# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage Mouse Phenotype Single KO absent pinna reflex 28 6.928216e-8 0.000022657740682857143 2.912189 34 0.02509225 337 0.028756050448071217 2.394598 15 63 0.00803428 Mouse Phenotype Single KO abnormal cochlear inner hair cell number 29 7.108058e-8 0.000022444305898620688 3.629099 25 0.01845018 344 0.0296484227994186 3.232707 9 28 0.004820568 Mouse Phenotype Single KO abnormal vestibular system physiology 33 1.872391e-7 0.00005195601329393939 2.956496 31 0.02287823 402 0.03927961207960199 2.567824 12 47 0.006427424 Mouse Phenotype Single KO abnormal pinna reflex 34 2.732083e-7 0.00007358142362058823 2.49689 40 0.0295203 120 0.00119319601725 2.793698 20 72 0.01071237 Mouse Phenotype Single KO abnormal outer hair cell stereociliary bundle morphology 35 2.79702e-7 0.00007317803468571429 3.03086 29 0.02140221 309 0.022502604422977347 2.560043 14 55 0.007498661 Mouse Phenotype Single KO abnormal cochlear hair cell stereociliary bundle morphology 40 0.00000143158 0.0003277244515 2.583965 33 0.02435424 254 0.011349283138188976 2.413755 18 75 0.009641136 Mouse Phenotype Single KO abnormal cochlear outer hair cell number 49 0.000009993049 0.0018674765243469386 2.46843 30 0.02214022 376 0.034332369324468086 2.623646 12 46 0.006427424 Mouse Phenotype Single KO abnormal thyroid follicle morphology 59 0.00004380211 0.0067982359537288135 4.201733 12 0.008856089 179 0.004609826148156425 4.310276 9 21 0.004820568 Mouse Phenotype Single KO abnormal cochlear hair cell number 62 0.00005713463 0.008438416240483871 2.145322 33 0.02435424 281 0.016468978555160142 2.556944 15 59 0.00803428 Mouse Phenotype Single KO disorganized yolk sac vascular plexus 75 0.0002201576 0.02687977524266667 3.525154 12 0.008856089 397 0.037586532617128465 3.705325 7 19 0.00374933 Mouse Phenotype Single KO abnormal circulating iron level 78 0.0002538898 0.029806011520512817 2.489088 20 0.01476015 419 0.047431030849642 2.174554 16 74 0.008569898 Mouse Phenotype Single KO disproportionate dwarf 90 0.0004260225 0.04334542258333333 2.276828 22 0.01623616 309 0.022502604422977347 2.560043 14 55 0.007498661 Mouse Phenotype unidirectional circling 8 1.678222e-12 2.00568506775e-9 7.737065 21 0.01549815 811 0.04960894024290998 4.190546 5 12 0.002678093 Mouse Phenotype decreased cochlear inner hair cell number 11 1.445732e-11 1.2566039683636363e-8 5.846471 24 0.01771218 426 0.008886258235211268 4.022924 8 20 0.004284949 Mouse Phenotype abnormal cochlear inner hair cell number 26 5.539853e-8 0.000020371744051153845 3.367841 28 0.02066421 277 0.002114863516028881 3.549639 12 34 0.006427424 Mouse Phenotype absent pinna reflex 32 2.861146e-7 0.00008548567783125 2.735397 34 0.02509225 624 0.02278030826923077 2.320918 15 65 0.00803428 Mouse Phenotype abnormal outer hair cell stereociliary bundle morphology 33 3.80812e-7 0.00011033162218181818 2.858078 31 0.02287823 434 0.008994664959677419 2.514328 16 64 0.008569898 Mouse Phenotype abnormal pinna reflex 34 8.445323e-7 0.0002374874505970588 2.384571 40 0.0295203 238 0.0009763323615126051 2.718192 20 74 0.01071237 Mouse Phenotype abnormal thyroid follicle morphology 37 0.000001074693 0.0002777064803513514 4.49622 16 0.01180812 240 0.001046819150125 4.097423 11 27 0.005891805 Mouse Phenotype abnormal utricle morphology 43 0.000005727278 0.0012734536036744185 2.54272 30 0.02214022 544 0.016443890083455884 2.614901 13 50 0.006963042 Mouse Phenotype abnormal thyroid physiology 44 0.000007462701 0.0016216110059318182 3.498767 18 0.01328413 192 0.00037600305675 3.961971 13 33 0.006963042 Mouse Phenotype abnormal cochlear hair cell stereociliary bundle morphology 46 0.00001035673 0.0021526238158695653 2.247458 36 0.02656827 339 0.004471135371681416 2.346706 21 90 0.01124799 Mouse Phenotype abnormal cochlear outer hair cell number 50 0.00001265083 0.0024190917126 2.321332 33 0.02435424 357 0.004726138885714286 2.793698 15 54 0.00803428 Mouse Phenotype decreased activity of thyroid 52 0.00001592176 0.0029274605261538464 4.043666 14 0.0103321 302 0.0028528618343046357 4.310276 9 21 0.004820568 Mouse Phenotype decreased cochlear outer hair cell number 53 0.00002479119 0.004472237124339622 2.533202 26 0.01918819 758 0.040671674125329814 2.646661 10 38 0.005356186 Mouse Phenotype abnormal neural fold elevation formation 58 0.00004735807 0.007806732883965517 4.16706 12 0.008856089 351 0.0047264435769230765 5.028656 7 14 0.00374933 Mouse Phenotype disorganized yolk sac vascular plexus 60 0.00008566364 0.013650501034 3.275775 15 0.01107011 290 0.002442845390689655 4.022924 10 25 0.005356186 Mouse Phenotype abnormal vestibular saccule morphology 64 0.0001305835 0.019507950679687497 2.135903 30 0.02214022 696 0.032877559060344834 2.377183 13 55 0.006963042 Mouse Phenotype increased thyroid-stimulating hormone level 72 0.0001770984 0.0235171917 3.060624 15 0.01107011 261 0.001787428583678161 4.190546 10 24 0.005356186 Mouse Phenotype decreased cochlear hair cell number 77 0.0002385973 0.029626347861038963 2.059937 30 0.02214022 506 0.014347982962648222 2.560043 14 55 0.007498661 Mouse Phenotype disproportionate dwarf 80 0.0002567104 0.03068010168 2.145908 27 0.0199262 244 0.0011354667110655737 2.769405 19 69 0.01017675 Mouse Phenotype increased circulating iron level 81 0.0002572674 0.030367081622222226 2.953374 15 0.01107011 712 0.03502253384831461 2.572801 11 43 0.005891805