# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of DNA-templated transcription in response to stress 152 3.740886e-73 3.238573610131579e-71 2.35148 576 0.01836735 954 0.028121086457023062 1.181807 95 119 0.007489751 GO Biological Process platelet-derived growth factor receptor signaling pathway 166 1.971336e-68 1.5626994231325302e-66 2.77647 397 0.01265944 930 0.024929102923655917 1.34579 30 33 0.002365184 GO Biological Process mammary gland epithelium development 219 1.890238e-57 1.1357827325114155e-55 2.070529 596 0.0190051 515 0.0015952701692621358 1.343298 49 54 0.003863135 GO Biological Process cholesterol metabolic process 265 3.426566e-52 1.7015163016603774e-50 2.075466 537 0.01712372 458 0.0007323882794104803 1.25567 95 112 0.007489751 GO Biological Process secondary alcohol metabolic process 266 3.622143e-52 1.7918714186842107e-50 2.053183 551 0.01757015 447 0.000631027039261745 1.25262 99 117 0.007805109 GO Biological Process negative regulation of Notch signaling pathway 272 1.297675e-51 6.27797989889706e-50 2.988794 264 0.008418367 930 0.024929102923655917 1.34579 30 33 0.002365184 GO Biological Process negative regulation of ERK1 and ERK2 cascade 353 8.43951e-45 3.1460485011331445e-43 2.022196 489 0.01559311 970 0.031056908615463917 1.25455 50 59 0.003941974 GO Biological Process cellular response to epidermal growth factor stimulus 410 6.957647e-40 2.2330652895853656e-38 2.319857 317 0.01010842 917 0.024109971460196295 1.324541 34 38 0.002680542 GO Biological Process response to epidermal growth factor 443 3.992791e-37 1.1860301753724604e-35 2.21072 326 0.01039541 951 0.027997993340694007 1.304135 37 42 0.002917061 GO Biological Process regulation of mitochondrial membrane permeability 484 2.30815e-34 6.275402035123967e-33 2.058093 355 0.01132015 910 0.02330130648021978 1.237021 61 73 0.004809208 GO Biological Process maintenance of protein location in cell 514 1.611307e-32 4.125134010311284e-31 2.017498 352 0.01122449 1044 0.03908791458716475 1.20957 67 82 0.005282245 GO Biological Process carbohydrate derivative transport 667 3.169328e-26 6.252651746926537e-25 2.147267 241 0.007684949 642 0.005321960779906542 1.315884 48 54 0.003784295 GO Biological Process regulation of protein kinase C signaling 707 1.146628e-24 2.1341552831683168e-23 2.392675 179 0.005707908 1015 0.03597823581477832 1.480369 15 15 0.001182592 GO Biological Process gene silencing by miRNA 757 3.119923e-23 5.4233905887714665e-22 2.145363 212 0.006760204 858 0.017773484013986016 1.312145 39 44 0.00307474 GO Biological Process positive regulation of adherens junction organization 924 6.165433e-20 8.780403987770562e-19 2.042325 202 0.006441327 1060 0.04064762960566038 1.366494 24 26 0.001892148 GO Biological Process regulation of production of miRNAs involved in gene silencing by miRNA 1161 4.205449e-16 4.766537759776055e-15 2.045168 159 0.005070153 1015 0.03597823581477832 1.480369 15 15 0.001182592 GO Cellular Component ruffle membrane 50 4.794239e-54 1.6568889984e-52 2.103648 539 0.0171875 88 0.002561247490909091 1.261678 75 88 0.005912961 GO Molecular Function phosphotyrosine binding 84 3.722049e-26 1.8707727235714286e-24 2.048175 269 0.008577806 135 0.029743101816296295 1.35348 32 35 0.002522863 GO Molecular Function myosin V binding 355 1.859924e-8 2.2119997543661974e-7 2.045868 75 0.002391582 143 0.037357732223776224 1.480369 17 17 0.001340271 Mouse Phenotype Single KO pale yolk sac 75 1.215311e-68 1.483813710266667e-66 2.078582 708 0.02257653 209 0.000031970592071770335 1.339381 76 84 0.005991801 Mouse Phenotype Single KO decreased fatty acid level 112 8.045494e-60 6.577909692678571e-58 2.081972 613 0.01954719 563 0.013575431411190053 1.196632 97 120 0.00764743 Mouse Phenotype Single KO abnormal body temperature 113 1.134517e-58 9.193603689380531e-57 2.03798 633 0.02018495 287 0.000387050756097561 1.277181 88 102 0.006937874 Mouse Phenotype Single KO decreased circulating free fatty acid level 117 2.596426e-58 2.0320916993162394e-56 2.201909 525 0.01674107 289 0.00038751219965397923 1.289354 81 93 0.006385998 Mouse Phenotype Single KO decreased sensitivity to induced cell death 122 7.122977e-57 5.346319704016394e-55 2.279131 475 0.01514668 629 0.01921019224165342 1.233641 65 78 0.005124566 Mouse Phenotype Single KO abnormal osteoblast differentiation 189 1.125581e-46 5.4534101677248677e-45 2.232418 405 0.01291454 754 0.036584182419098145 1.282986 39 45 0.00307474 Mouse Phenotype Single KO absent incisors 194 2.969663e-46 1.4017115510824742e-44 2.562015 305 0.009725765 454 0.00530386751938326 1.480369 21 21 0.001655629 Mouse Phenotype Single KO abnormal circulating tumor necrosis factor level 233 3.191213e-41 1.2541604051931329e-39 2.051103 433 0.0138074 763 0.038932707688073394 1.184295 84 105 0.006622517 Mouse Phenotype Single KO abnormal bone marrow morphology 245 3.58855e-40 1.3412388714285713e-38 2.350156 311 0.009917092 481 0.007256069623492723 1.34266 39 43 0.00307474 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 253 5.662959e-40 2.0496330262055335e-38 2.028562 431 0.01374362 473 0.00666131095243129 1.31278 47 53 0.003705456 Mouse Phenotype Single KO decreased placental labyrinth size 365 2.706268e-31 6.789396185205479e-30 2.190363 278 0.008864796 735 0.03317684505578231 1.299836 36 41 0.002838221 Mouse Phenotype Single KO abnormal B cell apoptosis 404 6.525594e-29 1.4790807984653467e-27 2.05747 296 0.009438776 619 0.018561431311793216 1.328536 35 39 0.002759382 Mouse Phenotype Single KO increased B cell apoptosis 467 4.369862e-26 8.568485296359744e-25 2.279354 210 0.006696429 644 0.02056686372204969 1.416005 22 23 0.001734469 Mouse Phenotype Single KO increased hepatocyte apoptosis 490 3.485352e-25 6.5133404620408165e-24 2.107738 241 0.007684949 510 0.009248882415294117 1.339381 38 42 0.0029959 Mouse Phenotype Single KO increased circulating interferon-gamma level 833 3.207913e-16 3.5263936783913566e-15 2.036501 162 0.005165816 649 0.02163375818027735 1.308233 38 43 0.0029959 Mouse Phenotype extramedullary hematopoiesis 34 9.075146e-122 2.551984438411765e-119 2.230792 1074 0.03424745 587 0.0027207169252129472 1.184295 140 175 0.01103753 Mouse Phenotype increased bone marrow cell number 193 3.167997e-53 1.5693896019170983e-51 2.482447 374 0.01192602 1144 0.04723535996590909 1.248154 43 51 0.003390098 Mouse Phenotype decreased sensitivity to induced cell death 198 6.442592e-52 3.110991015757576e-50 2.072409 536 0.01709184 735 0.009371230410204082 1.225682 77 93 0.00607064 Mouse Phenotype abnormal vertebral body morphology 215 2.889492e-50 1.2849503726511629e-48 2.027658 547 0.0174426 1100 0.04156534363909091 1.225931 53 64 0.004178493 Mouse Phenotype abnormal transitional stage T2 B cell morphology 317 9.443193e-41 2.8481504187066246e-39 2.757715 235 0.007493622 1161 0.048247260072351424 1.327227 26 29 0.002049827 Mouse Phenotype increased transitional stage B cell number 374 9.884336e-36 2.5268485694117647e-34 2.35058 275 0.008769133 970 0.029458998358762888 1.315884 32 36 0.002522863 Mouse Phenotype abnormal Paneth cell morphology 377 3.433145e-35 8.706710701591512e-34 2.150448 328 0.01045918 1176 0.048495692818877556 1.285584 33 38 0.002601703 Mouse Phenotype ruffled hair 502 2.988605e-28 5.692042311752988e-27 2.453771 197 0.006281888 765 0.011886217702745097 1.35348 32 35 0.002522863 Mouse Phenotype increased renal glomerulus basement membrane thickness 512 5.165696e-28 9.646331925e-27 2.079191 279 0.008896684 1085 0.04029617832718894 1.290578 34 39 0.002680542 Mouse Phenotype increased follicular B cell number 526 1.182802e-27 2.1499562589353614e-26 2.235692 233 0.007429847 925 0.024694326515675675 1.341584 29 32 0.002286345 Mouse Phenotype enlarged liver sinusoidal spaces 609 5.406689e-24 8.488235390640394e-23 2.010196 257 0.008195153 728 0.009123353104945055 1.335943 37 41 0.002917061 Mouse Phenotype increased circulating interferon-gamma level 637 2.937927e-23 4.409657778178964e-22 2.202419 200 0.006377551 844 0.01738996367772512 1.281089 45 52 0.003547777 Mouse Phenotype increased myocardial infarction size 828 1.101818e-18 1.2722804224637682e-17 2.212219 156 0.00497449 1001 0.031274288889110886 1.366494 24 26 0.001892148 Mouse Phenotype abnormal prechordal plate morphology 1235 1.18551e-12 9.177863246963564e-12 2.474768 80 0.00255102 1181 0.04926933070110076 1.480369 13 13 0.001024913 Mouse Phenotype decreased core body temperature 1270 2.270977e-12 1.7096701651181103e-11 2.367845 85 0.002710459 633 0.003971868984834123 1.480369 21 21 0.001655629