	0.01076227	980	0.04416415523469388	1.30903	52	77	0.005368019	
GO Cellular Component	ribosomal subunit	36	5.377376e-34	2.5811404799999995e-32	2.243427	286	0.01960515	39	5.341535999999999e-12	1.508786	144	185	0.01486528	
GO Cellular Component	large ribosomal subunit	46	5.072876e-25	1.9056368973913044e-23	2.379934	183	0.01254456	49	7.873060702040817e-9	1.550697	92	115	0.009497264	
GO Cellular Component	nuclear chromosome, telomeric region	66	5.211179e-19	1.364381410909091e-17	2.037527	192	0.0131615	167	0.03496804598802395	1.233509	84	132	0.008671415	
GO Cellular Component	cytosolic ribosome	68	8.184296e-19	2.0797740423529412e-17	2.003673	198	0.0135728	52	1.0031023384615383e-7	1.523006	88	112	0.00908434	
GO Cellular Component	catalytic step 2 spliceosome	74	3.520396e-16	8.22060038918919e-15	2.021262	164	0.01124212	96	0.0016776792	1.373013	68	96	0.007019717	
GO Cellular Component	mitochondrial ribosome	75	4.204847e-16	9.687967488e-15	2.403233	111	0.007608994	81	0.00036665621333333335	1.436675	63	85	0.006503561	
GO Cellular Component	cleavage furrow	76	6.482176e-16	1.4738421221052633e-14	2.183792	134	0.009185632	124	0.006434945187096774	1.453778	39	52	0.004026014	
GO Cellular Component	cytosolic large ribosomal subunit	78	2.339752e-15	5.183450584615384e-14	2.320437	113	0.007746093	68	0.000019169133458823534	1.588829	50	61	0.005161557	
GO Cellular Component	axon cytoplasm	87	2.65846e-13	5.2802515862068965e-12	2.321368	96	0.006580751	131	0.00894415438167939	1.502238	31	40	0.003200165	
GO Cellular Component	preribosome	88	3.246156e-13	6.374269963636364e-12	2.08503	121	0.008294489	85	0.00048394693270588233	1.453778	57	76	0.005884175	
GO Cellular Component	cytoplasmic stress granule	95	6.290252e-12	1.1441637322105263e-10	2.150925	100	0.006854949	129	0.008354395088372093	1.487587	33	43	0.003406627	
GO Cellular Component	small ribosomal subunit	96	1.166382e-11	2.0994876000000002e-10	2.067015	107	0.007334796	91	0.0007383155340659341	1.453778	54	72	0.005574481	
GO Cellular Component	mitochondrial large ribosomal subunit	106	1.257183e-10	2.049445494339623e-9	2.440557	67	0.004592816	112	0.0035432393142857148	1.482284	39	51	0.004026014	
GO Cellular Component	spliceosomal snRNP complex	110	5.045909e-10	7.92666432e-9	2.102709	86	0.005895256	127	0.008116315313385827	1.406882	45	62	0.004645401	
GO Cellular Component	mitochondrial nucleoid	123	1.283896e-8	1.8037173073170734e-7	2.151128	68	0.004661366	137	0.011855982061313868	1.476854	32	42	0.003303396	
GO Cellular Component	Sin3 complex	174	9.578571e-7	0.000009512511889655173	2.421113	39	0.00267343	107	0.0029497573682242986	1.938371	13	13	0.001342005	
GO Cellular Component	Sin3-type complex	200	0.000004036266	0.000034873338240000004	2.175109	43	0.002947628	120	0.005779556640000001	1.817223	15	16	0.001548467	
GO Cellular Component	Ino80 complex	313	0.0005341033	0.002948659752076677	2.414582	19	0.00130244	164	0.03217282068292683	1.696075	14	16	0.001445236	
GO Molecular Function	structural constituent of ribosome	10	2.425385e-27	1.0239975469999998e-24	2.14559	251	0.01720592	27	1.6249696148148146e-11	1.543518	129	162	0.01331682	
GO Molecular Function	rRNA binding	14	6.959893e-22	2.0989048747142856e-19	3.251254	94	0.006443652	100	0.007208554137999999	1.453778	45	60	0.004645401	
GO Molecular Function	snRNA binding	61	8.928931e-11	6.179991259344263e-9	2.718702	56	0.003838772	96	0.005392290022916667	1.581303	31	38	0.003200165	
GO Molecular Function	thyroid hormone receptor binding	126	3.31187e-7	0.000011097392968253968	2.141741	55	0.003770222	99	0.0071612156666666675	1.661461	24	28	0.002477547	
GO Molecular Function	leucine zipper domain binding	201	0.000006591513	0.00013845456659701492	2.200033	40	0.00274198	119	0.024376476250420165	1.938371	11	11	0.001135542	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	11	1.459472e-22	1.2149441003636363e-19	2.574765	141	0.009665478	250	0.0020794191764	1.486084	46	60	0.004748632	
Mouse Phenotype Single KO	pale placenta	14	4.910798e-20	3.212012663285715e-17	3.971837	66	0.004524267	303	0.005519972572937294	1.938371	13	13	0.001342005	
Mouse Phenotype Single KO	early cellular replicative senescence	21	1.01234e-18	4.4142844666666666e-16	2.50568	121	0.008294489	288	0.0048418782125	1.491055	40	52	0.004129245	
Mouse Phenotype Single KO	increased squamous cell carcinoma incidence	28	4.582016e-18	1.4984828754285715e-15	3.042337	84	0.005758157	362	0.011860510656353592	1.64016	22	26	0.002271085	
Mouse Phenotype Single KO	increased integument system tumor incidence	37	2.620578e-16	6.485576417837838e-14	2.098239	151	0.01035097	507	0.038440544165680476	1.326254	52	76	0.005368019	
Mouse Phenotype Single KO	increased hemangiosarcoma incidence	54	2.470267e-13	4.1889323924074075e-11	2.646857	75	0.005141212	320	0.006956200896874999	1.696075	21	24	0.002167854	
Mouse Phenotype Single KO	increased fibroblast apoptosis	104	1.943271e-10	1.7110127449038463e-8	2.168552	84	0.005758157	366	0.01228240419180328	1.550697	28	35	0.002890472	
Mouse Phenotype Single KO	small superior cervical ganglion	138	3.199957e-9	2.1233337861594202e-7	2.174776	72	0.004935563	486	0.03501576506995885	1.514352	25	32	0.002580778	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	145	4.083449e-9	2.5787684477931035e-7	2.483222	54	0.003701673	314	0.006387727811783439	1.824349	16	17	0.001651698	
Mouse Phenotype Single KO	thin interventricular septum	264	6.624893e-7	0.000022978842879166666	2.125811	53	0.003633123	374	0.014263337391711232	1.734332	17	19	0.001754929	
Mouse Phenotype Single KO	abnormal hepatic vein morphology	567	0.0001093091	0.0017653323257495592	2.31933	26	0.001782287	387	0.016257056228165374	1.938371	11	11	0.001135542	
Mouse Phenotype Single KO	spina bifida cystica	921	0.0014487	0.014403632899022802	2.074195	22	0.001508089	533	0.04439275803752345	1.938371	9	9	0.0009290802	
Mouse Phenotype	abnormal cellular replicative senescence	9	3.521861e-28	3.7413903356666667e-25	2.419899	201	0.01377845	237	0.00012193397453164557	1.476854	64	84	0.006606793	
Mouse Phenotype	early cellular replicative senescence	14	3.494282e-25	2.3863450144285715e-22	2.422058	178	0.01220181	197	0.00003673229912741117	1.540076	58	73	0.005987406	
Mouse Phenotype	abnormal liver sinusoid morphology	20	3.741201e-24	1.78848113805e-21	2.11647	227	0.01556073	550	0.008890346262545454	1.3668	55	78	0.005677712	
Mouse Phenotype	pale placenta	42	1.927905e-19	4.388738025e-17	3.816002	67	0.004592816	586	0.011957257440614336	1.809146	14	15	0.001445236	
Mouse Phenotype	enlarged liver sinusoidal spaces	48	5.081018e-18	1.012075272875e-15	2.303595	137	0.009391281	833	0.0454986411752701	1.41832	30	41	0.003096934	
Mouse Phenotype	increased skin papilloma incidence	86	4.721116e-14	5.248673264651163e-12	2.214206	113	0.007746093	483	0.005688244698136646	1.523006	33	42	0.003406627	
Mouse Phenotype	increased lung adenoma incidence	99	4.272317e-13	4.126022508787879e-11	2.035531	127	0.008705786	478	0.005610598821338912	1.453778	42	56	0.004335708	
Mouse Phenotype	abnormal lung adenoma incidence	101	5.914389e-13	5.5987597256435646e-11	2.025473	127	0.008705786	554	0.009235563579422382	1.428273	42	57	0.004335708	
Mouse Phenotype	increased fibroblast apoptosis	111	1.482486e-12	1.2769413194594595e-10	2.160609	105	0.007197697	374	0.0018793426264973262	1.534544	38	48	0.003922783	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	208	4.983956e-9	2.2909424671153848e-7	2.268405	64	0.004387168	300	0.0005932575004	1.783301	23	25	0.002374316	
Mouse Phenotype	absent ductus venosus valve	238	2.253126e-8	9.051318355462184e-7	2.105615	69	0.004729915	804	0.04028428648134328	1.58594	18	22	0.00185816	
Mouse Phenotype	absent stapedial artery	329	4.339588e-7	0.000012611185674164134	2.13943	54	0.003701673	801	0.03987266442696629	1.632312	16	19	0.001651698	
Mouse Phenotype	abnormal hepatic vein morphology	707	0.0001093091	0.0014782239110325318	2.31933	26	0.001782287	579	0.011345520193264248	1.938371	11	11	0.001135542